Aliases for SFRP4 Gene
External Ids for SFRP4 Gene
Previous GeneCards Identifiers for SFRP4 Gene
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]
GeneCards Summary for SFRP4 Gene
SFRP4 (Secreted Frizzled Related Protein 4) is a Protein Coding gene. Diseases associated with SFRP4 include Pyle Disease and Metaphyseal Dysplasia. Among its related pathways are Wnt Signaling Pathway and Pluripotency and Adipogenesis. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and Wnt-protein binding. An important paralog of this gene is FRZB.
UniProtKB/Swiss-Prot Summary for SFRP4 Gene
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).