Aliases for SFRP2 Gene
External Ids for SFRP2 Gene
Previous GeneCards Identifiers for SFRP2 Gene
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for SFRP2 Gene
SFRP2 (Secreted Frizzled Related Protein 2) is a Protein Coding gene. Diseases associated with SFRP2 include Esophageal Basaloid Squamous Cell Carcinoma and Synpolydactyly. Among its related pathways are Signaling by GPCR and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and PDZ domain binding. An important paralog of this gene is SFRP1.
UniProtKB/Swiss-Prot Summary for SFRP2 Gene
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.