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The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
SGPP2 (Sphingosine-1-Phosphate Phosphatase 2) is a Protein Coding gene. Among its related pathways are Sphingolipid signaling pathway and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include sphingosine-1-phosphate phosphatase activity. An important paralog of this gene is SGPP1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02J222423 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE | 600.7 | +2.1 | 2131 | 5.4 | CEBPG SP1 PRDM10 ZNF629 ZNF692 POLR2A BACH1 LARP7 ZNF143 RELA | SGPP2 CT75 RF00017-3434 FARSB | |
GH02J222787 | Enhancer | 1 | FANTOM5 ENCODE | 14.6 | +364.7 | 364654 | 3.1 | SP1 CREB1 PRDM1 ZSCAN4 PKNOX1 IKZF2 PBX2 RELA EED RUNX3 | SGPP2 piR-52438-066 lnc-MOGAT1-1 ACSL3 MOGAT1 | |
GH02J222751 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE CraniofacialAtlas | 9.1 | +328.6 | 328600 | 4 | PRDM10 ZNF629 ZNF7 PRDM1 ZIC2 PKNOX1 RXRB SP1 HDAC1 ZNF561 | SGPP2 LOC105373903 lnc-MOGAT1-1 piR-52438-066 MOGAT1 ACSL3 | |
GH02J222448 | Enhancer | 0.7 | FANTOM5 ENCODE | 16.9 | +25.0 | 25023 | 0.3 | SP1 ZNF623 NR2F2 TRIM28 ZNF488 | lnc-CCDC140-6 SGPP2 CT75 NANOGP2 FARSB | |
GH02J222358 | Enhancer | 0.7 | FANTOM5 Ensembl | 16.8 | -64.6 | -64587 | 2.8 | POLR2A SPI1 GABPA SMARCA4 MYC MAX | RF00951-080 SGPP2 ENSG00000200822 PAX3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016787 | hydrolase activity | IEA | -- |
GO:0042392 | sphingosine-1-phosphate phosphatase activity | IEA,IMP | 27059959 |
GO:0042577 | lipid phosphatase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IEA,IDA | 12411432 |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0016020 | membrane | IEA,IBA | 21873635 |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Sphingolipid metabolism | ||
2 | Metabolism |
.40
|
|
3 | Sphingolipid signaling pathway | ||
4 | sphingosine and sphingosine-1-phosphate metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006670 | sphingosine metabolic process | IDA | 12411432 |
GO:0016311 | dephosphorylation | IEA | -- |
GO:0030148 | sphingolipid biosynthetic process | TAS | -- |
GO:0046839 | phospholipid dephosphorylation | IBA | 21873635 |
GO:0061469 | regulation of type B pancreatic cell proliferation | IEA,ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Phosphoric acid | Approved | Pharma | 0 | |||
Water | Approved | Pharma | 0 | |||
Sphingosine | Experimental | Pharma | 0 | |||
sphinganine | Pharma | 0 | ||||
Sphingosine-1-phosphate | Pharma | Agonist, Full agonist | endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
sphinganine 1-phosphate |
|
19794-97-9 |
|
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SGPP2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SGPP2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Sgpp2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sgpp2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | SGPP2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SGPP2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SGPP2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SGPP2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SGPP2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sgpp2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100330698 30 |
|
||
SGPP2 31 |
|
OneToOne | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | LCB3 31 |
|
ManyToMany | |
YSR3 31 33 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.637 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2721515 | CNV | deletion | 23290073 |
esv2721516 | CNV | deletion | 23290073 |
esv275407 | CNV | loss | 21479260 |
esv3584358 | CNV | loss | 25503493 |
nsv528185 | CNV | loss | 19592680 |
nsv979178 | CNV | duplication | 23825009 |
No disorders were found for SGPP2 Gene.