Aliases for SETD6 Gene
External Ids for SETD6 Gene
Previous GeneCards Identifiers for SETD6 Gene
This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
GeneCards Summary for SETD6 Gene
SETD6 (SET Domain Containing 6, Protein Lysine Methyltransferase) is a Protein Coding gene. Diseases associated with SETD6 include Familial Colorectal Cancer Type X and Meningioma, Familial. Among its related pathways are Chromatin organization and PKMTs methylate histone lysines. Gene Ontology (GO) annotations related to this gene include NF-kappaB binding and protein-lysine N-methyltransferase activity. An important paralog of this gene is SETD3.
UniProtKB/Swiss-Prot Summary for SETD6 Gene
Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity (PubMed:21131967). Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity).