Aliases for SGCG Gene
External Ids for SGCG Gene
Previous HGNC Symbols for SGCG Gene
Previous GeneCards Identifiers for SGCG Gene
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]
GeneCards Summary for SGCG Gene
SGCG (Sarcoglycan Gamma) is a Protein Coding gene. Diseases associated with SGCG include Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 5 and Muscular Dystrophy. Among its related pathways are Dilated cardiomyopathy (DCM) and Arrhythmogenic right ventricular cardiomyopathy (ARVC). An important paralog of this gene is SGCZ.
UniProtKB/Swiss-Prot Summary for SGCG Gene
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.