Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epith... See more...

Aliases for SFRP5 Gene

Aliases for SFRP5 Gene

  • Secreted Frizzled Related Protein 5 2 3 5
  • Secreted Apoptosis Related Protein 3 2 3
  • Secreted Frizzled-Related Protein 5 3 4
  • Frizzled-Related Protein 1b 3 4
  • FRP-1b 3 4
  • SARP-3 3 4
  • SFRP-5 3 4
  • SARP3 3 4
  • Secreted Apoptosis-Related Protein 3 4
  • FRP1B 4

External Ids for SFRP5 Gene

Previous GeneCards Identifiers for SFRP5 Gene

  • GC10M098419
  • GC10M098760
  • GC10M099657
  • GC10M099190
  • GC10M099184
  • GC10M099516
  • GC10M093151

Summaries for SFRP5 Gene

Entrez Gene Summary for SFRP5 Gene

  • Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]

GeneCards Summary for SFRP5 Gene

SFRP5 (Secreted Frizzled Related Protein 5) is a Protein Coding gene. Diseases associated with SFRP5 include Ovarian Clear Cell Adenocarcinoma. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and Wnt-protein binding. An important paralog of this gene is SFRP1.

UniProtKB/Swiss-Prot Summary for SFRP5 Gene

  • Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

Gene Wiki entry for SFRP5 Gene

Additional gene information for SFRP5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SFRP5 Gene

Genomics for SFRP5 Gene

GeneHancer (GH) Regulatory Elements for SFRP5 Gene

Promoters and enhancers for SFRP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J097771 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 500.7 -0.2 -187 2 PHB2 ZIC2 ZBTB10 GABPA ZBTB26 CTBP1 ZEB1 EZH2 NCOR1 NEUROD1 SFRP5 ZFYVE27 CRTAC1 MARVELD1 piR-43107-046
GH10J097786 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 500.4 -16.3 -16301 3.8 CTCF NRF1 PHB2 ZNF10 ZIC2 ZBTB11 ZNF423 TARDBP REST TOE1 SFRP5 MARVELD1 CRTAC1 ZFYVE27 piR-43107-046 lnc-GOLGA7B-3
GH10J097837 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.2 -66.9 -66902 6.2 CTCF TCF12 RBAK JUND FOS ZBTB11 AFF1 REST TOE1 MYC piR-40459 SFRP5 CRTAC1 GOLGA7B piR-39488-046 piR-55281-062 piR-56022-052 piR-56088-003 LINC00866 lnc-GOLGA7B-2
GH10J097869 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.1 -97.5 -97501 2.2 ZNF217 CTCF NRF1 ZIC2 GABPA REST MYC TGIF2 RAD21 SKI GOLGA7B SFRP5 lnc-GOLGA7B-1 MIR3085-001 CRTAC1
GH10J097791 Enhancer 1 Ensembl ENCODE dbSUPER 11.8 -20.2 -20164 0.9 CTCF TCF12 ZIC2 REST RAD21 TRIM22 SMC3 FOSL2 YY1 IKZF3 SFRP5 CRTAC1 ZFYVE27 MARVELD1 piR-43107-046 lnc-GOLGA7B-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SFRP5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SFRP5

Top Transcription factor binding sites by QIAGEN in the SFRP5 gene promoter:
  • ATF6
  • E47
  • GATA-1
  • HFH-1
  • ITF-2
  • Lmo2
  • Nkx2-5
  • Tal-1beta

Genomic Locations for SFRP5 Gene

Genomic Locations for SFRP5 Gene
chr10:97,766,751-97,771,999
(GRCh38/hg38)
Size:
5,249 bases
Orientation:
Minus strand
chr10:99,526,508-99,531,756
(GRCh37/hg19)
Size:
5,249 bases
Orientation:
Minus strand

Genomic View for SFRP5 Gene

Genes around SFRP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFRP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFRP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFRP5 Gene

Proteins for SFRP5 Gene

  • Protein details for SFRP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4F7-SFRP5_HUMAN
    Recommended name:
    Secreted frizzled-related protein 5
    Protein Accession:
    Q5T4F7
    Secondary Accessions:
    • O14780
    • Q86TH7

    Protein attributes for SFRP5 Gene

    Size:
    317 amino acids
    Molecular mass:
    35563 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFRP5 Gene

Post-translational modifications for SFRP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFRP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFRP5 Gene

Domains & Families for SFRP5 Gene

Gene Families for SFRP5 Gene

Suggested Antigen Peptide Sequences for SFRP5 Gene

GenScript: Design optimal peptide antigens:
  • Secreted apoptosis-related protein 3 (SFRP5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T4F7

UniProtKB/Swiss-Prot:

SFRP5_HUMAN :
  • The FZ domain is involved in binding with Wnt ligands.
  • Belongs to the secreted frizzled-related protein (sFRP) family.
Domain:
  • The FZ domain is involved in binding with Wnt ligands.
Family:
  • Belongs to the secreted frizzled-related protein (sFRP) family.
genes like me logo Genes that share domains with SFRP5: view

Function for SFRP5 Gene

Molecular function for SFRP5 Gene

UniProtKB/Swiss-Prot Function:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.
GENATLAS Biochemistry:
Drosophila frizzled polarity homolog,secreted related protein 5,mouse sfrp 5 homolog,likely involved in WNT binding and signal transduction,expressed in the retinal epithelium and pancreas

Phenotypes From GWAS Catalog for SFRP5 Gene

Gene Ontology (GO) - Molecular Function for SFRP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017147 Wnt-protein binding NAS 24431302
genes like me logo Genes that share ontologies with SFRP5: view
genes like me logo Genes that share phenotypes with SFRP5: view

Animal Models for SFRP5 Gene

MGI Knock Outs for SFRP5:

Animal Model Products

  • Taconic Biosciences Mouse Models for SFRP5

CRISPR Products

miRNA for SFRP5 Gene

miRTarBase miRNAs that target SFRP5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SFRP5 Gene

Localization for SFRP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFRP5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SFRP5 gene
Compartment Confidence
plasma membrane 4
extracellular 4
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SFRP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS,IBA 21873635
genes like me logo Genes that share ontologies with SFRP5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SFRP5 Gene

Pathways & Interactions for SFRP5 Gene

genes like me logo Genes that share pathways with SFRP5: view

Pathways by source for SFRP5 Gene

1 KEGG pathway for SFRP5 Gene

Gene Ontology (GO) - Biological Process for SFRP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 9391078
GO:0007163 establishment or maintenance of cell polarity TAS 10072424
GO:0007165 signal transduction TAS 10072424
GO:0007275 multicellular organism development IEA --
GO:0007601 visual perception TAS 10072424
genes like me logo Genes that share ontologies with SFRP5: view

No data available for SIGNOR curated interactions for SFRP5 Gene

Drugs & Compounds for SFRP5 Gene

(1) Drugs for SFRP5 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bisphosphonates Pharma 0
genes like me logo Genes that share compounds with SFRP5: view

Transcripts for SFRP5 Gene

mRNA/cDNA for SFRP5 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFRP5 Gene

No ASD Table

Relevant External Links for SFRP5 Gene

GeneLoc Exon Structure for
SFRP5

Expression for SFRP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SFRP5 Gene

mRNA differential expression in normal tissues according to GTEx for SFRP5 Gene

This gene is overexpressed in Nerve - Tibial (x18.7), Pancreas (x10.7), and Heart - Atrial Appendage (x6.7).

Protein differential expression in normal tissues from HIPED for SFRP5 Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SFRP5 Gene



Protein tissue co-expression partners for SFRP5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SFRP5

SOURCE GeneReport for Unigene cluster for SFRP5 Gene:

Hs.279565

mRNA Expression by UniProt/SwissProt for SFRP5 Gene:

Q5T4F7-SFRP5_HUMAN
Tissue specificity: Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.

Evidence on tissue expression from TISSUES for SFRP5 Gene

  • Eye(4.4)
  • Pancreas(4.4)
  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SFRP5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SFRP5 Gene

Orthologs for SFRP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SFRP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SFRP5 31 30
  • 95.09 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SFRP5 31 30
  • 94.2 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sfrp5 17 31 30
  • 92.01 (n)
rat
(Rattus norvegicus)
Mammalia Sfrp5 30
  • 91.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SFRP5 31
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SFRP5 31
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFRP5 31 30
  • 78.78 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFRP5 31
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sfrp5 30
  • 69.82 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21815 30
zebrafish
(Danio rerio)
Actinopterygii sfrp5 31 30
  • 72.12 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y73B6BL.21 32
  • 38 (a)
sfrp-1 31
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8698 31
  • 37 (a)
OneToMany
Cin.5649 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5649 30
Species where no ortholog for SFRP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFRP5 Gene

ENSEMBL:
Gene Tree for SFRP5 (if available)
TreeFam:
Gene Tree for SFRP5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SFRP5: view image

Paralogs for SFRP5 Gene

Paralogs for SFRP5 Gene

(2) SIMAP similar genes for SFRP5 Gene using alignment to 1 proteins:

  • SFRP5_HUMAN
genes like me logo Genes that share paralogs with SFRP5: view

Variants for SFRP5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SFRP5 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
717162 Benign: not provided 97,767,816(-) G/A MISSENSE_VARIANT
rs11815012 - p.Gly7Ala

Additional dbSNP identifiers (rs#s) for SFRP5 Gene

Structural Variations from Database of Genomic Variants (DGV) for SFRP5 Gene

Variant ID Type Subtype PubMed ID
nsv552026 CNV loss 21841781

Variation tolerance for SFRP5 Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SFRP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFRP5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFRP5 Gene

Disorders for SFRP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SFRP5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian clear cell adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search SFRP5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SFRP5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SFRP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SFRP5 Gene

Publications for SFRP5 Gene

  1. SARPs: a family of secreted apoptosis-related proteins. (PMID: 9391078) Melkonyan HS … Umansky SR (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 54
  2. A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. (PMID: 19926868) Sharma S … Weiss ST (American journal of respiratory and critical care medicine 2010) 3 41 54
  3. Downregulation of SFRP5 expression and its inverse correlation with those of MMP-7 and MT1-MMP in gastric cancer. (PMID: 19586554) Zhao C … Wang W (BMC cancer 2009) 3 23 54
  4. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. (PMID: 18981481) Li Y … Zorn AM (Genes & development 2008) 3 23 54
  5. Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. (PMID: 18356147) Veeck J … Dahl E (Carcinogenesis 2008) 3 23 54

Products for SFRP5 Gene

Sources for SFRP5 Gene