Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SFT2D3 Gene

Aliases for SFT2D3 Gene

  • SFT2 Domain Containing 3 2 3 5
  • SFT2 Domain-Containing Protein 3 4

External Ids for SFT2D3 Gene

Previous GeneCards Identifiers for SFT2D3 Gene

  • GC02P128175
  • GC02P128458
  • GC02P120764

Summaries for SFT2D3 Gene

GeneCards Summary for SFT2D3 Gene

SFT2D3 (SFT2 Domain Containing 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SFT2D3 Gene

  • May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

Additional gene information for SFT2D3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFT2D3 Gene

Genomics for SFT2D3 Gene

GeneHancer (GH) Regulatory Elements for SFT2D3 Gene

Promoters and enhancers for SFT2D3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I127700 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.9 852 3.4 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 SFT2D3 PIR38126 MAP3K2 AMMECR1L WDR33 POLR2D PIR55015
GH02I127507 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.8 -191.3 -191315 4.9 PKNOX1 SIN3A FEZF1 ZNF2 ATF7 FOS REST TSHZ1 MAFF SMARCA4 SFT2D3 ENSG00000236682 MYO7B RNU4-48P LIMS2 ERCC3 IWS1 ENSG00000231731 AMMECR1L MAP3K2
GH02I127413 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.8 -285.8 -285779 4.3 HDGF CLOCK FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS ERCC3 MAP3K2 SFT2D3 ENSG00000236682 AMMECR1L IWS1 PROC GC02P127390 GC02P127379
GH02I127695 Enhancer 1 FANTOM5 Ensembl ENCODE 27.4 -5.0 -5027 1.2 CTCF JUND MAX SIN3A CTBP2 SFT2D3 GPR17 POLR2D AMMECR1L MAP3K2 IWS1 LIMS2
GH02I127385 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -312.6 -312596 5.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ENSG00000236682 MAP3K2 ERCC3 AMMECR1L GPR17 WDR33 ENSG00000231731 SFT2D3 GC02P127390 GC02P127379
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SFT2D3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SFT2D3 gene promoter:

Genomic Locations for SFT2D3 Gene

Genomic Locations for SFT2D3 Gene
4,220 bases
Plus strand

Genomic View for SFT2D3 Gene

Genes around SFT2D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFT2D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFT2D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFT2D3 Gene

Proteins for SFT2D3 Gene

  • Protein details for SFT2D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicle transport protein SFT2C
    Protein Accession:
    Secondary Accessions:
    • Q8N2P9

    Protein attributes for SFT2D3 Gene

    215 amino acids
    Molecular mass:
    21790 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFT2D3 Gene

Post-translational modifications for SFT2D3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFT2D3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFT2D3 Gene

Domains & Families for SFT2D3 Gene

Gene Families for SFT2D3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SFT2D3 Gene

Suggested Antigen Peptide Sequences for SFT2D3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SFT2 family.
  • Belongs to the SFT2 family.
genes like me logo Genes that share domains with SFT2D3: view

Function for SFT2D3 Gene

Molecular function for SFT2D3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

Phenotypes for SFT2D3 Gene

GenomeRNAi human phenotypes for SFT2D3:
genes like me logo Genes that share phenotypes with SFT2D3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SFT2D3 Gene

Localization for SFT2D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFT2D3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SFT2D3 gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for SFT2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SFT2D3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SFT2D3 Gene

Pathways & Interactions for SFT2D3 Gene

SuperPathways for SFT2D3 Gene

No Data Available

Interacting Proteins for SFT2D3 Gene

Gene Ontology (GO) - Biological Process for SFT2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IBA --
genes like me logo Genes that share ontologies with SFT2D3: view

No data available for Pathways by source and SIGNOR curated interactions for SFT2D3 Gene

Drugs & Compounds for SFT2D3 Gene

No Compound Related Data Available

Transcripts for SFT2D3 Gene

mRNA/cDNA for SFT2D3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(120) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFT2D3 Gene

SFT2 domain containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFT2D3 Gene

No ASD Table

Relevant External Links for SFT2D3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SFT2D3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SFT2D3 Gene

Protein differential expression in normal tissues from HIPED for SFT2D3 Gene

This gene is overexpressed in Bone (32.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SFT2D3 Gene

Protein tissue co-expression partners for SFT2D3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SFT2D3 Gene:


SOURCE GeneReport for Unigene cluster for SFT2D3 Gene:

genes like me logo Genes that share expression patterns with SFT2D3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SFT2D3 Gene

Orthologs for SFT2D3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SFT2D3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SFT2D3 33 34
  • 98.91 (n)
(Bos Taurus)
Mammalia SFT2D3 33 34
  • 81.22 (n)
(Mus musculus)
Mammalia Sft2d3 33 16 34
  • 79.4 (n)
(Rattus norvegicus)
Mammalia Sft2d3 33
  • 78.6 (n)
(Monodelphis domestica)
Mammalia SFT2D3 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8266 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.29830 33
(Danio rerio)
Actinopterygii sft2d3 33 34
  • 56.96 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009524 33
  • 47.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33635 33 34
  • 46.39 (n)
(Caenorhabditis elegans)
Secernentea C18E9.10 33 34
  • 43.2 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFT2 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
Species where no ortholog for SFT2D3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFT2D3 Gene

Gene Tree for SFT2D3 (if available)
Gene Tree for SFT2D3 (if available)

Paralogs for SFT2D3 Gene

No data available for Paralogs for SFT2D3 Gene

Variants for SFT2D3 Gene

Sequence variations from dbSNP and Humsavar for SFT2D3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000223586 -- 127,699,533(+) G/A upstream_transcript_variant
rs1000970695 -- 127,702,842(+) A/G 3_prime_UTR_variant
rs1001003241 -- 127,703,143(+) G/A 3_prime_UTR_variant
rs1001522379 -- 127,703,858(+) C/A downstream_transcript_variant
rs1002644080 -- 127,704,311(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SFT2D3 Gene

Variant ID Type Subtype PubMed ID
dgv4069n100 CNV gain 25217958
nsv1122007 CNV deletion 24896259
nsv1143959 CNV deletion 24896259
nsv470482 CNV loss 18288195
nsv583038 CNV loss 21841781

Variation tolerance for SFT2D3 Gene

Gene Damage Index Score: 9.47; 88.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SFT2D3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFT2D3 Gene

Disorders for SFT2D3 Gene

Additional Disease Information for SFT2D3

No disorders were found for SFT2D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFT2D3 Gene

Publications for SFT2D3 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for SFT2D3 Gene

Sources for SFT2D3 Gene

Loading form....