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Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008] See more...
Aliases for SFRP4 Gene
Aliases for SFRP4 Gene
External Ids for SFRP4 Gene
- HGNC: 10778
- Entrez Gene: 6424
- Ensembl: ENSG00000106483
- OMIM: 606570
- UniProtKB: Q6FHJ7
Previous GeneCards Identifiers for SFRP4 Gene
- GC07M037591
- GC07M037686
- GC07M037652
- GC07M037718
Summaries for SFRP4 Gene
-
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]
GeneCards Summary for SFRP4 Gene
SFRP4 (Secreted Frizzled Related Protein 4) is a Protein Coding gene. Diseases associated with SFRP4 include Pyle Disease and Osteomalacia. Among its related pathways are Wnt Signaling Pathway and Pluripotency and Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and Wnt-protein binding. An important paralog of this gene is FRZB.
UniProtKB/Swiss-Prot Summary for SFRP4 Gene
-
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).
Additional gene information for SFRP4 Gene
- Monarch Initiative
- Search for SFRP4 at DataMed
- Search for SFRP4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SFRP4 Gene
Genomics for SFRP4 Gene
GeneHancer (GH) Regulatory Elements for SFRP4 Gene
Promoters and enhancers for SFRP4 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07J037916 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE CraniofacialAtlas | 507.8 | +109.2 | 109181 | 2.6 | CTCF POLR2G NCOR1 PHF8 EP300 ZBTB10 GABPA ZBTB26 TGIF2 RAD21 | SFRP4 EPDR1 lnc-ELMO1-2 lnc-EPDR1-2 | |
| GH07J037901 | Enhancer | 0.9 | Ensembl ENCODE | 19.4 | +123.6 | 123603 | 1.8 | CTCF TCF12 JUND REST RAD21 TRIM22 SMC3 ZNF316 NFIC ZNF384 | SFRP4 EPDR1 piR-38344-126 lnc-ELMO1-2 | |
| GH07J037941 | Enhancer | 1 | ENCODE | 15.6 | +82.1 | 82053 | 4.3 | EP300 FOXK2 POLR2G NCOR1 KDM6A TCF7 RELA ZBTB25 ZBTB7A SMARCC2 | SFRP4 EPDR1 TRGC1 lnc-ELMO1-2 lnc-EPDR1-2 | |
| GH07J038215 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 10 | -194.1 | -194113 | 9.2 | CTCF REST MYC CTBP1 RAD21 TRIM22 SMC3 MXI1 FOXA2 TCF12 | NONHSAG047369.2 STARD3NL TRGC2 SFRP4 | |
| GH07J037928 | Enhancer | 0.7 | Ensembl ENCODE | 16.2 | +95.7 | 95745 | 2.9 | TCF12 FOSL2 TAL1 TCF7L2 ZNF316 FOXA1 CBFA2T3 | SFRP4 EPDR1 lnc-ELMO1-2 lnc-EPDR1-2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SFRP4 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SFRP4
- Top Transcription factor binding sites by QIAGEN in the SFRP4 gene promoter:
-
- AP-2alpha
- AREB6
- ATF-2
- CRE-BP1
- Nkx2-5
- p53
Genomic Locations for SFRP4 Gene
Genomic Locations for SFRP4 Gene
- chr7:37,905,932-38,025,695
- (GRCh38/hg38)
- Size:
- 119,764 bases
- Orientation:
- Minus strand
- chr7:37,945,534-38,065,297
- (GRCh37/hg19)
- Size:
- 119,764 bases
- Orientation:
- Minus strand
Genomic View for SFRP4 Gene
Genes around SFRP4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p14.1 by HGNC
- 7p14.1 by Entrez Gene
- 7p14.1 by Ensembl
SFRP4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SFRP4 Gene
Proteins for SFRP4 Gene
-
Protein details for SFRP4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6FHJ7-SFRP4_HUMAN
- Recommended name:
- Secreted frizzled-related protein 4
- Protein Accession:
- Q6FHJ7
- B4DYC1
- O14877
- Q05BG7
- Q1ZYW2
- Q4G124
- Q6FHM0
- Q6PD64
Protein attributes for SFRP4 Gene
- Size:
- 346 amino acids
- Molecular mass:
- 39827 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAG63683.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for SFRP4 Gene
Post-translational modifications for SFRP4 Gene
Other Protein References for SFRP4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents SFRP4 Antibody
- Creative Diagnostics Anti-SFRP4 monoclonal antibody, clone FQS0490
- Creative Biolabs Anti-Human SFRP4 Therapeutic Antibody
-
Custom Antibody ServicesOriGene Antibodies for SFRP4
- Novus Biologicals Antibodies for SFRP4
-
Abcam antibodies for SFRP4
- Invitrogen Antibodies for SFRP4 (AFLGC-SFRP4)
- Sino Biological Antibodies for SFRP4
Protein Products
-
OriGene Purified Proteins for SFRP4
- Search Origene for MassSpec and Protein Over-expression Lysates for SFRP4
- Origene Custom Protein Services for SFRP4
- Sino Biological Recombinant Proteins for SFRP4
- Sino Biological Cell Lysates for SFRP4
- ProSpec Recombinant Proteins for SFRP4
-
Abcam proteins for SFRP4
Assay Products
- Aviva Systems Biology SFRP4 ELISA Kit (Human) : 96 Wells (OKEH01190) and SFRP4 ELISA Kit (Human) (OKCD08854)
- antibodies-online: Show 33 available SFRP4 Elisa Kits ranked by validation data
- Compare Top SFRP4 Elisa Kits
-
Quality Products:
- ABIN6720591
- ABIN421482
- ABIN577936
- ABIN1572372
- ABIN5524812
- ABIN4993694
- ABIN5594766
- ABIN5658629
- ABIN2538824
- ABIN2951263
- ABIN822599
- ABIN428845
- ABIN1572373
- ABIN5658630
- ABIN2538825
- ABIN6229777
- ABIN4972776
- ABIN6730697
- ABIN1156641
- ABIN435689
- ABIN1572374
- ABIN5696709
- ABIN822600
- ABIN5658631
- ABIN2538826
- ABIN6229778
- ABIN4972777
- ABIN1156638
No data available for DME Specific Peptides for SFRP4 Gene
Domains & Families for SFRP4 Gene
Gene Families for SFRP4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for SFRP4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SFRP4 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ53955, highly similar to Secreted frizzled-related protein 4 (B4E1T4_HUMAN)
- Frizzled protein, human endometrium (SFRP4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6FHJ7UniProtKB/Swiss-Prot:
SFRP4_HUMAN :- The FZ domain is involved in binding with Wnt ligands.
- Belongs to the secreted frizzled-related protein (sFRP) family.
- Domain:
-
- The FZ domain is involved in binding with Wnt ligands.
- Family:
-
- Belongs to the secreted frizzled-related protein (sFRP) family.
Function for SFRP4 Gene
Molecular function for SFRP4 Gene
- UniProtKB/Swiss-Prot Function:
- Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).
- UniProtKB/Swiss-Prot Induction:
- Increased levels in failing myocardium. Up-regulated in several tumor types including ostomalacia-associated tumors and endometrial and breast carcinomas.
- GENATLAS Biochemistry:
- Drosophila frizzled polarity homolog,secreted related protein 4,mouse sfrp 4 homolog,likely involved in WNT binding and signal transduction
Phenotypes From GWAS Catalog for SFRP4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI,IEA | 15607035 |
| GO:0017147 | Wnt-protein binding | NAS,IDA | 24431302 |
Phenotypes for SFRP4 Gene
- MGI mutant phenotypes for SFRP4:
-
inferred from 2 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- mortality/aging
- reproductive system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for SFRP4:
-
- Decreased viability ratio
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased ionizing radiation sensitivity
- Decreased viability
- no effect
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
Animal Model Products
-
Taconic Biosciences Mouse Models for SFRP4
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SFRP4 - Select products 50% OFF >
- * SFRP4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * SFRP4 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for SFRP4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SFRP4
- genomics-online: gRNA clones - Search for available SFRP4 gRNA products
- Overview of 124 available SFRP4 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for SFRP4
miRNA for SFRP4 Gene
- miRTarBase miRNAs that target SFRP4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SFRP4
- Browse OriGene Inhibitory RNA Products For SFRP4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SFRP4
- genomics-online: shRNA clones - Search for available SFRP4 shRNA products
- Overview of 124 available SFRP4 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for SFRP4 - Select products 50% OFF >
- * SFRP4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * SFRP4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for SFRP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SFRP4
- genomics-online: cdna clones - Search for available SFRP4 CDNA products
- Overview of 124 available SFRP4 gene related products
- orf clones - Search for available SFRP4 ORF products
- Overview of 124 available SFRP4 gene related products
Cell Line Products
-
Horizon Cell Lines for SFRP4
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SFRP4 Gene
Localization for SFRP4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SFRP4 Gene
- Secreted. Note=Cytoplasmic in ovarian tumor cells.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IDA,IBA | 14760084 |
| GO:0005634 | nucleus | IDA | 18938133 |
| GO:0005737 | cytoplasm | IBA,IDA | 11793365 |
| GO:0009986 | cell surface | IDA | 14760084 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SFRP4 Gene
Pathways & Interactions for SFRP4 Gene
Pathways by source for SFRP4 Gene
3 BioSystems pathways for SFRP4 Gene
1 KEGG pathway for SFRP4 Gene
1 R&D Systems pathway for SFRP4 Gene
Interacting Proteins for SFRP4 Gene
GPS-Prot Interaction Network for SFRP4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002092 | positive regulation of receptor internalization | IDA | 16151791 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0008285 | negative regulation of cell proliferation | IMP | 14760084 |
| GO:0009725 | response to hormone | NAS | 10211996 |
| GO:0010628 | positive regulation of gene expression | IDA | 18938133 |
No data available for SIGNOR curated interactions for SFRP4 Gene
Drugs & Compounds for SFRP4 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| sodium |
|
7440-23-5 |
|
Transcripts for SFRP4 Gene
mRNA/cDNA for SFRP4 Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000436072 2868 bps (ENST00000436072.7)
- ENST00000447200 849 bps (ENST00000447200.2)
- ENST00000478975 626 bps (ENST00000478975.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SFRP4 - Select products 50% OFF >
- * SFRP4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * SFRP4 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for SFRP4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SFRP4
- genomics-online: gRNA clones - Search for available SFRP4 gRNA products
- Overview of 124 available SFRP4 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for SFRP4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SFRP4
- Browse OriGene Inhibitory RNA Products For SFRP4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SFRP4
- genomics-online: shRNA clones - Search for available SFRP4 shRNA products
- Overview of 124 available SFRP4 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for SFRP4 - Select products 50% OFF >
- * SFRP4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * SFRP4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for SFRP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SFRP4
- genomics-online: cdna clones - Search for available SFRP4 CDNA products
- Overview of 124 available SFRP4 gene related products
- orf clones - Search for available SFRP4 ORF products
- Overview of 124 available SFRP4 gene related products
Relevant External Links for SFRP4 Gene
- GeneLoc Exon Structure for
- SFRP4
Expression for SFRP4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
- Granulosa Cells Primary Follicle
- Neural Tube (Nervous System)
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Eye (Sensory Organs)
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Heart (Cardiovascular System)
-
Uterus (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for SFRP4 Gene
This gene is overexpressed in Cervix - Endocervix (x10.8), Nerve - Tibial (x6.4), Uterus (x5.8), and Cervix - Ectocervix (x5.3).
This gene is overexpressed in Cervix (32.2), Pancreas (18.8), and Breast (12.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SFRP4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SFRP4
SOURCE GeneReport for Unigene cluster for SFRP4 Gene:
Hs.658169mRNA Expression by UniProt/SwissProt for SFRP4 Gene:
Q6FHJ7-SFRP4_HUMAN
Tissue specificity:
Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).
Evidence on tissue expression from TISSUES for SFRP4 Gene
- Nervous system(4.5)
- Lung(2.3)
- Muscle(2.1)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for SFRP4
-
OriGene qPCR primer pairs and template standards for SFRP4
- genomics-online: primer clones - Search for available SFRP4 Primer products
- Overview of 124 available SFRP4 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SFRP4 Gene
Orthologs for SFRP4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SFRP4 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SFRP4 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SFRP4 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Sfrp4 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Sfrp4 17 31 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SFRP4 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SFRP4 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SFRP4 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SFRP4 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sfrp4 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | FP102169.1 31 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | fz4 31 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | mig-1 31 |
|
OneToMany |
- Species where no ortholog for SFRP4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for SFRP4 Gene
- ENSEMBL:
- Gene Tree for SFRP4 (if available)
- TreeFam:
- Gene Tree for SFRP4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SFRP4: view image
Paralogs for SFRP4 Gene
Variants for SFRP4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SFRP4 Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs755007671 | Pathogenic: Pyle metaphyseal dysplasia | 37,912,216(-) | G/A | NONSENSE | |
| rs879253778 | Pathogenic: Pyle metaphyseal dysplasia | 37,914,411(-) | TCCTGTAC/T | FRAMESHIFT_VARIANT | |
| rs879255603 | Pathogenic: Pyle metaphyseal dysplasia | 37,914,399(-) | T/TC | FRAMESHIFT_VARIANT | |
| rs1802073 | - | p.Pro320Thr | |||
| rs1802074 | - | p.Arg340Lys |
Residual Variation Intolerance Score:
25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.04;
68.68% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SFRP4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFRP4 Gene
Disorders for SFRP4 Gene
(10) MalaCards diseases for SFRP4 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pyle disease |
|
|
| osteomalacia |
|
|
| hypophosphatemic rickets, autosomal dominant |
|
|
| hypophosphatemia |
|
|
| hypophosphatemic rickets, x-linked recessive |
|
Search SFRP4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SFRP4_HUMAN- Pyle disease (PYL) [MIM:265900]: A disorder characterized by cortical-bone thinning, limb deformity, bone fragility and fractures. {ECO:0000269 PubMed:27355534}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for SFRP4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for SFRP4 Gene
Publications for SFRP4 Gene
- Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy. (PMID: 10211996) Abu-Jawdeh G … Kocher O (Laboratory investigation; a journal of technical methods and pathology 1999) 2 3 4 23 54
- Wnt antagonist gene polymorphisms and renal cancer. (PMID: 19562778) Hirata H … Dahiya R (Cancer 2009) 3 23 41 54
- Expression of secreted frizzled-related protein 4 (SFRP4) in primary serous ovarian tumours. (PMID: 19480240) Drake J … Dharmarajan A (European journal of gynaecological oncology 2009) 3 4 23 54
- Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. (PMID: 12952927) Berndt T … Kumar R (The Journal of clinical investigation 2003) 3 4 23 54
- Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease. (PMID: 27355534) Kiper POS … Baron R (The New England journal of medicine 2016) 3 4 54
ExternalLinks
Products for SFRP4 Gene
- View all 3 R&D Systems SFRP4 (sFRP-4) Products
- View all R&D Systems SFRP4 (sFRP-4) Proteins and Enzymes
- View all R&D Systems SFRP4 (sFRP-4) Primary Antibodies
- View all R&D Systems SFRP4 (sFRP-4) cDNA Clones
- Learn more about R&D Systems custom SFRP4 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for SFRP4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SFRP4
- Search Origene for MassSpec and Protein Over-expression Lysates for SFRP4
- Origene Custom Protein Services for SFRP4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SFRP4
- Browse OriGene Inhibitory RNA Products For SFRP4
- OriGene qPCR primer pairs for SFRP4
- OriGene qPCR primer pairs and template standards for SFRP4
- OriGene CRISPR knockouts for SFRP4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SFRP4
- Sino Biological Human cDNA Clone for SFRP4
- Sino Biological Recombinant Proteins for SFRP4
- Sino Biological Cell Lysates for SFRP4
- Sino Biological Antibodies for SFRP4
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SFRP4
- Novus Biologicals proteins and lysates for SFRP4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SFRP4
- Abcam proteins for SFRP4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for SFRP4
- Taconic Biosciences Mouse Models for SFRP4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for SFRP4 (AFLGC-SFRP4)
- antibodies-online: Show 29 available SFRP4 Antibodies ranked by validation data
- Compare Top SFRP4 Antibodies
- antibodies-online: Show 33 available SFRP4 Elisa Kits ranked by validation data
- Compare Top SFRP4 Elisa Kits
- Quality Products:
- ABIN6720591
- ABIN421482
- ABIN577936
- ABIN1572372
- ABIN5524812
- ABIN4993694
- ABIN5594766
- ABIN5658629
- ABIN2538824
- ABIN2951263
- ABIN822599
- ABIN428845
- ABIN1572373
- ABIN5658630
- ABIN2538825
- ABIN6229777
- ABIN4972776
- ABIN6730697
- ABIN1156641
- ABIN435689
- ABIN1572374
- ABIN5696709
- ABIN822600
- ABIN5658631
- ABIN2538826
- ABIN6229778
- ABIN4972777
- ABIN1156638
- antibodies-online: Show 21 available SFRP4 Proteins ranked by validation data
- Compare Top SFRP4 Proteins
- Horizon Cell Lines for SFRP4
- genomics-online: cdna clones - Search for available SFRP4 CDNA products
- Overview of 124 available SFRP4 gene related products
- orf clones - Search for available SFRP4 ORF products
- Overview of 124 available SFRP4 gene related products
- genomics-online: gRNA clones - Search for available SFRP4 gRNA products
- Overview of 124 available SFRP4 gene related products
- genomics-online: primer clones - Search for available SFRP4 Primer products
- Overview of 124 available SFRP4 gene related products
- genomics-online: shRNA clones - Search for available SFRP4 shRNA products
- Overview of 124 available SFRP4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SFRP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SFRP4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SFRP4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SFRP4
Sources for SFRP4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource