Aliases for SETD9 Gene

Aliases for SETD9 Gene

  • SET Domain Containing 9 2 3 5
  • SET Domain-Containing Protein 9 3 4
  • C5orf35 3 4
  • Chromosome 5 Open Reading Frame 35 2
  • EC 2.1.1.- 4
  • MGC33648 2
  • SETD9 5

External Ids for SETD9 Gene

Previous HGNC Symbols for SETD9 Gene

  • C5orf35

Previous GeneCards Identifiers for SETD9 Gene

  • GC05P056206

Summaries for SETD9 Gene

GeneCards Summary for SETD9 Gene

SETD9 (SET Domain Containing 9) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include methyltransferase activity.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SETD9 Gene

Genomics for SETD9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SETD9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SETD9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SETD9

Genomic Locations for SETD9 Gene

Latest Assembly
chr5:56,909,260-56,928,900
(GRCh38/hg38)
Size:
19,641 bases
Orientation:
Plus strand

Previous Assembly
chr5:56,205,087-56,224,727
(GRCh37/hg19 by Entrez Gene)
Size:
19,641 bases
Orientation:
Plus strand

chr5:56,205,087-56,221,359
(GRCh37/hg19 by Ensembl)
Size:
16,273 bases
Orientation:
Plus strand

Genomic View for SETD9 Gene

Genes around SETD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SETD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SETD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SETD9 Gene

Proteins for SETD9 Gene

  • Protein details for SETD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE22-SETD9_HUMAN
    Recommended name:
    SET domain-containing protein 9
    Protein Accession:
    Q8NE22
    Secondary Accessions:
    • F5H713

    Protein attributes for SETD9 Gene

    Size:
    299 amino acids
    Molecular mass:
    34095 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SETD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SETD9 Gene

Post-translational modifications for SETD9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SETD9 Gene

Domains & Families for SETD9 Gene

Gene Families for SETD9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SETD9 Gene

InterPro:

Graphical View of Domain Structure for InterPro Entry

Q8NE22

UniProtKB/Swiss-Prot:

SETD9_HUMAN :
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
genes like me logo Genes that share domains with SETD9: view

No data available for Suggested Antigen Peptide Sequences for SETD9 Gene

Function for SETD9 Gene

Enzyme Numbers (IUBMB) for SETD9 Gene

Phenotypes From GWAS Catalog for SETD9 Gene

Gene Ontology (GO) - Molecular Function for SETD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008168 methyltransferase activity IEA --
GO:0016278 lysine N-methyltransferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SETD9: view
genes like me logo Genes that share phenotypes with SETD9: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SETD9

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SETD9 Gene

Localization for SETD9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SETD9 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytoskeleton 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SETD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with SETD9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SETD9 Gene

Pathways & Interactions for SETD9 Gene

genes like me logo Genes that share pathways with SETD9: view

Pathways by source for SETD9 Gene

Gene Ontology (GO) - Biological Process for SETD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
GO:1901796 regulation of signal transduction by p53 class mediator TAS --
genes like me logo Genes that share ontologies with SETD9: view

No data available for SIGNOR curated interactions for SETD9 Gene

Drugs & Compounds for SETD9 Gene

No Compound Related Data Available

Transcripts for SETD9 Gene

mRNA/cDNA for SETD9 Gene

6 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SETD9

Alternative Splicing Database (ASD) splice patterns (SP) for SETD9 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP7:

Relevant External Links for SETD9 Gene

GeneLoc Exon Structure for
SETD9

Expression for SETD9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SETD9 Gene

mRNA differential expression in normal tissues according to GTEx for SETD9 Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for SETD9 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SETD9 Gene



Protein tissue co-expression partners for SETD9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SETD9

SOURCE GeneReport for Unigene cluster for SETD9 Gene:

Hs.85950
genes like me logo Genes that share expression patterns with SETD9: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SETD9 Gene

Orthologs for SETD9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SETD9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SETD9 29 30
  • 99.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SETD9 29 30
  • 93.31 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SETD9 29 30
  • 92.87 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SETD9 30
  • 72 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SETD9 30
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CZH5ORF35 29
  • 67.12 (n)
SETD9 30
  • 66 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SETD9 30
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia setd9 29
  • 65.86 (n)
Zebrafish
(Danio rerio)
Actinopterygii SETD9 30
  • 60 (a)
OneToOne
LOC793111 29
  • 59.64 (n)
Dr.16643 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7120 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 46 (a)
OneToOne
Species where no ortholog for SETD9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SETD9 Gene

ENSEMBL:
Gene Tree for SETD9 (if available)
TreeFam:
Gene Tree for SETD9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SETD9: view image
Alliance of Genome Resources:
Additional Orthologs for SETD9

Paralogs for SETD9 Gene

No data available for Paralogs for SETD9 Gene

Variants for SETD9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SETD9 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs1554039146 Uncertain Significance: Ependymoma 56,914,938(+) AACATTGCCT/A
NM_153706.4(SETD9):c.788_796del (p.Ile263_Tyr265del)
NON_CODING_TRANSCRIPT_VARIANT,INFRAME_DELETION
rs2257505 -- p.Ser76Thr
rs40497 -- p.Lys209Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SETD9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SETD9 Gene

Variant ID Type Subtype PubMed ID
nsv598210 CNV loss 21841781

Variation tolerance for SETD9 Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.04; 96.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SETD9 Gene

Human Gene Mutation Database (HGMD)
SETD9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SETD9
Leiden Open Variation Database (LOVD)
SETD9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SETD9 Gene

Disorders for SETD9 Gene

Additional Disease Information for SETD9

No disorders were found for SETD9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SETD9 Gene

Publications for SETD9 Gene

  1. Uncovering the human methyltransferasome. (PMID: 20930037) Petrossian TC … Clarke SG (Molecular & cellular proteomics : MCP 2011) 2 3
  2. SNP variants at the MAP3K1/SETD9 locus 5q11.2 associate with somatic PIK3CA variants in breast cancers. (PMID: 28029147) Puzone R … Pfeffer U (European journal of human genetics : EJHG 2017) 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3

Products for SETD9 Gene

Sources for SETD9 Gene