Aliases for SGSM2 Gene
External Ids for SGSM2 Gene
Previous HGNC Symbols for SGSM2 Gene
Previous GeneCards Identifiers for SGSM2 Gene
The protein encoded by this gene is a GTPase activator with activity towards RAB32 and RAB33B, which are regulators of membrane trafficking. The encoded protein inactivates RAB32 and can bind RAB9A-GTP, a protein required for RAB32 activation. [provided by RefSeq, Oct 2016]
GeneCards Summary for SGSM2 Gene
SGSM2 (Small G Protein Signaling Modulator 2) is a Protein Coding gene. Diseases associated with SGSM2 include Diabetes Mellitus, Insulin-Dependent, 19 and Chromosome 17P13.3, Centromeric, Duplication Syndrome. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is SGSM1.
UniProtKB/Swiss-Prot Summary for SGSM2 Gene
Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:26620560, PubMed:21808068). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560).