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This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]
SFRP2 (Secreted Frizzled Related Protein 2) is a Protein Coding gene. Diseases associated with SFRP2 include Esophageal Basaloid Squamous Cell Carcinoma and Synpolydactyly. Among its related pathways are Signaling by GPCR and Negative regulation of TCF-dependent signaling by WNT ligand antagonists. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and PDZ domain binding. An important paralog of this gene is SFRP1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001968 | fibronectin binding | ISS | -- |
GO:0005178 | integrin binding | ISS | -- |
GO:0005515 | protein binding | IEA | -- |
GO:0008047 | enzyme activator activity | IEA | -- |
GO:0017147 | Wnt-protein binding | NAS | 24431302 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IEA,ISS | -- |
GO:0062023 | collagen-containing extracellular matrix | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by Wnt |
.71
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2 | Wnt signaling pathway | ||
3 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists | ||
4 | Signaling by GPCR |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001569 | branching involved in blood vessel morphogenesis | IEA,ISS | -- |
GO:0001756 | somitogenesis | IEA | -- |
GO:0001843 | neural tube closure | IEA | -- |
GO:0002063 | chondrocyte development | IEA | -- |
GO:0003151 | outflow tract morphogenesis | IMP | 19593212 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SFRP2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SFRP2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SFRP2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SFRP2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SFRP2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sfrp2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Sfrp2 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SFRP2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SFRP2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sfrp2 30 |
|
||
MGC75789 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | sfrp2-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | sfrp2 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6215 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | sfrp-1 30 31 |
|
OneToMany | |
Y73B6BL.21 32 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs546360010 | Likely Benign: not provided | 153,781,664(-) |
G/A NM_003013.3(SFRP2):c.675C>T (p.Asn225=) |
SYNONYMOUS | |
rs770485715 | Likely Benign: Anophthalmia-microphthalmia syndrome | 153,781,713(-) |
T/C NM_003013.3(SFRP2):c.626A>G (p.Asp209Gly) |
MISSENSE | |
rs78004612 | Benign: not provided | 153,781,759(-) |
T/A NM_003013.3(SFRP2):c.584-4A>T |
INTRON | |
rs79844222 | Benign: not provided | 153,788,590(-) |
C/T NM_003013.3(SFRP2):c.246G>A (p.Leu82=) |
SYNONYMOUS | |
rs4643790 | - |
p.Ala45Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1022081 | CNV | gain | 25217958 |
nsv595749 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
esophageal basaloid squamous cell carcinoma |
|
|
synpolydactyly |
|
|
colorectal cancer |
|
|
retinal degeneration |
|
|
bone disease |
|
|