Aliases for SGO2 Gene

Aliases for SGO2 Gene

  • Shugoshin 2 2 3 4 5
  • Shugoshin-Like 2 3 4
  • SGOL2 3 4
  • Shugoshin-Like 2 (S. Pombe) 2
  • Shugoshin-2 4
  • TRIPIN 3
  • Tripin 4

External Ids for SGO2 Gene

Previous HGNC Symbols for SGO2 Gene

  • SGOL2

Summaries for SGO2 Gene

GeneCards Summary for SGO2 Gene

SGO2 (Shugoshin 2) is a Protein Coding gene. Diseases associated with SGO2 include Perrault Syndrome and Premature Ovarian Failure 1. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by GPCR. An important paralog of this gene is SGO1.

UniProtKB/Swiss-Prot Summary for SGO2 Gene

  • Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase.

Gene Wiki entry for SGO2 Gene

Additional gene information for SGO2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SGO2 Gene

Genomics for SGO2 Gene

GeneHancer (GH) Regulatory Elements for SGO2 Gene

Promoters and enhancers for SGO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J200525 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 507.1 +16.5 16493 2.6 ZBTB40 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 PHF8 ZNF639 ZNF10 SGO2 AOX1 BZW1 BZW1-AS1 KCTD18 HSALNG0021474 piR-46256-019
GH02J200508 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 508.5 -0.2 -206 2.4 HNRNPK ZBTB40 EP300 CTCF POLR2G SP1 PHF8 ZFX ZIC2 POLR2A SGO2 HSALNG0021474 KCTD18 AOX1 ENSG00000287299
GH02J200608 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 11.1 +99.4 99370 2.1 JUND FOS EP300 RBM25 SMARCC1 FOSL2 CEBPB JUN BATF IRF4 AOX1 KCTD18 SGO2 BICD1P1 AOX3P
GH02J200585 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 7.5 +76.3 76292 1.8 ZBTB40 POLR2G USF1 NCOR1 SAP30 ZBTB25 TGIF2 ZBTB26 ZKSCAN8 HDAC2 AOX1 SGO2 AOX3P
GH02J200603 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.7 +94.2 94193 3.2 EP300 TCF12 NCOR1 ZBTB7A TEAD1 FOXA2 CEBPB FOS SAP130 FOSL2 SGO2 AOX1 AOX3P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SGO2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SGO2

Genomic Locations for SGO2 Gene

Genomic Locations for SGO2 Gene
chr2:200,510,008-200,584,096
(GRCh38/hg38)
Size:
74,089 bases
Orientation:
Plus strand
chr2:201,374,731-201,448,818
(GRCh37/hg19)
Size:
74,088 bases
Orientation:
Plus strand

Genomic View for SGO2 Gene

Genes around SGO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGO2 Gene

Proteins for SGO2 Gene

  • Protein details for SGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q562F6-SGO2_HUMAN
    Recommended name:
    Shugoshin 2
    Protein Accession:
    Q562F6
    Secondary Accessions:
    • Q53RR9
    • Q53T20
    • Q86XY4
    • Q8IWK2
    • Q8IZK1
    • Q8N1Q5
    • Q96LQ3

    Protein attributes for SGO2 Gene

    Size:
    1265 amino acids
    Molecular mass:
    144739 Da
    Quaternary structure:
    • Directly interacts with PPP2CA. Part of an astrin (SPAG5) -kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with CDCA8.
    Miscellaneous:
    • Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin).
    SequenceCaution:
    • Sequence=AAH35764.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB71617.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC04524.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for SGO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SGO2 Gene

Post-translational modifications for SGO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SGO2 Gene

Domains & Families for SGO2 Gene

Gene Families for SGO2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SGO2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SGO2 Gene

GenScript: Design optimal peptide antigens:
  • Tripin (SGOL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q562F6

UniProtKB/Swiss-Prot:

SGO2_HUMAN :
  • Belongs to the shugoshin family.
Family:
  • Belongs to the shugoshin family.
genes like me logo Genes that share domains with SGO2: view

Function for SGO2 Gene

Molecular function for SGO2 Gene

UniProtKB/Swiss-Prot Function:
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase.

Phenotypes From GWAS Catalog for SGO2 Gene

Gene Ontology (GO) - Molecular Function for SGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17485487
genes like me logo Genes that share ontologies with SGO2: view
genes like me logo Genes that share phenotypes with SGO2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SGO2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SGO2 Gene

Localization for SGO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGO2 Gene

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (By similarity). SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (By similarity). During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity). In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase (PubMed:17485487). Centromeric localization requires the presence of BUB1 and AUKRB (PubMed:17485487). {ECO:0000250 UniProtKB:Q7TSY8, ECO:0000269 PubMed:17485487}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGO2 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
plasma membrane 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 17485487
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SGO2: view

Pathways & Interactions for SGO2 Gene

genes like me logo Genes that share pathways with SGO2: view

Pathways by source for SGO2 Gene

Gene Ontology (GO) - Biological Process for SGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IEA --
GO:0051301 cell division IEA --
GO:0051321 meiotic cell cycle IEA --
GO:0051754 meiotic sister chromatid cohesion, centromeric IEA --
genes like me logo Genes that share ontologies with SGO2: view

No data available for SIGNOR curated interactions for SGO2 Gene

Drugs & Compounds for SGO2 Gene

No Compound Related Data Available

Transcripts for SGO2 Gene

mRNA/cDNA for SGO2 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SGO2

Alternative Splicing Database (ASD) splice patterns (SP) for SGO2 Gene

No ASD Table

Relevant External Links for SGO2 Gene

GeneLoc Exon Structure for
SGO2

Expression for SGO2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SGO2

Evidence on tissue expression from TISSUES for SGO2 Gene

  • Intestine(4.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGO2 Gene

Orthologs for SGO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SGO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGOL2 31 30
  • 99.42 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SGOL2 31 30
  • 82.5 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sgol2 31 30
  • 75.38 (n)
OneToMany
Gm4975 31
  • 49 (a)
OneToMany
Sgo2b 17
rat
(Rattus norvegicus)
Mammalia Sgol2 30
  • 75 (n)
cow
(Bos Taurus)
Mammalia SGOL2 31
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SGOL2 31
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 55 (a)
OneToMany
-- 31
  • 19 (a)
OneToMany
Species where no ortholog for SGO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SGO2 Gene

ENSEMBL:
Gene Tree for SGO2 (if available)
TreeFam:
Gene Tree for SGO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SGO2: view image

Paralogs for SGO2 Gene

Paralogs for SGO2 Gene

genes like me logo Genes that share paralogs with SGO2: view

Variants for SGO2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SGO2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
737298 Benign: not provided 200,571,292(+) A/G MISSENSE_VARIANT
737299 Benign: not provided 200,571,375(+) G/T MISSENSE_VARIANT
737300 Benign: not provided 200,571,756(+) A/C SYNONYMOUS_VARIANT
rs1057519602 Pathogenic: Premature ovarian failure 200,571,795(+) CAG/C FRAMESHIFT_VARIANT
rs1036533 - p.Gly9Asp

Additional dbSNP identifiers (rs#s) for SGO2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SGO2 Gene

Variant ID Type Subtype PubMed ID
esv6840 CNV gain 19470904

Variation tolerance for SGO2 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SGO2 Gene

Human Gene Mutation Database (HGMD)
SGO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SGO2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGO2 Gene

Disorders for SGO2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SGO2 Gene - From: ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
perrault syndrome
  • gonadal dysgenesis, xx type
premature ovarian failure 1
  • pof1
olfactory groove meningioma
  • meningioma of the olfactory groove
anterior cranial fossa meningioma
  • meningioma of the anterior fossa
brain cancer
  • adult brain tumor
- elite association - COSMIC cancer census association via MalaCards
Search SGO2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SGO2

genes like me logo Genes that share disorders with SGO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SGO2 Gene

Publications for SGO2 Gene

  1. Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. (PMID: 17485487) Huang H … Yen TJ (The Journal of cell biology 2007) 3 4 23 54
  2. Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation. (PMID: 20739936) Tsukahara T … Watanabe Y (Nature 2010) 3 4 54
  3. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima TS … Watanabe Y (Nature 2006) 3 4 54
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for SGO2 Gene

Sources for SGO2 Gene