Aliases for SETD1B Gene
External Ids for SETD1B Gene
Previous GeneCards Identifiers for SETD1B Gene
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SETD1B Gene
SETD1B (SET Domain Containing 1B, Histone Lysine Methyltransferase) is a Protein Coding gene. Diseases associated with SETD1B include Intellectual Developmental Disorder With Seizures And Language Delay and Epilepsy. Among its related pathways are Chromatin organization and Lysine degradation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SETD1A.
UniProtKB/Swiss-Prot Summary for SETD1B Gene
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.