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Aliases for SGF29 Gene

Aliases for SGF29 Gene

  • SAGA Complex Associated Factor 29 2 3 5
  • Coiled-Coil Domain-Containing Protein 101 3 4
  • Coiled-Coil Domain Containing 101 2 3
  • CCDC101 3 4
  • SAGA-Associated Factor 29 Homolog (Yeast) 2
  • SAGA-Associated Factor 29 Homolog 3
  • SAGA Complex-Associated Factor 29 4
  • SAGA-Associated Factor 29 3
  • STAF36 3
  • TDRD29 3

External Ids for SGF29 Gene

Previous HGNC Symbols for SGF29 Gene

  • CCDC101

Summaries for SGF29 Gene

Entrez Gene Summary for SGF29 Gene

  • CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]

GeneCards Summary for SGF29 Gene

SGF29 (SAGA Complex Associated Factor 29) is a Protein Coding gene. Diseases associated with SGF29 include Granulomatous Hepatitis. Among its related pathways are Chromatin organization. An important paralog of this gene is LOC613038.

UniProtKB/Swiss-Prot for SGF29 Gene

  • Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated Lys-4 of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581).

Additional gene information for SGF29 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGF29 Gene

Genomics for SGF29 Gene

GeneHancer (GH) Regulatory Elements for SGF29 Gene

Promoters and enhancers for SGF29 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I028553 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 562.7 +0.2 195 1.7 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SGF29 ENSG00000275441 SULT1A2 ATXN2L NFATC2IP SPNS1 ENSG00000260853 ENSG00000260367 NPIPB12 NPIPB10P
GH16I028950 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 36.1 +397.4 397405 2.4 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B YY1 POLR2B E2F8 ZNF143 NFATC2IP SGF29 ATXN2L ENSG00000260853 SMG1P2 SPNS1 ENSG00000260367 EIF3C SULT1A2 NPIPB8
GH16I029273 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.1 +720.0 719985 0.6 HDGF PKNOX1 FOXA2 ARNT YBX1 ZBTB7B TCF12 ZNF280A E2F8 ZNF207 ENSG00000277999 ENSG00000260853 NPIPB12 ATXN2L INO80E SPNS1 NFATC2IP NPIPB13 ENSG00000260367 SMG1P2
GH16I029271 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.1 +718.3 718333 2.5 HDGF PKNOX1 FOXA2 ARNT SIN3A YBX1 ZBTB7B TCF12 ZNF280A E2F8 ENSG00000277999 NFATC2IP SPNS1 ENSG00000260853 INO80E ATXN2L SMG1P2 ENSG00000260367 SGF29 PPP4C
GH16I028936 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 20.2 +382.7 382672 1.1 HDGF ATF1 ARID4B E2F8 ATF7 SP3 SP5 NFYC MXD4 SNIP1 RABEP2 ENSG00000260853 SPNS1 NFATC2IP ATXN2L SMG1P2 ENSG00000260367 NPIPB12 ENSG00000198106 SGF29
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SGF29 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SGF29 Gene

Genomic Locations for SGF29 Gene
chr16:28,553,915-28,591,790
(GRCh38/hg38)
Size:
37,876 bases
Orientation:
Plus strand
chr16:28,565,236-28,603,111
(GRCh37/hg19)

Genomic View for SGF29 Gene

Genes around SGF29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGF29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGF29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGF29 Gene

Proteins for SGF29 Gene

  • Protein details for SGF29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ES7-SGF29_HUMAN
    Recommended name:
    SAGA-associated factor 29
    Protein Accession:
    Q96ES7
    Secondary Accessions:
    • Q96MF5

    Protein attributes for SGF29 Gene

    Size:
    293 amino acids
    Molecular mass:
    33238 Da
    Quaternary structure:
    • Interacts with dimethylated and trimethylated Lys-4 of histone H3 (H3K4me2 and H3K4me3), with a preference for the trimethylated form (H3K4me3) (PubMed:21685874, PubMed:26578293). Component of some SAGA-type complexes (PubMed:20850016). Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (PubMed:19103755). Interacts with TADA3L, GCN5L2, SUPT3H and MYC (By similarity).

    Three dimensional structures from OCA and Proteopedia for SGF29 Gene

neXtProt entry for SGF29 Gene

Post-translational modifications for SGF29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SGF29 Gene

No data available for DME Specific Peptides for SGF29 Gene

Domains & Families for SGF29 Gene

Gene Families for SGF29 Gene

Protein Domains for SGF29 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SGF29 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96ES7

UniProtKB/Swiss-Prot:

SGF29_HUMAN :
  • The SGF29 C-terminal (also named tudor-like) domain mediates binding to methylated Lys-4 of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3).
  • Belongs to the SGF29 family.
Domain:
  • The SGF29 C-terminal (also named tudor-like) domain mediates binding to methylated Lys-4 of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3).
Family:
  • Belongs to the SGF29 family.
genes like me logo Genes that share domains with SGF29: view

Function for SGF29 Gene

Molecular function for SGF29 Gene

UniProtKB/Swiss-Prot Function:
Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated Lys-4 of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581).

Phenotypes From GWAS Catalog for SGF29 Gene

Gene Ontology (GO) - Molecular Function for SGF29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019899 enzyme binding IEA --
GO:0035064 methylated histone binding IDA 20850016
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with SGF29: view
genes like me logo Genes that share phenotypes with SGF29: view

Animal Models for SGF29 Gene

MGI Knock Outs for SGF29:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SGF29

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SGF29 Gene

Localization for SGF29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGF29 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGF29 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SGF29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA,IEA 18838386
GO:0070461 SAGA-type complex IDA 18838386
genes like me logo Genes that share ontologies with SGF29: view

Pathways & Interactions for SGF29 Gene

genes like me logo Genes that share pathways with SGF29: view

Pathways by source for SGF29 Gene

Interacting Proteins for SGF29 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000316114%0d%0a9606.ENSP00000307684%0d%0a9606.ENSP00000308022%0d%0a9606.ENSP00000225916%0d%0a9606.ENSP00000263754%0d%0a9606.ENSP00000360515%0d%0a
Selected Interacting proteins: Q96ES7-SGF29_HUMAN ENSP00000316114 for SGF29 Gene via IID STRING UniProtKB MINT

Symbol External ID(s) Details
HIST1H3D
HIST1H3H
HIST1H3J
HIST1H3A
HIST1H3B

Gene Ontology (GO) - Biological Process for SGF29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016569 covalent chromatin modification IEA --
GO:0016573 histone acetylation IDA 23894581
GO:0043966 histone H3 acetylation IDA 18838386
genes like me logo Genes that share ontologies with SGF29: view

No data available for SIGNOR curated interactions for SGF29 Gene

Drugs & Compounds for SGF29 Gene

No Compound Related Data Available

Transcripts for SGF29 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SGF29

Alternative Splicing Database (ASD) splice patterns (SP) for SGF29 Gene

No ASD Table

Relevant External Links for SGF29 Gene

GeneLoc Exon Structure for
SGF29
ECgene alternative splicing isoforms for
SGF29

Expression for SGF29 Gene

NURSA nuclear receptor signaling pathways regulating expression of SGF29 Gene:

SGF29

Evidence on tissue expression from TISSUES for SGF29 Gene

  • Muscle(4.5)
  • Skin(2.1)
  • Lung(2)
  • Nervous system(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGF29 Gene

Orthologs for SGF29 Gene

This gene was present in the common ancestor of animals.

Orthologs for SGF29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC101 33 34
  • 99.2 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 99 (a)
OneToMany
CCDC101 33
  • 92.61 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCDC101 33
  • 93.06 (n)
-- 34
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ccdc101 33 34
  • 90.78 (n)
Sgf29 16
rat
(Rattus norvegicus)
Mammalia Ccdc101 33
  • 89.8 (n)
chicken
(Gallus gallus)
Aves CCDC101 33 34
  • 81 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 96 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc101 33
  • 81.34 (n)
Str.1997 33
zebrafish
(Danio rerio)
Actinopterygii ccdc101 33 34
  • 76.04 (n)
Dr.13656 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11051 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005116 33
  • 58.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sgf29 33 34
  • 54.74 (n)
worm
(Caenorhabditis elegans)
Secernentea Y17G9B.8 33 34
  • 47.12 (n)
T22B7.4 34
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3192 33
Species where no ortholog for SGF29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGF29 Gene

ENSEMBL:
Gene Tree for SGF29 (if available)
TreeFam:
Gene Tree for SGF29 (if available)

Paralogs for SGF29 Gene

Paralogs for SGF29 Gene

Pseudogenes.org Pseudogenes for SGF29 Gene

genes like me logo Genes that share paralogs with SGF29: view

Variants for SGF29 Gene

Sequence variations from dbSNP and Humsavar for SGF29 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000042689 -- 28,558,302(+) G/A intron_variant
rs1000045131 -- 28,554,446(+) C/T intron_variant
rs1000149731 -- 28,561,128(+) A/C intron_variant
rs1000152063 -- 28,588,439(+) C/T intron_variant
rs1000235224 -- 28,571,728(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SGF29 Gene

Variant ID Type Subtype PubMed ID
esv2758640 CNV gain+loss 17122850
esv3638337 CNV gain 21293372
esv3892823 CNV gain 25118596
nsv1059555 CNV gain 25217958
nsv1066415 CNV gain 25217958
nsv1138423 CNV deletion 24896259
nsv509608 CNV insertion 20534489
nsv833180 CNV loss 17160897
nsv833182 CNV gain 17160897
nsv9416 CNV gain+loss 18304495

Variation tolerance for SGF29 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SGF29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SGF29

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGF29 Gene

Disorders for SGF29 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SGF29 Gene - From: DISEASES

Disorder Aliases PubMed IDs
granulomatous hepatitis
- elite association - COSMIC cancer census association via MalaCards
Search SGF29 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with SGF29: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SGF29 Gene

Publications for SGF29 Gene

  1. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. (PMID: 21685874) Bian C … Min J (The EMBO journal 2011) 2 3 4 58
  2. The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain. (PMID: 26421618) Pieters BJ … Mecinović J (PloS one 2015) 3 4 58
  3. A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation. (PMID: 23894581) Schram AW … Timmers HT (PloS one 2013) 3 4 58
  4. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (PMID: 20850016) Vermeulen M … Mann M (Cell 2010) 3 4 58
  5. Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc. (PMID: 17334388) Kurabe N … Tashiro F (Oncogene 2007) 2 3 58

Products for SGF29 Gene

  • Addgene plasmids for SGF29

Sources for SGF29 Gene

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