This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individu... See more...

Aliases for SERPINF1 Gene

Aliases for SERPINF1 Gene

  • Serpin Family F Member 1 2 3 5
  • Pigment Epithelium-Derived Factor 2 3 4
  • EPC-1 2 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 2 3
  • Cell Proliferation-Inducing Gene 35 Protein 3 4
  • Alpha-2 Antiplasmin 2 3
  • PIG35 2 3
  • PEDF 3 4
  • Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 3
  • Testis Tissue Sperm-Binding Protein Li 70n 3
  • Proliferation-Inducing Protein 35 2
  • Serpin F1 4
  • SERPINF1 5
  • OI12 3
  • OI6 3

External Ids for SERPINF1 Gene

Previous HGNC Symbols for SERPINF1 Gene

  • PEDF

Previous GeneCards Identifiers for SERPINF1 Gene

  • GC17P001954
  • GC17P002005
  • GC17P001616
  • GC17P001876
  • GC17P001872
  • GC17P001612
  • GC17P001665

Summaries for SERPINF1 Gene

Entrez Gene Summary for SERPINF1 Gene

  • This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016]

GeneCards Summary for SERPINF1 Gene

SERPINF1 (Serpin Family F Member 1) is a Protein Coding gene. Diseases associated with SERPINF1 include Osteogenesis Imperfecta, Type Vi and Brittle Bone Disorder. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINF2.

UniProtKB/Swiss-Prot Summary for SERPINF1 Gene

  • Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Gene Wiki entry for SERPINF1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERPINF1 Gene

Genomics for SERPINF1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SERPINF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERPINF1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERPINF1

Top Transcription factor binding sites by QIAGEN in the SERPINF1 gene promoter:
  • CREB
  • deltaCREB
  • RFX1
  • Sox9
  • STAT3
  • YY1

Genomic Locations for SERPINF1 Gene

Latest Assembly
chr17:1,762,029-1,777,565
(GRCh38/hg38)
Size:
15,537 bases
Orientation:
Plus strand

Previous Assembly
chr17:1,665,354-1,680,859
(GRCh37/hg19 by Entrez Gene)
Size:
15,506 bases
Orientation:
Plus strand

chr17:1,665,253-1,680,868
(GRCh37/hg19 by Ensembl)
Size:
15,616 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr17(ALT_REF_LOCI_1):190,927-195,947 (+)

Genomic View for SERPINF1 Gene

Genes around SERPINF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINF1 Gene

Proteins for SERPINF1 Gene

  • Protein details for SERPINF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36955-PEDF_HUMAN
    Recommended name:
    Pigment epithelium-derived factor
    Protein Accession:
    P36955
    Secondary Accessions:
    • F1T092
    • Q13236
    • Q2TU83
    • Q96CT1
    • Q96R01
    • Q9BWA4

    Protein attributes for SERPINF1 Gene

    Size:
    418 amino acids
    Molecular mass:
    46312 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA84914.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAA93524.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SERPINF1 Gene

neXtProt entry for SERPINF1 Gene

Post-translational modifications for SERPINF1 Gene

  • The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity.
  • N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
  • Glycosylation at Asn285
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PEDF_HUMAN (645)

Protein products for research

  • Abcam proteins for SERPINF1

No data available for DME Specific Peptides for SERPINF1 Gene

Domains & Families for SERPINF1 Gene

Gene Families for SERPINF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SERPINF1 Gene

Suggested Antigen Peptide Sequences for SERPINF1 Gene

GenScript: Design optimal peptide antigens:
  • Pigment epithelium-derived factor (F1T092_HUMAN)
  • Serpin F1 (PEDF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P36955

UniProtKB/Swiss-Prot:

PEDF_HUMAN :
  • The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.
  • Belongs to the serpin family.
Domain:
  • The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINF1: view

Function for SERPINF1 Gene

Molecular function for SERPINF1 Gene

UniProtKB/Swiss-Prot Function:
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Phenotypes From GWAS Catalog for SERPINF1 Gene

Gene Ontology (GO) - Molecular Function for SERPINF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SERPINF1: view
genes like me logo Genes that share phenotypes with SERPINF1: view

Human Phenotype Ontology for SERPINF1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SERPINF1 Gene

MGI Knock Outs for SERPINF1:

Animal Models for research

  • Taconic Biosciences Mouse Models for SERPINF1

miRNA for SERPINF1 Gene

miRTarBase miRNAs that target SERPINF1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINF1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SERPINF1 Gene

Localization for SERPINF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINF1 Gene

Secreted. Melanosome. Note=Enriched in stage I melanosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINF1 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SERPINF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IDA 12737624
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IEA,IBA 21873635
GO:0030424 axon IEA --
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with SERPINF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINF1 Gene

Pathways & Interactions for SERPINF1 Gene

PathCards logo

SuperPathways for SERPINF1 Gene

SuperPathway Contained pathways
1 Wnt signaling pathway
2 Apoptotic Pathways in Synovial Fibroblasts
.74
3 PEDF Induced Signaling
.73
genes like me logo Genes that share pathways with SERPINF1: view

Pathways by source for SERPINF1 Gene

1 KEGG pathway for SERPINF1 Gene
2 Qiagen pathways for SERPINF1 Gene
  • DHA Signaling
  • PEDF Induced Signaling

SIGNOR curated interactions for SERPINF1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SERPINF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0007568 aging IEA --
GO:0007614 short-term memory IEA --
GO:0010447 response to acidic pH IEA --
GO:0010596 negative regulation of endothelial cell migration IEA --
genes like me logo Genes that share ontologies with SERPINF1: view

Drugs & Compounds for SERPINF1 Gene

(17) Drugs for SERPINF1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 276

(12) Additional Compounds for SERPINF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINF1: view

Transcripts for SERPINF1 Gene

mRNA/cDNA for SERPINF1 Gene

4 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINF1

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7:
SP8:
SP9: - -

Relevant External Links for SERPINF1 Gene

GeneLoc Exon Structure for
SERPINF1

Expression for SERPINF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERPINF1 Gene

Protein differential expression in normal tissues from HIPED for SERPINF1 Gene

This gene is overexpressed in Vitreous humor (49.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SERPINF1 Gene



Protein tissue co-expression partners for SERPINF1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERPINF1

SOURCE GeneReport for Unigene cluster for SERPINF1 Gene:

Hs.532768

mRNA Expression by UniProt/SwissProt for SERPINF1 Gene:

P36955-PEDF_HUMAN
Tissue specificity: Retinal pigment epithelial cells and blood plasma.

Evidence on tissue expression from TISSUES for SERPINF1 Gene

  • Eye(5)
  • Nervous system(4.9)
  • Liver(4.8)
  • Muscle(4.7)
  • Bone marrow(4.4)
  • Skin(3.7)
  • Pancreas(3.4)
  • Blood(3.2)
  • Heart(3.1)
  • Bone(3)
  • Lung(2.7)
  • Intestine(2.7)
  • Spleen(2.7)
  • Lymph node(2.6)
  • Gall bladder(2.5)
  • Kidney(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINF1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • skull
  • tongue
  • tooth
  • vocal cord
Thorax:
  • chest wall
  • clavicle
  • heart
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • abdominal wall
  • biliary tract
  • intestine
  • kidney
  • liver
  • stomach
Pelvis:
  • pelvis
  • ureter
  • uterus
  • vagina
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • skin
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with SERPINF1: view

No data available for mRNA differential expression in normal tissues for SERPINF1 Gene

Orthologs for SERPINF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINF1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SERPINF1 29 30
  • 99.04 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SERPINF1 29 30
  • 87.46 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SERPINF1 29 30
  • 87.07 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Serpinf1 29 16 30
  • 84.5 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Serpinf1 29
  • 83.78 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia SERPINF1 30
  • 77 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SERPINF1 30
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SERPINF1 29 30
  • 66.75 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SERPINF1 30
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia serpinf1 29
  • 61.07 (n)
MGC76294 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.4797 29
Zebrafish
(Danio rerio)
Actinopterygii serpinf1 29 30
  • 49.96 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Spn88Eb 30
  • 21 (a)
ManyToMany
Spn5 30
  • 20 (a)
ManyToMany
Spn27A 30
  • 17 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10120 30
  • 21 (a)
ManyToMany
-- 30
  • 18 (a)
ManyToMany
Species where no ortholog for SERPINF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SERPINF1 Gene

ENSEMBL:
Gene Tree for SERPINF1 (if available)
TreeFam:
Gene Tree for SERPINF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERPINF1: view image
Alliance of Genome Resources:
Additional Orthologs for SERPINF1

Paralogs for SERPINF1 Gene

(4) SIMAP similar genes for SERPINF1 Gene using alignment to 9 proteins:

  • PEDF_HUMAN
  • I3L107_HUMAN
  • I3L1U4_HUMAN
  • I3L2R7_HUMAN
  • I3L3Z3_HUMAN
  • I3L425_HUMAN
  • I3L4F9_HUMAN
  • I3L4N7_HUMAN
  • I3L4Z0_HUMAN
genes like me logo Genes that share paralogs with SERPINF1: view

Variants for SERPINF1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERPINF1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
870122 Pathogenic: Osteogenesis imperfecta 1,776,669(+) GCA/G
NM_002615.7(SERPINF1):c.925_926del (p.Gln309fs)
FRAMESHIFT
889435 Uncertain Significance: Osteogenesis imperfecta, type VI 1,775,129(+) G/A
NM_002615.7(SERPINF1):c.715G>A (p.Val239Met)
MISSENSE
890115 Uncertain Significance: Osteogenesis imperfecta, type VI 1,776,553(+) G/A
NM_002615.7(SERPINF1):c.808G>A (p.Gly270Arg)
MISSENSE
890116 Uncertain Significance: Osteogenesis imperfecta, type VI 1,776,571(+) T/A
NM_002615.7(SERPINF1):c.826T>A (p.Phe276Ile)
MISSENSE
890117 Uncertain Significance: Osteogenesis imperfecta, type VI 1,776,580(+) C/T
NM_002615.7(SERPINF1):c.835C>T (p.Pro279Ser)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SERPINF1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SERPINF1 Gene

Variant ID Type Subtype PubMed ID
nsv1065585 CNV gain 25217958
nsv1946 CNV insertion 18451855
nsv833335 CNV gain+loss 17160897
nsv9490 CNV loss 18304495

Variation tolerance for SERPINF1 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINF1 Gene

Human Gene Mutation Database (HGMD)
SERPINF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINF1
Leiden Open Variation Database (LOVD)
SERPINF1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINF1 Gene

Disorders for SERPINF1 Gene

MalaCards: The human disease database

(45) MalaCards diseases for SERPINF1 Gene - From: OMI, CVR, GTR, ORP, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PEDF_HUMAN
  • Osteogenesis imperfecta 6 (OI6) [MIM:613982]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI6 is a severe, autosomal recessive form compatible with OI type III in the Sillence classification. {ECO:0000269 PubMed:21353196}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for SERPINF1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SERPINF1: view

No data available for Genatlas for SERPINF1 Gene

Publications for SERPINF1 Gene

  1. Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family. (PMID: 8434014) Steele FR … Tombran-Tink J (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 4 22
  2. Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal-recessive osteogenesis imperfecta. (PMID: 21353196) Becker J … Netzer C (American journal of human genetics 2011) 3 4 72
  3. Protein kinase C beta (PRKCB1) and pigment epithelium derived factor (PEDF) gene polymorphisms and diabetic retinopathy in a south Indian cohort. (PMID: 20141354) Uthra S … Kumaramanickavel G (Ophthalmic genetics 2010) 3 22 40
  4. Phenotype and genotype characteristics of age-related macular degeneration in a Japanese population. (PMID: 20132989) Mori K … Inoue S (Ophthalmology 2010) 3 22 40
  5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A … Hunt DF (Journal of proteome research 2006) 3 4 22

Products for SERPINF1 Gene

Sources for SERPINF1 Gene