Aliases for SGPL1 Gene
External Ids for SGPL1 Gene
Previous GeneCards Identifiers for SGPL1 Gene
GeneCards Summary for SGPL1 Gene
SGPL1 (Sphingosine-1-Phosphate Lyase 1) is a Protein Coding gene. Diseases associated with SGPL1 include Nephrotic Syndrome 14 and Charcot-Marie-Tooth Disease. Among its related pathways are Metabolism and S1P3 pathway. Gene Ontology (GO) annotations related to this gene include pyridoxal phosphate binding and sphinganine-1-phosphate aldolase activity.
UniProtKB/Swiss-Prot for SGPL1 Gene
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.