Aliases for SGTB Gene

Aliases for SGTB Gene

  • Small Glutamine Rich Tetratricopeptide Repeat Containing Beta 2 3 5
  • Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Beta 3 4
  • Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, Beta 2 3
  • Beta-SGT 3 4
  • SGT2 3 4
  • Small Glutamine Rich Protein With Tetratricopeptide Repeats 2 3
  • Small Glutamine-Rich Protein With Tetratricopeptide Repeats 2 4

External Ids for SGTB Gene

Previous GeneCards Identifiers for SGTB Gene

  • GC05M064980
  • GC05M064979
  • GC05M065000
  • GC05M061917

Summaries for SGTB Gene

GeneCards Summary for SGTB Gene

SGTB (Small Glutamine Rich Tetratricopeptide Repeat Containing Beta) is a Protein Coding gene. An important paralog of this gene is SGTA.

UniProtKB/Swiss-Prot Summary for SGTB Gene

  • Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

Additional gene information for SGTB Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SGTB Gene

Genomics for SGTB Gene

GeneHancer (GH) Regulatory Elements for SGTB Gene

Promoters and enhancers for SGTB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SGTB on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SGTB

Top Transcription factor binding sites by QIAGEN in the SGTB gene promoter:
  • c-Myc
  • E47
  • GR
  • GR-alpha
  • Lmo2
  • Max
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for SGTB Gene

Genomic Locations for SGTB Gene
chr5:65,665,928-65,723,035
(GRCh38/hg38)
Size:
57,108 bases
Orientation:
Minus strand
chr5:64,961,755-65,018,862
(GRCh37/hg19)
Size:
57,108 bases
Orientation:
Minus strand

Genomic View for SGTB Gene

Genes around SGTB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGTB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGTB Gene

Proteins for SGTB Gene

  • Protein details for SGTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EQ0-SGTB_HUMAN
    Recommended name:
    Small glutamine-rich tetratricopeptide repeat-containing protein beta
    Protein Accession:
    Q96EQ0

    Protein attributes for SGTB Gene

    Size:
    304 amino acids
    Molecular mass:
    33429 Da
    Quaternary structure:
    • Homooligomerize.

neXtProt entry for SGTB Gene

Post-translational modifications for SGTB Gene

  • Ubiquitination at Lys5
  • Modification sites at PhosphoSitePlus

Other Protein References for SGTB Gene

No data available for DME Specific Peptides for SGTB Gene

Domains & Families for SGTB Gene

Gene Families for SGTB Gene

Protein Domains for SGTB Gene

Suggested Antigen Peptide Sequences for SGTB Gene

GenScript: Design optimal peptide antigens:
  • Small glutamine-rich protein with tetratricopeptide repeats 2 (SGTB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96EQ0

UniProtKB/Swiss-Prot:

SGTB_HUMAN :
  • Belongs to the SGT family.
Family:
  • Belongs to the SGT family.
genes like me logo Genes that share domains with SGTB: view

Function for SGTB Gene

Molecular function for SGTB Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

Phenotypes From GWAS Catalog for SGTB Gene

Gene Ontology (GO) - Molecular Function for SGTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SGTB: view
genes like me logo Genes that share phenotypes with SGTB: view

Animal Model Products

CRISPR Products

miRNA for SGTB Gene

miRTarBase miRNAs that target SGTB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SGTB Gene

Localization for SGTB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGTB gene
Compartment Confidence
cytosol 4
mitochondrion 2
plasma membrane 1
extracellular 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SGTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA 21873635
GO:0016020 membrane IBA 21873635
GO:0072380 TRC complex IBA 21873635
genes like me logo Genes that share ontologies with SGTB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SGTB Gene

Pathways & Interactions for SGTB Gene

PathCards logo

SuperPathways for SGTB Gene

No Data Available

Gene Ontology (GO) - Biological Process for SGTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane IBA 21873635
GO:0030433 ubiquitin-dependent ERAD pathway IBA 21873635
GO:1903646 positive regulation of chaperone-mediated protein folding IBA 21873635
genes like me logo Genes that share ontologies with SGTB: view

No data available for Pathways by source and SIGNOR curated interactions for SGTB Gene

Drugs & Compounds for SGTB Gene

No Compound Related Data Available

Transcripts for SGTB Gene

mRNA/cDNA for SGTB Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGTB Gene

No ASD Table

Relevant External Links for SGTB Gene

GeneLoc Exon Structure for
SGTB

Expression for SGTB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SGTB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SGTB Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.3) and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for SGTB Gene

This gene is overexpressed in Bone (50.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SGTB Gene



Protein tissue co-expression partners for SGTB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SGTB

SOURCE GeneReport for Unigene cluster for SGTB Gene:

Hs.482301

Evidence on tissue expression from TISSUES for SGTB Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with SGTB: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGTB Gene

Orthologs for SGTB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGTB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGTB 31 30
  • 99.67 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SGTB 31
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SGTB 31 30
  • 94.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SGTB 31 30
  • 94.19 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sgtb 30
  • 88.27 (n)
mouse
(Mus musculus)
Mammalia Sgtb 17 31 30
  • 87.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 79 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves SGTB 31 30
  • 80.37 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SGTB 31
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sgtb 30
  • 70.39 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13292 30
zebrafish
(Danio rerio)
Actinopterygii sgtb 31
  • 70 (a)
OneToOne
sgta 30
  • 68.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003052 30
  • 49.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sgt 31 30
  • 49.79 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sgt-1 31
  • 34 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR005W 30
  • 48.6 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01155g 30
  • 48.15 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 31 30
  • 47.35 (n)
OneToMany
TAH1 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1142.02c 30
  • 50.26 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10273 30
  • 43.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10634 31
  • 38 (a)
OneToMany
Species where no ortholog for SGTB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGTB Gene

ENSEMBL:
Gene Tree for SGTB (if available)
TreeFam:
Gene Tree for SGTB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SGTB: view image

Paralogs for SGTB Gene

(5) SIMAP similar genes for SGTB Gene using alignment to 2 proteins:

  • SGTB_HUMAN
  • D6RFW1_HUMAN
genes like me logo Genes that share paralogs with SGTB: view

Variants for SGTB Gene

Additional dbSNP identifiers (rs#s) for SGTB Gene

Structural Variations from Database of Genomic Variants (DGV) for SGTB Gene

Variant ID Type Subtype PubMed ID
esv3367273 CNV insertion 20981092
esv3894204 CNV loss 25118596
nsv517021 CNV loss 19592680

Variation tolerance for SGTB Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SGTB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SGTB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SGTB Gene

Disorders for SGTB Gene

Additional Disease Information for SGTB

No disorders were found for SGTB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGTB Gene

Publications for SGTB Gene

  1. SGTb regulates a surface localization of a guidance receptor BOC to promote neurite outgrowth. (PMID: 30639199) Vuong TA … Kang JS (Cellular signalling 2019) 2 3 54
  2. Up-regulation of SGTB is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide. (PMID: 23820636) Cao M … Wu Q (Journal of molecular histology 2013) 2 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 54

Products for SGTB Gene

Sources for SGTB Gene