This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017] See more...

Aliases for SFN Gene

Aliases for SFN Gene

  • Stratifin 2 3 4 5
  • Epithelial Cell Marker Protein 1 3 4
  • 14-3-3 Protein Sigma 3 4
  • YWHAS 2 3
  • 14-3-3 Sigma 2
  • HME1 4
  • SFN 5

External Ids for SFN Gene

Previous GeneCards Identifiers for SFN Gene

  • GC01M028401
  • GC01P026221
  • GC01P026422
  • GC01P026795
  • GC01P026796
  • GC01P027062
  • GC01P027189
  • GC01P025443

Summaries for SFN Gene

Entrez Gene Summary for SFN Gene

  • This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017]

GeneCards Summary for SFN Gene

SFN (Stratifin) is a Protein Coding gene. Diseases associated with SFN include Benign Breast Adenomyoepithelioma and Fetal Encasement Syndrome. Among its related pathways are Apoptosis Modulation and Signaling and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. Gene Ontology (GO) annotations related to this gene include protein kinase binding and phosphoprotein binding. An important paralog of this gene is YWHAZ.

UniProtKB/Swiss-Prot Summary for SFN Gene

  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
  • p53-regulated inhibitor of G2/M progression.

Gene Wiki entry for SFN Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SFN Gene

Genomics for SFN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SFN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SFN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SFN

Top Transcription factor binding sites by QIAGEN in the SFN gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun

Genomic Locations for SFN Gene

Genomic Locations for SFN Gene
chr1:26,863,149-26,864,456
(GRCh38/hg38)
Size:
1,308 bases
Orientation:
Plus strand
chr1:27,189,633-27,190,947
(GRCh37/hg19)
Size:
1,315 bases
Orientation:
Plus strand

Genomic View for SFN Gene

Genes around SFN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFN Gene

Proteins for SFN Gene

  • Protein details for SFN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31947-1433S_HUMAN
    Recommended name:
    14-3-3 protein sigma
    Protein Accession:
    P31947
    Secondary Accessions:
    • Q6FH30
    • Q6FH51
    • Q96DH0

    Protein attributes for SFN Gene

    Size:
    248 amino acids
    Molecular mass:
    27774 Da
    Quaternary structure:
    • Homodimer (PubMed:28202711). Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with COP1; this interaction leads to proteasomal degradation. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509). Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (PubMed:28202711).

    Three dimensional structures from OCA and Proteopedia for SFN Gene

    Alternative splice isoforms for SFN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SFN Gene

Post-translational modifications for SFN Gene

  • Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.
  • Ubiquitination at Lys49
  • Modification sites at PhosphoSitePlus

Other Protein References for SFN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SFN Gene

Domains & Families for SFN Gene

Gene Families for SFN Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SFN Gene

InterPro:
Blocks:
  • 14-3-3 protein
ProtoNet:

Suggested Antigen Peptide Sequences for SFN Gene

GenScript: Design optimal peptide antigens:
  • Stratifin (1433S_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P31947

UniProtKB/Swiss-Prot:

1433S_HUMAN :
  • Belongs to the 14-3-3 family.
Family:
  • Belongs to the 14-3-3 family.
genes like me logo Genes that share domains with SFN: view

Function for SFN Gene

Molecular function for SFN Gene

UniProtKB/Swiss-Prot Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
UniProtKB/Swiss-Prot Function:
p53-regulated inhibitor of G2/M progression.

Phenotypes From GWAS Catalog for SFN Gene

Gene Ontology (GO) - Molecular Function for SFN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11574543
GO:0008426 protein kinase C inhibitor activity TAS 8515476
GO:0019901 protein kinase binding IEA --
GO:0019904 protein domain specific binding IEA --
GO:0042802 identical protein binding IPI 15778465
genes like me logo Genes that share ontologies with SFN: view
genes like me logo Genes that share phenotypes with SFN: view

Animal Models for SFN Gene

MGI Knock Outs for SFN:
  • Sfn Sfn<tm1Mak>

Animal Model Products

CRISPR Products

miRNA for SFN Gene

miRTarBase miRNAs that target SFN

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SFN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SFN Gene

Localization for SFN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFN Gene

Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SFN gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
plasma membrane 3
mitochondrion 3
cytoskeleton 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SFN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 8515476
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with SFN: view

Pathways & Interactions for SFN Gene

genes like me logo Genes that share pathways with SFN: view

Pathways by source for SFN Gene

4 GeneGo (Thomson Reuters) pathways for SFN Gene
  • Apoptosis and survival BAD phosphorylation
  • Cell cycle Role of 14-3-3 proteins in cell cycle regulation
  • Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
  • Immune response Function of MEF2 in T lymphocytes
2 Qiagen pathways for SFN Gene
  • DNA Damage Induced 14-3-3Sigma Signaling
  • p53 Signaling
4 Cell Signaling Technology pathways for SFN Gene
3 GeneTex pathways for SFN Gene

SIGNOR curated interactions for SFN Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SFN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0001836 release of cytochrome c from mitochondria IDA 11574543
GO:0003334 keratinocyte development IEA --
GO:0006469 negative regulation of protein kinase activity TAS 8515476
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with SFN: view

Drugs & Compounds for SFN Gene

(4) Drugs for SFN Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic acid Approved Nutra Agonist, Full agonist 304
Excitatory Amino Acid Antagonists Pharma 1480
Neurotransmitter Agents Pharma 19550

(2) Additional Compounds for SFN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SFN: view

Transcripts for SFN Gene

mRNA/cDNA for SFN Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SFN

Alternative Splicing Database (ASD) splice patterns (SP) for SFN Gene

No ASD Table

Relevant External Links for SFN Gene

GeneLoc Exon Structure for
SFN

Expression for SFN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SFN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFN Gene

This gene is overexpressed in Esophagus - Mucosa (x17.9), Skin - Not Sun Exposed (Suprapubic) (x10.4), Skin - Sun Exposed (Lower leg) (x7.8), Minor Salivary Gland (x5.6), and Vagina (x4.3).

Protein differential expression in normal tissues from HIPED for SFN Gene

This gene is overexpressed in Hair follicle (13.2) and Oral epithelium (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SFN Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SFN

SOURCE GeneReport for Unigene cluster for SFN Gene:

Hs.523718

mRNA Expression by UniProt/SwissProt for SFN Gene:

P31947-1433S_HUMAN
Tissue specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.

Evidence on tissue expression from TISSUES for SFN Gene

  • Skin(4.8)
  • Lung(4.7)
  • Nervous system(4.2)
  • Pancreas(3.1)
  • Intestine(3.1)
  • Blood(2.7)
  • Heart(2.7)
  • Stomach(2.6)
  • Liver(2.4)
  • Kidney(2.3)
  • Eye(2)
genes like me logo Genes that share expression patterns with SFN: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SFN Gene

Orthologs for SFN Gene

This gene was present in the common ancestor of animals.

Orthologs for SFN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SFN 30 31
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SFN 30 31
  • 94.02 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SFN 30 31
  • 92.17 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sfn 30
  • 90.59 (n)
Mouse
(Mus musculus)
Mammalia Sfn 30 17 31
  • 90.32 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SFN 31
  • 88 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SFN 31
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SFN 30 31
  • 81.44 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SFN 31
  • 79 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ywhabl 31
  • 66 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta 14-3-3zeta 31
  • 64 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea par-5 31
  • 63 (a)
ManyToMany
ftt-2 31
  • 63 (a)
ManyToMany
Species where no ortholog for SFN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for SFN Gene

ENSEMBL:
Gene Tree for SFN (if available)
TreeFam:
Gene Tree for SFN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SFN: view image

Paralogs for SFN Gene

Paralogs for SFN Gene

(8) SIMAP similar genes for SFN Gene using alignment to 1 proteins:

  • 1433S_HUMAN
genes like me logo Genes that share paralogs with SFN: view

Variants for SFN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SFN Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs11542705 - p.Met155Ile

Additional dbSNP identifiers (rs#s) for SFN Gene

Structural Variations from Database of Genomic Variants (DGV) for SFN Gene

Variant ID Type Subtype PubMed ID
nsv1000012 CNV gain 25217958
nsv7535 CNV insertion 18451855
nsv834524 CNV gain+loss 17160897

Variation tolerance for SFN Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SFN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFN Gene

Disorders for SFN Gene

MalaCards: The human disease database

(9) MalaCards diseases for SFN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
benign breast adenomyoepithelioma
  • benign adenomyoepithelioma of the breast
fetal encasement syndrome
  • cocoon syndrome
colloid carcinoma of the pancreas
popliteal pterygium syndrome
  • pps
ductal carcinoma in situ
  • noninfiltrating intraductal carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search SFN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SFN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SFN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SFN Gene

Publications for SFN Gene

  1. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. (PMID: 8515476) Leffers H … Celis JE (Journal of molecular biology 1993) 2 3 4 23
  2. Structural interface between LRRK2 and 14-3-3 protein. (PMID: 28202711) Stevers LM … Ottmann C (The Biochemical journal 2017) 3 4
  3. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PMID: 23572552) Greninger AL … DeRisi JL (mBio 2013) 3 4
  4. Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. (PMID: 22634725) Rose R … Ottmann C (Journal of structural biology 2012) 3 4
  5. COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ. (PMID: 21625211) Choi HH … Lee MH (Oncogene 2011) 3 4

Products for SFN Gene

Sources for SFN Gene