Aliases for SETSIP Gene

Aliases for SETSIP Gene

  • SET Like Protein 2 3 5
  • SET Similar Protein 2 3 4
  • SET Pseudogene Protein 18 3 4
  • SET Pseudogene 18 2 3
  • Protein SETSIP 3 4
  • SETP18 3 4
  • Similar To SET Translocation Protein 4
  • SET Nuclear Oncogene Pseudogene 3
  • SETSIP 5

External Ids for SETSIP Gene

Previous HGNC Symbols for SETSIP Gene

  • SETP18

Previous GeneCards Identifiers for SETSIP Gene

  • GC01M092543

Summaries for SETSIP Gene

GeneCards Summary for SETSIP Gene

SETSIP (SET Like Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is SET.

UniProtKB/Swiss-Prot Summary for SETSIP Gene

  • Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells into endothelial cells and the formation of vascular-like tubes (in vitro). Involved in the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SETSIP Gene

Genomics for SETSIP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SETSIP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J092029 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 0.3 +45.1 45079 2.4 ZNF600 ZNF580 ZNF223 ZNF10 ZIC2 ZBTB10 ZNF639 ZNF341 KLF9 ZNF610 EPHX4 lnc-SETSIP-2 DIPK1A SNORA66 SETSIP
GH01J092070 Enhancer 0.2 Ensembl 0.7 +4.6 4571 0.2 LPCAT2BP SETSIP EPHX4
GH01J092031 Enhancer 0.4 FANTOM5 0.3 +43.5 43536 0.2 ZNF341 ZNF189 EPHX4 HSALNG0005184 lnc-SETSIP-2 BTBD8 SETSIP
GH01J092036 Enhancer 0.4 Ensembl 0.3 +38.3 38271 1.2 ZNF316 MAFK ATF3 DIPK1A HSALNG0005184 piR-35674-028 EPHX4 SETSIP
GH01J092049 Enhancer 0.2 Ensembl 0.3 +26.0 25971 1.4 BTBD8 DIPK1A piR-35674-028 EPHX4 LPCAT2BP SETSIP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SETSIP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SETSIP

Genomic Locations for SETSIP Gene

Latest Assembly
chr1:92,074,436-92,075,472
(GRCh38/hg38)
Size:
1,037 bases
Orientation:
Minus strand

Previous Assembly
chr1:92,539,993-92,541,029
(GRCh37/hg19 by Entrez Gene)
Size:
1,037 bases
Orientation:
Minus strand

chr1:92,540,090-92,540,968
(GRCh37/hg19 by Ensembl)
Size:
879 bases
Orientation:
Minus strand

Genomic View for SETSIP Gene

Genes around SETSIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SETSIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SETSIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SETSIP Gene

Proteins for SETSIP Gene

  • Protein details for SETSIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DME0-SETLP_HUMAN
    Recommended name:
    Protein SETSIP
    Protein Accession:
    P0DME0

    Protein attributes for SETSIP Gene

    Size:
    302 amino acids
    Molecular mass:
    34882 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Probable retrogene derived from SET transcript.

neXtProt entry for SETSIP Gene

Post-translational modifications for SETSIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SETSIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SETSIP Gene

Domains & Families for SETSIP Gene

Gene Families for SETSIP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SETSIP Gene

Graphical View of Domain Structure for InterPro Entry

P0DME0

UniProtKB/Swiss-Prot:

SETLP_HUMAN :
  • Belongs to the nucleosome assembly protein (NAP) family.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with SETSIP: view

No data available for Suggested Antigen Peptide Sequences for SETSIP Gene

Function for SETSIP Gene

Molecular function for SETSIP Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells into endothelial cells and the formation of vascular-like tubes (in vitro). Involved in the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter.
UniProtKB/Swiss-Prot Induction:
Up-regulated during protein-induced pluripotent stem (PiPS) endothelial cell differention. Up-regulated by VEGFA and POU2F1 (at protein level).

Gene Ontology (GO) - Molecular Function for SETSIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 22869753
GO:0042393 histone binding IBA 21873635
genes like me logo Genes that share ontologies with SETSIP: view

Phenotypes for SETSIP Gene

genes like me logo Genes that share phenotypes with SETSIP: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SETSIP

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SETSIP Gene

Localization for SETSIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SETSIP Gene

Cytoplasm. Nucleus. Note=Translocated from the cytoplasm to the nucleus in protein-induced pluripotent stem (PiPS) endothelial cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SETSIP gene
Compartment Confidence
nucleus 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Lipid droplets (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SETSIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA 21873635
GO:0005634 nucleus IBA,IDA 22869753
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 22869753
GO:0005811 lipid droplet IDA --
genes like me logo Genes that share ontologies with SETSIP: view

Pathways & Interactions for SETSIP Gene

PathCards logo

SuperPathways for SETSIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SETSIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0030154 cell differentiation IEA --
GO:0045446 endothelial cell differentiation IDA 22869753
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 22869753
genes like me logo Genes that share ontologies with SETSIP: view

No data available for Pathways by source and SIGNOR curated interactions for SETSIP Gene

Drugs & Compounds for SETSIP Gene

No Compound Related Data Available

Transcripts for SETSIP Gene

mRNA/cDNA for SETSIP Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SETSIP

Alternative Splicing Database (ASD) splice patterns (SP) for SETSIP Gene

No ASD Table

Relevant External Links for SETSIP Gene

GeneLoc Exon Structure for
SETSIP

Expression for SETSIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SETSIP Gene

mRNA differential expression in normal tissues according to GTEx for SETSIP Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.7).

mRNA Expression by UniProt/SwissProt for SETSIP Gene:

P0DME0-SETLP_HUMAN
Tissue specificity: Expressed in endothelial cell (EC) and protein-induced pluripotent stem (PiPS) endothelial cell (EC) (at protein level).
genes like me logo Genes that share expression patterns with SETSIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SETSIP Gene

Orthologs for SETSIP Gene

This gene was present in the common ancestor of mammals.

Orthologs for SETSIP Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia LOC403555 29
  • 89.5 (n)
Rat
(Rattus norvegicus)
Mammalia Setl1 29
  • 87.34 (n)
Species where no ortholog for SETSIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SETSIP Gene

ENSEMBL:
Gene Tree for SETSIP (if available)
TreeFam:
Gene Tree for SETSIP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SETSIP: view image
Alliance of Genome Resources:
Additional Orthologs for SETSIP

Paralogs for SETSIP Gene

Variants for SETSIP Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SETSIP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SETSIP Gene

Variant ID Type Subtype PubMed ID
dgv365n54 CNV gain 21841781
esv2714684 CNV deletion 23290073
esv2750842 CNV gain 17911159
nsv1002730 CNV gain 25217958
nsv1006318 CNV gain 25217958
nsv1009079 CNV gain 25217958
nsv1855 CNV insertion 18451855
nsv462517 CNV gain 19166990
nsv524845 CNV gain 19592680
nsv546821 CNV gain 21841781
nsv946073 CNV duplication 23825009

Additional Variant Information for SETSIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SETSIP
Leiden Open Variation Database (LOVD)
SETSIP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SETSIP Gene

Disorders for SETSIP Gene

Additional Disease Information for SETSIP

No disorders were found for SETSIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SETSIP Gene

Publications for SETSIP Gene

  1. Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels. (PMID: 22869753) Margariti A … Xu Q (Proceedings of the National Academy of Sciences of the United States of America 2012) 2 3 4
  2. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. (PMID: 31753913) Kim JJ … Miller KM (Genes & development 2019) 3
  3. BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression. (PMID: 30463901) Yu L … Engel JD (Genes & development 2018) 3
  4. Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation. (PMID: 30110629) Raisner R … Gascoigne KE (Cell reports 2018) 3
  5. Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. (PMID: 29229926) Lu H … Bohr VA (Nature communications 2017) 3

Products for SETSIP Gene

Sources for SETSIP Gene