Aliases for SERPINF2 Gene
- Serpin Family F Member 2 2 3 5
- Alpha-2-Plasmin Inhibitor 2 3 4
- Alpha-2-Antiplasmin 2 3 4
- Serine (Or Cysteine) Proteinase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 2 2 3
- Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 2 2 3
- Alpha-2-AP 3 4
- Serpin F2 3 4
External Ids for SERPINF2 Gene
Previous HGNC Symbols for SERPINF2 Gene
Previous GeneCards Identifiers for SERPINF2 Gene
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for SERPINF2 Gene
SERPINF2 (Serpin Family F Member 2) is a Protein Coding gene. Diseases associated with SERPINF2 include Alpha-2-Plasmin Inhibitor Deficiency and Anti-Plasmin Deficiency, Congenital. Among its related pathways are Complement and coagulation cascades and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protease binding. An important paralog of this gene is SERPING1.
UniProtKB/Swiss-Prot Summary for SERPINF2 Gene
Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.