Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009] See more...

Aliases for SGPP1 Gene

Aliases for SGPP1 Gene

  • Sphingosine-1-Phosphate Phosphatase 1 2 3 4 5
  • Sphingosine-1-Phosphate Phosphohydrolase 1 3 4
  • Sphingosine-1-Phosphatase 1 3 4
  • HSPPase1 3 4
  • SPPase1 3 4
  • SPP-1 3 4
  • HSPP1 3 4
  • Spp1 3 4
  • EC 3.1.3.- 4
  • EC 3.1.3 52
  • SPP1 4

External Ids for SGPP1 Gene

Previous GeneCards Identifiers for SGPP1 Gene

  • GC14M057945
  • GC14M062141
  • GC14M062140
  • GC14M063220
  • GC14M064150
  • GC14M044317

Summaries for SGPP1 Gene

Entrez Gene Summary for SGPP1 Gene

  • Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SGPP1 Gene

SGPP1 (Sphingosine-1-Phosphate Phosphatase 1) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include sphingosine-1-phosphate phosphatase activity. An important paralog of this gene is SGPP2.

UniProtKB/Swiss-Prot Summary for SGPP1 Gene

  • Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed:16782891). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (PubMed:12815058, PubMed:11756451, PubMed:16782891). Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:11756451, PubMed:12815058, PubMed:16782891). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic retiulum to the Golgi apparatus (PubMed:16782891). The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713). Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed:20798685, PubMed:18583713). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity).

Gene Wiki entry for SGPP1 Gene

Additional gene information for SGPP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SGPP1 Gene

Genomics for SGPP1 Gene

GeneHancer (GH) Regulatory Elements for SGPP1 Gene

Promoters and enhancers for SGPP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SGPP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SGPP1

Top Transcription factor binding sites by QIAGEN in the SGPP1 gene promoter:
  • AML1a
  • Brachyury
  • GCNF
  • GCNF-1
  • GCNF-2
  • GR
  • GR-alpha
  • LCR-F1
  • NF-1
  • ZID

Genomic Locations for SGPP1 Gene

Genomic Locations for SGPP1 Gene
chr14:63,684,216-63,728,095
(GRCh38/hg38)
Size:
43,880 bases
Orientation:
Minus strand
chr14:64,150,932-64,194,757
(GRCh37/hg19)
Size:
43,826 bases
Orientation:
Minus strand

Genomic View for SGPP1 Gene

Genes around SGPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGPP1 Gene

Proteins for SGPP1 Gene

  • Protein details for SGPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BX95-SGPP1_HUMAN
    Recommended name:
    Sphingosine-1-phosphate phosphatase 1
    Protein Accession:
    Q9BX95
    Secondary Accessions:
    • B2RAH0
    • Q9H189

    Protein attributes for SGPP1 Gene

    Size:
    441 amino acids
    Molecular mass:
    49108 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SGPP1 Gene

Selected DME Specific Peptides for SGPP1 Gene

Q9BX95:
  • MPSTHAM
  • IWVLVMY

Post-translational modifications for SGPP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SGPP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SGPP1 Gene

Gene Families for SGPP1 Gene

Protein Domains for SGPP1 Gene

Blocks:
  • PA-phosphatase related phosphoesterase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SGPP1 Gene

GenScript: Design optimal peptide antigens:
  • Sphingosine-1-phosphatase 1 (SGPP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BX95

UniProtKB/Swiss-Prot:

SGPP1_HUMAN :
  • Belongs to the type 2 lipid phosphate phosphatase family.
Family:
  • Belongs to the type 2 lipid phosphate phosphatase family.
genes like me logo Genes that share domains with SGPP1: view

Function for SGPP1 Gene

Molecular function for SGPP1 Gene

UniProtKB/Swiss-Prot Function:
Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed:16782891). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (PubMed:12815058, PubMed:11756451, PubMed:16782891). Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:11756451, PubMed:12815058, PubMed:16782891). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic retiulum to the Golgi apparatus (PubMed:16782891). The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713). Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed:20798685, PubMed:18583713). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + sphinganine 1-phosphate = phosphate + sphinganine; Xref=Rhea:RHEA:27514, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57817, ChEBI:CHEBI:57939; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27515; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine; Xref=Rhea:RHEA:27518, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57756, ChEBI:CHEBI:60119; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27519; Evidence=. ;.

Enzyme Numbers (IUBMB) for SGPP1 Gene

Phenotypes From GWAS Catalog for SGPP1 Gene

Gene Ontology (GO) - Molecular Function for SGPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0042392 sphingosine-1-phosphate phosphatase activity IEA,IDA 16782891
genes like me logo Genes that share ontologies with SGPP1: view
genes like me logo Genes that share phenotypes with SGPP1: view

Animal Models for SGPP1 Gene

MGI Knock Outs for SGPP1:
  • Sgpp1 Sgpp1<tm1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for SGPP1

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SGPP1 Gene

Localization for SGPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGPP1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGPP1 gene
Compartment Confidence
plasma membrane 4
nucleus 4
endoplasmic reticulum 4
extracellular 2
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SGPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SGPP1: view

Pathways & Interactions for SGPP1 Gene

genes like me logo Genes that share pathways with SGPP1: view

Gene Ontology (GO) - Biological Process for SGPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process IEA --
GO:0006668 sphinganine-1-phosphate metabolic process IEA --
GO:0006670 sphingosine metabolic process IEA --
GO:0016311 dephosphorylation IEA --
GO:0030148 sphingolipid biosynthetic process TAS --
genes like me logo Genes that share ontologies with SGPP1: view

No data available for SIGNOR curated interactions for SGPP1 Gene

Drugs & Compounds for SGPP1 Gene

(5) Drugs for SGPP1 Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Sonepcizumab Investigational Pharma Antibody Others 0
sphinganine Pharma 0

(2) Additional Compounds for SGPP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sphinganine 1-phosphate
  • (2S,3R)-2-amino-3-Hydroxyoctadecyl dihydrogen phosphate
  • Dihydrosphingosine 1-phosphate
  • Dihydrosphingosine-1-phosphate
  • (2S,3R)-2-amino-3-Hydroxyoctadecyl dihydrogen phosphoric acid
  • Sphinganine 1-phosphoric acid
19794-97-9
genes like me logo Genes that share compounds with SGPP1: view

Transcripts for SGPP1 Gene

mRNA/cDNA for SGPP1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGPP1 Gene

No ASD Table

Relevant External Links for SGPP1 Gene

GeneLoc Exon Structure for
SGPP1

Expression for SGPP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SGPP1 Gene

Protein differential expression in normal tissues from HIPED for SGPP1 Gene

This gene is overexpressed in Breast (36.3) and Lung (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SGPP1 Gene



Protein tissue co-expression partners for SGPP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SGPP1

SOURCE GeneReport for Unigene cluster for SGPP1 Gene:

Hs.24678

mRNA Expression by UniProt/SwissProt for SGPP1 Gene:

Q9BX95-SGPP1_HUMAN
Tissue specificity: Ubiquitous, with the strongest level in placenta and kidney.

Evidence on tissue expression from TISSUES for SGPP1 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with SGPP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGPP1 Gene

Orthologs for SGPP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGPP1 31 30
  • 99.02 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SGPP1 31 30
  • 92.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SGPP1 31 30
  • 91.08 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sgpp1 17 31 30
  • 82.79 (n)
rat
(Rattus norvegicus)
Mammalia Sgpp1 30
  • 81.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SGPP1 31
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SGPP1 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SGPP1 30
  • 78.98 (n)
lizard
(Anolis carolinensis)
Reptilia SGPP1 31
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sgpp1 30
  • 69.78 (n)
Str.6321 30
zebrafish
(Danio rerio)
Actinopterygii sgpp1 31 30
  • 61.33 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009675 30
  • 48.64 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LCB3 33 31
  • 22 (a)
YSR3 31
  • 20 (a)
ManyToMany
Species where no ortholog for SGPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SGPP1 Gene

ENSEMBL:
Gene Tree for SGPP1 (if available)
TreeFam:
Gene Tree for SGPP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SGPP1: view image

Paralogs for SGPP1 Gene

Paralogs for SGPP1 Gene

(1) SIMAP similar genes for SGPP1 Gene using alignment to 1 proteins:

  • SGPP1_HUMAN
genes like me logo Genes that share paralogs with SGPP1: view

Variants for SGPP1 Gene

Additional dbSNP identifiers (rs#s) for SGPP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SGPP1 Gene

Variant ID Type Subtype PubMed ID
dgv137n21 CNV gain 19592680
esv2748779 CNV deletion 23290073
esv3426790 CNV insertion 20981092
esv3892555 CNV loss 25118596
nsv1037824 CNV gain 25217958
nsv1038825 CNV gain 25217958
nsv1044325 CNV gain 25217958
nsv1116513 OTHER inversion 24896259
nsv1138309 CNV deletion 24896259

Variation tolerance for SGPP1 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SGPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SGPP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SGPP1 Gene

Disorders for SGPP1 Gene

Additional Disease Information for SGPP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SGPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGPP1 Gene

Publications for SGPP1 Gene

  1. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. (PMID: 12815058) Johnson KR … Obeid LM (The Journal of biological chemistry 2003) 3 4 23 54
  2. Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. (PMID: 20798685) Lépine S … Spiegel S (Cell death and differentiation 2011) 3 4 54
  3. Genetic determinants of circulating sphingolipid concentrations in European populations. (PMID: 19798445) Hicks AA … Campbell H (PLoS genetics 2009) 3 41 54
  4. Role of sphingosine-1-phosphate phosphohydrolase 1 in the regulation of resistance artery tone. (PMID: 18583713) Peter BF … Bolz SS (Circulation research 2008) 4 23 54
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54

Products for SGPP1 Gene

Sources for SGPP1 Gene