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Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]
SFRP4 (Secreted Frizzled Related Protein 4) is a Protein Coding gene. Diseases associated with SFRP4 include Pyle Disease and Osteomalacia. Among its related pathways are Wnt signaling pathway and Adipogenesis. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and Wnt-protein binding. An important paralog of this gene is FRZB.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA,IPI | 15607035 |
GO:0017147 | Wnt-protein binding | IDA,NAS | 24431302 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IBA,IDA | 14760084 |
GO:0005634 | nucleus | IDA | 18938133 |
GO:0005737 | cytoplasm | IBA,IDA | 11793365 |
GO:0009986 | cell surface | IDA | 14760084 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Wnt signaling pathway | ||
2 | Adipogenesis | ||
3 | Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds | ||
4 | Wnt Signaling Pathway and Pluripotency |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002092 | positive regulation of receptor internalization | IDA | 16151791 |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0008285 | negative regulation of cell proliferation | IMP | 14760084 |
GO:0009725 | response to hormone | NAS | 10211996 |
GO:0010628 | positive regulation of gene expression | IDA | 18938133 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
sodium |
|
7440-23-5 |
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SFRP4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SFRP4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SFRP4 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sfrp4 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Sfrp4 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SFRP4 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SFRP4 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SFRP4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SFRP4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sfrp4 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | FP102169.1 31 |
|
ManyToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | fz4 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | mig-1 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
726596 | Likely Benign: not provided | 37,912,292(-) | C/T | SYNONYMOUS_VARIANT | |
771723 | Benign: not provided | 37,916,436(-) | G/A | SYNONYMOUS_VARIANT | |
788420 | Benign: not provided | 37,907,482(-) | C/G | SYNONYMOUS_VARIANT | |
rs755007671 | Pathogenic: Pyle metaphyseal dysplasia | 37,912,216(-) | G/A | NONSENSE | |
rs879253778 | Pathogenic: Pyle metaphyseal dysplasia | 37,914,411(-) | TCCTGTAC/T | FRAMESHIFT_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
pyle disease |
|
|
osteomalacia |
|
|
hypophosphatemic rickets, autosomal dominant |
|
|
hypophosphatemia |
|
|
metaphyseal dysplasia |
|
|