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SGPP2 Gene(Protein Coding)

Sphingosine-1-Phosphate Phosphatase 2

GCID:
GC02P222424
GIFtS:
44
Genes Participants
UDN Logo

Aliases for SGPP2 Gene

Aliases for SGPP2 Gene

  • Sphingosine-1-Phosphate Phosphatase 2 2 3 5
  • Sphingosine-1-Phosphatase 2 3 4
  • SPPase2 3 4
  • Spp2 3 4
  • Sphingosine 1-Phosphate Phosphohydrolase 2 3
  • Sphingosine-1-Phosphate Phosphotase 2 3
  • EC 3.1.3.- 4
  • EC 3.1.3 56
  • HSPP2 4

External Ids for SGPP2 Gene

Previous GeneCards Identifiers for SGPP2 Gene

  • GC02P222010
  • GC02P223252
  • GC02P223491
  • GC02P223114
  • GC02P222997
  • GC02P223288
  • GC02P215143

Summaries for SGPP2 Gene

Entrez Gene Summary for SGPP2 Gene

  • The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

GeneCards Summary for SGPP2 Gene

SGPP2 (Sphingosine-1-Phosphate Phosphatase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include sphingosine-1-phosphate phosphatase activity. An important paralog of this gene is SGPP1.

UniProtKB/Swiss-Prot for SGPP2 Gene

  • Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling.

Additional gene information for SGPP2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGPP2 Gene

Genomics for SGPP2 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for SGPP2 Gene

Promoters and enhancers for SGPP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02I222423 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +2.1 2080 5.4 HDGF PKNOX1 SMAD1 SIN3A FEZF1 GLIS2 ZNF213 ZNF143 ATF7 RUNX3 SGPP2 LOC440934 ENSG00000261428 NANOGP2
GH02I222787 Enhancer 1.2 FANTOM5 Ensembl ENCODE 14.6 +364.6 364590 3.1 MEIS2 IRF2 PKNOX1 FOXA2 ZSCAN4 SIN3A IRF4 RAD21 RELA CTBP1 SGPP2 LOC105373903 ACSL3
GH02I222448 Enhancer 0.9 FANTOM5 Ensembl ENCODE 16.9 +25.0 24989 0.7 ZNF488 ZNF623 SGPP2 LOC440934 NANOGP2
GH02I222363 Enhancer 1 FANTOM5 Ensembl ENCODE 14.3 -59.6 -59570 1.1 JUN BACH1 NFE2 NFE2L2 SGPP2 PAX3 GC02P222405
GH02I222791 Enhancer 1 FANTOM5 Ensembl ENCODE 10.5 +368.1 368149 1.2 RXRA MAX REST RAD21 RARA YY1 SKI ETV4 NFE2 HNF4A SGPP2 LOC105373903 ACSL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SGPP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SGPP2 gene promoter:

Genomic Locations for SGPP2 Gene

Genomic Locations for SGPP2 Gene
chr2:222,424,052-222,561,842
(GRCh38/hg38)
Size:
137,791 bases
Orientation:
Plus strand
chr2:223,289,236-223,425,667
(GRCh37/hg19)

Genomic View for SGPP2 Gene

Genes around SGPP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGPP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGPP2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SGPP2 Gene

Proteins for SGPP2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SGPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWX5-SGPP2_HUMAN
    Recommended name:
    Sphingosine-1-phosphate phosphatase 2
    Protein Accession:
    Q8IWX5
    Secondary Accessions:
    • A3KPB4
    • Q8N8Q6

    Protein attributes for SGPP2 Gene

    Size:
    399 amino acids
    Molecular mass:
    44741 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SGPP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SGPP2 Gene

Protein Expression for SGPP2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for SGPP2 Gene

Q8IWX5:
  • MPSTHAM
  • IWVLVMY

Post-translational modifications for SGPP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SGPP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SGPP2 Gene

Gene Families for SGPP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SGPP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SGPP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWX5

UniProtKB/Swiss-Prot:

SGPP2_HUMAN :
  • Belongs to the type 2 lipid phosphate phosphatase family.
Family:
  • Belongs to the type 2 lipid phosphate phosphatase family.
genes like me logo Genes that share domains with SGPP2: view

Function for SGPP2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for SGPP2 Gene

UniProtKB/Swiss-Prot Function:
Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling.
UniProtKB/Swiss-Prot Induction:
Strongly induced by TNF, also induced by bacterial lipopolycaccharides (LPS) in neutrophils, endothelial cells, and other cell types. Not induced by growth-related factors.

Enzyme Numbers (IUBMB) for SGPP2 Gene

Phenotypes From GWAS Catalog for SGPP2 Gene

Gene Ontology (GO) - Molecular Function for SGPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0042392 sphingosine-1-phosphate phosphatase activity TAS,IDA --
GO:0070780 dihydrosphingosine-1-phosphate phosphatase activity TAS --
genes like me logo Genes that share ontologies with SGPP2: view
genes like me logo Genes that share phenotypes with SGPP2: view

Animal Models for SGPP2 Gene

MGI Knock Outs for SGPP2:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SGPP2 Gene

Localization for SGPP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGPP2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGPP2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SGPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 12411432
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SGPP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SGPP2 Gene

Pathways & Interactions for SGPP2 Gene

genes like me logo Genes that share pathways with SGPP2: view

Gene Ontology (GO) - Biological Process for SGPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006670 sphingosine metabolic process IDA 12411432
GO:0016311 dephosphorylation IEA --
GO:0030148 sphingolipid biosynthetic process TAS --
genes like me logo Genes that share ontologies with SGPP2: view

No data available for SIGNOR curated interactions for SGPP2 Gene

Drugs & Compounds for SGPP2 Gene

Products:

  1. Drug

(5) Drugs for SGPP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
sphingosine 1-phosphate Pharma Full agonist, Agonist 0

(1) Additional Compounds for SGPP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sphinganine 1-phosphate
  • 2-Amino-3-hydroxyoctadecyl dihydrogen phosphate
  • Dihydrosphingosine 1-phosphate
  • Dihydrosphingosine-1-phosphate
  • Sphinganine 1-phosphate
 19794-97-9
genes like me logo Genes that share compounds with SGPP2: view

Transcripts for SGPP2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SGPP2 Gene

(4) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(92) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SGPP2 Gene

Sphingosine-1-phosphate phosphatase 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGPP2 Gene

No ASD Table

Relevant External Links for SGPP2 Gene

GeneLoc Exon Structure for
SGPP2
ECgene alternative splicing isoforms for
SGPP2

Expression for SGPP2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SGPP2 Gene

mRNA expression in normal human tissues for SGPP2 Gene
mRNA expression by GTEx for SGPP2 GenemRNA expression by BioGPS for SGPP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SGPP2 Gene

This gene is overexpressed in Heart (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SGPP2 Gene



Protein tissue co-expression partners for SGPP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SGPP2 Gene:

SGPP2

SOURCE GeneReport for Unigene cluster for SGPP2 Gene:

Hs.591604

mRNA Expression by UniProt/SwissProt for SGPP2 Gene:

Q8IWX5-SGPP2_HUMAN
Tissue specificity: Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for SGPP2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SGPP2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGPP2 Gene

Orthologs for SGPP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGPP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia SGPP2 33 34
  • 99 (n)
cow
(Bos Taurus)
 Mammalia SGPP2 33 34
  • 87.77 (n)
mouse
(Mus musculus)
 Mammalia Sgpp2 33 16 34
  • 86.87 (n)
rat
(Rattus norvegicus)
 Mammalia Sgpp2 33
  • 85.36 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia SGPP2 34
  • 77 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia SGPP2 34
  • 73 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia SGPP2 34
  • 65 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves SGPP2 33 34
  • 65.55 (n)
lizard
(Anolis carolinensis)
 Reptilia SGPP2 34
  • 57 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia sgpp2 33
  • 58.18 (n)
zebrafish
(Danio rerio)
 Actinopterygii LOC100330698 33
  • 54.99 (n)
SGPP2 34
  • 45 (a)
 OneToOne
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes LCB3 34
  • 19 (a)
 ManyToMany
YSR3 34 36
  • 17 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.637 34
  • 34 (a)
 OneToOne
Species where no ortholog for SGPP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SGPP2 Gene

ENSEMBL:
Gene Tree for SGPP2 (if available)
TreeFam:
Gene Tree for SGPP2 (if available)

Paralogs for SGPP2 Gene

Paralogs for SGPP2 Gene

(1) SIMAP similar genes for SGPP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SGPP2: view

Variants for SGPP2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for SGPP2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000001077 -- 222,529,711(+) G/A intron_variant
rs1000005376 -- 222,453,561(+) C/T intron_variant
rs1000033695 -- 222,530,044(+) AATAATA/AATA intron_variant
rs1000034753 -- 222,446,092(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000043457 -- 222,536,702(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SGPP2 Gene

Variant ID Type Subtype PubMed ID
esv2721515 CNV deletion 23290073
esv2721516 CNV deletion 23290073
esv275407 CNV loss 21479260
esv3584358 CNV loss 25503493
nsv528185 CNV loss 19592680
nsv979178 CNV duplication 23825009

Variation tolerance for SGPP2 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SGPP2 Gene

Human Gene Mutation Database (HGMD)
SGPP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SGPP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGPP2 Gene

Disorders for SGPP2 Gene

Additional Disease Information for SGPP2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SGPP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGPP2 Gene

Publications for SGPP2 Gene

  1. Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2. (PMID: 12411432) Ogawa C … Igarashi Y (The Journal of biological chemistry 2003) 2 3 4 22 58
  2. Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. (PMID: 17113265) Mechtcheriakova D … Billich A (Cellular signalling 2007) 3 4 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Tumor suppressor microRNA-31 inhibits gastric carcinogenesis by targeting Smad4 and SGPP2. (PMID: 26494556) Ruoming W … Jisheng H (Cancer gene therapy 2015) 3 58
  5. Genetic variants associated with disordered eating. (PMID: 23568457) Wade TD … Martin NG (The International journal of eating disorders 2013) 3 58

Products for SGPP2 Gene

Sources for SGPP2 Gene

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