This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions... See more...

Aliases for SGK1 Gene

Aliases for SGK1 Gene

  • Serum/Glucocorticoid Regulated Kinase 1 2 3 5
  • Serine/Threonine-Protein Kinase Sgk1 3 4
  • EC 2.7.11.1 4 51
  • SGK 3 4
  • Serum/Glucocorticoid-Regulated Kinase 1 4
  • Serum/Glucocorticoid Regulated Kinase 2
  • Serine/Threonine Protein Kinase SGK 3
  • Sgk1 Variant I3 3
  • EC 2.7.11 51
  • SGK1 5

External Ids for SGK1 Gene

Previous HGNC Symbols for SGK1 Gene

  • SGK

Previous GeneCards Identifiers for SGK1 Gene

  • GC06M134533
  • GC06M134490
  • GC06M132059

Summaries for SGK1 Gene

Entrez Gene Summary for SGK1 Gene

  • This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

CIViC Summary for SGK1 Gene

GeneCards Summary for SGK1 Gene

SGK1 (Serum/Glucocorticoid Regulated Kinase 1) is a Protein Coding gene. Diseases associated with SGK1 include Gastric Cancer and Pseudohypoaldosteronism. Among its related pathways are mTOR signaling pathway (Pathway Interaction Database) and MECP2 and Associated Rett Syndrome. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is C8orf44-SGK3.

UniProtKB/Swiss-Prot Summary for SGK1 Gene

  • Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1.

Tocris Summary for SGK1 Gene

Gene Wiki entry for SGK1 Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SGK1 Gene

Genomics for SGK1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SGK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J134169 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 611.3 +143.7 143653 10.1 GATAD2A CTCF HNRNPL TEAD4 PRDM10 ZNF629 REST TFE3 ZNF512 IKZF1 SGK1 MN298325 ENSG00000240056 CT69 lnc-SLC2A12-7 lnc-TBPL1-6 piR-46677-010 MN298678-088 SLC2A12
GH06J134316 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.6 612 2.2 PRDM10 PRDM1 ZIC2 ZNF600 ZNF341 RAD21 CEBPB EZH2 OSR2 ZBTB17 SGK1 KRT8P42 SLC2A12
GH06J134318 Enhancer 0.6 Ensembl dbSUPER 600.7 -0.8 -789 0.2 ATF7 ZNF24 ATF2 YY1 SGK1 HSALNG0053616 ALDH8A1
GH06J134286 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 39.6 +26.1 26102 11 CREB1 ZNF629 RFX1 LEF1 IKZF1 ZNF692 JUND PRDM1 MTA2 PKNOX1 SGK1 ENSG00000286887 ENSG00000201309 KRT8P42 SLC2A12
GH06J134419 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 42.9 -105.6 -105589 10.2 JUND IKZF2 GABPA PKNOX1 SP1 DPF2 HMBOX1 RELB CEBPB RUNX3 lnc-SGK1-5 SGK1 ENSG00000234084 LINC01010 RF00017-5787 CT69 ALDH8A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SGK1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SGK1

Top Transcription factor binding sites by QIAGEN in the SGK1 gene promoter:
  • CREB
  • deltaCREB
  • p53

Genomic Locations for SGK1 Gene

Genomic Locations for SGK1 Gene
chr6:134,169,246-134,318,112
(GRCh38/hg38)
Size:
148,867 bases
Orientation:
Minus strand
chr6:134,490,384-134,639,250
(GRCh37/hg19)
Size:
148,867 bases
Orientation:
Minus strand

Genomic View for SGK1 Gene

Genes around SGK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGK1 Gene

Proteins for SGK1 Gene

  • Protein details for SGK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00141-SGK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Sgk1
    Protein Accession:
    O00141
    Secondary Accessions:
    • B7UUP7
    • B7UUP8
    • B7UUP9
    • B7Z5B2
    • E1P583
    • Q5TCN2
    • Q5TCN3
    • Q5TCN4
    • Q5VY65
    • Q9UN56

    Protein attributes for SGK1 Gene

    Size:
    431 amino acids
    Molecular mass:
    48942 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Forms a trimeric complex with FBXW7 and NOTCH1. Interacts with MAPK3/ERK1, MAPK1/ERK2, MAP2K1/MEK1, MAP2K2/MEK2, NEDD4, NEDD4L, MAPT/TAU, MAPK7, CREB1, SLC9A3R2/NHERF2 and KCNJ1/ROMK1. Associates with the mammalian target of rapamycin complex 2 (mTORC2) via an interaction with MAPKAP1/SIN1.
    Miscellaneous:
    • [Isoform 2]: Produced by alternative promoter usage.
    • [Isoform 3]: Produced by alternative promoter usage.
    • [Isoform 4]: Produced by alternative splicing of isoform 1.
    • [Isoform 5]: Produced by alternative promoter usage.

    Three dimensional structures from OCA and Proteopedia for SGK1 Gene

    Alternative splice isoforms for SGK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SGK1 Gene

Selected DME Specific Peptides for SGK1 Gene

O00141:
  • AFLGFSYA
  • FYAAEIA
  • EPRARFY
  • GKGSFGKV
  • RDLKPENILLDSQGH
  • GTPEYLAPE
  • VDWWCLGAVLYEML
  • GGELFYH
  • RDLKPEN
  • DLRHFDPEFTEEPVP
  • ERNVLLKNVKHPFLVGLH
  • FYAVKVLQKK
  • DFGLCKE
  • YLAPEVL
  • KPENILLD

Post-translational modifications for SGK1 Gene

  • Regulated by phosphorylation. Activated by phosphorylation on Ser-422 by mTORC2, transforming it into a substrate for PDPK1 which phosphorylates it on Thr-256. Phosphorylation on Ser-397 and Ser-401 are also essential for its activity. Phosphorylation on Ser-78 by MAPK7 is required for growth factor-induced cell cycle progression.
  • Ubiquitinated by NEDD4L; which promotes proteasomal degradation. Ubiquitinated by SYVN1 at the endoplasmic reticulum; which promotes rapid proteasomal degradation and maintains a high turnover rate in resting cells. Isoform 2 shows enhanced stability.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for SGK1

Domains & Families for SGK1 Gene

Gene Families for SGK1 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SGK1 Gene

InterPro:
Blocks:
  • Protein kinase C-terminal domain
ProtoNet:

Suggested Antigen Peptide Sequences for SGK1 Gene

GenScript: Design optimal peptide antigens:
  • Serum and glucocorticoid regulated kinase (Q8IZV4_HUMAN)
  • Serum/glucocorticoid-regulated kinase 1 (SGK1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00141

UniProtKB/Swiss-Prot:

SGK1_HUMAN :
  • Isoform 2 subcellular localization at the cell membrane and resistance to proteasomal degradation is mediated by the sequences within the first 120 amino acids.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Domain:
  • Isoform 2 subcellular localization at the cell membrane and resistance to proteasomal degradation is mediated by the sequences within the first 120 amino acids.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with SGK1: view

Function for SGK1 Gene

Molecular function for SGK1 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot Induction:
Induced by a very large spectrum of stimuli distinct from glucocorticoids and serum. These include aldosterone, cell shrinkage, cell swelling, TGF-beta, ischemic injury of the brain, neuronal excitotoxicity memory consolidation, chronic viral hepatitis, DNA-damaging agents, vitamin D3 psychophysiological stress, iron, glucose, EDN1, CSF2, fibroblast growth factor, platelet-derived growth factor, phorbolesters, follicle-stimulating hormone, sorbitol, heat shock, oxidative stress, UV irradiation, and p53/TP53. Many of these stimuli are highly cell-specific, as is the case, for example for aldosterone, which has been found to stimulate its expression only in cells derived from aldosterone-responsive epithelia. Isoform 2 is not induced by glucocorticoids but by excessive extracellular glucose and by TGFB1, in cultured cells.
UniProtKB/Swiss-Prot EnzymeRegulation:
Two specific sites, one in the kinase domain (Thr-256) and the other in the C-terminal regulatory region (Ser-422), need to be phosphorylated for its full activation. Phosphorylation at Ser-397 and Ser-401 are also essential for its activity. Activated by WNK1, WNK2, WNK3 and WNK4.

Enzyme Numbers (IUBMB) for SGK1 Gene

Phenotypes From GWAS Catalog for SGK1 Gene

Gene Ontology (GO) - Molecular Function for SGK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0004712 protein serine/threonine/tyrosine kinase activity IDA 22797923
GO:0005246 calcium channel regulator activity TAS 20530112
genes like me logo Genes that share ontologies with SGK1: view
genes like me logo Genes that share phenotypes with SGK1: view

Animal Models for SGK1 Gene

MGI Knock Outs for SGK1:
  • Sgk1 Sgk1<tm1.2Palm>
  • Sgk1 Sgk1<tm1Kuhl>

Animal Model Products

CRISPR Products

miRNA for SGK1 Gene

miRTarBase miRNAs that target SGK1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SGK1

Clone Products

  • Addgene plasmids for SGK1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SGK1 Gene

Localization for SGK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGK1 Gene

Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Cell membrane. Mitochondrion. Note=The subcellular localization is controlled by the cell cycle, as well as by exposure to specific hormones and environmental stress stimuli. In proliferating cells, it shuttles between the nucleus and cytoplasm in synchrony with the cell cycle, and in serum/growth factor-stimulated cells it resides in the nucleus. In contrast, after exposure to environmental stress or treatment with glucocorticoids, it is detected in the cytoplasm and with certain stress conditions is associated with the mitochondria. In osmoregulation through the epithelial sodium channel, it can be localized to the cytoplasmic surface of the cell membrane. Nuclear, upon phosphorylation.
[Isoform 2]: Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGK1 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
extracellular 2
cytoskeleton 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SGK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with SGK1: view

Pathways & Interactions for SGK1 Gene

genes like me logo Genes that share pathways with SGK1: view

SIGNOR curated interactions for SGK1 Gene

Gene Ontology (GO) - Biological Process for SGK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth TAS 20919962
GO:0006468 protein phosphorylation IEA,TAS 9114008
GO:0006814 sodium ion transport TAS 10884438
GO:0006915 apoptotic process IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with SGK1: view

Drugs & Compounds for SGK1 Gene

(28) Drugs for SGK1 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Flavin Mononucleotide Approved, Investigational Pharma Target 12
[4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid Experimental Pharma Target 0
4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid Experimental Pharma Target 0
Aldosterone Experimental, Investigational Pharma Agonist 0
Chloride ion Experimental Pharma 0

(22) Additional Compounds for SGK1 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
7440-23-5
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
MRT 68601 hydrochloride
MRT 68921 dihydrochloride
TNP
519178-28-0

(5) Tocris Compounds for SGK1 Gene

Compound Action Cas Number
MRT 68601 hydrochloride Potent TBK1 inhibitor
MRT 68921 dihydrochloride Potent ULK inhibitor; inhibits autophagy
Necrostatin-1 RIPK1 inhibitor; inhibits necroptosis 4311-88-0
TNP Inhibitor of IP6K; also inhibits IP3K 519178-28-0
XL 413 hydrochloride Potent and selective Cdc7 inhibitor 1169562-71-3

(2) ApexBio Compounds for SGK1 Gene

Compound Action Cas Number
EMD638683 SGK1 inhibitor 1181770-72-8
GSK 650394 SGK1 inhibitor 890842-28-1
genes like me logo Genes that share compounds with SGK1: view

Drug Products

Transcripts for SGK1 Gene

mRNA/cDNA for SGK1 Gene

5 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
30 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SGK1

Clone Products

  • Addgene plasmids for SGK1

Alternative Splicing Database (ASD) splice patterns (SP) for SGK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - -
SP6: - -
SP7: - -
SP8: - -
SP9: - -
SP10: -
SP11: -
SP12:
SP13: -
SP14: - -

ExUns: 14b ^ 15a · 15b
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SGK1 Gene

GeneLoc Exon Structure for
SGK1

Expression for SGK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SGK1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SGK1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SGK1

SOURCE GeneReport for Unigene cluster for SGK1 Gene:

Hs.510078

mRNA Expression by UniProt/SwissProt for SGK1 Gene:

O00141-SGK1_HUMAN
Tissue specificity: Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and skeletal muscle.

Evidence on tissue expression from TISSUES for SGK1 Gene

  • Nervous system(5)
  • Skin(4.8)
  • Blood(4.3)
  • Kidney(4.3)
  • Lung(4.3)
  • Intestine(3.7)
  • Liver(3.3)
  • Adrenal gland(3.3)
  • Eye(3.2)
  • Pancreas(3.1)
  • Muscle(3)
  • Stomach(3)
  • Heart(2.9)
  • Thyroid gland(2.9)
  • Spleen(2.8)
  • Bone marrow(2.8)
  • Lymph node(2.8)
  • Gall bladder(2.2)
genes like me logo Genes that share expression patterns with SGK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGK1 Gene

Orthologs for SGK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGK1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SGK1 30 31
  • 96.7 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SGK 31
  • 96 (a)
OneToOne
SGK1 30
  • 92.71 (n)
Oppossum
(Monodelphis domestica)
Mammalia SGK1 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia SGK1 30 31
  • 91.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Sgk1 30 17 31
  • 88.74 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sgk1 30
  • 88.59 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia SGK1 31
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SGK1 30 31
  • 84.56 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SGK1 31
  • 90 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sgk1 30
  • 79.64 (n)
Str.10900 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7842 30
Zebrafish
(Danio rerio)
Actinopterygii sgk1 30 31
  • 76.85 (n)
OneToOne
sgk 30
Worm
(Caenorhabditis elegans)
Secernentea sgk-1 30 31
  • 55.5 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK2 31
  • 29 (a)
ManyToMany
YPK1 31
  • 29 (a)
ManyToMany
Species where no ortholog for SGK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SGK1 Gene

ENSEMBL:
Gene Tree for SGK1 (if available)
TreeFam:
Gene Tree for SGK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SGK1: view image

Paralogs for SGK1 Gene

genes like me logo Genes that share paralogs with SGK1: view

Variants for SGK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SGK1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
769694 Benign: not provided 134,170,319(-) G/A SYNONYMOUS_VARIANT
790351 Likely Benign: not provided 134,174,596(-) A/G INTRON_VARIANT
800349 Likely Pathogenic: Multiple myeloma 134,170,860(-) T/C MISSENSE_VARIANT
rs34133418 - p.Val219Ile
rs55932330 - p.Ala342Val

Additional dbSNP identifiers (rs#s) for SGK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SGK1 Gene

Variant ID Type Subtype PubMed ID
dgv10944n54 CNV loss 21841781
dgv10945n54 CNV loss 21841781
dgv10946n54 CNV loss 21841781
dgv1152e199 CNV deletion 23128226
dgv1153e199 CNV deletion 23128226
dgv1833e212 CNV loss 25503493
dgv395n21 CNV gain 19592680
esv1004173 CNV deletion 20482838
esv25399 CNV loss 19812545
esv2674292 CNV deletion 23128226
esv2732732 CNV deletion 23290073
esv2759471 CNV loss 17122850
esv3540499 CNV deletion 23714750
esv3540501 CNV deletion 23714750
esv3571410 CNV loss 25503493
esv3571411 CNV loss 25503493
esv3610874 CNV loss 21293372
esv3610875 CNV loss 21293372
esv3610876 CNV loss 21293372
esv3890950 CNV loss 25118596
nsv1132014 CNV deletion 24896259
nsv1133635 CNV deletion 24896259
nsv441702 CNV loss 18776908
nsv499444 CNV loss 21111241
nsv514390 CNV loss 21397061
nsv604704 CNV loss 21841781
nsv604720 CNV loss 21841781
nsv7971 CNV loss 18304495
nsv819323 CNV loss 19587683
nsv823844 CNV loss 20364138
nsv956954 CNV deletion 24416366
nsv981186 CNV duplication 23825009

Variation tolerance for SGK1 Gene

Residual Variation Intolerance Score: 31.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 39.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SGK1 Gene

Human Gene Mutation Database (HGMD)
SGK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SGK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGK1 Gene

Disorders for SGK1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for SGK1 Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search SGK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SGK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SGK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SGK1 Gene

Publications for SGK1 Gene

  1. Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. (PMID: 9114008) Waldegger S … Lang F (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 23
  2. mTOR complex-2 activates ENaC by phosphorylating SGK1. (PMID: 20338997) Lu M … Pearce D (Journal of the American Society of Nephrology : JASN 2010) 3 4 23
  3. Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration. (PMID: 19447520) Won M … Hur GM (Journal of hepatology 2009) 3 4 23
  4. Regulation of a third conserved phosphorylation site in SGK1. (PMID: 19068477) Chen W … Cobb MH (The Journal of biological chemistry 2009) 3 4 23
  5. Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies. (PMID: 18985156) Friedrich B … Häring HU (PloS one 2008) 3 23 41

Products for SGK1 Gene

  • Addgene plasmids for SGK1

Sources for SGK1 Gene