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Aliases for SF3A2 Gene

Aliases for SF3A2 Gene

  • Splicing Factor 3a Subunit 2 2 3 5
  • Splicing Factor 3a, Subunit 2, 66kDa 2 3
  • Splicing Factor 3a, Subunit 2, 66kD 2 3
  • Splicing Factor 3A Subunit 2 3 4
  • SAP 62 3 4
  • SF3a66 3 4
  • SAP62 3 4
  • Pre-MRNA Splicing Factor SF3A, Subunit 2 3
  • Spliceosome Associated Protein 62 3
  • Spliceosome-Associated Protein 62 4
  • PRPF11 3
  • PRP11 3

External Ids for SF3A2 Gene

Previous GeneCards Identifiers for SF3A2 Gene

  • GC19P002299
  • GC19P002176
  • GC19P002187
  • GC19P002174
  • GC19P002007

Summaries for SF3A2 Gene

Entrez Gene Summary for SF3A2 Gene

  • This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SF3A2 Gene

SF3A2 (Splicing Factor 3a Subunit 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SF3A2 Gene

  • Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex (PubMed:29361316, PubMed:29360106, PubMed:30315277). Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106).

Gene Wiki entry for SF3A2 Gene

Additional gene information for SF3A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SF3A2 Gene

Genomics for SF3A2 Gene

GeneHancer (GH) Regulatory Elements for SF3A2 Gene

Promoters and enhancers for SF3A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J002234 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 641.6 +2.7 2698 10.6 ZNF652 ELF3 ZFX CTCF MNT NKRF POLR2A MLLT1 ZNF121 CEBPG SF3A2 PLEKHJ1 DAZAP1 ZNF77 AMH GNA11 LOC100288123 TCF3 DOT1L TLE2
GH19J001382 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 142.6 -852.7 -852716 3 ZNF473 ZFX SP1 ELF3 MNT SIX5 CBFA2T2 ZNF148 NKRF MLLT1 PIR43938 NDUFS7 PIR60228 TRF-GAA1-6 TRN-GTT2-6 CIRBP SF3A2 TMEM259 DAZAP1 LOC100288123
GH19J001236 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 114.8 -980.0 -980014 41.2 HDGF MTA3 SP1 ZFX CC2D1A ZNF652 ELF3 CTCF MNT SIX5 CIRBP C19orf24 MIDN CBARP ATP5F1D SF3A2 TMEM259 TCF3 LOC100288123 DAZAP1
GH19J001437 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 80.9 -797.3 -797334 4.3 HDGF ZFX SP1 CC2D1A CTCF ELF3 ZKSCAN8 MNT NKRF POLR2A RPS15 ENSG00000268798 SF3A2 TMEM259 TCF3 LOC100288123 DAZAP1 GRIN3B PTBP1 ENSG00000267317
GH19J002474 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 66.9 +240.4 240406 6 MTA3 SP1 CTCF ELF3 MNT ZNF148 NKRF POLR2A MLLT1 ZNF121 GADD45B GC19P002477 SF3A2 TCF3 LOC100288123 ZNF77 ENSG00000267139 ENSG00000267283 DOT1L ZNF554
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SF3A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SF3A2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • GATA-1
  • NF-kappaB1
  • p53
  • Spz1

Genomic Locations for SF3A2 Gene

Genomic Locations for SF3A2 Gene
chr19:2,236,817-2,248,679
(GRCh38/hg38)
Size:
11,863 bases
Orientation:
Plus strand
chr19:2,236,520-2,248,678
(GRCh37/hg19)
Size:
12,159 bases
Orientation:
Plus strand

Genomic View for SF3A2 Gene

Genes around SF3A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SF3A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SF3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SF3A2 Gene

Proteins for SF3A2 Gene

  • Protein details for SF3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15428-SF3A2_HUMAN
    Recommended name:
    Splicing factor 3A subunit 2
    Protein Accession:
    Q15428
    Secondary Accessions:
    • B2RBU1
    • D6W605
    • O75245

    Protein attributes for SF3A2 Gene

    Size:
    464 amino acids
    Molecular mass:
    49256 Da
    Quaternary structure:
    • Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62 and SF3A1/SAP114 (PubMed:10882114, PubMed:11533230, PubMed:21349847). SF3A1 functions as scaffold that interacts directly with both SF3A2 and SF3A3 (PubMed:11533230, PubMed:21349847). SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the mature 17S U2 small nuclear ribonucleoprotein complex (17S U2 snRNP) (PubMed:10882114, PubMed:11533230). Identified in the spliceosome 'E' complex, a precursor of the spliceosome 'A' complex (PubMed:10882114). Identified in the spliceosome 'A' and 'B' complexes (PubMed:10882114, PubMed:29361316, PubMed:29360106, PubMed:30315277). Identified in the spliceosome 'C' complex (PubMed:11991638). Interacts with HTATSF1 (PubMed:9710584).

    Three dimensional structures from OCA and Proteopedia for SF3A2 Gene

neXtProt entry for SF3A2 Gene

Post-translational modifications for SF3A2 Gene

  • Ubiquitination at posLast=194194, isoforms=48, and isoforms=10
  • Modification sites at PhosphoSitePlus

Other Protein References for SF3A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SF3A2 Gene

Domains & Families for SF3A2 Gene

Gene Families for SF3A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SF3A2 Gene

Suggested Antigen Peptide Sequences for SF3A2 Gene

GenScript: Design optimal peptide antigens:
  • SF3A2 protein (Q05DF2_HUMAN)
  • Spliceosome-associated protein 62 (SF3A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15428

UniProtKB/Swiss-Prot:

SF3A2_HUMAN :
  • Belongs to the SF3A2 family.
Family:
  • Belongs to the SF3A2 family.
genes like me logo Genes that share domains with SF3A2: view

Function for SF3A2 Gene

Molecular function for SF3A2 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex (PubMed:29361316, PubMed:29360106, PubMed:30315277). Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106).

Phenotypes From GWAS Catalog for SF3A2 Gene

Gene Ontology (GO) - Molecular Function for SF3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 17332742
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SF3A2: view
genes like me logo Genes that share phenotypes with SF3A2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SF3A2

Clone Products

  • Applied Biological Materials (abm): Clones for SF3A2 - Now 50% OFF >
  • * SF3A2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SF3A2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SF3A2 Gene

Localization for SF3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SF3A2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SF3A2 gene
Compartment Confidence
nucleus 5
cytosol 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SF3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 29360106
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005686 U2 snRNP IDA 11533230
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with SF3A2: view

Pathways & Interactions for SF3A2 Gene

genes like me logo Genes that share pathways with SF3A2: view

Pathways by source for SF3A2 Gene

1 KEGG pathway for SF3A2 Gene

Gene Ontology (GO) - Biological Process for SF3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly IBA 21873635
GO:0000389 mRNA 3'-splice site recognition TAS 15647371
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IMP 15647371
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SF3A2: view

No data available for SIGNOR curated interactions for SF3A2 Gene

Drugs & Compounds for SF3A2 Gene

(1) Drugs for SF3A2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 226
genes like me logo Genes that share compounds with SF3A2: view

Transcripts for SF3A2 Gene

mRNA/cDNA for SF3A2 Gene

Unigene Clusters for SF3A2 Gene

Splicing factor 3a, subunit 2, 66kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SF3A2

Clone Products

  • Applied Biological Materials (abm): Clones for SF3A2 - Now 50% OFF >
  • * SF3A2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SF3A2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for SF3A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for SF3A2 Gene

GeneLoc Exon Structure for
SF3A2
ECgene alternative splicing isoforms for
SF3A2

Expression for SF3A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SF3A2 Gene

Protein differential expression in normal tissues from HIPED for SF3A2 Gene

This gene is overexpressed in Nasal epithelium (10.3), Bone (8.6), and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SF3A2 Gene



Protein tissue co-expression partners for SF3A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SF3A2 Gene:

SF3A2

SOURCE GeneReport for Unigene cluster for SF3A2 Gene:

Hs.115232

Evidence on tissue expression from TISSUES for SF3A2 Gene

  • Blood(4.2)
  • Lung(4.2)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with SF3A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SF3A2 Gene

Orthologs for SF3A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SF3A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SF3A2 35 34
  • 99.5 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SF3A2 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SF3A2 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sf3a2 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SF3A2 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SF3A2 35 34
  • 87.83 (n)
OneToOne
chicken
(Gallus gallus)
Aves SF3A2 35
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sf3a2-prov 34
zebrafish
(Danio rerio)
Actinopterygii sf3a2 35
  • 87 (a)
OneToOne
zgc56097 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.198 34
fruit fly
(Drosophila melanogaster)
Insecta CG10754 35 36
  • 78 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F11A10.2 36
  • 78 (a)
repo-1 35
  • 77 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP11 35 37
  • 27 (a)
OneToOne
corn
(Zea mays)
Liliopsida Zm.8991 34
wheat
(Triticum aestivum)
Liliopsida Ta.8406 34
rice
(Oryza sativa)
Liliopsida Os.5848 34
barley
(Hordeum vulgare)
Liliopsida Hv.954 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2750 35
  • 62 (a)
OneToOne
Cin.2164 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2164 34
Species where no ortholog for SF3A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for SF3A2 Gene

ENSEMBL:
Gene Tree for SF3A2 (if available)
TreeFam:
Gene Tree for SF3A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SF3A2: view image

Paralogs for SF3A2 Gene

Pseudogenes.org Pseudogenes for SF3A2 Gene

genes like me logo Genes that share paralogs with SF3A2: view

No data available for Paralogs for SF3A2 Gene

Variants for SF3A2 Gene

Sequence variations from dbSNP and Humsavar for SF3A2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000550001 -- 2,241,422(+) G/T intron_variant
rs1000622553 -- 2,238,022(+) G/C intron_variant
rs1000720009 -- 2,237,005(+) G/C intron_variant
rs1000948863 -- 2,247,231(+) G/A intron_variant
rs1000979992 -- 2,237,137(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SF3A2 Gene

Variant ID Type Subtype PubMed ID
dgv6218n54 CNV loss 21841781
esv1711865 CNV insertion 17803354
esv2717881 CNV deletion 23290073
nsv1110726 CNV insertion 24896259
nsv1125666 CNV tandem duplication 24896259
nsv2389 CNV insertion 18451855
nsv476713 CNV novel sequence insertion 20440878
nsv578382 CNV loss 21841781
nsv578383 CNV loss 21841781
nsv828396 CNV loss 20364138
nsv833706 CNV loss 17160897
nsv833707 CNV loss 17160897

Variation tolerance for SF3A2 Gene

Gene Damage Index Score: 1.21; 24.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SF3A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SF3A2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SF3A2 Gene

Disorders for SF3A2 Gene

Additional Disease Information for SF3A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SF3A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SF3A2 Gene

Publications for SF3A2 Gene

  1. Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation. (PMID: 11533230) Nesic D … Krämer A (Molecular and cellular biology 2001) 3 4 23 58
  2. Correspondence between a mammalian spliceosome component and an essential yeast splicing factor. (PMID: 8211113) Bennett M … Reed R (Science (New York, N.Y.) 1993) 2 3 4 58
  3. Structure of the human activated spliceosome in three conformational states. (PMID: 29360106) Zhang X … Shi Y (Cell research 2018) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58

Products for SF3A2 Gene

Sources for SF3A2 Gene

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