Aliases for SETD1B Gene
External Ids for SETD1B Gene
Previous GeneCards Identifiers for SETD1B Gene
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SETD1B Gene
SETD1B (SET Domain Containing 1B, Histone Lysine Methyltransferase) is a Protein Coding gene. Diseases associated with SETD1B include Intellectual Developmental Disorder With Seizures And Language Delay and Epilepsy. Among its related pathways are Chromatin Regulation / Acetylation and Chromatin organization. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SETD1A.
UniProtKB/Swiss-Prot Summary for SETD1B Gene
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.