External Ids for SESN3 Gene
Previous GeneCards Identifiers for SESN3 Gene
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
GeneCards Summary for SESN3 Gene
SESN3 (Sestrin 3) is a Protein Coding gene. Diseases associated with SESN3 include Endometrial Adenosquamous Carcinoma. Among its related pathways are TP53 Regulates Metabolic Genes and Gene Expression. An important paralog of this gene is SESN1.
UniProtKB/Swiss-Prot Summary for SESN3 Gene
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity).