CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).... See more...

Aliases for SGF29 Gene

Aliases for SGF29 Gene

  • SAGA Complex Associated Factor 29 2 3 5
  • Coiled-Coil Domain-Containing Protein 101 3 4
  • Coiled-Coil Domain Containing 101 2 3
  • SAGA-Associated Factor 29 3 4
  • CCDC101 3 4
  • TDRD29 2 3
  • SAGA-Associated Factor 29 Homolog (Yeast) 2
  • SAGA-Associated Factor 29 Homolog 3
  • SAGA Complex-Associated Factor 29 4
  • FLJ32446 2
  • STAF36 3
  • SGF29 5

External Ids for SGF29 Gene

Previous HGNC Symbols for SGF29 Gene

  • CCDC101

Previous GeneCards Identifiers for SGF29 Gene

  • GC16P028554

Summaries for SGF29 Gene

Entrez Gene Summary for SGF29 Gene

  • CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]

GeneCards Summary for SGF29 Gene

SGF29 (SAGA Complex Associated Factor 29) is a Protein Coding gene. Diseases associated with SGF29 include Angular Blepharoconjunctivitis and Osteogenesis Imperfecta, Type X. Among its related pathways are Chromatin organization.

UniProtKB/Swiss-Prot Summary for SGF29 Gene

  • Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SGF29 Gene

Genomics for SGF29 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SGF29 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SGF29 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SGF29

Genomic Locations for SGF29 Gene

Genomic Locations for SGF29 Gene
chr16:28,553,915-28,591,790
(GRCh38/hg38)
Size:
37,876 bases
Orientation:
Plus strand
chr16:28,565,236-28,603,111
(GRCh37/hg19)
Size:
37,876 bases
Orientation:
Plus strand

Genomic View for SGF29 Gene

Genes around SGF29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGF29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGF29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGF29 Gene

Proteins for SGF29 Gene

  • Protein details for SGF29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ES7-SGF29_HUMAN
    Recommended name:
    SAGA-associated factor 29
    Protein Accession:
    Q96ES7
    Secondary Accessions:
    • Q96MF5

    Protein attributes for SGF29 Gene

    Size:
    293 amino acids
    Molecular mass:
    33238 Da
    Quaternary structure:
    • Interacts with dimethylated and trimethylated 'Lys-4' of histone H3 (H3K4me2 and H3K4me3), with a preference for the trimethylated form (H3K4me3) (PubMed:21685874, PubMed:26578293). Component of some SAGA-type complexes (PubMed:20850016). Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (PubMed:19103755). Interacts with TADA3L, GCN5L2, SUPT3H and MYC (By similarity).

    Three dimensional structures from OCA and Proteopedia for SGF29 Gene

neXtProt entry for SGF29 Gene

Post-translational modifications for SGF29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SGF29 Gene

Antibody Products

  • Abcam antibodies for SGF29
  • Santa Cruz Biotechnology (SCBT) Antibodies for SGF29

No data available for DME Specific Peptides for SGF29 Gene

Domains & Families for SGF29 Gene

Gene Families for SGF29 Gene

Protein Domains for SGF29 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SGF29 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 101 (SGF29_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96ES7

UniProtKB/Swiss-Prot:

SGF29_HUMAN :
  • The SGF29 C-terminal (also named tudor-like) domain mediates binding to methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3).
  • Belongs to the SGF29 family.
Domain:
  • The SGF29 C-terminal (also named tudor-like) domain mediates binding to methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3).
Family:
  • Belongs to the SGF29 family.
genes like me logo Genes that share domains with SGF29: view

Function for SGF29 Gene

Molecular function for SGF29 Gene

UniProtKB/Swiss-Prot Function:
Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581).

Phenotypes From GWAS Catalog for SGF29 Gene

Gene Ontology (GO) - Molecular Function for SGF29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription coregulator activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0019899 enzyme binding IEA --
GO:0035064 methylated histone binding IBA,IDA 20850016
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with SGF29: view
genes like me logo Genes that share phenotypes with SGF29: view

Animal Models for SGF29 Gene

MGI Knock Outs for SGF29:
  • Sgf29 Sgf29<tm1a(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SGF29

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SGF29 Gene

Localization for SGF29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGF29 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGF29 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SGF29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IEA,IBA 21873635
GO:0005634 nucleus IEA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA,IDA 18838386
GO:0070461 SAGA-type complex IDA 18838386
genes like me logo Genes that share ontologies with SGF29: view

Pathways & Interactions for SGF29 Gene

PathCards logo

SuperPathways for SGF29 Gene

genes like me logo Genes that share pathways with SGF29: view

Pathways by source for SGF29 Gene

Gene Ontology (GO) - Biological Process for SGF29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0016573 histone acetylation IDA 23894581
GO:0043966 histone H3 acetylation IBA,IDA 18838386
GO:0071169 establishment of protein localization to chromatin TAS 20850016
GO:1903506 regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with SGF29: view

No data available for SIGNOR curated interactions for SGF29 Gene

Drugs & Compounds for SGF29 Gene

No Compound Related Data Available

Transcripts for SGF29 Gene

mRNA/cDNA for SGF29 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SGF29

Alternative Splicing Database (ASD) splice patterns (SP) for SGF29 Gene

No ASD Table

Relevant External Links for SGF29 Gene

GeneLoc Exon Structure for
SGF29

Expression for SGF29 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SGF29

Evidence on tissue expression from TISSUES for SGF29 Gene

  • Muscle(4.6)
  • Skin(2.9)
  • Nervous system(2.7)
  • Heart(2.5)
  • Blood(2.4)
  • Liver(2.4)
  • Intestine(2.4)
  • Kidney(2.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with SGF29: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGF29 Gene

Orthologs for SGF29 Gene

This gene was present in the common ancestor of animals.

Orthologs for SGF29 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC101 30 31
  • 99.2 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 99 (a)
OneToMany
CCDC101 30
  • 92.61 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 97 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 97 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia CCDC101 30
  • 93.06 (n)
-- 31
  • 92 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ccdc101 30 31
  • 90.78 (n)
OneToMany
Sgf29 17
Rat
(Rattus norvegicus)
Mammalia Ccdc101 30
  • 89.8 (n)
Chicken
(Gallus gallus)
Aves CCDC101 30 31
  • 81 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 96 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccdc101 30
  • 81.34 (n)
Str.1997 30
Zebrafish
(Danio rerio)
Actinopterygii ccdc101 30 31
  • 76.04 (n)
OneToMany
Dr.13656 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11051 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005116 30
  • 58.18 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Sgf29 30 31
  • 54.74 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y17G9B.8 30 31
  • 47.12 (n)
ManyToMany
T22B7.4 31
  • 14 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3192 30
Species where no ortholog for SGF29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SGF29 Gene

ENSEMBL:
Gene Tree for SGF29 (if available)
TreeFam:
Gene Tree for SGF29 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SGF29: view image

Paralogs for SGF29 Gene

Pseudogenes.org Pseudogenes for SGF29 Gene

genes like me logo Genes that share paralogs with SGF29: view

No data available for Paralogs for SGF29 Gene

Variants for SGF29 Gene

Additional dbSNP identifiers (rs#s) for SGF29 Gene

Structural Variations from Database of Genomic Variants (DGV) for SGF29 Gene

Variant ID Type Subtype PubMed ID
esv2758640 CNV gain+loss 17122850
esv3638337 CNV gain 21293372
esv3892823 CNV gain 25118596
nsv1059555 CNV gain 25217958
nsv1066415 CNV gain 25217958
nsv1138423 CNV deletion 24896259
nsv509608 CNV insertion 20534489
nsv833180 CNV loss 17160897
nsv833182 CNV gain 17160897
nsv9416 CNV gain+loss 18304495

Variation tolerance for SGF29 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SGF29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SGF29

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SGF29 Gene

Disorders for SGF29 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SGF29 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search SGF29 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with SGF29: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SGF29 Gene

Publications for SGF29 Gene

  1. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. (PMID: 21685874) Bian C … Min J (The EMBO journal 2011) 2 3 4
  2. The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain. (PMID: 26421618) Pieters BJ … Mecinović J (PloS one 2015) 3 4
  3. A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation. (PMID: 23894581) Schram AW … Timmers HT (PloS one 2013) 3 4
  4. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (PMID: 20850016) Vermeulen M … Mann M (Cell 2010) 3 4
  5. Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc. (PMID: 17334388) Kurabe N … Tashiro F (Oncogene 2007) 2 3

Products for SGF29 Gene

Sources for SGF29 Gene