The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine resi... See more...

Aliases for SGCZ Gene

Aliases for SGCZ Gene

  • Sarcoglycan Zeta 2 3 5
  • Zeta-Sarcoglycan 2 3 4
  • Zeta-SG 2 3 4
  • ZSG1 2 3 4
  • SGCZ 5

External Ids for SGCZ Gene

Previous GeneCards Identifiers for SGCZ Gene

  • GC08M013721
  • GC08M013908
  • GC08M013957
  • GC08M013991
  • GC08M012489

Summaries for SGCZ Gene

Entrez Gene Summary for SGCZ Gene

  • The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extra-cellular matrix. [provided by RefSeq, Jul 2008]

GeneCards Summary for SGCZ Gene

SGCZ (Sarcoglycan Zeta) is a Protein Coding gene. Diseases associated with SGCZ include Hallucinogen Abuse and Generalized Epilepsy With Febrile Seizures Plus. An important paralog of this gene is SGCD.

UniProtKB/Swiss-Prot Summary for SGCZ Gene

  • Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity).

Gene Wiki entry for SGCZ Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SGCZ Gene

Genomics for SGCZ Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SGCZ Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J015236 Promoter 1.1 Ensembl CraniofacialAtlas 263.8 +0.8 830 1.6 ZBTB10 CTCF SIN3A RAD21 EGR1 TRIM28 PKNOX1 ZNF660 EZH2 ZNF143 SGCZ HSALNG0063584 piR-32214-632
GH08J015210 Enhancer 0.2 FANTOM5 2.8 +27.3 27297 0.3 SGCZ piR-32214-632 HSALNG0063584
GH08J014755 Enhancer 0.2 FANTOM5 1.5 +482.4 482375 0.3 FJ601678-101 SGCZ HSALNG0063578
GH08J015209 Enhancer 0.2 Ensembl 0.3 +29.3 29330 0.2 piR-32214-632 SGCZ HSALNG0063584
GH08J015211 Enhancer 0.2 Ensembl 0.3 +28.0 28030 0.4 piR-32214-632 SGCZ HSALNG0063584
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SGCZ on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SGCZ

Top Transcription factor binding sites by QIAGEN in the SGCZ gene promoter:
  • CUTL1
  • GCNF
  • GCNF-1
  • GCNF-2
  • IRF-2
  • NF-AT
  • NF-AT1
  • NF-AT2
  • Nkx3-1 v2
  • Pax-3

Genomic Locations for SGCZ Gene

Latest Assembly
1,153,587 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
1,153,587 bases
Minus strand

(GRCh37/hg19 by Ensembl)
1,148,476 bases
Minus strand

Genomic View for SGCZ Gene

Genes around SGCZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGCZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGCZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGCZ Gene

Proteins for SGCZ Gene

  • Protein details for SGCZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6REU0

    Protein attributes for SGCZ Gene

    299 amino acids
    Molecular mass:
    32949 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SGCZ Gene


neXtProt entry for SGCZ Gene

Post-translational modifications for SGCZ Gene

  • Glycosylation at Asn62 and Asn110
  • Modification sites at PhosphoSitePlus

Other Protein References for SGCZ Gene

No data available for DME Specific Peptides for SGCZ Gene

Domains & Families for SGCZ Gene

Gene Families for SGCZ Gene

Protein Domains for SGCZ Gene

  • Sarcoglycan complex subunit protein

Suggested Antigen Peptide Sequences for SGCZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sarcoglycan beta/delta/gamma/zeta family.
  • Belongs to the sarcoglycan beta/delta/gamma/zeta family.
genes like me logo Genes that share domains with SGCZ: view

Function for SGCZ Gene

Molecular function for SGCZ Gene

UniProtKB/Swiss-Prot Function:
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity).

Phenotypes From GWAS Catalog for SGCZ Gene

Gene Ontology (GO) - Molecular Function for SGCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with SGCZ: view
genes like me logo Genes that share phenotypes with SGCZ: view

Animal Models for research

  • Taconic Biosciences Mouse Models for SGCZ

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SGCZ

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SGCZ Gene

Localization for SGCZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGCZ Gene

Cell membrane, sarcolemma. Single-pass type II membrane protein. Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGCZ gene
Compartment Confidence
plasma membrane 4
cytoskeleton 4
extracellular 2
nucleus 1
endoplasmic reticulum 1
cytosol 0

Gene Ontology (GO) - Cellular Components for SGCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0016012 sarcoglycan complex IEA,TAS 17438352
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SGCZ: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SGCZ Gene

Pathways & Interactions for SGCZ Gene

PathCards logo

SuperPathways for SGCZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for SGCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046716 muscle cell cellular homeostasis TAS 17438352
GO:0048738 cardiac muscle tissue development IBA 21873635
GO:0055001 muscle cell development TAS 17438352
GO:0060047 heart contraction IBA 21873635
GO:0061024 membrane organization TAS 17438352
genes like me logo Genes that share ontologies with SGCZ: view

No data available for Pathways by source and SIGNOR curated interactions for SGCZ Gene

Drugs & Compounds for SGCZ Gene

No Compound Related Data Available

Transcripts for SGCZ Gene

mRNA/cDNA for SGCZ Gene

5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SGCZ

Alternative Splicing Database (ASD) splice patterns (SP) for SGCZ Gene

No ASD Table

Relevant External Links for SGCZ Gene

GeneLoc Exon Structure for

Expression for SGCZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SGCZ Gene

mRNA differential expression in normal tissues according to GTEx for SGCZ Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for SGCZ Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SGCZ Gene

Protein tissue co-expression partners for SGCZ Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SGCZ

SOURCE GeneReport for Unigene cluster for SGCZ Gene:


Evidence on tissue expression from TISSUES for SGCZ Gene

  • Muscle(4.3)
genes like me logo Genes that share expression patterns with SGCZ: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGCZ Gene

Orthologs for SGCZ Gene

This gene was present in the common ancestor of animals.

Orthologs for SGCZ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SGCZ 29 30
  • 99.89 (n)
(Canis familiaris)
Mammalia SGCZ 29 30
  • 93.76 (n)
(Bos Taurus)
Mammalia SGCZ 29
  • 91.08 (n)
(Rattus norvegicus)
Mammalia Sgcz 29
  • 90.25 (n)
(Mus musculus)
Mammalia Sgcz 29 16 30
  • 90.03 (n)
(Ornithorhynchus anatinus)
Mammalia SGCZ 30
  • 87 (a)
(Monodelphis domestica)
Mammalia SGCZ 30
  • 86 (a)
(Gallus gallus)
Aves SGCZ 29 30
  • 83.66 (n)
(Anolis carolinensis)
Reptilia SGCZ 30
  • 89 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sgcz 29
  • 77.74 (n)
(Danio rerio)
Actinopterygii LOC100334126 29
  • 69.01 (n)
  • 68 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta Scgdelta 30
  • 26 (a)
(Caenorhabditis elegans)
Secernentea sgn-1 30
  • 29 (a)
Species where no ortholog for SGCZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SGCZ Gene

Gene Tree for SGCZ (if available)
Gene Tree for SGCZ (if available)
Evolutionary constrained regions (ECRs) for SGCZ: view image
Alliance of Genome Resources:
Additional Orthologs for SGCZ

Paralogs for SGCZ Gene

Paralogs for SGCZ Gene

(2) SIMAP similar genes for SGCZ Gene using alignment to 2 proteins:

  • Q08AT0_HUMAN
genes like me logo Genes that share paralogs with SGCZ: view

Variants for SGCZ Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SGCZ Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SGCZ Gene

Variant ID Type Subtype PubMed ID
dgv11999n54 CNV loss 21841781
dgv12000n54 CNV loss 21841781
dgv12001n54 CNV loss 21841781
dgv12002n54 CNV loss 21841781
dgv12003n54 CNV loss 21841781
dgv12004n54 CNV loss 21841781
dgv12005n54 CNV loss 21841781
dgv12006n54 CNV loss 21841781
dgv12007n54 CNV gain 21841781
dgv12008n54 CNV loss 21841781
dgv12009n54 CNV loss 21841781
dgv12010n54 CNV loss 21841781
dgv12011n54 CNV loss 21841781
dgv1273e199 CNV deletion 23128226
dgv1380e214 CNV loss 21293372
dgv2044e212 CNV loss 25503493
dgv2045e212 CNV loss 25503493
dgv2046e212 CNV loss 25503493
dgv2047e212 CNV loss 25503493
dgv241n6 CNV deletion 16902084
dgv248e55 CNV loss 17911159
dgv3781n106 CNV deletion 24896259
dgv4092e59 CNV tandem duplication 20981092
dgv449n21 CNV loss 19592680
dgv7101n100 CNV gain 25217958
dgv7102n100 CNV gain 25217958
dgv7103n100 CNV loss 25217958
dgv7104n100 CNV loss 25217958
dgv7105n100 CNV gain 25217958
dgv7106n100 CNV loss 25217958
dgv870n27 CNV loss 19166990
dgv871n27 CNV loss 19166990
dgv872n27 CNV loss 19166990
esv1051749 CNV insertion 17803354
esv1232453 CNV deletion 17803354
esv2024165 CNV deletion 18987734
esv22173 CNV loss 19812545
esv23545 CNV loss 19812545
esv2421743 CNV deletion 20811451
esv2566045 CNV deletion 19546169
esv2657342 CNV deletion 23128226
esv2659369 CNV deletion 23128226
esv2661741 CNV deletion 23128226
esv2664957 CNV deletion 23128226
esv2674136 CNV deletion 23128226
esv2674687 CNV deletion 23128226
esv2676987 CNV deletion 23128226
esv2736646 CNV deletion 23290073
esv2736647 CNV deletion 23290073
esv2736648 CNV deletion 23290073
esv2736649 CNV deletion 23290073
esv2736650 CNV deletion 23290073
esv2736652 CNV deletion 23290073
esv2736653 CNV deletion 23290073
esv2736654 CNV deletion 23290073
esv275224 CNV loss 21479260
esv2759596 CNV loss 17122850
esv2759597 CNV loss 17122850
esv2759598 CNV loss 17122850
esv2761223 CNV loss 21179565
esv2761413 CNV loss 21179565
esv2761414 CNV loss 21179565
esv2761415 CNV gain 21179565
esv2762729 CNV loss 21179565
esv2762730 CNV loss 21179565
esv2762731 CNV loss 21179565
esv28622 CNV loss 19812545
esv28727 CNV gain 19812545
esv28913 CNV loss 19812545
esv29360 CNV loss 19812545
esv3303115 CNV mobile element insertion 20981092
esv3309112 CNV mobile element insertion 20981092
esv3330944 CNV insertion 20981092
esv3352277 CNV duplication 20981092
esv3376584 CNV insertion 20981092
esv3408794 CNV insertion 20981092
esv3410308 CNV duplication 20981092
esv3411623 CNV insertion 20981092
esv3424800 CNV insertion 20981092
esv3425725 CNV insertion 20981092
esv35026 CNV loss 17911159
esv3543104 CNV deletion 23714750
esv3543108 CNV deletion 23714750
esv3543110 CNV deletion 23714750
esv3543112 CNV deletion 23714750
esv3572541 CNV loss 25503493
esv3572554 CNV loss 25503493
esv3572555 CNV loss 25503493
esv3572556 CNV loss 25503493
esv3616348 CNV loss 21293372
esv3616349 CNV gain 21293372
esv3616352 CNV loss 21293372
esv3616353 CNV gain 21293372
esv3616358 CNV gain 21293372
esv3616359 CNV gain 21293372
esv3616361 CNV loss 21293372
esv3616362 CNV loss 21293372
esv3616363 CNV gain 21293372
esv3616364 CNV loss 21293372
esv3616366 CNV loss 21293372
esv3616367 CNV loss 21293372
esv3616368 CNV loss 21293372
esv3616369 CNV loss 21293372
esv3616371 CNV loss 21293372
esv3616372 CNV gain 21293372
esv3616373 CNV loss 21293372
esv3616374 CNV loss 21293372
esv3616375 CNV loss 21293372
esv3616376 CNV loss 21293372
esv3616377 CNV loss 21293372
esv3616378 CNV loss 21293372
esv3616380 CNV loss 21293372
esv3616381 CNV loss 21293372
esv3616383 CNV loss 21293372
esv3616385 CNV loss 21293372
esv3616386 CNV loss 21293372
esv3616387 CNV loss 21293372
esv3616388 CNV loss 21293372
esv3616390 CNV loss 21293372
esv3616391 CNV loss 21293372
esv3891345 CNV loss 25118596
esv3891346 CNV loss 25118596
esv3891347 CNV gain+loss 25118596
esv3950 CNV loss 18987735
esv6670 CNV loss 19470904
esv994811 CNV deletion 20482838
esv995763 CNV loss 20482838
nsv1015699 CNV loss 25217958
nsv1017010 CNV gain 25217958
nsv1017324 CNV loss 25217958
nsv1017866 CNV gain+loss 25217958
nsv1019218 CNV gain 25217958
nsv1020168 CNV loss 25217958
nsv1020704 CNV loss 25217958
nsv1021965 CNV loss 25217958
nsv1022834 CNV gain 25217958
nsv1023680 CNV loss 25217958
nsv1024069 CNV gain 25217958
nsv1026109 CNV loss 25217958
nsv1026823 CNV gain 25217958
nsv1028791 CNV gain 25217958
nsv1029026 CNV loss 25217958
nsv1029399 CNV gain 25217958
nsv1031428 CNV loss 25217958
nsv1031710 CNV loss 25217958
nsv1031995 CNV gain 25217958
nsv1033159 CNV loss 25217958
nsv1033883 CNV gain 25217958
nsv1073357 CNV deletion 25765185
nsv1075116 CNV deletion 25765185
nsv1075534 CNV deletion 25765185
nsv1109951 CNV deletion 24896259
nsv1115067 CNV deletion 24896259
nsv1117809 CNV deletion 24896259
nsv1126846 CNV deletion 24896259
nsv1128402 CNV deletion 24896259
nsv1140896 CNV deletion 24896259
nsv1152508 CNV duplication 26484159
nsv396378 CNV deletion 16902084
nsv396791 CNV insertion 16902084
nsv433245 CNV loss 18776910
nsv437048 CNV loss 16327808
nsv437049 CNV loss 16327808
nsv437050 CNV loss 16327808
nsv437051 CNV loss 16327808
nsv437052 CNV loss 16327808
nsv437053 CNV loss 16327808
nsv438040 CNV loss 16468122
nsv438041 CNV loss 16468122
nsv442098 CNV loss 18776908
nsv442099 CNV loss 18776908
nsv465524 CNV gain 19166990
nsv465531 CNV loss 19166990
nsv465535 CNV loss 19166990
nsv465536 CNV loss 19166990
nsv465537 CNV loss 19166990
nsv465538 CNV loss 19166990
nsv465540 CNV loss 19166990
nsv465541 CNV gain 19166990
nsv465542 CNV loss 19166990
nsv465543 CNV loss 19166990
nsv465544 CNV loss 19166990
nsv465545 CNV loss 19166990
nsv465546 CNV loss 19166990
nsv465547 CNV loss 19166990
nsv465548 CNV loss 19166990
nsv465549 CNV loss 19166990
nsv465551 CNV loss 19166990
nsv469745 CNV loss 16826518
nsv470190 CNV gain 18288195
nsv470191 CNV loss 18288195
nsv472718 CNV novel sequence insertion 20440878
nsv476607 CNV novel sequence insertion 20440878
nsv477157 CNV novel sequence insertion 20440878
nsv478866 CNV novel sequence insertion 20440878
nsv499586 CNV loss 21111241
nsv507442 OTHER sequence alteration 20534489
nsv514475 CNV gain+loss 21397061
nsv514476 CNV loss 21397061
nsv516690 CNV loss 19592680
nsv517019 CNV gain+loss 19592680
nsv518542 CNV gain 19592680
nsv519666 CNV gain 19592680
nsv520158 CNV loss 19592680
nsv520590 CNV loss 19592680
nsv520906 CNV gain 19592680
nsv523294 CNV loss 19592680
nsv524304 CNV loss 19592680
nsv524332 CNV loss 19592680
nsv524809 CNV loss 19592680
nsv524888 CNV loss 19592680
nsv525799 CNV loss 19592680
nsv527437 CNV loss 19592680
nsv528003 CNV loss 19592680
nsv6086 CNV deletion 18451855
nsv610411 CNV loss 21841781
nsv610452 CNV loss 21841781
nsv610460 CNV gain 21841781
nsv610461 CNV loss 21841781
nsv610462 CNV loss 21841781
nsv610465 CNV loss 21841781
nsv610466 CNV loss 21841781
nsv610467 CNV loss 21841781
nsv610471 CNV loss 21841781
nsv610474 CNV loss 21841781
nsv610475 CNV loss 21841781
nsv610476 CNV loss 21841781
nsv610485 CNV loss 21841781
nsv610487 CNV loss 21841781
nsv610488 CNV loss 21841781
nsv610489 CNV loss 21841781
nsv610490 CNV loss 21841781
nsv610491 CNV loss 21841781
nsv610492 CNV loss 21841781
nsv610495 CNV loss 21841781
nsv610496 CNV loss 21841781
nsv610497 CNV loss 21841781
nsv610504 CNV loss 21841781
nsv610507 CNV loss 21841781
nsv610508 CNV loss 21841781
nsv610511 CNV loss 21841781
nsv610512 CNV loss 21841781
nsv610513 CNV loss 21841781
nsv610514 CNV loss 21841781
nsv610515 CNV gain 21841781
nsv610516 CNV loss 21841781
nsv610517 CNV loss 21841781
nsv610520 CNV loss 21841781
nsv818603 CNV gain 17921354
nsv818604 CNV loss 17921354
nsv818605 CNV loss 17921354
nsv818606 CNV loss 17921354
nsv824549 CNV loss 20364138
nsv824550 CNV loss 20364138
nsv8296 CNV loss 18304495
nsv8297 CNV loss 18304495
nsv8298 CNV gain+loss 18304495
nsv831240 CNV gain 17160897
nsv956082 CNV deletion 24416366
nsv957668 CNV deletion 24416366
nsv967567 CNV duplication 23825009

Variation tolerance for SGCZ Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SGCZ Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SGCZ Gene

Disorders for SGCZ Gene

MalaCards: The human disease database

(6) MalaCards diseases for SGCZ Gene - From: COP and GCD

Disorder Aliases PubMed IDs
hallucinogen abuse
generalized epilepsy with febrile seizures plus
  • gefs+
embryonal testis carcinoma
  • embryonal carcinoma of testis
dystonia 11, myoclonic
  • dyt11
  • dystonic disease
- elite association - COSMIC cancer census association via MalaCards
Search SGCZ in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SGCZ

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SGCZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SGCZ Gene

Publications for SGCZ Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  2. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. (PMID: 20526338) Johnson AD … Becker LC (Nature genetics 2010) 3 40
  3. Candidate-gene testing for orphan limb-girdle muscular dystrophies. (PMID: 19472918) Aurino S … Nigro V (Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 2008) 3 40
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy. (PMID: 12189167) Wheeler MT … McNally EM (Human molecular genetics 2002) 2 3

Products for SGCZ Gene

Sources for SGCZ Gene