Aliases for SERTAD2 Gene

Aliases for SERTAD2 Gene

  • SERTA Domain Containing 2 2 3 5
  • Transcriptional Regulator Interacting With The PHD-Bromodomain 2 3 4
  • Transcriptional Regulator Interacting With The PHS-Bromodomain 2 2 3
  • SERTA Domain-Containing Protein 2 3 4
  • TRIP-Br2 3 4
  • TRIPBR2 3 4
  • KIAA0127 4
  • Sei-2 3

External Ids for SERTAD2 Gene

Previous GeneCards Identifiers for SERTAD2 Gene

  • GC02M064834
  • GC02M064770
  • GC02M064592
  • GC02M064858

Summaries for SERTAD2 Gene

GeneCards Summary for SERTAD2 Gene

SERTAD2 (SERTA Domain Containing 2) is a Protein Coding gene. Diseases associated with SERTAD2 include Retinitis Pigmentosa 28. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is CDCA4.

UniProtKB/Swiss-Prot Summary for SERTAD2 Gene

  • Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.

Additional gene information for SERTAD2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERTAD2 Gene

Genomics for SERTAD2 Gene

GeneHancer (GH) Regulatory Elements for SERTAD2 Gene

Promoters and enhancers for SERTAD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERTAD2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERTAD2

Top Transcription factor binding sites by QIAGEN in the SERTAD2 gene promoter:
  • Evi-1
  • GATA-1
  • GATA-6
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Olf-1
  • POU6F1 (c2)

Genomic Locations for SERTAD2 Gene

Genomic Locations for SERTAD2 Gene
chr2:64,631,621-64,751,091
(GRCh38/hg38)
Size:
119,471 bases
Orientation:
Minus strand
chr2:64,858,755-64,978,139
(GRCh37/hg19)
Size:
119,385 bases
Orientation:
Minus strand

Genomic View for SERTAD2 Gene

Genes around SERTAD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERTAD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERTAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERTAD2 Gene

Proteins for SERTAD2 Gene

  • Protein details for SERTAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14140-SRTD2_HUMAN
    Recommended name:
    SERTA domain-containing protein 2
    Protein Accession:
    Q14140
    Secondary Accessions:
    • Q53TS2

    Protein attributes for SERTAD2 Gene

    Size:
    314 amino acids
    Molecular mass:
    33897 Da
    Quaternary structure:
    • Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes.
    SequenceCaution:
    • Sequence=BAA09476.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for SERTAD2 Gene

Post-translational modifications for SERTAD2 Gene

  • Polyubiquitinated, which promotes proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERTAD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERTAD2 Gene

Domains & Families for SERTAD2 Gene

Gene Families for SERTAD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SERTAD2 Gene

Blocks:
  • SERTA
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERTAD2 Gene

GenScript: Design optimal peptide antigens:
  • Transcriptional regulator interacting with the PHD-bromodomain 2 (SRTD2_HUMAN)
genes like me logo Genes that share domains with SERTAD2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SERTAD2 Gene

Function for SERTAD2 Gene

Molecular function for SERTAD2 Gene

UniProtKB/Swiss-Prot Function:
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.

Phenotypes From GWAS Catalog for SERTAD2 Gene

Gene Ontology (GO) - Molecular Function for SERTAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IEA --
genes like me logo Genes that share ontologies with SERTAD2: view
genes like me logo Genes that share phenotypes with SERTAD2: view

Animal Model Products

CRISPR Products

miRNA for SERTAD2 Gene

miRTarBase miRNAs that target SERTAD2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERTAD2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERTAD2 Gene

Localization for SERTAD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERTAD2 Gene

Nucleus. Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERTAD2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SERTAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16098148
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 16098148
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SERTAD2: view

Pathways & Interactions for SERTAD2 Gene

PathCards logo

SuperPathways for SERTAD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERTAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030308 negative regulation of cell growth IDA 16098148
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SERTAD2: view

No data available for Pathways by source and SIGNOR curated interactions for SERTAD2 Gene

Drugs & Compounds for SERTAD2 Gene

No Compound Related Data Available

Transcripts for SERTAD2 Gene

mRNA/cDNA for SERTAD2 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERTAD2

Alternative Splicing Database (ASD) splice patterns (SP) for SERTAD2 Gene

No ASD Table

Relevant External Links for SERTAD2 Gene

GeneLoc Exon Structure for
SERTAD2

Expression for SERTAD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERTAD2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERTAD2

SOURCE GeneReport for Unigene cluster for SERTAD2 Gene:

Hs.591569

mRNA Expression by UniProt/SwissProt for SERTAD2 Gene:

Q14140-SRTD2_HUMAN
Tissue specificity: Expressed in adipose tissue.

Evidence on tissue expression from TISSUES for SERTAD2 Gene

  • Bone marrow(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SERTAD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERTAD2 Gene

Orthologs for SERTAD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERTAD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERTAD2 31 30
  • 99.58 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sertad2 17 31 30
  • 87.4 (n)
rat
(Rattus norvegicus)
Mammalia Sertad2 30
  • 87.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SERTAD2 31
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERTAD2 31 30
  • 81.79 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SERTAD2 31 30
  • 81 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERTAD2 31
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERTAD2 31 30
  • 80.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERTAD2 31
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sertad2 30
  • 75.19 (n)
Str.19163 30
zebrafish
(Danio rerio)
Actinopterygii sertad2b 31 30
  • 68.54 (n)
OneToOne
Species where no ortholog for SERTAD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERTAD2 Gene

ENSEMBL:
Gene Tree for SERTAD2 (if available)
TreeFam:
Gene Tree for SERTAD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERTAD2: view image

Paralogs for SERTAD2 Gene

Paralogs for SERTAD2 Gene

genes like me logo Genes that share paralogs with SERTAD2: view

Variants for SERTAD2 Gene

Additional dbSNP identifiers (rs#s) for SERTAD2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SERTAD2 Gene

Variant ID Type Subtype PubMed ID
nsv2756 CNV deletion 18451855
nsv582127 CNV gain 21841781
nsv7313 OTHER inversion 18451855
nsv820222 CNV loss 19587683

Variation tolerance for SERTAD2 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERTAD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERTAD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERTAD2 Gene

Disorders for SERTAD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SERTAD2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 28
  • rp28
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERTAD2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SERTAD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERTAD2 Gene

Publications for SERTAD2 Gene

  1. CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. (PMID: 18316374) Cheong JK … Hsu SI (The Journal of biological chemistry 2008) 3 4 23 54
  2. TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. (PMID: 11331592) Hsu SI … Bonventre JV (The EMBO journal 2001) 2 3 4 54
  3. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4 54
  4. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. (PMID: 23291629) Liew CW … Kulkarni RN (Nature medicine 2013) 3 4 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for SERTAD2 Gene

Sources for SERTAD2 Gene