Aliases for SESTD1 Gene
External Ids for SESTD1 Gene
Previous GeneCards Identifiers for SESTD1 Gene
GeneCards Summary for SESTD1 Gene
SESTD1 (SEC14 And Spectrin Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and phosphatidylserine binding. An important paralog of this gene is MCF2L.
UniProtKB/Swiss-Prot Summary for SESTD1 Gene
May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.