The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been o... See more...

Aliases for SERTAD3 Gene

Aliases for SERTAD3 Gene

  • SERTA Domain Containing 3 2 3 5
  • RPA-Binding Trans-Activator 2 3 4
  • Replication Protein-Binding Trans-Activator 3 4
  • SERTA Domain-Containing Protein 3 3 4
  • RBT1 3 4

External Ids for SERTAD3 Gene

Previous GeneCards Identifiers for SERTAD3 Gene

  • GC19M045639
  • GC19M045640
  • GC19M040946
  • GC19M037383
  • GC19M040441
  • GC19M040442
  • GC19M040748

Summaries for SERTAD3 Gene

Entrez Gene Summary for SERTAD3 Gene

  • The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for SERTAD3 Gene

SERTAD3 (SERTA Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is SERTAD1.

UniProtKB/Swiss-Prot Summary for SERTAD3 Gene

Additional gene information for SERTAD3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERTAD3 Gene

Genomics for SERTAD3 Gene

GeneHancer (GH) Regulatory Elements for SERTAD3 Gene

Promoters and enhancers for SERTAD3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERTAD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERTAD3 gene promoter:
  • Bach1
  • c-Ets-1
  • IRF-2
  • p53

Genomic Locations for SERTAD3 Gene

Genomic Locations for SERTAD3 Gene
chr19:40,440,841-40,444,375
(GRCh38/hg38)
Size:
3,535 bases
Orientation:
Minus strand
chr19:40,946,748-40,950,612
(GRCh37/hg19)
Size:
3,865 bases
Orientation:
Minus strand

Genomic View for SERTAD3 Gene

Genes around SERTAD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERTAD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERTAD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERTAD3 Gene

Proteins for SERTAD3 Gene

  • Protein details for SERTAD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJW9-SRTD3_HUMAN
    Recommended name:
    SERTA domain-containing protein 3
    Protein Accession:
    Q9UJW9
    Secondary Accessions:
    • B3KQB3
    • Q96CQ2

    Protein attributes for SERTAD3 Gene

    Size:
    196 amino acids
    Molecular mass:
    21769 Da
    Quaternary structure:
    • Interacts with RPA2.

neXtProt entry for SERTAD3 Gene

Post-translational modifications for SERTAD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERTAD3 Gene

No data available for DME Specific Peptides for SERTAD3 Gene

Domains & Families for SERTAD3 Gene

Gene Families for SERTAD3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SERTAD3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERTAD3 Gene

GenScript: Design optimal peptide antigens:
  • Replication protein-binding trans-activator (SRTD3_HUMAN)
genes like me logo Genes that share domains with SERTAD3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SERTAD3 Gene

Function for SERTAD3 Gene

Molecular function for SERTAD3 Gene

UniProtKB/Swiss-Prot Function:
Strong transcriptional coactivator.

Phenotypes From GWAS Catalog for SERTAD3 Gene

Gene Ontology (GO) - Molecular Function for SERTAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10982866
genes like me logo Genes that share ontologies with SERTAD3: view
genes like me logo Genes that share phenotypes with SERTAD3: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERTAD3 Gene

Localization for SERTAD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERTAD3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERTAD3 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SERTAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IBA 10982866
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SERTAD3: view

Pathways & Interactions for SERTAD3 Gene

PathCards logo

SuperPathways for SERTAD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERTAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA,IEA 10982866
GO:0030308 negative regulation of cell growth IDA 16098148
GO:0045893 positive regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with SERTAD3: view

No data available for Pathways by source and SIGNOR curated interactions for SERTAD3 Gene

Drugs & Compounds for SERTAD3 Gene

No Compound Related Data Available

Transcripts for SERTAD3 Gene

mRNA/cDNA for SERTAD3 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERTAD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5:

Relevant External Links for SERTAD3 Gene

GeneLoc Exon Structure for
SERTAD3
ECgene alternative splicing isoforms for
SERTAD3

Expression for SERTAD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERTAD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERTAD3 Gene:

SERTAD3

SOURCE GeneReport for Unigene cluster for SERTAD3 Gene:

Hs.515412
genes like me logo Genes that share expression patterns with SERTAD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERTAD3 Gene

Orthologs for SERTAD3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SERTAD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERTAD3 33 32
  • 99.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SERTAD3 33 32
  • 88.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SERTAD3 33 32
  • 88.21 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sertad3 32
  • 84.1 (n)
mouse
(Mus musculus)
Mammalia Sertad3 17 33 32
  • 83.76 (n)
Species where no ortholog for SERTAD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERTAD3 Gene

ENSEMBL:
Gene Tree for SERTAD3 (if available)
TreeFam:
Gene Tree for SERTAD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERTAD3: view image

Paralogs for SERTAD3 Gene

Paralogs for SERTAD3 Gene

genes like me logo Genes that share paralogs with SERTAD3: view

Variants for SERTAD3 Gene

Sequence variations from dbSNP and Humsavar for SERTAD3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000655884 -- 40,441,150(-) CTTTCTTT/CTTT 3_prime_UTR_variant
rs1000760729 -- 40,446,330(-) C/T upstream_transcript_variant
rs1001386106 -- 40,444,780(-) C/G upstream_transcript_variant
rs1001534190 -- 40,442,124(-) C/T intron_variant
rs1001560658 -- 40,441,832(-) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for SERTAD3 Gene

Variant ID Type Subtype PubMed ID
nsv819017 CNV loss 19587683
nsv833831 CNV loss 17160897

Variation tolerance for SERTAD3 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERTAD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERTAD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERTAD3 Gene

Disorders for SERTAD3 Gene

Additional Disease Information for SERTAD3

No disorders were found for SERTAD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERTAD3 Gene

Publications for SERTAD3 Gene

  1. RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A. (PMID: 10982866) Cho JM … Alaoui-Jamali MA (Nucleic acids research 2000) 2 3 4 23 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PMID: 11331592) Hsu SI … Bonventre JV (The EMBO journal 2001) 2 3 56
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 56
  5. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 56

Products for SERTAD3 Gene

Sources for SERTAD3 Gene