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This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008] See more...
Aliases for SFRP2 Gene
Aliases for SFRP2 Gene
External Ids for SFRP2 Gene
- HGNC: 10777
- Entrez Gene: 6423
- Ensembl: ENSG00000145423
- OMIM: 604157
- UniProtKB: Q96HF1
Previous GeneCards Identifiers for SFRP2 Gene
- GC04M155550
- GC04M155090
- GC04M155279
- GC04M155059
- GC04M154921
- GC04M154701
- GC04M150432
Summaries for SFRP2 Gene
-
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for SFRP2 Gene
SFRP2 (Secreted Frizzled Related Protein 2) is a Protein Coding gene. Diseases associated with SFRP2 include Esophageal Basaloid Squamous Cell Carcinoma and Synpolydactyly. Among its related pathways are Signaling by GPCR and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and PDZ domain binding. An important paralog of this gene is SFRP1.
UniProtKB/Swiss-Prot Summary for SFRP2 Gene
-
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.
Additional gene information for SFRP2 Gene
- HGNC(10777)
- Entrez Gene(6423)
- Ensembl(ENSG00000145423)
- OMIM(604157)
- UniProtKB(Q96HF1)
- Open Targets Platform(ENSG00000145423)
- Monarch Initiative
- Search for SFRP2 at DataMed
- Search for SFRP2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SFRP2 Gene
Genomics for SFRP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SFRP2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J153786 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 602.2 | -0.6 | -618 | 7.4 | RNF2 CREB1 CTCF ATF7 JUND FOXA1 POLR2A RAD21 EZH2 ZNF341 | SFRP2 LOC101927947 TLR2 RNF175 MN298141 DCHS2 | |
| GH04J153933 | Enhancer | 0.7 | Ensembl ENCODE CraniofacialAtlas | 4.4 | -145.4 | -145417 | 2.2 | PKNOX1 SMARCA4 ATF2 | SFRP2 HSALNG0037979 piR-34093-023 LOC101927947 DCHS2 | |
| GH04J153334 | Enhancer | 0.4 | Ensembl | 4.4 | +453.7 | 453682 | 1.2 | PKNOX1 CEBPB BHLHE40 MEIS2 | SFRP2 MND1 ANXA2P1 TRIM2 | |
| GH04J153781 | Enhancer | 1.2 | Ensembl ENCODE CraniofacialAtlas | 0.4 | +6.9 | 6928 | 1.7 | PRDM10 ZNF629 ZNF692 PRDM1 ZSCAN4 ZNF501 POLR2A ZNF600 ZNF561 SCRT2 | TLR2 SFRP2 RNF175 | |
| GH04J153793 | Enhancer | 0.7 | CraniofacialAtlas | 0.7 | -4.9 | -4866 | 0.2 | ZNF629 ZIC2 ZNF600 ZNF561 ZBTB44 TCF7L2 ZXDB CTBP1 ZNF580 SCRT1 | RNF175 LOC101927947 SFRP2 MN298141 DCHS2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SFRP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SFRP2
- Top Transcription factor binding sites by QIAGEN in the SFRP2 gene promoter:
-
- Brachyury
- C/EBPalpha
- CHOP-10
- CREB
- deltaCREB
- FOXF2
- MAZR
- Pax-2
- Pax-2a
- ZIC2
Genomic Locations for SFRP2 Gene
Genomic Locations for SFRP2 Gene
- chr4:153,780,591-153,789,083
- (GRCh38/hg38)
- Size:
- 8,493 bases
- Orientation:
- Minus strand
- chr4:154,701,742-154,710,272
- (GRCh37/hg19)
- Size:
- 8,531 bases
- Orientation:
- Minus strand
Genomic View for SFRP2 Gene
Genes around SFRP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q31.3 by HGNC
- 4q31.3 by Entrez Gene
- 4q31.3 by Ensembl
SFRP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SFRP2 Gene
Proteins for SFRP2 Gene
-
Protein details for SFRP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96HF1-SFRP2_HUMAN
- Recommended name:
- Secreted frizzled-related protein 2
- Protein Accession:
- Q96HF1
- B3KQR2
- O14778
- Q9HAP5
Protein attributes for SFRP2 Gene
- Size:
- 295 amino acids
- Molecular mass:
- 33490 Da
- Quaternary structure:
- No Data Available
Protein Expression for SFRP2 Gene
Post-translational modifications for SFRP2 Gene
Other Protein References for SFRP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ SFRP2 Antibody
- Novus Biologicals Antibodies for SFRP2
-
Abcam antibodies for SFRP2
- Invitrogen Antibodies for SFRP2 (AFLGC-SFRP2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for SFRP2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SFRP2
- Origene Custom Protein Services for SFRP2
- Sino Biological Cell Lysates for SFRP2
- Sino Biological Recombinant Proteins for SFRP2
- ProSpec Recombinant Proteins for SFRP2
-
Signalway Proteins for SFRP2
Assay Products
- antibodies-online: Show 53 available SFRP2 Elisa Kits ranked by validation data
- Compare Top SFRP2 Elisa Kits
-
Quality Products:
- ABIN1117030
- ABIN421483
- ABIN822597
- ABIN1572369
- ABIN5524236
- ABIN5669306
- ABIN1743798
- ABIN5658626
- ABIN4972775
- ABIN2538821
- ABIN822598
- ABIN428846
- ABIN5524237
- ABIN1572370
- ABIN5594387
- ABIN455159
- ABIN5658627
- ABIN4972773
- ABIN2538822
- ABIN2951262
- ABIN435690
- ABIN1572371
- ABIN1745016
- ABIN5658628
- ABIN2538823
- ABIN6227224
- ABIN1769807
- ABIN1156632
No data available for DME Specific Peptides for SFRP2 Gene
Domains & Families for SFRP2 Gene
Gene Families for SFRP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for SFRP2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SFRP2 Gene
- GenScript: Design optimal peptide antigens:
-
- Secreted apoptosis-related protein 1 (SFRP2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96HF1UniProtKB/Swiss-Prot:
SFRP2_HUMAN :- The FZ domain is involved in binding with Wnt ligands.
- Belongs to the secreted frizzled-related protein (sFRP) family.
- Domain:
-
- The FZ domain is involved in binding with Wnt ligands.
- Family:
-
- Belongs to the secreted frizzled-related protein (sFRP) family.
Function for SFRP2 Gene
Molecular function for SFRP2 Gene
- UniProtKB/Swiss-Prot Function:
- Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.
- GENATLAS Biochemistry:
- Drosophila frizzled polarity homolog,secreted related protein 2,mouse sfrp 2 homolog,likely involved in WNT binding and signal transduction,expressed in inner nuclear layer of the retina
Phenotypes From GWAS Catalog for SFRP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001968 | fibronectin binding | ISS | -- |
| GO:0005178 | integrin binding | ISS | -- |
| GO:0005515 | protein binding | IEA | -- |
| GO:0008047 | enzyme activator activity | IEA | -- |
| GO:0017147 | Wnt-protein binding | NAS | 24431302 |
Phenotypes for SFRP2 Gene
- MGI mutant phenotypes for SFRP2:
-
inferred from 7 alleles
- nervous system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- embryo phenotype
- craniofacial phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for SFRP2:
Animal Models for SFRP2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for SFRP2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SFRP2 - Select products 50% OFF >
- * SFRP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SFRP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SFRP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SFRP2
miRNA for SFRP2 Gene
- miRTarBase miRNAs that target SFRP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SFRP2
- Browse OriGene Inhibitory RNA Products For SFRP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SFRP2
Clone Products
- Applied Biological Materials (abm): Clones for SFRP2 - Select products 50% OFF >
- * SFRP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SFRP2
- Addgene plasmids for SFRP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SFRP2
Cell Line Products
- ESI BIO PureStem MEL2, NCr-fac Progenitor and PureStem SK11, NCr-fac & Meso-prx Progenitor for SFRP2
-
Horizon Cell Lines for SFRP2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SFRP2 Gene
Localization for SFRP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SFRP2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Intermediate filaments (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA,ISS | -- |
| GO:0062023 | collagen-containing extracellular matrix | ISS | -- |
Pathways & Interactions for SFRP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by Wnt |
.71
|
|
| 2 | Wnt signaling pathway | ||
| 3 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists | ||
| 4 | Signaling by GPCR | ||
Pathways by source for SFRP2 Gene
4 Reactome pathways for SFRP2 Gene
1 KEGG pathway for SFRP2 Gene
2 GeneTex pathways for SFRP2 Gene
Interacting Proteins for SFRP2 Gene
GPS-Prot Interaction Network for SFRP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001569 | branching involved in blood vessel morphogenesis | IEA,ISS | -- |
| GO:0001756 | somitogenesis | IEA | -- |
| GO:0001843 | neural tube closure | IEA | -- |
| GO:0002063 | chondrocyte development | IEA | -- |
| GO:0003151 | outflow tract morphogenesis | IMP | 19593212 |
No data available for SIGNOR curated interactions for SFRP2 Gene
Transcripts for SFRP2 Gene
mRNA/cDNA for SFRP2 Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000274063 1996 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SFRP2 - Select products 50% OFF >
- * SFRP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SFRP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SFRP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SFRP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SFRP2
- Browse OriGene Inhibitory RNA Products For SFRP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SFRP2
Clone Products
- Applied Biological Materials (abm): Clones for SFRP2 - Select products 50% OFF >
- * SFRP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SFRP2
- Addgene plasmids for SFRP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SFRP2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: |
Relevant External Links for SFRP2 Gene
- GeneLoc Exon Structure for
- SFRP2
Expression for SFRP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Preplacodal Lens Ectoderm Cells Ocular Surface Ectoderm
mRNA differential expression in normal tissues according to GTEx for SFRP2 Gene
This gene is overexpressed in Artery - Tibial (x8.8).
This gene is overexpressed in Vitreous humor (39.2), Skin (10.9), and Breast (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SFRP2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SFRP2
SOURCE GeneReport for Unigene cluster for SFRP2 Gene:
Hs.481022mRNA Expression by UniProt/SwissProt for SFRP2 Gene:
Q96HF1-SFRP2_HUMAN
Tissue specificity:
Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.
Evidence on tissue expression from TISSUES for SFRP2 Gene
- Eye(4.7)
- Nervous system(4.3)
- Pancreas(3.8)
- Intestine(3.8)
- Skin(3)
- Muscle(3)
- Heart(2.9)
- Stomach(2.8)
- Gall bladder(2.6)
- Lung(2.5)
- Blood(2.5)
- Bone(2.3)
- Kidney(2.2)
- Lymph node(2.2)
Primer Products
-
OriGene qPCR primer pairs for SFRP2
-
OriGene qPCR primer pairs and template standards for SFRP2
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SFRP2 Gene
Orthologs for SFRP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SFRP2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SFRP2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SFRP2 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SFRP2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SFRP2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Sfrp2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Sfrp2 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SFRP2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SFRP2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sfrp2 30 |
|
||
| MGC75789 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | sfrp2-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | sfrp2 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6215 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | sfrp-1 30 31 |
|
OneToMany | |
| Y73B6BL.21 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for SFRP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SFRP2 Gene
- ENSEMBL:
- Gene Tree for SFRP2 (if available)
- TreeFam:
- Gene Tree for SFRP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SFRP2: view image
Paralogs for SFRP2 Gene
Variants for SFRP2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SFRP2 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 753909 | Likely Benign: not provided | 153,781,664(-) | G/A | SYNONYMOUS_VARIANT | |
| 776024 | Benign: not provided | 153,781,759(-) | T/A | INTRON_VARIANT | |
| 776025 | Benign: not provided | 153,788,590(-) | C/T | SYNONYMOUS_VARIANT | |
| rs770485715 | Likely Benign: Anophthalmia - microphthalmia | 153,781,713(-) | T/C | MISSENSE_VARIANT | |
| rs4643790 | - | p.Ala45Val |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1022081 | CNV | gain | 25217958 |
| nsv595749 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.23;
76.17% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SFRP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SFRP2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFRP2 Gene
Disorders for SFRP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| esophageal basaloid squamous cell carcinoma |
|
|
| synpolydactyly |
|
|
| colorectal cancer |
|
|
| retinal degeneration |
|
|
| colorectal adenoma |
|
|
Search SFRP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SFRP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SFRP2 Gene
Publications for SFRP2 Gene
- SARPs: a family of secreted apoptosis-related proteins. (PMID: 9391078) Melkonyan HS … Umansky SR (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4
- A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. (PMID: 19926868) Sharma S … Weiss ST (American journal of respiratory and critical care medicine 2010) 3 41
- Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. (PMID: 20403915) Frank B … Brenner H (Carcinogenesis 2010) 3 41
- Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer. (PMID: 20682398) Pehlivan S … Pehlivan M (Cancer genetics and cytogenetics 2010) 3 41
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 41
ExternalLinks
Products for SFRP2 Gene
- View all 5 R&D Systems SFRP2 (sFRP-2) Products
- View all R&D Systems SFRP2 (sFRP-2) Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for SFRP2
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- OriGene qPCR primer pairs for SFRP2
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Browse Sino Biological Antibodies
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SFRP2
- Novus Biologicals proteins and lysates for SFRP2
- Browse Antibodies
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- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for SFRP2
- ESI BIO PureStem MEL2, NCr-fac Progenitor and PureStem SK11, NCr-fac & Meso-prx Progenitor for SFRP2
- Taconic Biosciences Mouse Models for SFRP2
- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- Invitrogen Antibodies for SFRP2 (AFLGC-SFRP2)
- VectorBuilder Custom and pre-made DNA vectors for SFRP2 (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Stable cell line generation for SFRP2
- Addgene plasmids for SFRP2
- antibodies-online: Show 35 available SFRP2 Antibodies ranked by validation data
- Compare Top SFRP2 Antibodies
- antibodies-online: Show 53 available SFRP2 Elisa Kits ranked by validation data
- Compare Top SFRP2 Elisa Kits
- Quality Products:
- ABIN1117030
- ABIN421483
- ABIN822597
- ABIN1572369
- ABIN5524236
- ABIN5669306
- ABIN1743798
- ABIN5658626
- ABIN4972775
- ABIN2538821
- ABIN822598
- ABIN428846
- ABIN5524237
- ABIN1572370
- ABIN5594387
- ABIN455159
- ABIN5658627
- ABIN4972773
- ABIN2538822
- ABIN2951262
- ABIN435690
- ABIN1572371
- ABIN1745016
- ABIN5658628
- ABIN2538823
- ABIN6227224
- ABIN1769807
- ABIN1156632
- antibodies-online: Show 15 available SFRP2 Proteins ranked by validation data
- Compare Top SFRP2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for SFRP2
- Search Santa Cruz Biotechnology (SCBT) for SFRP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SFRP2
- Horizon Cell Lines for SFRP2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SFRP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SFRP2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SFRP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SFRP2
Sources for SFRP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB