Aliases for SFRP1 Gene
External Ids for SFRP1 Gene
Previous GeneCards Identifiers for SFRP1 Gene
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
GeneCards Summary for SFRP1 Gene
SFRP1 (Secreted Frizzled Related Protein 1) is a Protein Coding gene. Diseases associated with SFRP1 include Glucocorticoid-Induced Osteoporosis and Colorectal Adenoma. Among its related pathways are Signaling by Wnt and Negative regulation of TCF-dependent signaling by WNT ligand antagonists. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and heparin binding. An important paralog of this gene is SFRP5.
UniProtKB/Swiss-Prot Summary for SFRP1 Gene
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.