This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the ... See more...

Aliases for SFTPC Gene

Aliases for SFTPC Gene

  • Surfactant Protein C 2 3 5
  • SP-C 2 3 4
  • Pulmonary Surfactant-Associated Proteolipid SPL(Val) 3 4
  • Pulmonary Surfactant-Associated Protein C 3 4
  • BRICHOS Domain Containing 6 2 3
  • BRICD6 2 3
  • PSP-C 2 3
  • SFTP2 3 4
  • SMDP2 2 3
  • SP5 3 4
  • Surfactant, Pulmonary-Associated Protein C 2
  • Pulmonary Surfactant Apoprotein-2 SP-C 3
  • SFTPC 5

External Ids for SFTPC Gene

Previous HGNC Symbols for SFTPC Gene

  • SFTP2

Previous GeneCards Identifiers for SFTPC Gene

  • GC08P021778
  • GC08P022368
  • GC08P021836
  • GC08P022041
  • GC08P022072
  • GC08P022075
  • GC08P022019
  • GC08P020561

Summaries for SFTPC Gene

Entrez Gene Summary for SFTPC Gene

  • This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]

GeneCards Summary for SFTPC Gene

SFTPC (Surfactant Protein C) is a Protein Coding gene. Diseases associated with SFTPC include Surfactant Metabolism Dysfunction, Pulmonary, 2 and Pulmonary Fibrosis, Idiopathic. Among its related pathways are Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) and Diseases of metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot Summary for SFTPC Gene

  • Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.

Gene Wiki entry for SFTPC Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SFTPC Gene

Genomics for SFTPC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SFTPC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J022053 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 250.2 -101.3 -101294 4.8 ZNF654 IKZF1 SSRP1 ZNF223 NFIC MXD4 REST ZNF341 CTCF IRF2 SFTPC ENSG00000253200 C8orf58 CCAR2 DMTN FHIP2B POLR3D BIN3 HR lnc-FGF17-2
GH08J022155 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 250.7 0.0 -13 1.4 EZH2 ZNF600 ZIC2 KLF9 ZKSCAN1 ZBTB48 ZNF2 CBX8 CTCF NRF1 LGI3 SFTPC lnc-BMP1-1 lnc-BMP1-2 FGF17 NPM2 REEP4 lnc-LGI3-1 RF00017-6325
GH08J022161 Promoter/Enhancer 0.8 EPDnew Ensembl dbSUPER 250.7 +4.7 4702 0.4 CEBPB NONHSAG049714.2 SFTPC BMP1 LGI3 lnc-BMP1-1 RF00017-6325
GH08J022158 Enhancer 0.3 Ensembl dbSUPER 250.7 +2.0 1988 0.2 LGI3 SFTPC lnc-BMP1-1 lnc-BMP1-2 NONHSAG049714.2 BMP1 RF00017-6325
GH08J021917 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.1 -236.5 -236537 4.9 ZNF207 ZNF654 MYC NCOR1 IKZF1 ZNF600 SIX5 ZNF580 ATF2 POLR2A XPO7 HSALNG0063869 ENSG00000253200 FHIP2B C8orf58 CCAR2 POLR3D FGF17 BMP1 BIN3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SFTPC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SFTPC

Top Transcription factor binding sites by QIAGEN in the SFTPC gene promoter:
  • ATF-2
  • C/EBPalpha
  • CREB
  • deltaCREB
  • p53
  • Sp1

Genomic Locations for SFTPC Gene

Latest Assembly
chr8:22,156,913-22,164,479
(GRCh38/hg38)
Size:
7,567 bases
Orientation:
Plus strand

Previous Assembly
chr8:22,014,896-22,021,992
(GRCh37/hg19 by Entrez Gene)
Size:
7,097 bases
Orientation:
Plus strand

chr8:22,014,426-22,021,992
(GRCh37/hg19 by Ensembl)
Size:
7,567 bases
Orientation:
Plus strand

Genomic View for SFTPC Gene

Genes around SFTPC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFTPC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFTPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFTPC Gene

Proteins for SFTPC Gene

  • Protein details for SFTPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11686-PSPC_HUMAN
    Recommended name:
    Pulmonary surfactant-associated protein C
    Protein Accession:
    P11686
    Secondary Accessions:
    • A6XNE4
    • B2RE00
    • E9PGX3
    • P11687
    • Q12793
    • Q7Z5D0

    Protein attributes for SFTPC Gene

    Size:
    197 amino acids
    Molecular mass:
    21053 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

    Three dimensional structures from OCA and Proteopedia for SFTPC Gene

    Alternative splice isoforms for SFTPC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SFTPC Gene

Post-translational modifications for SFTPC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SFTPC Gene

Domains & Families for SFTPC Gene

Gene Families for SFTPC Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SFTPC Gene

InterPro:
Blocks:
  • BRICHOS domain
  • Surfactant-associated polypeptide/chondromodulin-I precursor

Suggested Antigen Peptide Sequences for SFTPC Gene

GenScript: Design optimal peptide antigens:
  • SP5 (PSPC_HUMAN)
genes like me logo Genes that share domains with SFTPC: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SFTPC Gene

Function for SFTPC Gene

Molecular function for SFTPC Gene

UniProtKB/Swiss-Prot Function:
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
GENATLAS Biochemistry:
surfactant-associated glycoprotein c,pulmonary 2 (5-8kDa),alternatively spliced

Phenotypes From GWAS Catalog for SFTPC Gene

Gene Ontology (GO) - Molecular Function for SFTPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19815549
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with SFTPC: view
genes like me logo Genes that share phenotypes with SFTPC: view

Human Phenotype Ontology for SFTPC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SFTPC Gene

MGI Knock Outs for SFTPC:

miRNA for SFTPC Gene

miRTarBase miRNAs that target SFTPC

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SFTPC

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SFTPC Gene

Localization for SFTPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFTPC Gene

Secreted, extracellular space, surface film.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SFTPC gene
Compartment Confidence
extracellular 5
endosome 4
plasma membrane 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SFTPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IBA 21873635
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SFTPC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SFTPC Gene

Pathways & Interactions for SFTPC Gene

genes like me logo Genes that share pathways with SFTPC: view

SIGNOR curated interactions for SFTPC Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SFTPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007585 respiratory gaseous exchange IEA --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SFTPC: view

Drugs & Compounds for SFTPC Gene

(23) Drugs for SFTPC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(26) Additional Compounds for SFTPC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SFTPC: view

Transcripts for SFTPC Gene

mRNA/cDNA for SFTPC Gene

14 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SFTPC

Alternative Splicing Database (ASD) splice patterns (SP) for SFTPC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - -
SP6: -
SP7:
SP8:

Relevant External Links for SFTPC Gene

GeneLoc Exon Structure for
SFTPC

Expression for SFTPC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SFTPC Gene

mRNA differential expression in normal tissues according to GTEx for SFTPC Gene

This gene is overexpressed in Lung (x51.9).

Protein differential expression in normal tissues from HIPED for SFTPC Gene

This gene is overexpressed in Lung (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SFTPC Gene



Protein tissue co-expression partners for SFTPC Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SFTPC

SOURCE GeneReport for Unigene cluster for SFTPC Gene:

Hs.1074

Evidence on tissue expression from TISSUES for SFTPC Gene

  • Lung(5)
  • Heart(2.3)
  • Intestine(2.3)
  • Skin(2.2)
  • Spleen(2.1)
  • Thyroid gland(2.1)
  • Blood(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SFTPC Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • ear
  • epiglottis
  • head
  • larynx
  • mouth
  • neck
  • pharynx
  • salivary gland
Thorax:
  • breast
  • bronchus
  • diaphragm
  • esophagus
  • heart
  • lung
  • trachea
Abdomen:
  • kidney
  • liver
  • spleen
Pelvis:
  • testicle
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with SFTPC: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt for SFTPC Gene

Orthologs for SFTPC Gene

This gene was present in the common ancestor of chordates.

Orthologs for SFTPC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SFTPC 29 30
  • 99.66 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SFTPC 29 30
  • 84.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SFTPC 29
  • 84.21 (n)
SP-C 30
  • 80 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Sftpc 29 16 30
  • 82.02 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sftpc 29
  • 81.15 (n)
Oppossum
(Monodelphis domestica)
Mammalia SP-C 30
  • 68 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 38 (a)
OneToMany
-- 30
  • 26 (a)
OneToMany
-- 30
  • 26 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sftpc 29
  • 52.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23810 29
Species where no ortholog for SFTPC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SFTPC Gene

ENSEMBL:
Gene Tree for SFTPC (if available)
TreeFam:
Gene Tree for SFTPC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SFTPC: view image
Alliance of Genome Resources:
Additional Orthologs for SFTPC

Paralogs for SFTPC Gene

No data available for Paralogs for SFTPC Gene

Variants for SFTPC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SFTPC Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
1040401 Uncertain Significance: not provided 22,164,039(+) T/C
NM_001317778.2(SFTPC):c.574T>C (p.Ter192Gln)
STOP_LOST
908425 Uncertain Significance: Idiopathic Pulmonary Fibrosis; Surfactant metabolism dysfunction, pulmonary, 2 22,163,115(+) G/A
NM_001317778.2(SFTPC):c.237G>A (p.Gln79=)
SYNONYMOUS
908426 Benign: Idiopathic Pulmonary Fibrosis; Surfactant metabolism dysfunction, pulmonary, 2 22,163,181(+) C/T
NM_001317778.2(SFTPC):c.303C>T (p.Leu101=)
SYNONYMOUS
908497 Likely Benign: Idiopathic Pulmonary Fibrosis; Surfactant metabolism dysfunction, pulmonary, 2 22,164,418(+) G/A
NM_001317778.2(SFTPC):c.*171G>A
THREE_PRIME_UTR
909206 Benign: Idiopathic Pulmonary Fibrosis; Surfactant metabolism dysfunction, pulmonary, 2 22,162,599(+) G/A
NM_001317778.2(SFTPC):c.68G>A (p.Arg23Gln)
MISSENSE_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SFTPC Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SFTPC Gene

Variant ID Type Subtype PubMed ID
dgv12054n54 CNV loss 21841781
dgv2060e212 CNV loss 25503493
dgv881n27 CNV loss 19166990
esv2759604 CNV loss 17122850
nsv465613 CNV loss 19166990
nsv470204 CNV loss 18288195
nsv527293 CNV loss 19592680
nsv528590 CNV loss 19592680
nsv610771 CNV loss 21841781
nsv831263 CNV loss 17160897
nsv831264 CNV gain+loss 17160897

Variation tolerance for SFTPC Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.36; 94.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SFTPC Gene

Human Gene Mutation Database (HGMD)
SFTPC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFTPC
Leiden Open Variation Database (LOVD)
SFTPC

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFTPC Gene

Disorders for SFTPC Gene

MalaCards: The human disease database

(46) MalaCards diseases for SFTPC Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search SFTPC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PSPC_HUMAN
  • Pulmonary surfactant metabolism dysfunction 2 (SMDP2) [MIM:610913]: A rare disease associated with progressive respiratory insufficiency and lung disease with a variable clinical course, due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. {ECO:0000269 PubMed:11991887, ECO:0000269 PubMed:15039969, ECO:0000269 PubMed:15293602, ECO:0000269 PubMed:15557112, ECO:0000269 PubMed:15572558}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Respiratory distress syndrome in premature infants (RDS) [MIM:267450]: A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. {ECO:0000269 PubMed:14735158}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.

Additional Disease Information for SFTPC

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SFTPC: view

No data available for Genatlas for SFTPC Gene

Publications for SFTPC Gene

  1. Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF. (PMID: 15516475) Lawson WE … du Bois RM (Thorax 2004) 3 22 40 72
  2. Mutation of SFTPC in infantile pulmonary alveolar proteinosis with or without fibrosing lung disease. (PMID: 15039969) Tredano M … Bahuau M (American journal of medical genetics. Part A 2004) 3 4 22 40
  3. Surfactant protein C gene variation in the Finnish population - association with perinatal respiratory disease. (PMID: 14735158) Lahti M … Hallman M (European journal of human genetics : EJHG 2004) 3 4 22 40
  4. New surfactant protein C gene mutations associated with diffuse lung disease. (PMID: 19443464) Guillot L … Feldmann D (Journal of medical genetics 2009) 3 22 40
  5. Genetic association of SP-C with duration of preterm premature rupture of fetal membranes and expression in gestational tissues. (PMID: 19735006) Salminen A … Hallman M (Annals of medicine 2009) 3 22 40

Products for SFTPC Gene

Sources for SFTPC Gene