Aliases for SETD3 Gene
External Ids for SETD3 Gene
Previous HGNC Symbols for SETD3 Gene
Previous GeneCards Identifiers for SETD3 Gene
GeneCards Summary for SETD3 Gene
SETD3 (SET Domain Containing 3, Actin Histidine Methyltransferase) is a Protein Coding gene. Among its related pathways are PKMTs methylate histone lysines and Chromatin organization. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and histone methyltransferase activity (H3-K4 specific). An important paralog of this gene is SETD6.
UniProtKB/Swiss-Prot Summary for SETD3 Gene
Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395).