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Aliases for SGK494 Gene

Aliases for SGK494 Gene

  • Uncharacterized Serine/Threonine-Protein Kinase SgK494 3 5
  • Sugen Kinase 494 4
  • EC 4

External Ids for SGK494 Gene

Previous GeneCards Identifiers for SGK494 Gene

  • GC17M026930
  • GC17M023143
  • GC17M026907
  • GC17M026939
  • GC17M026992
  • GC17M027138

Summaries for SGK494 Gene

GeneCards Summary for SGK494 Gene

SGK494 (Uncharacterized Serine/Threonine-Protein Kinase SgK494) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKG1.

Additional gene information for SGK494 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGK494 Gene

Genomics for SGK494 Gene

GeneHancer (GH) Regulatory Elements for SGK494 Gene

Promoters and enhancers for SGK494 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I028614 Promoter 0.7 EPDnew 550.8 0.0 -5 0.1 POLR2A ZIC2 SUPT5H ENSG00000258472 SGK494 SPAG5-AS1 ENSG00000264044
GH17I028613 Enhancer 0.6 ENCODE 550.8 +0.8 752 0.2 CTCF ZNF654 TRIM22 REST RAD21 ZBTB48 POLR2A ZNF143 FOS HOMEZ ENSG00000258472 SGK494 GC17M029116 SPAG5-AS1
GH17I028660 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.1 -48.2 -48225 3.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SUPT6H SDF2 PROCA1 ENSG00000264044 SNORD42A SNORD4B SGK494 SPAG5-AS1 NEK8 TLCD1
GH17I028576 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12 +37.0 36998 1.6 HDGF FOXA2 PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ALDOC SUPT6H ENSG00000264577 PHF12 NUFIP2 TMEM199 SDF2 SPAG5-AS1 SGK494 RPL23A
GH17I029041 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 11.2 -428.8 -428795 2.6 SMAD1 MLX ZFP64 FEZF1 DMAP1 GLI4 ZNF48 YY1 ETS1 GLIS2 PIPOX ENSG00000264044 TIAF1 SUPT6H PHF12 MYO18A SEZ6 SGK494 TMEM199 ERAL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SGK494 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SGK494 Gene

Genomic Locations for SGK494 Gene
6,237 bases
Minus strand

Genomic View for SGK494 Gene

Genes around SGK494 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGK494 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGK494 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGK494 Gene

Proteins for SGK494 Gene

  • Protein details for SGK494 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized serine/threonine-protein kinase SgK494
    Protein Accession:
    Secondary Accessions:
    • B4DFP4
    • Q49A48

    Protein attributes for SGK494 Gene

    274 amino acids
    Molecular mass:
    31044 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SGK494 Gene


neXtProt entry for SGK494 Gene

Post-translational modifications for SGK494 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SGK494 Gene

No data available for DME Specific Peptides for SGK494 Gene

Domains & Families for SGK494 Gene

Gene Families for SGK494 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SGK494 Gene

Suggested Antigen Peptide Sequences for SGK494 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with SGK494: view

Function for SGK494 Gene

Molecular function for SGK494 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for SGK494 Gene

Phenotypes From GWAS Catalog for SGK494 Gene

Gene Ontology (GO) - Molecular Function for SGK494 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SGK494: view
genes like me logo Genes that share phenotypes with SGK494: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SGK494 Gene

Localization for SGK494 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGK494 gene
Compartment Confidence
plasma membrane 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SGK494 Gene

Pathways & Interactions for SGK494 Gene

SuperPathways for SGK494 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SGK494 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with SGK494: view

No data available for Pathways by source and SIGNOR curated interactions for SGK494 Gene

Drugs & Compounds for SGK494 Gene

No Compound Related Data Available

Transcripts for SGK494 Gene

mRNA/cDNA for SGK494 Gene

Unigene Clusters for SGK494 Gene

Uncharacterized serine/threonine-protein kinase SgK494:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGK494 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -
SP6: - - - - - - - - -

Relevant External Links for SGK494 Gene

GeneLoc Exon Structure for

Expression for SGK494 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SGK494 Gene

Protein differential expression in normal tissues from HIPED for SGK494 Gene

This gene is overexpressed in Platelet (45.5) and Cerebrospinal fluid (20.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SGK494 Gene

Protein tissue co-expression partners for SGK494 Gene

SOURCE GeneReport for Unigene cluster for SGK494 Gene:


Evidence on tissue expression from TISSUES for SGK494 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SGK494: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGK494 Gene

Orthologs for SGK494 Gene

This gene was present in the common ancestor of animals.

Orthologs for SGK494 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC737514 33
  • 99.11 (n)
-- 34
  • 99 (a)
(Bos Taurus)
Mammalia SGK494 33
  • 89.28 (n)
-- 34
  • 83 (a)
(Canis familiaris)
Mammalia SGK494 33
  • 88.69 (n)
-- 34
  • 85 (a)
(Mus musculus)
Mammalia BC030499 16 34 33
  • 87.66 (n)
(Rattus norvegicus)
Mammalia Sgk494 33
  • 86.61 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
(Gallus gallus)
Aves -- 34
  • 76 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494554 33
  • 62.57 (n)
(Danio rerio)
Actinopterygii LOC101883587 33
  • 60.12 (n)
si:dkeyp-118e10.5 34
  • 44 (a)
sgk494b 34
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pk17E 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea F31E3.2 33 34
  • 49 (n)
Species where no ortholog for SGK494 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGK494 Gene

Gene Tree for SGK494 (if available)
Gene Tree for SGK494 (if available)

Paralogs for SGK494 Gene

Variants for SGK494 Gene

Sequence variations from dbSNP and Humsavar for SGK494 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000450802 -- 28,609,748(-) A/G 3_prime_UTR_variant
rs1000479887 -- 28,610,299(-) C/T 3_prime_UTR_variant
rs1000783666 -- 28,608,092(-) A/C 3_prime_UTR_variant
rs1000974955 -- 28,614,946(-) C/T upstream_transcript_variant
rs1001345139 -- 28,614,690(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SGK494 Gene

Variant ID Type Subtype PubMed ID
nsv1064087 CNV gain 25217958
nsv482200 CNV loss 20164927

Variation tolerance for SGK494 Gene

Gene Damage Index Score: 2.27; 40.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Additional Variant Information for SGK494 Gene

Disorders for SGK494 Gene

Additional Disease Information for SGK494

No disorders were found for SGK494 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGK494 Gene

Publications for SGK494 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The protein kinase complement of the human genome. (PMID: 12471243) Manning G … Sudarsanam S (Science (New York, N.Y.) 2002) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E … Simpson AJ (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 58

Products for SGK494 Gene

Sources for SGK494 Gene

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