Aliases for SFXN1 Gene
External Ids for SFXN1 Gene
Previous GeneCards Identifiers for SFXN1 Gene
GeneCards Summary for SFXN1 Gene
SFXN1 (Sideroflexin 1) is a Protein Coding gene. Diseases associated with SFXN1 include Aceruloplasminemia. Gene Ontology (GO) annotations related to this gene include cation transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SFXN3.
UniProtKB/Swiss-Prot Summary for SFXN1 Gene
Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). Transports both D-serine and L-serine (PubMed:30442778). Also able to transport other amino-acids, such as alanine (PubMed:30442778). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity).