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The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar... See more...
Aliases for SGPP2 Gene
Aliases for SGPP2 Gene
External Ids for SGPP2 Gene
- HGNC: 19953
- NCBI Entrez Gene: 130367
- Ensembl: ENSG00000163082
- OMIM®: 612827
- UniProtKB/Swiss-Prot: Q8IWX5
Previous GeneCards Identifiers for SGPP2 Gene
- GC02P222010
- GC02P223252
- GC02P223491
- GC02P223114
- GC02P222997
- GC02P223288
- GC02P215143
Summaries for SGPP2 Gene
-
The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
GeneCards Summary for SGPP2 Gene
SGPP2 (Sphingosine-1-Phosphate Phosphatase 2) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include sphingosine-1-phosphate phosphatase activity. An important paralog of this gene is SGPP1.
UniProtKB/Swiss-Prot Summary for SGPP2 Gene
-
Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (PubMed:12411432). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (PubMed:17113265). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity).
Additional gene information for SGPP2 Gene
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SGPP2 Gene
Genomics for SGPP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SGPP2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J222423 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE | 250.7 | +2.1 | 2131 | 5.4 | BCLAF1 SP1 ZNF600 POLR2A ZIC2 SIN3A TARDBP TRIM22 FEZF1 ZNF341 | SGPP2 AC010980.2 CT75 RF00017-3095 FARSB | |
| GH02J222787 | Enhancer | 0.9 | FANTOM5 ENCODE | 14.6 | +364.7 | 364654 | 3.1 | BCLAF1 SP1 TARDBP IRF2 FOXA2 CTBP1 IRF4 ASH2L PKNOX1 STAT5A | HSALNG0022543 SGPP2 lnc-MOGAT1-1 ACSL3 MOGAT1 | |
| GH02J222448 | Enhancer | 0.7 | FANTOM5 ENCODE | 16.9 | +25.0 | 25023 | 0.3 | ZNF623 ZNF488 SP1 TRIM28 NR2F2 | lnc-CCDC140-6 SGPP2 AC010980.2 CT75 NANOGP2 FARSB | |
| GH02J222358 | Enhancer | 0.7 | FANTOM5 Ensembl | 16.8 | -64.6 | -64587 | 2.8 | GABPA SPI1 MYC MAX POLR2A EP300 | RF00951-080 SGPP2 ENSG00000288658 ENSG00000200822 | |
| GH02J222363 | Enhancer | 0.7 | FANTOM5 ENCODE | 14.3 | -59.5 | -59506 | 1.1 | NFE2 NFE2L2 MAFK BACH1 | SGPP2 RF00951-080 ENSG00000200822 ENSG00000288658 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SGPP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SGPP2
- Top Transcription factor binding sites by QIAGEN in the SGPP2 gene promoter:
-
- Gfi-1
- HOXA9
- LCR-F1
- LyF-1
- MIF-1
- MyoD
- SREBP-1a
- SREBP-1b
- SREBP-1c
- ZID
Genomic Locations for SGPP2 Gene
Latest Assembly
- chr2:222,423,988-222,562,621
- (GRCh38/hg38)
- Size:
- 138,634 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:223,288,707-223,427,340
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 138,634 bases
- Orientation:
- Plus strand
Genomic View for SGPP2 Gene
Genes around SGPP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q36.1 by HGNC
- 2q36.1 by Entrez Gene
- 2q36.1 by Ensembl
SGPP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SGPP2 Gene
Proteins for SGPP2 Gene
-
Protein details for SGPP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IWX5-SGPP2_HUMAN
- Recommended name:
- Sphingosine-1-phosphate phosphatase 2
- Protein Accession:
- Q8IWX5
- A3KPB4
- Q8N8Q6
Protein attributes for SGPP2 Gene
- Size:
- 399 amino acids
- Molecular mass:
- 44741 Da
- Quaternary structure:
- No Data Available
Protein Expression for SGPP2 Gene
Selected DME Specific Peptides for SGPP2 Gene
- Q8IWX5:
-
- MPSTHAM
- IWVLVMY
Post-translational modifications for SGPP2 Gene
Other Protein References for SGPP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for SGPP2
- Novus Biologicals Antibodies for SGPP2
- Invitrogen Antibodies for SGPP2 (AFLGC-SGPP2)
-
Custom Antibody ServicesProSci Antibodies for SGPP2
Protein products for research
-
OriGene Purified Proteins for SGPP2
- Search Origene for MassSpec and Protein Over-expression Lysates for SGPP2
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- Novus Biologicals proteins for SGPP2
- antibodies-online: Show 4 available SGPP2 Proteins ranked by validation data
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-
Quality Products:
-
Abcam proteins for SGPP2
Assay products for research
- antibodies-online: Show 11 available SGPP2 Elisa Kits ranked by validation data
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-
Quality Products:
Domains & Families for SGPP2 Gene
Gene Families for SGPP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for SGPP2 Gene
- InterPro:
- Blocks:
-
- PA-phosphatase related phosphoesterase
Suggested Antigen Peptide Sequences for SGPP2 Gene
- GenScript: Design optimal peptide antigens:
-
- SGPP2 protein (Q3B870_HUMAN)
- Sphingosine-1-phosphatase 2 (SGPP2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8IWX5- Family:
-
- Belongs to the type 2 lipid phosphate phosphatase family.
Function for SGPP2 Gene
Molecular function for SGPP2 Gene
- UniProtKB/Swiss-Prot Function:
- Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (PubMed:12411432). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (PubMed:17113265). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + sphinganine 1-phosphate = phosphate + sphinganine; Xref=Rhea:RHEA:27514, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57817, ChEBI:CHEBI:57939; Evidence={ECO:0000269|PubMed:12411432};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine; Xref=Rhea:RHEA:27518, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57756, ChEBI:CHEBI:60119; Evidence={ECO:0000269|PubMed:12411432, ECO:0000269|PubMed:27059959, ECO:0000269|PubMed:31916624};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(4R)-hydroxysphinganine 1-phosphate + H2O = (4R)-hydroxysphinganine + phosphate; Xref=Rhea:RHEA:33067, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:64124, ChEBI:CHEBI:64795; Evidence={ECO:0000269|PubMed:31916624};.
- UniProtKB/Swiss-Prot Induction:
- Strongly induced by TNF, also induced by bacterial lipopolycaccharides (LPS) in neutrophils, endothelial cells, and other cell types. Not induced by growth-related factors.
Enzyme Numbers (IUBMB) for SGPP2 Gene
Phenotypes From GWAS Catalog for SGPP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0042392 | sphingosine-1-phosphate phosphatase activity | IEA,IMP | 27059959 |
Phenotypes for SGPP2 Gene
- MGI mutant phenotypes for SGPP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SGPP2:
Animal Models for SGPP2 Gene
- MGI Knock Outs for SGPP2:
-
- Sgpp2 Sgpp2<tm1Rlp>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SGPP2 - Starting at $85 >
- * SGPP2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SGPP2
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-
Santa Cruz Biotechnology (SCBT) CRISPR for SGPP2
miRNA for SGPP2 Gene
- miRTarBase miRNAs that target SGPP2
-
- hsa-miR-99a-5p (MIRT048643)
- hsa-miR-6516-5p (MIRT458628)
- hsa-miR-550b-2-5p (MIRT458629)
- hsa-miR-1273e (MIRT458630)
- hsa-miR-455-3p (MIRT458631)
- hsa-miR-6807-5p (MIRT458632)
- hsa-miR-650 (MIRT458633)
- hsa-miR-3612 (MIRT458634)
- hsa-miR-6894-5p (MIRT458635)
- hsa-miR-6499-3p (MIRT458636)
- hsa-miR-4722-5p (MIRT458637)
- hsa-miR-1827 (MIRT458638)
- hsa-miR-4487 (MIRT458639)
- hsa-miR-558 (MIRT458640)
- hsa-miR-3160-3p (MIRT458641)
- hsa-miR-1233-3p (MIRT458642)
- hsa-miR-1225-3p (MIRT458643)
- hsa-miR-5186 (MIRT458644)
- hsa-miR-1247-3p (MIRT458645)
- hsa-miR-4692 (MIRT458646)
- hsa-miR-4514 (MIRT458647)
- hsa-miR-4269 (MIRT458648)
- hsa-miR-6715b-5p (MIRT458649)
- hsa-miR-4742-5p (MIRT458650)
- hsa-miR-4459 (MIRT458651)
- hsa-miR-940 (MIRT458652)
- hsa-miR-6893-5p (MIRT458653)
- hsa-miR-6808-5p (MIRT458654)
- hsa-miR-6511a-5p (MIRT458655)
- hsa-miR-1910-3p (MIRT458656)
- hsa-miR-3940-3p (MIRT458657)
- hsa-miR-1277-5p (MIRT544881)
- hsa-miR-190a-3p (MIRT544882)
- hsa-miR-5011-5p (MIRT544883)
- hsa-miR-410-3p (MIRT544884)
- hsa-miR-3163 (MIRT544885)
- hsa-miR-3662 (MIRT544886)
- mmu-miR-5101 (MIRT585969)
- mmu-miR-335-3p (MIRT585970)
- mmu-miR-1896 (MIRT585971)
- mmu-miR-129-1-3p (MIRT585972)
- mmu-miR-129-2-3p (MIRT585973)
- mmu-miR-3064-5p (MIRT585974)
- mmu-miR-3085-3p (MIRT585975)
- mmu-miR-3087-3p (MIRT585976)
- mmu-miR-3470b (MIRT585977)
- hsa-miR-572 (MIRT629717)
- hsa-miR-4284 (MIRT629718)
- hsa-miR-2276-3p (MIRT629719)
- hsa-miR-4638-5p (MIRT629720)
- hsa-miR-1307-3p (MIRT629721)
- hsa-miR-1304-3p (MIRT629722)
- hsa-miR-6741-3p (MIRT629723)
- hsa-miR-6890-3p (MIRT629724)
- hsa-miR-181d-3p (MIRT629725)
- hsa-miR-31-5p (MIRT733128)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SGPP2
- Browse OriGene Inhibitory RNA Products For SGPP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SGPP2
Clone products for research
- Applied Biological Materials (abm): Clones for SGPP2 - Starting at $45 >
- * SGPP2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SGPP2
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Cell Lines for research
-
Horizon Cell Lines for SGPP2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SGPP2 Gene
Localization for SGPP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SGPP2 Gene
- Endoplasmic reticulum membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| plasma membrane | 3 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA,IDA | 12411432 |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0016020 | membrane | IBA | 21873635 |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SGPP2 Gene
Pathways & Interactions for SGPP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sphingolipid metabolism | ||
| 2 | Metabolism |
.40
|
|
| 3 | Sphingolipid signaling pathway | ||
| 4 | sphingosine and sphingosine-1-phosphate metabolism | ||
Pathways by source for SGPP2 Gene
2 BioSystems pathways for SGPP2 Gene
4 Reactome pathways for SGPP2 Gene
3 KEGG pathways for SGPP2 Gene
Interacting Proteins for SGPP2 Gene
GPS-Prot Interaction Network for SGPP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006670 | sphingosine metabolic process | IBA,IDA | 12411432 |
| GO:0030148 | sphingolipid biosynthetic process | TAS | -- |
| GO:0046839 | phospholipid dephosphorylation | IBA | 21873635 |
| GO:0061469 | regulation of type B pancreatic cell proliferation | IEA,ISS | -- |
No data available for SIGNOR curated interactions for SGPP2 Gene
Drugs & Compounds for SGPP2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| sphinganine 1-phosphate |
|
19794-97-9 |
|
Transcripts for SGPP2 Gene
mRNA/cDNA for SGPP2 Gene
- 3 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000321276 4983 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SGPP2 - Starting at $85 >
- * SGPP2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SGPP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SGPP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SGPP2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SGPP2
- Browse OriGene Inhibitory RNA Products For SGPP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SGPP2
Clone products for research
- Applied Biological Materials (abm): Clones for SGPP2 - Starting at $45 >
- * SGPP2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SGPP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SGPP2
Relevant External Links for SGPP2 Gene
- GeneLoc Exon Structure for
- SGPP2
Expression for SGPP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
- Ureteric Bud
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
-
Brain (Nervous System)
- Adult Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
- Head Mesenchyme (Muscoskeletal System)
- Neural Ectoderm (Nervous System)
- Heart (Cardiovascular System)
- Neural Tube (Nervous System)
This gene is overexpressed in Heart (68.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SGPP2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SGPP2
SOURCE GeneReport for Unigene cluster for SGPP2 Gene:
Hs.591604mRNA Expression by UniProt/SwissProt for SGPP2 Gene:
Q8IWX5-SGPP2_HUMAN
Tissue specificity:
Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes.
Evidence on tissue expression from TISSUES for SGPP2 Gene
- Nervous system(4.3)
Primer products for research
-
OriGene qPCR primer pairs for SGPP2
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGPP2 Gene
Orthologs for SGPP2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SGPP2 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SGPP2 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Sgpp2 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Sgpp2 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SGPP2 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SGPP2 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SGPP2 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SGPP2 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SGPP2 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sgpp2 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100330698 29 |
|
||
| SGPP2 30 |
|
OneToOne | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | LCB3 30 |
|
ManyToMany | |
| YSR3 30 32 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.637 30 |
|
OneToOne |
- Species where no ortholog for SGPP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SGPP2 Gene
- ENSEMBL:
- Gene Tree for SGPP2 (if available)
- TreeFam:
- Gene Tree for SGPP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SGPP2: view image
- Alliance of Genome Resources:
- Additional Orthologs for SGPP2
Paralogs for SGPP2 Gene
Variants for SGPP2 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2721515 | CNV | deletion | 23290073 |
| esv2721516 | CNV | deletion | 23290073 |
| esv275407 | CNV | loss | 21479260 |
| esv3584358 | CNV | loss | 25503493 |
| nsv528185 | CNV | loss | 19592680 |
| nsv979178 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.59;
30.67% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SGPP2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SGPP2 Gene
Disorders for SGPP2 Gene
Additional Disease Information for SGPP2
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for SGPP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGPP2 Gene
Publications for SGPP2 Gene
- Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2. (PMID: 12411432) Ogawa C … Igarashi Y (The Journal of biological chemistry 2003) 2 3 4 22
- Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. (PMID: 17113265) Mechtcheriakova D … Billich A (Cellular signalling 2007) 3 4 22
- Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation. (PMID: 27059959) Taguchi Y … Proia RL (The Journal of biological chemistry 2016) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Biosynthesis of the anti-lipid-microdomain sphingoid base 4,14-sphingadiene by the ceramide desaturase FADS3. (PMID: 31916624) Jojima K … Kihara A (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020) 4
ExternalLinks
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- Custom Assay Services
- OriGene Purified Proteins for SGPP2
- Search Origene for MassSpec and Protein Over-expression Lysates for SGPP2
- Origene Custom Protein Services for SGPP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SGPP2
- Browse OriGene Inhibitory RNA Products For SGPP2
- OriGene qPCR primer pairs for SGPP2
- OriGene CRISPR knockouts for SGPP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SGPP2
- Sino Biological Human cDNA Clone for SGPP2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SGPP2
- Novus Biologicals proteins for SGPP2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
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- Abcam proteins for SGPP2
- Find your target
- Browse Primary Antibodies
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- Invitrogen Antibodies for SGPP2 (AFLGC-SGPP2)
- VectorBuilder Custom and pre-made DNA vectors for SGPP2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SGPP2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SGPP2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SGPP2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SGPP2
- antibodies-online: Show 12 available SGPP2 Antibodies ranked by validation data
- Compare Top SGPP2 Antibodies
- antibodies-online: Show 11 available SGPP2 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 4 available SGPP2 Proteins ranked by validation data
- Compare Top SGPP2 Proteins
- Quality Products:
- Custom Antibody ServicesProSci Antibodies for SGPP2
- Search for SGPP2 Proteins at ProSci
- Horizon Cell Lines for SGPP2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SGPP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SGPP2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SGPP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SGPP2
Sources for SGPP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources