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Aliases for SERPINE3 Gene

Aliases for SERPINE3 Gene

  • Serpin Family E Member 3 2 3 5
  • Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 3 2

External Ids for SERPINE3 Gene

Previous GeneCards Identifiers for SERPINE3 Gene

  • GC13P050814
  • GC13P051909
  • GC13P032704
  • GC13P051917

Summaries for SERPINE3 Gene

GeneCards Summary for SERPINE3 Gene

SERPINE3 (Serpin Family E Member 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINE2.

UniProtKB/Swiss-Prot for SERPINE3 Gene

  • Probable serine protease inhibitor.

Additional gene information for SERPINE3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINE3 Gene

Genomics for SERPINE3 Gene

GeneHancer (GH) Regulatory Elements for SERPINE3 Gene

Promoters and enhancers for SERPINE3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I051341 Promoter 0.5 EPDnew 550.4 +5.3 5306 0.1 SERPINE3 FAM124A MIR5693
GH13I052193 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 22.4 +858.9 858887 2.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MRPS31P5 ALG11 RPS4XP16 UTP14C SUGT1 CKAP2 INTS6 SERPINE3 INTS6-AS1 TPTE2P2
GH13I051450 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.3 +117.3 117285 5.6 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 RPS4XP16 INTS6 INTS6-AS1 MRPS31P5 SERPINE3 DHRS12 ENSG00000231856 UTP14C ALG11
GH13I050908 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 -422.7 -422659 10 HDGF FOXA2 ARNT SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B E2F8 RNASEH2B RNASEH2B-AS1 DLEU7-AS1 DLEU7 KCNRG SERPINE3 TRIM13 RPS4XP16 INTS6 GC13M050919
GH13I050526 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.7 -807.0 -807047 5 PKNOX1 INSM2 MZF1 FEZF1 RAD21 ZBTB40 YY1 ZNF121 ZNF213 ZNF366 DLEU1-AS1 GC13P050529 GC13P050528 GC13P050527 RPL34P26 SERPINE3 KCNRG RNASEH2B-AS1 RNASEH2B DLEU7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERPINE3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERPINE3 gene promoter:

Genomic Locations for SERPINE3 Gene

Genomic Locations for SERPINE3 Gene
chr13:51,335,773-51,365,454
(GRCh38/hg38)
Size:
29,682 bases
Orientation:
Plus strand
chr13:51,909,909-51,938,871
(GRCh37/hg19)

Genomic View for SERPINE3 Gene

Genes around SERPINE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINE3 Gene

Proteins for SERPINE3 Gene

  • Protein details for SERPINE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MV23-SERP3_HUMAN
    Recommended name:
    Serpin E3
    Protein Accession:
    A8MV23
    Secondary Accessions:
    • B1V8P3

    Protein attributes for SERPINE3 Gene

    Size:
    424 amino acids
    Molecular mass:
    46963 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINE3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINE3 Gene

Post-translational modifications for SERPINE3 Gene

  • Glycosylation at isoforms=246
  • Modification sites at PhosphoSitePlus

Other Protein References for SERPINE3 Gene

No data available for DME Specific Peptides for SERPINE3 Gene

Domains & Families for SERPINE3 Gene

Gene Families for SERPINE3 Gene

Protein Domains for SERPINE3 Gene

Suggested Antigen Peptide Sequences for SERPINE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MV23

UniProtKB/Swiss-Prot:

SERP3_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINE3: view

Function for SERPINE3 Gene

Molecular function for SERPINE3 Gene

UniProtKB/Swiss-Prot Function:
Probable serine protease inhibitor.

Phenotypes From GWAS Catalog for SERPINE3 Gene

Gene Ontology (GO) - Molecular Function for SERPINE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINE3: view

Phenotypes for SERPINE3 Gene

GenomeRNAi human phenotypes for SERPINE3:
genes like me logo Genes that share phenotypes with SERPINE3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINE3 Gene

Localization for SERPINE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINE3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINE3 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for SERPINE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with SERPINE3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINE3 Gene

Pathways & Interactions for SERPINE3 Gene

SuperPathways for SERPINE3 Gene

No Data Available

Interacting Proteins for SERPINE3 Gene

Gene Ontology (GO) - Biological Process for SERPINE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SERPINE3: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINE3 Gene

Drugs & Compounds for SERPINE3 Gene

No Compound Related Data Available

Transcripts for SERPINE3 Gene

mRNA/cDNA for SERPINE3 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINE3 Gene

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINE3 Gene

No ASD Table

Relevant External Links for SERPINE3 Gene

GeneLoc Exon Structure for
SERPINE3
ECgene alternative splicing isoforms for
SERPINE3

Expression for SERPINE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERPINE3 Gene

This gene is overexpressed in Thyroid (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINE3 Gene



Protein tissue co-expression partners for SERPINE3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERPINE3 Gene:

SERPINE3

SOURCE GeneReport for Unigene cluster for SERPINE3 Gene:

Hs.685891
genes like me logo Genes that share expression patterns with SERPINE3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINE3 Gene

Orthologs for SERPINE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINE3 33 34
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia SERPINE3 33 34
  • 79.62 (n)
rat
(Rattus norvegicus)
Mammalia Serpine3 33
  • 76.66 (n)
mouse
(Mus musculus)
Mammalia Serpine3 33 16 34
  • 74.28 (n)
dog
(Canis familiaris)
Mammalia SERPINE3 33 34
  • 72.76 (n)
oppossum
(Monodelphis domestica)
Mammalia SERPINE3 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERPINE3 33 34
  • 61.37 (n)
lizard
(Anolis carolinensis)
Reptilia SERPINE3 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serpine3 33
  • 61.04 (n)
zebrafish
(Danio rerio)
Actinopterygii serpine3 33 34
  • 54.35 (n)
Species where no ortholog for SERPINE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINE3 Gene

ENSEMBL:
Gene Tree for SERPINE3 (if available)
TreeFam:
Gene Tree for SERPINE3 (if available)

Paralogs for SERPINE3 Gene

(11) SIMAP similar genes for SERPINE3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SERPINE3: view

Variants for SERPINE3 Gene

Sequence variations from dbSNP and Humsavar for SERPINE3 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000428063 -- 51,335,631(+) G/A/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000526505 -- 51,359,654(+) A/G intron_variant
rs1000643609 -- 51,341,645(+) G/A 5_prime_UTR_variant, intron_variant
rs1001172741 -- 51,353,532(+) C/A intron_variant
rs1001255695 -- 51,362,483(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINE3 Gene

Variant ID Type Subtype PubMed ID
dgv1000e59 CNV tandem duplication 20981092
esv3424137 CNV duplication 20981092
nsv1041 CNV insertion 18451855
nsv1116727 CNV tandem duplication 24896259
nsv561618 CNV loss 21841781
nsv832611 CNV loss 17160897

Variation tolerance for SERPINE3 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINE3 Gene

Disorders for SERPINE3 Gene

Additional Disease Information for SERPINE3

No disorders were found for SERPINE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINE3 Gene

Publications for SERPINE3 Gene

  1. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3 58
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  3. A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels. (PMID: 25240745) López S … Soria JM (Mitochondrion 2014) 3 58

Products for SERPINE3 Gene

Sources for SERPINE3 Gene

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