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Aliases for SGTB Gene

Aliases for SGTB Gene

  • Small Glutamine Rich Tetratricopeptide Repeat Containing Beta 2 3 5
  • Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, Beta 2 3
  • Beta-SGT 3 4
  • SGT2 3 4
  • Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Beta 3
  • Small Glutamine Rich Protein With Tetratricopeptide Repeats 2 3
  • Small Glutamine-Rich Protein With Tetratricopeptide Repeats 2 4

External Ids for SGTB Gene

Previous GeneCards Identifiers for SGTB Gene

  • GC05M064980
  • GC05M064979
  • GC05M065000
  • GC05M061917

Summaries for SGTB Gene

GeneCards Summary for SGTB Gene

SGTB (Small Glutamine Rich Tetratricopeptide Repeat Containing Beta) is a Protein Coding gene. An important paralog of this gene is SGTA.

UniProtKB/Swiss-Prot for SGTB Gene

  • Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

Additional gene information for SGTB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGTB Gene

Genomics for SGTB Gene

GeneHancer (GH) Regulatory Elements for SGTB Gene

Promoters and enhancers for SGTB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I065720 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.9 889 2.9 PKNOX1 ZNF133 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 YY1 ZNF121 NLN SGTB PPWD1 SREK1 CENPK ENSG00000250081 TRIM23
GH05I066142 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 -421.6 -421615 4.2 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D GLIS1 SREK1 ENSG00000253744 PPWD1 TRAPPC13 TRIM23 NLN SGTB
GH05I065623 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.3 +98.2 98222 3.2 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B TRAPPC13 ENSG00000253251 TRIM23 PPWD1 CENPK SREK1 RNU6-540P NLN SGTB
GH05I065809 Enhancer 1.2 Ensembl ENCODE dbSUPER 14.9 -89.0 -89003 4.6 MZF1 FEZF1 RAD21 RFX5 ZNF335 TCF12 RCOR1 FOS CEBPB TSHZ1 SGTB NLN ENSG00000252904 TRAPPC13 CENPK GC05P065768 ENSG00000269961
GH05I065790 Enhancer 0.6 ENCODE 16.3 -67.5 -67466 0.6 PKNOX1 KLF1 ZIC2 ZNF274 ZFHX2 ZNF143 PRDM10 EGR2 SPI1 SGTB NLN PPWD1 SREK1 ERBIN ENSG00000252904 GC05P065768 ENSG00000269961
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SGTB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SGTB gene promoter:

Genomic Locations for SGTB Gene

Genomic Locations for SGTB Gene
57,108 bases
Minus strand

Genomic View for SGTB Gene

Genes around SGTB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGTB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGTB Gene

Proteins for SGTB Gene

  • Protein details for SGTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small glutamine-rich tetratricopeptide repeat-containing protein beta
    Protein Accession:

    Protein attributes for SGTB Gene

    304 amino acids
    Molecular mass:
    33429 Da
    Quaternary structure:
    • Homooligomerize.

neXtProt entry for SGTB Gene

Post-translational modifications for SGTB Gene

  • Ubiquitination at isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for SGTB Gene

No data available for DME Specific Peptides for SGTB Gene

Domains & Families for SGTB Gene

Gene Families for SGTB Gene

Protein Domains for SGTB Gene

Suggested Antigen Peptide Sequences for SGTB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SGT family.
  • Belongs to the SGT family.
genes like me logo Genes that share domains with SGTB: view

Function for SGTB Gene

Molecular function for SGTB Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

Phenotypes From GWAS Catalog for SGTB Gene

Gene Ontology (GO) - Molecular Function for SGTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SGTB: view

Phenotypes for SGTB Gene

genes like me logo Genes that share phenotypes with SGTB: view

Animal Model Products

miRNA for SGTB Gene

miRTarBase miRNAs that target SGTB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SGTB Gene

Localization for SGTB Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGTB gene
Compartment Confidence
mitochondrion 2
peroxisome 2
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SGTB Gene

Pathways & Interactions for SGTB Gene

No Data Available

Gene Ontology (GO) - Biological Process for SGTB Gene


No data available for Pathways by source and SIGNOR curated interactions for SGTB Gene

Drugs & Compounds for SGTB Gene

No Compound Related Data Available

Transcripts for SGTB Gene

mRNA/cDNA for SGTB Gene

Unigene Clusters for SGTB Gene

Small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGTB Gene

No ASD Table

Relevant External Links for SGTB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SGTB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SGTB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SGTB Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.3) and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for SGTB Gene

This gene is overexpressed in Bone (50.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SGTB Gene

Protein tissue co-expression partners for SGTB Gene

NURSA nuclear receptor signaling pathways regulating expression of SGTB Gene:


SOURCE GeneReport for Unigene cluster for SGTB Gene:


Evidence on tissue expression from TISSUES for SGTB Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with SGTB: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGTB Gene

Orthologs for SGTB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGTB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SGTB 33 34
  • 99.67 (n)
(Monodelphis domestica)
Mammalia SGTB 34
  • 96 (a)
(Bos Taurus)
Mammalia SGTB 33 34
  • 94.3 (n)
(Canis familiaris)
Mammalia SGTB 33 34
  • 94.19 (n)
(Rattus norvegicus)
Mammalia Sgtb 33
  • 88.27 (n)
(Mus musculus)
Mammalia Sgtb 33 16 34
  • 87.72 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 79 (a)
-- 34
  • 51 (a)
(Gallus gallus)
Aves SGTB 33 34
  • 80.37 (n)
(Anolis carolinensis)
Reptilia SGTB 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sgtb 33
  • 70.39 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13292 33
(Danio rerio)
Actinopterygii sgtb 34
  • 70 (a)
sgta 33
  • 68.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003052 33
  • 49.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sgt 33 34
  • 49.79 (n)
(Caenorhabditis elegans)
Secernentea sgt-1 34
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR005W 33
  • 48.6 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01155g 33
  • 48.15 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 33 34
  • 47.35 (n)
TAH1 36
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1142.02c 33
  • 50.26 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10273 33
  • 43.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10634 34
  • 38 (a)
Species where no ortholog for SGTB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGTB Gene

Gene Tree for SGTB (if available)
Gene Tree for SGTB (if available)

Paralogs for SGTB Gene

Paralogs for SGTB Gene

(5) SIMAP similar genes for SGTB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SGTB: view

Variants for SGTB Gene

Sequence variations from dbSNP and Humsavar for SGTB Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000094207 -- 65,686,884(-) C/T intron_variant
rs1000100769 -- 65,672,575(-) G/C intron_variant
rs1000125559 -- 65,686,660(-) C/T intron_variant
rs1000160309 -- 65,708,970(-) G/A intron_variant
rs1000185231 -- 65,691,443(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SGTB Gene

Variant ID Type Subtype PubMed ID
esv3367273 CNV insertion 20981092
esv3894204 CNV loss 25118596
nsv517021 CNV loss 19592680

Variation tolerance for SGTB Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SGTB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGTB Gene

Disorders for SGTB Gene

Additional Disease Information for SGTB

No disorders were found for SGTB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGTB Gene

Publications for SGTB Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58
  5. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 58

Products for SGTB Gene

Sources for SGTB Gene

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