Aliases for SFN Gene
External Ids for SFN Gene
Previous GeneCards Identifiers for SFN Gene
This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017]
GeneCards Summary for SFN Gene
SFN (Stratifin) is a Protein Coding gene. Diseases associated with SFN include Benign Breast Adenomyoepithelioma and Fetal Encasement Syndrome. Among its related pathways are Apoptosis Modulation and Signaling and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. Gene Ontology (GO) annotations related to this gene include protein kinase binding and phosphoprotein binding. An important paralog of this gene is YWHAZ.
UniProtKB/Swiss-Prot Summary for SFN Gene
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
p53-regulated inhibitor of G2/M progression.