This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008] See more...

Aliases for SGTA Gene

Aliases for SGTA Gene

  • Small Glutamine Rich Tetratricopeptide Repeat Containing Alpha 2 3 5
  • Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha 3 4
  • Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, Alpha 2 3
  • Vpu-Binding Protein 3 4
  • Alpha-SGT 3 4
  • SGT 3 4
  • UBP 3 4
  • Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing 2
  • Protein Containing Three Tetratricopeptide Repeats 3
  • AlphaSGT 3
  • HSGT 3
  • SGTA 5
  • SGT1 4

External Ids for SGTA Gene

Previous HGNC Symbols for SGTA Gene

  • SGT

Previous GeneCards Identifiers for SGTA Gene

  • GC19M002705
  • GC19M002525

Summaries for SGTA Gene

Entrez Gene Summary for SGTA Gene

  • This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]

GeneCards Summary for SGTA Gene

SGTA (Small Glutamine Rich Tetratricopeptide Repeat Containing Alpha) is a Protein Coding gene. Diseases associated with SGTA include Central Nervous System Rhabdomyosarcoma and Pulp Degeneration. An important paralog of this gene is SGTB.

UniProtKB/Swiss-Prot Summary for SGTA Gene

  • Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).
  • (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744).

Gene Wiki entry for SGTA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SGTA Gene

Genomics for SGTA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SGTA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SGTA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SGTA

Top Transcription factor binding sites by QIAGEN in the SGTA gene promoter:
  • CREB
  • deltaCREB
  • NF-kappaB
  • NF-kappaB1
  • SRY

Genomic Locations for SGTA Gene

Genomic Locations for SGTA Gene
chr19:2,754,714-2,783,317
(GRCh38/hg38)
Size:
28,604 bases
Orientation:
Minus strand
chr19:2,754,712-2,783,369
(GRCh37/hg19)
Size:
28,658 bases
Orientation:
Minus strand

Genomic View for SGTA Gene

Genes around SGTA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGTA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGTA Gene

Proteins for SGTA Gene

  • Protein details for SGTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43765-SGTA_HUMAN
    Recommended name:
    Small glutamine-rich tetratricopeptide repeat-containing protein alpha
    Protein Accession:
    O43765
    Secondary Accessions:
    • D6W610
    • Q6FIA9
    • Q9BTZ9

    Protein attributes for SGTA Gene

    Size:
    313 amino acids
    Molecular mass:
    34063 Da
    Quaternary structure:
    • Homodimer (PubMed:15708368). Homooligomer (By similarity). Interacts with DNAJC5 and DNAJC5B. Interacts (via TPR repeats) with HSP90AA1 (PubMed:15708368). Interacts (via Gln-rich region) with SLC2A1 (PubMed:15708368). Interacts with HSP90AB1 (PubMed:16580629). Interacts (via TPR repeats) with HSPA8/Hsc70; the interaction is direct (PubMed:24675744). Interacts with BAG6 (via ubiquitin-like domain); interaction prevents interaction between BAG6 and RNF126 (PubMed:23129660, PubMed:25179605, PubMed:27193484). Forms a multiprotein complex, at least composed of DNAJB12, DNAJB14, HSPA8/Hsc70 and SGTA; interaction with DNAJB14 and HSPA8/Hsc70 is direct (PubMed:24675744).
    • (Microbial infection) Interacts with Vpu and Gag from HIV-1.
    • (Microbial infection) Interacts with SARS-CoV accessory protein 7a.

    Three dimensional structures from OCA and Proteopedia for SGTA Gene

neXtProt entry for SGTA Gene

Post-translational modifications for SGTA Gene

  • Ubiquitination at Lys103, Lys116, Lys137, Lys160, Lys174, Lys183, Lys184, and Lys200
  • Modification sites at PhosphoSitePlus

Other Protein References for SGTA Gene

No data available for DME Specific Peptides for SGTA Gene

Domains & Families for SGTA Gene

Protein Domains for SGTA Gene

Suggested Antigen Peptide Sequences for SGTA Gene

GenScript: Design optimal peptide antigens:
  • Vpu-binding protein (SGTA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43765

UniProtKB/Swiss-Prot:

SGTA_HUMAN :
  • The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a.
  • Belongs to the SGT family.
Domain:
  • The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a.
Family:
  • Belongs to the SGT family.
genes like me logo Genes that share domains with SGTA: view

Function for SGTA Gene

Molecular function for SGTA Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744).

Gene Ontology (GO) - Molecular Function for SGTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 14667819
GO:0042802 identical protein binding IPI 25036637
GO:0043621 protein self-association IDA 15708368
GO:0060090 molecular adaptor activity IBA 21873635
GO:1904288 BAT3 complex binding IPI 23246001
genes like me logo Genes that share ontologies with SGTA: view
genes like me logo Genes that share phenotypes with SGTA: view

Animal Models for SGTA Gene

MGI Knock Outs for SGTA:
  • Sgta Sgta<tm1.1Drmcr>
  • Sgta Sgta<tm1b(KOMP)Mbp>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SGTA

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SGTA Gene

Localization for SGTA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGTA Gene

Cytoplasm. Nucleus. Note=Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis. {ECO:0000269 PubMed:16580629}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGTA gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SGTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16580629
GO:0005737 cytoplasm IEA,IDA 16580629
GO:0005829 cytosol IDA 23246001
GO:0016020 membrane IDA 23246001
GO:0072380 TRC complex IBA 21873635
genes like me logo Genes that share ontologies with SGTA: view

Pathways & Interactions for SGTA Gene

PathCards logo

SuperPathways for SGTA Gene

No Data Available

Gene Ontology (GO) - Biological Process for SGTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane IBA 21873635
GO:0016032 viral process IEA --
GO:0030433 ubiquitin-dependent ERAD pathway IBA,IDA 23129660
GO:0061077 chaperone-mediated protein folding IEA --
GO:0071816 tail-anchored membrane protein insertion into ER membrane IDA 25535373
genes like me logo Genes that share ontologies with SGTA: view

No data available for Pathways by source and SIGNOR curated interactions for SGTA Gene

Drugs & Compounds for SGTA Gene

(1) Drugs for SGTA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SGTA: view

Transcripts for SGTA Gene

mRNA/cDNA for SGTA Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SGTA

Alternative Splicing Database (ASD) splice patterns (SP) for SGTA Gene

No ASD Table

Relevant External Links for SGTA Gene

GeneLoc Exon Structure for
SGTA

Expression for SGTA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SGTA Gene

Protein differential expression in normal tissues from HIPED for SGTA Gene

This gene is overexpressed in Bone (23.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SGTA Gene



Protein tissue co-expression partners for SGTA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SGTA

SOURCE GeneReport for Unigene cluster for SGTA Gene:

Hs.203910

mRNA Expression by UniProt/SwissProt for SGTA Gene:

O43765-SGTA_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for SGTA Gene

  • Muscle(4.6)
  • Lung(4.6)
  • Liver(4.5)
  • Nervous system(4.4)
  • Eye(2.9)
  • Skin(2.8)
  • Kidney(2.7)
  • Blood(2.5)
  • Intestine(2.5)
  • Heart(2.5)
  • Pancreas(2.3)
  • Spleen(2.2)
  • Lymph node(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with SGTA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGTA Gene

Orthologs for SGTA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGTA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SGTA 30 31
  • 98.94 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SGTA 30 31
  • 89.78 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SGTA 30 31
  • 88.39 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 84 (a)
OneToMany
-- 31
  • 66 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia SGTA 31
  • 84 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sgta 30
  • 83.92 (n)
Mouse
(Mus musculus)
Mammalia Sgta 30 17 31
  • 82.96 (n)
OneToOne
Chicken
(Gallus gallus)
Aves SGTA 30 31
  • 74.06 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SGTA 31
  • 77 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sgta 30
  • 68.49 (n)
LOC394994 30
Zebrafish
(Danio rerio)
Actinopterygii sgta 31
  • 69 (a)
OneToMany
SGTA (1 of 2) 31
  • 67 (a)
OneToMany
zgc:55741 30
  • 66.56 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Sgt 31
  • 30 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea sgt-1 30 31
  • 50.72 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 31 33
  • 31 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10634 31
  • 40 (a)
OneToMany
Species where no ortholog for SGTA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SGTA Gene

ENSEMBL:
Gene Tree for SGTA (if available)
TreeFam:
Gene Tree for SGTA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SGTA: view image

Paralogs for SGTA Gene

(2) SIMAP similar genes for SGTA Gene using alignment to 3 proteins:

  • SGTA_HUMAN
  • K7EMD6_HUMAN
  • K7ERW5_HUMAN
genes like me logo Genes that share paralogs with SGTA: view

Variants for SGTA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SGTA Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
690305 Uncertain Significance: not provided 2,757,697(-) G/A NONSENSE
712653 Benign: not provided 2,759,289(-) C/T SYNONYMOUS_VARIANT
713387 Benign: not provided 2,767,212(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SGTA Gene

Structural Variations from Database of Genomic Variants (DGV) for SGTA Gene

Variant ID Type Subtype PubMed ID
esv1158443 CNV deletion 17803354
esv1403577 CNV deletion 17803354
esv2363232 CNV deletion 18987734
esv2605105 CNV deletion 19546169
esv29323 CNV loss 19812545
nsv509714 CNV insertion 20534489
nsv578412 CNV gain 21841781
nsv828397 CNV gain 20364138

Variation tolerance for SGTA Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SGTA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SGTA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGTA Gene

Disorders for SGTA Gene

MalaCards: The human disease database

(6) MalaCards diseases for SGTA Gene - From: DISEASES

Disorder Aliases PubMed IDs
central nervous system rhabdomyosarcoma
  • rhabdomyosarcoma of the cns
pulp degeneration
mucocele of salivary gland
  • mucous retention cyst of salivary gland
otomycosis
  • singapore ear
pontiac fever
- elite association - COSMIC cancer census association via MalaCards
Search SGTA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SGTA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SGTA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SGTA Gene

Publications for SGTA Gene

  1. Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans. (PMID: 9740675) Kordes E … Cziepluch C (Genomics 1998) 2 3 4 23
  2. Structural and functional characterization of human SGT and its interaction with Vpu of the human immunodeficiency virus type 1. (PMID: 18759457) Dutta S … Tan YJ (Biochemistry 2008) 3 4 23
  3. Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome. (PMID: 18332089) Goodarzi MO … Azziz R (Human reproduction (Oxford, England) 2008) 3 23 41
  4. Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT. (PMID: 16580632) Fielding BC … Tan YJ (Biochemical and biophysical research communications 2006) 3 4 23
  5. SGT, a Hsp90beta binding partner, is accumulated in the nucleus during cell apoptosis. (PMID: 16580629) Yin H … Gu J (Biochemical and biophysical research communications 2006) 3 4 23

Products for SGTA Gene

Sources for SGTA Gene