Aliases for SETD1A Gene
External Ids for SETD1A Gene
Previous GeneCards Identifiers for SETD1A Gene
The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Dec 2016]
GeneCards Summary for SETD1A Gene
SETD1A (SET Domain Containing 1A, Histone Lysine Methyltransferase) is a Protein Coding gene. Diseases associated with SETD1A include Schizophrenia and Anus Benign Neoplasm. Among its related pathways are Chromatin Regulation / Acetylation and Lysine degradation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SETD1B.
UniProtKB/Swiss-Prot for SETD1A Gene
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.