Aliases for SERTAD4 Gene

Aliases for SERTAD4 Gene

  • SERTA Domain Containing 4 2 3 5
  • SERTA Domain-Containing Protein 4 3 4
  • DJ667H12.2 3

External Ids for SERTAD4 Gene

Previous GeneCards Identifiers for SERTAD4 Gene

  • GC01P207486
  • GC01P206794
  • GC01P208472
  • GC01P210406
  • GC01P181079

Summaries for SERTAD4 Gene

GeneCards Summary for SERTAD4 Gene

SERTAD4 (SERTA Domain Containing 4) is a Protein Coding gene. Diseases associated with SERTAD4 include Cone-Rod Dystrophy 6.

Additional gene information for SERTAD4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERTAD4 Gene

Genomics for SERTAD4 Gene

GeneHancer (GH) Regulatory Elements for SERTAD4 Gene

Promoters and enhancers for SERTAD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J210232 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.4 395 3.5 EP300 JUND FOS ZNF10 ZIC2 ZBTB10 ZNF423 ZBTB26 KLF7 CHD1 SERTAD4-AS1 SERTAD4 lnc-SERTAD4-1 TRAF3IP3
GH01J210328 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 9.8 +96.2 96233 2.3 ZBTB40 SIN3A USF1 POLR2G PHF8 ZFX ZNF10 POLR2A ZBTB26 SKI HHAT RCOR3 SERTAD4-AS1 SERTAD4 RF00017-464
GH01J210371 Promoter/Enhancer 1.4 Ensembl ENCODE 13.8 +140.9 140866 3.4 EP300 FOXK2 CTCF MYC TCF12 USF1 POLR2G NCOR1 GTF2E2 JUND RF00020-005 RNU5A-8P RCOR3 SERTAD4-AS1 SERTAD4 ST13P19 HHAT ENSG00000287354
GH01J210259 Enhancer 1.2 VISTA Ensembl ENCODE CraniofacialAtlas 11.2 +30.3 30262 6.4 TEAD4 TEAD1 CTCF ZBTB17 CEBPB POLR2A ZFHX2 ZNF335 EBF1 ZNF189 SERTAD4-AS1 SERTAD4 TRAF3IP3 IRF6 ST13P19 piR-43106-017
GH01J210331 Enhancer 1.2 FANTOM5 Ensembl ENCODE 9.8 +100.1 100105 2.2 CTCF ZNF510 MEF2C TRIM22 NFYB OSR2 BCL11A RELA TCF12 WT1 SERTAD4-AS1 HHAT SERTAD4 RF00017-464
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERTAD4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERTAD4

Top Transcription factor binding sites by QIAGEN in the SERTAD4 gene promoter:
  • aMEF-2
  • CUTL1
  • GATA-1
  • GATA-2
  • GATA-3
  • HFH-1
  • Hlf
  • MEF-2A
  • RFX1

Genomic Locations for SERTAD4 Gene

Genomic Locations for SERTAD4 Gene
chr1:210,232,796-210,246,858
(GRCh38/hg38)
Size:
14,063 bases
Orientation:
Plus strand
chr1:210,406,144-210,419,976
(GRCh37/hg19)
Size:
13,833 bases
Orientation:
Plus strand

Genomic View for SERTAD4 Gene

Genes around SERTAD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERTAD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERTAD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERTAD4 Gene

Proteins for SERTAD4 Gene

  • Protein details for SERTAD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUC0-SRTD4_HUMAN
    Recommended name:
    SERTA domain-containing protein 4
    Protein Accession:
    Q9NUC0
    Secondary Accessions:
    • B2RD32

    Protein attributes for SERTAD4 Gene

    Size:
    356 amino acids
    Molecular mass:
    39348 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERTAD4 Gene

Post-translational modifications for SERTAD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERTAD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERTAD4 Gene

Domains & Families for SERTAD4 Gene

Gene Families for SERTAD4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SERTAD4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERTAD4 Gene

GenScript: Design optimal peptide antigens:
  • SERTA domain-containing protein 4 (SRTD4_HUMAN)
genes like me logo Genes that share domains with SERTAD4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SERTAD4 Gene

Function for SERTAD4 Gene

Phenotypes From GWAS Catalog for SERTAD4 Gene

genes like me logo Genes that share phenotypes with SERTAD4: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERTAD4 Gene

Localization for SERTAD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERTAD4 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SERTAD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SERTAD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SERTAD4 Gene

Pathways & Interactions for SERTAD4 Gene

PathCards logo

SuperPathways for SERTAD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERTAD4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SERTAD4 Gene

Drugs & Compounds for SERTAD4 Gene

No Compound Related Data Available

Transcripts for SERTAD4 Gene

mRNA/cDNA for SERTAD4 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERTAD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: -
SP2: -
SP3:
SP4: - - -
SP5: -

Relevant External Links for SERTAD4 Gene

GeneLoc Exon Structure for
SERTAD4

Expression for SERTAD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERTAD4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERTAD4

SOURCE GeneReport for Unigene cluster for SERTAD4 Gene:

Hs.600545

Evidence on tissue expression from TISSUES for SERTAD4 Gene

  • Kidney(4.4)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SERTAD4: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERTAD4 Gene

Orthologs for SERTAD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERTAD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERTAD4 31 30
  • 93.04 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SERTAD4 31 30
  • 92.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SERTAD4 31 30
  • 92.52 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sertad4 17 31 30
  • 82.34 (n)
rat
(Rattus norvegicus)
Mammalia Sertad4 30
  • 81.87 (n)
oppossum
(Monodelphis domestica)
Mammalia SERTAD4 31
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERTAD4 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 31
  • 86 (a)
OneToMany
SERTAD4 30
  • 71.1 (n)
-- 31
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SERTAD4 31
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sertad4 30
  • 65.86 (n)
zebrafish
(Danio rerio)
Actinopterygii SERTAD4 31
  • 32 (a)
OneToOne
Species where no ortholog for SERTAD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERTAD4 Gene

ENSEMBL:
Gene Tree for SERTAD4 (if available)
TreeFam:
Gene Tree for SERTAD4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERTAD4: view image

Paralogs for SERTAD4 Gene

Pseudogenes.org Pseudogenes for SERTAD4 Gene

genes like me logo Genes that share paralogs with SERTAD4: view

No data available for Paralogs for SERTAD4 Gene

Variants for SERTAD4 Gene

Additional dbSNP identifiers (rs#s) for SERTAD4 Gene

Structural Variations from Database of Genomic Variants (DGV) for SERTAD4 Gene

Variant ID Type Subtype PubMed ID
nsv1068469 CNV deletion 25765185
nsv1121788 CNV deletion 24896259
nsv8769 CNV gain 18304495

Variation tolerance for SERTAD4 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERTAD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERTAD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERTAD4 Gene

Disorders for SERTAD4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SERTAD4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cone-rod dystrophy 6
  • retinitis pigmentosa 6
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERTAD4

genes like me logo Genes that share disorders with SERTAD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERTAD4 Gene

Publications for SERTAD4 Gene

  1. I-mfa domain proteins specifically interact with SERTA domain proteins and repress their transactivating functions. (PMID: 21664411) Kusano S … Eizuru Y (Biochimie 2011) 2 3 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 54
  5. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. (PMID: 28330616) Yadav L … Varjosalo M (Cell systems 2017) 3 54

Products for SERTAD4 Gene

Sources for SERTAD4 Gene