Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SFT2D2 Gene

Aliases for SFT2D2 Gene

  • SFT2 Domain Containing 2 2 3 5
  • SFT2 Domain-Containing Protein 2 3 4
  • Vesicle Transport Protein SFT2B 3
  • DJ747L4.C1.2 3
  • UNQ512 3

External Ids for SFT2D2 Gene

Previous GeneCards Identifiers for SFT2D2 Gene

  • GC01P164927
  • GC01P166462
  • GC01P166463
  • GC01P168195
  • GC01P139439

Summaries for SFT2D2 Gene

GeneCards Summary for SFT2D2 Gene

SFT2D2 (SFT2 Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is SFT2D1.

UniProtKB/Swiss-Prot for SFT2D2 Gene

  • May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

Additional gene information for SFT2D2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFT2D2 Gene

Genomics for SFT2D2 Gene

GeneHancer (GH) Regulatory Elements for SFT2D2 Gene

Promoters and enhancers for SFT2D2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I168225 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.2 1169 4.2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF766 CBX5 SFT2D2 TBX19 RNU6-1310P TIPRL MPZL1 GC01P168246 PIR32870 GC01M168113
GH01I168135 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 10.5 -89.2 -89208 2.3 RB1 KLF17 MZF1 ZNF76 SIN3A GLI4 ZNF2 ZNF335 GLIS2 ZNF213 GPR161 TIPRL SFT2D2 MPC2 GC01M168079 GC01M168113
GH01I168202 Enhancer 0.9 Ensembl ENCODE 12.5 -22.6 -22624 1.6 SOX13 FOXA2 ZFP64 ARID4B CEBPG DMAP1 ZNF644 THRB TEAD3 ZNF766 TIPRL SFT2D2 MPC2 RPL34P1 GC01M168113
GH01I168300 Enhancer 0.9 Ensembl ENCODE 10.5 +75.8 75825 2.6 MXI1 JUN MAX SIN3A RAD21 BRCA1 RFX5 NFYB SMARCC2 RCOR1 TBX19 MIR557 SFT2D2 LOC441914 GC01M168113
GH01I168145 Enhancer 0.9 Ensembl ENCODE 10 -79.9 -79928 1.2 CTCF PKNOX1 RB1 NFATC3 MAX SIN3A RAD21 FOSL1 VEZF1 SMC3 TIPRL SFT2D2 MPZL1 TBX19 GPR161 GC01M168113
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SFT2D2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SFT2D2 gene promoter:

Genomic Locations for SFT2D2 Gene

Genomic Locations for SFT2D2 Gene
27,088 bases
Plus strand

Genomic View for SFT2D2 Gene

Genes around SFT2D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFT2D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFT2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFT2D2 Gene

Proteins for SFT2D2 Gene

  • Protein details for SFT2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicle transport protein SFT2B
    Protein Accession:
    Secondary Accessions:
    • A8K2R0
    • Q6UWR8

    Protein attributes for SFT2D2 Gene

    160 amino acids
    Molecular mass:
    17779 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ89038.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SFT2D2 Gene

Post-translational modifications for SFT2D2 Gene

No Post-translational modifications

Other Protein References for SFT2D2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFT2D2 Gene

Domains & Families for SFT2D2 Gene

Gene Families for SFT2D2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SFT2D2 Gene

Suggested Antigen Peptide Sequences for SFT2D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SFT2 family.
  • Belongs to the SFT2 family.
genes like me logo Genes that share domains with SFT2D2: view

Function for SFT2D2 Gene

Molecular function for SFT2D2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

Gene Ontology (GO) - Molecular Function for SFT2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SFT2D2: view

Phenotypes for SFT2D2 Gene

GenomeRNAi human phenotypes for SFT2D2:
genes like me logo Genes that share phenotypes with SFT2D2: view

Animal Model Products

miRNA for SFT2D2 Gene

miRTarBase miRNAs that target SFT2D2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SFT2D2 Gene

Localization for SFT2D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFT2D2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SFT2D2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endosome 1

Gene Ontology (GO) - Cellular Components for SFT2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IBA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with SFT2D2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SFT2D2 Gene

Pathways & Interactions for SFT2D2 Gene

SuperPathways for SFT2D2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SFT2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA,IBA --
genes like me logo Genes that share ontologies with SFT2D2: view

No data available for Pathways by source and SIGNOR curated interactions for SFT2D2 Gene

Drugs & Compounds for SFT2D2 Gene

No Compound Related Data Available

Transcripts for SFT2D2 Gene

Unigene Clusters for SFT2D2 Gene

SFT2 domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFT2D2 Gene

No ASD Table

Relevant External Links for SFT2D2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SFT2D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SFT2D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SFT2D2 Gene

This gene is overexpressed in Nasal epithelium (46.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SFT2D2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SFT2D2 Gene:


SOURCE GeneReport for Unigene cluster for SFT2D2 Gene:

genes like me logo Genes that share expression patterns with SFT2D2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SFT2D2 Gene

Orthologs for SFT2D2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SFT2D2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SFT2D2 33 34
  • 99.79 (n)
(Bos Taurus)
Mammalia SFT2D2 33 34
  • 90.42 (n)
(Rattus norvegicus)
Mammalia Sft2d2 33
  • 88.11 (n)
(Canis familiaris)
Mammalia SFT2D2 33 34
  • 87.42 (n)
(Mus musculus)
Mammalia Sft2d2 33 16 34
  • 86.58 (n)
(Ornithorhynchus anatinus)
Mammalia SFT2D2 34
  • 78 (a)
(Monodelphis domestica)
Mammalia SFT2D2 34
  • 72 (a)
(Gallus gallus)
Aves SFT2D2 33 34
  • 74.58 (n)
(Anolis carolinensis)
Reptilia SFT2D2 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sft2d2 33
  • 70.62 (n)
Str.6270 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7785 33
(Danio rerio)
Actinopterygii SFT2D2 (2 of 2) 34
  • 65 (a)
zgc:112392 33
  • 63.94 (n)
SFT2D2 (1 of 2) 34
  • 51 (a)
zgc64053 33
fruit fly
(Drosophila melanogaster)
Insecta CG5104 34
  • 58 (a)
(Caenorhabditis elegans)
Secernentea F27D4.7 34
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G23550 33
  • 48.9 (n)
(Oryza sativa)
Liliopsida Os02g0564500 33
  • 48.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.278 33
Species where no ortholog for SFT2D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFT2D2 Gene

Gene Tree for SFT2D2 (if available)
Gene Tree for SFT2D2 (if available)

Paralogs for SFT2D2 Gene

Paralogs for SFT2D2 Gene

(1) SIMAP similar genes for SFT2D2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SFT2D2: view

Variants for SFT2D2 Gene

Sequence variations from dbSNP and Humsavar for SFT2D2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000003376 -- 168,229,651(+) G/T intron_variant
rs1000014559 -- 168,226,337(+) C/A intron_variant
rs1000069963 -- 168,238,890(+) A/G intron_variant
rs1000156149 -- 168,235,742(+) G/C intron_variant
rs1000284430 -- 168,231,719(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SFT2D2 Gene

Variant ID Type Subtype PubMed ID
nsv831825 CNV gain+loss 17160897
nsv1078878 OTHER inversion 25765185
nsv1002007 CNV gain 25217958

Variation tolerance for SFT2D2 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SFT2D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFT2D2 Gene

Disorders for SFT2D2 Gene

Additional Disease Information for SFT2D2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SFT2D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFT2D2 Gene

Publications for SFT2D2 Gene

  1. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung CL … Kung AW (Human molecular genetics 2009) 3 44 58
  2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SFT2D2 Gene

Sources for SFT2D2 Gene

Loading form....