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Aliases for SERTM1 Gene

Aliases for SERTM1 Gene

  • Serine Rich And Transmembrane Domain Containing 1 2 3 5
  • C13orf36 3 4
  • Serine-Rich And Transmembrane Domain-Containing Protein 1 3
  • Serine-Rich And Transmembrane Domain Containing 1 2
  • Chromosome 13 Open Reading Frame 36 2

External Ids for SERTM1 Gene

Previous HGNC Symbols for SERTM1 Gene

  • C13orf36

Previous GeneCards Identifiers for SERTM1 Gene

  • GC13P037250

Summaries for SERTM1 Gene

GeneCards Summary for SERTM1 Gene

SERTM1 (Serine Rich And Transmembrane Domain Containing 1) is a Protein Coding gene.

Additional gene information for SERTM1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERTM1 Gene

Genomics for SERTM1 Gene

GeneHancer (GH) Regulatory Elements for SERTM1 Gene

Promoters and enhancers for SERTM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I036673 Promoter/Enhancer 1.2 EPDnew ENCODE 550.8 +0.0 47 0.2 ZBTB6 ZNF449 BACH1 ZIC2 ZNF324 ZNF335 ZFHX2 GLIS2 POLR2A PATZ1 SERTM1 RFXAP SPART-AS1 GAPDHP34 LOC102723490
GH13I036918 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 2.6 +246.0 245978 3.2 FOXA2 ARID4B ZNF48 ZNF335 GLIS2 CREM EGR2 SP5 MXD4 ZNF398 SMAD9 SERTM1 RFXAP SMAD9-IT1
GH13I036717 Enhancer 0.2 ENCODE 10.8 +44.2 44163 0.7 SERTM1 CCNA1 RFXAP GAPDHP34 LOC102723490
GH13I036519 Enhancer 0.2 ENCODE 10.6 -154.4 -154375 0.8 SERTM1 HIST1H2APS6
GH13I036899 Enhancer 0.2 FANTOM5 1.5 +226.0 225987 0.2 SMAD9 SERTM1 SMAD9-IT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERTM1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SERTM1 Gene

Genomic Locations for SERTM1 Gene
chr13:36,673,912-36,697,839
(GRCh38/hg38)
Size:
23,928 bases
Orientation:
Plus strand
chr13:37,248,049-37,271,976
(GRCh37/hg19)

Genomic View for SERTM1 Gene

Genes around SERTM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERTM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERTM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERTM1 Gene

Proteins for SERTM1 Gene

  • Protein details for SERTM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2A2V5-SRTM1_HUMAN
    Recommended name:
    Serine-rich and transmembrane domain-containing protein 1
    Protein Accession:
    A2A2V5
    Secondary Accessions:
    • Q8N469

    Protein attributes for SERTM1 Gene

    Size:
    107 amino acids
    Molecular mass:
    11458 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERTM1 Gene

Post-translational modifications for SERTM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERTM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERTM1 Gene

Domains & Families for SERTM1 Gene

Gene Families for SERTM1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SERTM1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SERTM1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SERTM1 Gene

Function for SERTM1 Gene

Phenotypes for SERTM1 Gene

GenomeRNAi human phenotypes for SERTM1:
genes like me logo Genes that share phenotypes with SERTM1: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERTM1 Gene

Localization for SERTM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERTM1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERTM1 gene
Compartment Confidence
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SERTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SERTM1: view

Pathways & Interactions for SERTM1 Gene

SuperPathways for SERTM1 Gene

No Data Available

Interacting Proteins for SERTM1 Gene

Selected Interacting proteins: A2A2V5-SRTM1_HUMAN for SERTM1 Gene via IID

Symbol External ID(s) Details
APP

Gene Ontology (GO) - Biological Process for SERTM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SERTM1 Gene

Drugs & Compounds for SERTM1 Gene

No Compound Related Data Available

Transcripts for SERTM1 Gene

mRNA/cDNA for SERTM1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERTM1 Gene

Serine-rich and transmembrane domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERTM1 Gene

No ASD Table

Relevant External Links for SERTM1 Gene

GeneLoc Exon Structure for
SERTM1
ECgene alternative splicing isoforms for
SERTM1

Expression for SERTM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERTM1 Gene

mRNA differential expression in normal tissues according to GTEx for SERTM1 Gene

This gene is overexpressed in Fallopian Tube (x10.0), Cervix - Endocervix (x5.0), Cervix - Ectocervix (x4.7), and Uterus (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of SERTM1 Gene:

SERTM1

SOURCE GeneReport for Unigene cluster for SERTM1 Gene:

Hs.422375

Evidence on tissue expression from TISSUES for SERTM1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SERTM1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERTM1 Gene

Orthologs for SERTM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERTM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERTM1 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia C13ORF36 34
  • 97 (a)
OneToOne
SERTM1 33
  • 92.21 (n)
oppossum
(Monodelphis domestica)
Mammalia SERTM1 34
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERTM1 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERTM1 33 34
  • 91.9 (n)
rat
(Rattus norvegicus)
Mammalia Sertm1 33
  • 86.29 (n)
mouse
(Mus musculus)
Mammalia Sertm1 33 16 34
  • 84.74 (n)
chicken
(Gallus gallus)
Aves SERTM1 33
  • 78.82 (n)
lizard
(Anolis carolinensis)
Reptilia SERTM1 34
  • 83 (a)
OneToOne
Species where no ortholog for SERTM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERTM1 Gene

ENSEMBL:
Gene Tree for SERTM1 (if available)
TreeFam:
Gene Tree for SERTM1 (if available)

Paralogs for SERTM1 Gene

No data available for Paralogs for SERTM1 Gene

Variants for SERTM1 Gene

Sequence variations from dbSNP and Humsavar for SERTM1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000107074 -- 36,681,669(+) T/A intron_variant
rs1000169550 -- 36,675,334(+) T/C intron_variant
rs1000387287 -- 36,687,858(+) A/G intron_variant
rs1000436425 -- 36,697,237(+) A/G 3_prime_UTR_variant
rs1000566025 -- 36,673,156(+) A/ upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SERTM1 Gene

Variant ID Type Subtype PubMed ID
nsv524665 CNV loss 19592680

Variation tolerance for SERTM1 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERTM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERTM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERTM1 Gene

Disorders for SERTM1 Gene

Additional Disease Information for SERTM1

No disorders were found for SERTM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERTM1 Gene

Publications for SERTM1 Gene

  1. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for SERTM1 Gene

Sources for SERTM1 Gene

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