SFRP2 Gene (Protein Coding)

Secreted Frizzled Related Protein 2

GC04M153780
GIFtS:
43
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008] See more...

Aliases for SFRP2 Gene

Aliases for SFRP2 Gene

  • Secreted Frizzled Related Protein 2 2 3 5
  • FRP-2 2 3 4
  • SARP1 2 3 4
  • Secreted Frizzled-Related Protein 2 3 4
  • SARP-1 3 4
  • SFRP-2 3 4
  • SDF-5 2 3
  • Secreted Apoptosis Related Protein 1 3
  • Secreted Apoptosis-Related Protein 1 4
  • Testicular Tissue Protein Li 170 3
  • SFRP2 5
  • FRP2 4

External Ids for SFRP2 Gene

Previous GeneCards Identifiers for SFRP2 Gene

  • GC04M155550
  • GC04M155090
  • GC04M155279
  • GC04M155059
  • GC04M154921
  • GC04M154701
  • GC04M150432

Summaries for SFRP2 Gene

Entrez Gene Summary for SFRP2 Gene

  • This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for SFRP2 Gene

SFRP2 (Secreted Frizzled Related Protein 2) is a Protein Coding gene. Diseases associated with SFRP2 include Esophageal Basaloid Squamous Cell Carcinoma and Synpolydactyly. Among its related pathways are Signaling by GPCR and Negative regulation of TCF-dependent signaling by WNT ligand antagonists. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and PDZ domain binding. An important paralog of this gene is SFRP1.

UniProtKB/Swiss-Prot Summary for SFRP2 Gene

  • Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

Gene Wiki entry for SFRP2 Gene

Additional gene information for SFRP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SFRP2 Gene

Genomics for SFRP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SFRP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SFRP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SFRP2

Top Transcription factor binding sites by QIAGEN in the SFRP2 gene promoter:
  • Brachyury
  • C/EBPalpha
  • CHOP-10
  • CREB
  • deltaCREB
  • FOXF2
  • MAZR
  • Pax-2
  • Pax-2a
  • ZIC2

Genomic Locations for SFRP2 Gene

Latest Assembly
chr4:153,780,591-153,789,083
(GRCh38/hg38)
Size:
8,493 bases
Orientation:
Minus strand

Previous Assembly
chr4:154,701,743-154,710,235
(GRCh37/hg19 by Entrez Gene)
Size:
8,493 bases
Orientation:
Minus strand

chr4:154,701,744-154,710,272
(GRCh37/hg19 by Ensembl)
Size:
8,529 bases
Orientation:
Minus strand

Genomic View for SFRP2 Gene

Genes around SFRP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFRP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFRP2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SFRP2 Gene

Proteins for SFRP2 Gene

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  3. Assay products for research

  • Protein details for SFRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HF1-SFRP2_HUMAN
    Recommended name:
    Secreted frizzled-related protein 2
    Protein Accession:
    Q96HF1
    Secondary Accessions:
    • B3KQR2
    • O14778
    • Q9HAP5

    Protein attributes for SFRP2 Gene

    Size:
    295 amino acids
    Molecular mass:
    33490 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFRP2 Gene

Protein Expression for SFRP2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SFRP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFRP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFRP2 Gene

Domains & Families for SFRP2 Gene

Gene Families for SFRP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SFRP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SFRP2 Gene

GenScript: Design optimal peptide antigens:
  • Secreted apoptosis-related protein 1 (SFRP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96HF1

UniProtKB/Swiss-Prot:

SFRP2_HUMAN :
  • The FZ domain is involved in binding with Wnt ligands.
  • Belongs to the secreted frizzled-related protein (sFRP) family.
Domain:
  • The FZ domain is involved in binding with Wnt ligands.
Family:
  • Belongs to the secreted frizzled-related protein (sFRP) family.
genes like me logo Genes that share domains with SFRP2: view

Function for SFRP2 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for SFRP2 Gene

UniProtKB/Swiss-Prot Function:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.
GENATLAS Biochemistry:
Drosophila frizzled polarity homolog,secreted related protein 2,mouse sfrp 2 homolog,likely involved in WNT binding and signal transduction,expressed in inner nuclear layer of the retina

Phenotypes From GWAS Catalog for SFRP2 Gene

Gene Ontology (GO) - Molecular Function for SFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding ISS --
GO:0005178 integrin binding ISS --
GO:0005515 protein binding IEA --
GO:0008047 enzyme activator activity IEA --
GO:0017147 Wnt-protein binding NAS 24431302
genes like me logo Genes that share ontologies with SFRP2: view
genes like me logo Genes that share phenotypes with SFRP2: view

Animal Models for SFRP2 Gene

MGI Knock Outs for SFRP2:

Animal Models for research

  • Taconic Biosciences Mouse Models for SFRP2

miRNA for SFRP2 Gene

miRTarBase miRNAs that target SFRP2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SFRP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SFRP2 Gene

Localization for SFRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFRP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SFRP2 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,ISS --
GO:0062023 collagen-containing extracellular matrix ISS --
genes like me logo Genes that share ontologies with SFRP2: view

Pathways & Interactions for SFRP2 Gene

genes like me logo Genes that share pathways with SFRP2: view

Pathways by source for SFRP2 Gene

1 KEGG pathway for SFRP2 Gene
2 GeneTex pathways for SFRP2 Gene

Gene Ontology (GO) - Biological Process for SFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001569 branching involved in blood vessel morphogenesis IEA,ISS --
GO:0001756 somitogenesis IEA --
GO:0001843 neural tube closure IEA --
GO:0002063 chondrocyte development IEA --
GO:0003151 outflow tract morphogenesis IMP 19593212
genes like me logo Genes that share ontologies with SFRP2: view

No data available for SIGNOR curated interactions for SFRP2 Gene

Drugs & Compounds for SFRP2 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for SFRP2 Gene

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  2. miRNA products for research
  3. Inhibitory RNAs for research
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mRNA/cDNA for SFRP2 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SFRP2

Alternative Splicing Database (ASD) splice patterns (SP) for SFRP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2:

Relevant External Links for SFRP2 Gene

GeneLoc Exon Structure for
SFRP2

Expression for SFRP2 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SFRP2 Gene

mRNA expression in normal human tissues for SFRP2 Gene
mRNA expression by GTEx for SFRP2 GenemRNA expression by BioGPS for SFRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFRP2 Gene

This gene is overexpressed in Artery - Tibial (x8.8).

Protein differential expression in normal tissues from HIPED for SFRP2 Gene

This gene is overexpressed in Vitreous humor (39.2), Skin (10.9), and Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SFRP2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SFRP2

SOURCE GeneReport for Unigene cluster for SFRP2 Gene:

Hs.481022

mRNA Expression by UniProt/SwissProt for SFRP2 Gene:

Q96HF1-SFRP2_HUMAN
Tissue specificity: Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.

Evidence on tissue expression from TISSUES for SFRP2 Gene

  • Eye(4.7)
  • Nervous system(4.2)
  • Pancreas(3.8)
  • Intestine(3.7)
  • Skin(2.9)
  • Muscle(2.8)
  • Heart(2.8)
  • Stomach(2.7)
  • Lung(2.4)
  • Gall bladder(2.3)
  • Blood(2.3)
  • Bone(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with SFRP2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SFRP2 Gene

Orthologs for SFRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SFRP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SFRP2 30 31
  • 99.44 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia SFRP2 31
  • 98 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia SFRP2 31
  • 96 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SFRP2 30 31
  • 95.01 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SFRP2 30 31
  • 94.1 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Sfrp2 30
  • 93.9 (n)
Mouse
(Mus musculus)
 Mammalia Sfrp2 30 17 31
  • 93.79 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves SFRP2 30 31
  • 79.84 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia SFRP2 31
  • 78 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia sfrp2 30
  • 78.94 (n)
MGC75789 30
African clawed frog
(Xenopus laevis)
 Amphibia sfrp2-prov 30
Zebrafish
(Danio rerio)
 Actinopterygii sfrp2 30 31
  • 70.96 (n)
 OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.6215 30
Worm
(Caenorhabditis elegans)
 Secernentea sfrp-1 30 31
  • 47 (n)
 OneToMany
Y73B6BL.21 32
  • 35 (a)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 36 (a)
 OneToOne
Species where no ortholog for SFRP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SFRP2 Gene

ENSEMBL:
Gene Tree for SFRP2 (if available)
TreeFam:
Gene Tree for SFRP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SFRP2: view image

Paralogs for SFRP2 Gene

Paralogs for SFRP2 Gene

(2) SIMAP similar genes for SFRP2 Gene using alignment to 1 proteins:

  • SFRP2_HUMAN
genes like me logo Genes that share paralogs with SFRP2: view

Variants for SFRP2 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SFRP2 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs546360010 Likely Benign: not provided 153,781,664(-) G/A
NM_003013.3(SFRP2):c.675C>T (p.Asn225=) 		SYNONYMOUS
rs770485715 Likely Benign: Anophthalmia-microphthalmia syndrome 153,781,713(-) T/C
NM_003013.3(SFRP2):c.626A>G (p.Asp209Gly) 		MISSENSE
rs78004612 Benign: not provided 153,781,759(-) T/A
NM_003013.3(SFRP2):c.584-4A>T 		INTRON
rs79844222 Benign: not provided 153,788,590(-) C/T
NM_003013.3(SFRP2):c.246G>A (p.Leu82=) 		SYNONYMOUS
rs4643790 - p.Ala45Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SFRP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SFRP2 Gene

Variant ID Type Subtype PubMed ID
nsv1022081 CNV gain 25217958
nsv595749 CNV gain 21841781

Variation tolerance for SFRP2 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.23; 76.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SFRP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFRP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFRP2 Gene

Disorders for SFRP2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for SFRP2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
esophageal basaloid squamous cell carcinoma
  • basaloid squamous carcinoma of esophagus
synpolydactyly
  • syndactyly type 2
colorectal cancer
  • crc
retinal degeneration
  • degeneration of retina
bone disease
  • skeletal disease
- elite association - COSMIC cancer census association via MalaCards
Search SFRP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SFRP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SFRP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SFRP2 Gene

Publications for SFRP2 Gene

  1. SARPs: a family of secreted apoptosis-related proteins. (PMID: 9391078) Melkonyan HS … Umansky SR (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4
  2. A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. (PMID: 19926868) Sharma S … Weiss ST (American journal of respiratory and critical care medicine 2010) 3 41
  3. Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. (PMID: 20403915) Frank B … Brenner H (Carcinogenesis 2010) 3 41
  4. Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer. (PMID: 20682398) Pehlivan S … Pehlivan M (Cancer genetics and cytogenetics 2010) 3 41
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 41

ExternalLinks

View latest publications for SFRP2 gene in Mastermind

Products for SFRP2 Gene

  • Addgene plasmids for SFRP2

Sources for SFRP2 Gene