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Aliases for SFXN3 Gene

Aliases for SFXN3 Gene

  • Sideroflexin 3 2 3 5
  • Sideroflexin-3 3
  • BA108L7.2 3
  • SLC56A3 3
  • SFX3 3

External Ids for SFXN3 Gene

Previous GeneCards Identifiers for SFXN3 Gene

  • GC00U991057
  • GC10P102781
  • GC10P096420

Summaries for SFXN3 Gene

GeneCards Summary for SFXN3 Gene

SFXN3 (Sideroflexin 3) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional repression. Gene Ontology (GO) annotations related to this gene include cation transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SFXN1.

UniProtKB/Swiss-Prot for SFXN3 Gene

  • Potential iron transporter.

Additional gene information for SFXN3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFXN3 Gene

Genomics for SFXN3 Gene

GeneHancer (GH) Regulatory Elements for SFXN3 Gene

Promoters and enhancers for SFXN3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J101028 Enhancer 0.8 ENCODE dbSUPER 650.7 -2.0 -1954 1.1 CTCF ZNF3 MAZ ZIC2 RARA TEAD3 ATF4 GATA3 POLR2A VEZF1 SFXN3 TWNK ENSG00000236662 MRPL43 SEMA4G PDZD7 LZTS2
GH10J101059 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 7.5 +32.6 32613 8.7 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 SSRP1 KAZALD1 BTRC ENSG00000272572 KCNIP2-AS1 SFXN3 MRPL43 ENSG00000273162 GC10M101091
GH10J101030 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 7.7 +2.0 2018 6.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 FOS PDZD7 MRPL43 TWNK KAZALD1 TLX1 TLX1NB SEMA4G ENSG00000236662 MIR608 CWF19L1
GH10J101224 Promoter/Enhancer 1.4 EPDnew ENCODE 4.2 +196.7 196725 6.5 PKNOX1 ZNF133 FEZF1 GLI4 ZNF2 GLIS2 ZNF548 SP3 TSHZ1 ZNF623 LBX1-AS1 GC10M101227 LBX1 PHBP9 PPRC1 LDB1 CHUK ENSG00000231188 ENSG00000272572 ARMH3
GH10J101012 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.5 -18.1 -18130 1.6 ARID4B SIN3A ZNF48 GLIS2 ZNF143 ATF7 FOS RUNX3 REST MYNN ENSG00000272572 SFXN3 PDZD7 LZTS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SFXN3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SFXN3 gene promoter:
  • AREB6
  • GATA-1
  • RFX1
  • PPAR-alpha
  • C/EBPalpha
  • c-Rel
  • CUTL1
  • Bach1
  • MRF-2
  • PPAR-gamma1

Genomic Locations for SFXN3 Gene

Genomic Locations for SFXN3 Gene
10,016 bases
Plus strand
10,008 bases
Plus strand

Genomic View for SFXN3 Gene

Genes around SFXN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFXN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFXN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFXN3 Gene

Proteins for SFXN3 Gene

  • Protein details for SFXN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8NCJ0
    • Q9NTP4

    Protein attributes for SFXN3 Gene

    321 amino acids
    Molecular mass:
    35503 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH00124.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11151.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI10936.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SFXN3 Gene

Post-translational modifications for SFXN3 Gene

  • Ubiquitination at isoforms=173 and posLast=7575
  • Modification sites at PhosphoSitePlus

Other Protein References for SFXN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFXN3 Gene

Domains & Families for SFXN3 Gene

Gene Families for SFXN3 Gene

Protein Domains for SFXN3 Gene


Suggested Antigen Peptide Sequences for SFXN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sideroflexin family.
  • Belongs to the sideroflexin family.
genes like me logo Genes that share domains with SFXN3: view

Function for SFXN3 Gene

Molecular function for SFXN3 Gene

UniProtKB/Swiss-Prot Function:
Potential iron transporter.

Phenotypes From GWAS Catalog for SFXN3 Gene

Gene Ontology (GO) - Molecular Function for SFXN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015075 ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SFXN3: view
genes like me logo Genes that share phenotypes with SFXN3: view

Animal Models for SFXN3 Gene

MGI Knock Outs for SFXN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SFXN3

Clone Products

  • Addgene plasmids for SFXN3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SFXN3 Gene

Localization for SFXN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFXN3 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SFXN3 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SFXN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with SFXN3: view

Pathways & Interactions for SFXN3 Gene

genes like me logo Genes that share pathways with SFXN3: view

Pathways by source for SFXN3 Gene

1 BioSystems pathway for SFXN3 Gene

Gene Ontology (GO) - Biological Process for SFXN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0055072 iron ion homeostasis IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SFXN3: view

No data available for SIGNOR curated interactions for SFXN3 Gene

Drugs & Compounds for SFXN3 Gene

(1) Additional Compounds for SFXN3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • FE (II) ion
  • Fe(II)
  • Fe(2+)
  • Ferrous ion
  • Iron ion(2+)
genes like me logo Genes that share compounds with SFXN3: view

Transcripts for SFXN3 Gene

mRNA/cDNA for SFXN3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(162) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFXN3 Gene

Sideroflexin 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for SFXN3

Alternative Splicing Database (ASD) splice patterns (SP) for SFXN3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: -
SP8: -

Relevant External Links for SFXN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SFXN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SFXN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SFXN3 Gene

This gene is overexpressed in Nasal epithelium (15.6) and Bone (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SFXN3 Gene

Protein tissue co-expression partners for SFXN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SFXN3 Gene:


SOURCE GeneReport for Unigene cluster for SFXN3 Gene:


Evidence on tissue expression from TISSUES for SFXN3 Gene

  • Nervous system(4.3)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with SFXN3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SFXN3 Gene

Orthologs for SFXN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SFXN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SFXN3 34 33
  • 99.18 (n)
(Canis familiaris)
Mammalia SFXN3 34 33
  • 91.59 (n)
(Bos Taurus)
Mammalia SFXN3 34 33
  • 90.13 (n)
(Mus musculus)
Mammalia Sfxn3 16 34 33
  • 88.47 (n)
(Rattus norvegicus)
Mammalia Sfxn3 33
  • 87.64 (n)
(Monodelphis domestica)
Mammalia SFXN3 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SFXN3 34
  • 62 (a)
(Gallus gallus)
Aves SFXN3 34
  • 76 (a)
(Anolis carolinensis)
Reptilia SFXN3 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sfxn3 33
  • 70.53 (n)
(Danio rerio)
Actinopterygii sfxn3 34 33
  • 70.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11739 34
  • 54 (a)
(Caenorhabditis elegans)
Secernentea sfxn-1.4 34 33
  • 55.35 (n)
sfxn-1.5 34
  • 52 (a)
sfxn-1.1 34
  • 47 (a)
sfxn-1.2 34
  • 46 (a)
sfxn-1.3 34
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FSF1 34
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10377 34
  • 60 (a)
Cin.4566 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4566 33
Species where no ortholog for SFXN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFXN3 Gene

Gene Tree for SFXN3 (if available)
Gene Tree for SFXN3 (if available)
Evolutionary constrained regions (ECRs) for SFXN3: view image

Paralogs for SFXN3 Gene

Paralogs for SFXN3 Gene

(3) SIMAP similar genes for SFXN3 Gene using alignment to 2 proteins:

  • S4R3N9_HUMAN
genes like me logo Genes that share paralogs with SFXN3: view

Variants for SFXN3 Gene

Sequence variations from dbSNP and Humsavar for SFXN3 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs587776894 risk-factor, Usher syndrome, type 2A 101,030,054(+) GGGGGGG/GGGGGGGG upstream_transcript_variant
rs150917752 likely-benign, not specified 101,030,064(+) G/A/T upstream_transcript_variant
rs78072468 benign, not specified 101,030,061(+) C/A/G/T upstream_transcript_variant
rs1001168908 -- 101,031,719(+) C/G intron_variant
rs1001229174 -- 101,037,802(+) C/T intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SFXN3 Gene

Variant ID Type Subtype PubMed ID
esv3624367 CNV loss 21293372
nsv476347 CNV novel sequence insertion 20440878
nsv7525 CNV insertion 18451855
nsv831965 CNV loss 17160897

Variation tolerance for SFXN3 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.27; 52.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SFXN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFXN3 Gene

Disorders for SFXN3 Gene

Additional Disease Information for SFXN3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SFXN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFXN3 Gene

Publications for SFXN3 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. (PMID: 29128334) Malty RH … Babu M (Cell systems 2017) 3 58
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58

Products for SFXN3 Gene

  • Addgene plasmids for SFXN3

Sources for SFXN3 Gene

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