Aliases for SERPINE2 Gene
Aliases for SERPINE2 Gene
External Ids for SERPINE2 Gene
- HGNC: 8951
- Entrez Gene: 5270
- Ensembl: ENSG00000135919
- OMIM: 177010
- UniProtKB: P07093
Previous HGNC Symbols for SERPINE2 Gene
- PI7
Previous GeneCards Identifiers for SERPINE2 Gene
- GC02M222862
- GC02M223560
- GC02M224803
- GC02M225042
- GC02M224665
- GC02M224548
- GC02M224839
- GC02M216691
Summaries for SERPINE2 Gene
-
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for SERPINE2 Gene
SERPINE2 (Serpin Family E Member 2) is a Protein Coding gene. Diseases associated with SERPINE2 include Visceral Heterotaxy. Among its related pathways are Cell adhesion_ECM remodeling and Formation of Fibrin Clot (Clotting Cascade). Gene Ontology (GO) annotations related to this gene include signaling receptor binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINE1.
UniProtKB/Swiss-Prot for SERPINE2 Gene
-
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
Additional gene information for SERPINE2 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINE2 Gene
Genomics for SERPINE2 Gene
GeneHancer (GH) Regulatory Elements for SERPINE2 Gene
Promoters and enhancers for SERPINE2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J224037 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 650.7 | +0.2 | 245 | 2.5 | ARID4B SIN3A ZNF48 GLIS2 SP3 MXD4 MIER2 NFIL3 MYRF CTCF | SERPINE2 PIR58995 | |
| GH02J224008 | Enhancer | 0.9 | Ensembl ENCODE | 25.2 | +30.0 | 30005 | 2.2 | ZNF614 ZNF316 POLR2A HNF4G PRPF4 RCOR1 NFE2 MAFK CHD2 NFE2L2 | SERPINE2 PIR58995 ENSG00000228802 | |
| GH02J224084 | Enhancer | 0.9 | Ensembl ENCODE | 12.3 | -46.8 | -46825 | 2.8 | KLF1 JUN MAX RAD21 BRCA1 RFX5 ZKSCAN1 POLR2A FOSL2 FOS | SERPINE2 PIR36342 GC02M224071 LOC100420435 | |
| GH02J223994 | Enhancer | 0.9 | ENCODE | 12.1 | +43.7 | 43746 | 2.1 | PKNOX1 ATF1 FOXA2 ARNT ETS1 ZNF143 FOS ATF7 KAT8 MEF2D | SERPINE2 MRPL44 WDFY1 ENSG00000228802 PIR58995 | |
| GH02J223997 | Enhancer | 0.8 | ENCODE | 12.1 | +41.2 | 41197 | 0.9 | ELF3 FOXA2 RARA CREM MIXL1 NFKBIZ RXRA CEBPB MIER2 KAT8 | SERPINE2 MRPL44 WDFY1 ENSG00000228802 PIR58995 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SERPINE2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SERPINE2 gene promoter:
-
- Nkx3-1
- Nkx3-1 v1
- FAC1
- Chx10
- RORalpha1
Regulatory Element Products
Genomic Locations for SERPINE2 Gene
Genomic Locations for SERPINE2 Gene
- chr2:223,975,048-224,039,319
- (GRCh38/hg38)
- Size:
- 64,272 bases
- Orientation:
- Minus strand
- chr2:224,839,765-224,904,036
- (GRCh37/hg19)
- Size:
- 64,272 bases
- Orientation:
- Minus strand
Genomic View for SERPINE2 Gene
Genes around SERPINE2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q36.1 by Entrez Gene
- 2q36.1 by HGNC
- 2q36.1 by Ensembl
SERPINE2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SERPINE2 Gene
Proteins for SERPINE2 Gene
-
Protein details for SERPINE2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07093-GDN_HUMAN
- Recommended name:
- Glia-derived nexin
- Protein Accession:
- P07093
- B2R6A4
- B4DIF2
- Q53S15
- Q5D0C4
Protein attributes for SERPINE2 Gene
- Size:
- 398 amino acids
- Molecular mass:
- 44002 Da
- Quaternary structure:
- No Data Available
Protein Expression for SERPINE2 Gene
Post-translational modifications for SERPINE2 Gene
Other Protein References for SERPINE2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for SERPINE2 (Serpin E2/PN1)
-
Custom Antibody ServicesOriGene Antibodies for SERPINE2
- Novus Biologicals Antibodies for SERPINE2
-
Abcam antibodies for SERPINE2
- Invitrogen Antibodies for SERPINE2
- GeneTex SERPINE2 Antibody for SERPINE2
-
Boster Bio Antibodies for SERPINE2
-
Santa Cruz Biotechnology (SCBT) Antibodies for SERPINE2
Protein Products
- R&D Systems Proteins and Enzymes for SERPINE2 (Serpin E2/PN1)
-
OriGene Purified Proteins for SERPINE2
- Search Origene for MassSpec and Protein Over-expression Lysates for SERPINE2
- Origene Custom Protein Services for SERPINE2
- Search GeneTex for Proteins for SERPINE2
-
ProSci Proteins for SERPINE2
-
Abcam proteins for SERPINE2
Assay Products
No data available for DME Specific Peptides for SERPINE2 Gene
Domains & Families for SERPINE2 Gene
Gene Families for SERPINE2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted secreted proteins
Protein Domains for SERPINE2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SERPINE2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P07093- Family:
-
- Belongs to the serpin family.
Function for SERPINE2 Gene
Molecular function for SERPINE2 Gene
- UniProtKB/Swiss-Prot Function:
- Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
Phenotypes From GWAS Catalog for SERPINE2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity | IMP | 19855083 |
| GO:0005102 | signaling receptor binding | IPI,IEA | 17379830 |
| GO:0005515 | protein binding | IPI | 3279057 |
| GO:0005539 | glycosaminoglycan binding | IDA | 19855083 |
| GO:0008201 | heparin binding | IDA | 1939253 |
Phenotypes for SERPINE2 Gene
- MGI mutant phenotypes for SERPINE2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SERPINE2:
Animal Models for SERPINE2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for SERPINE2
- Cyagen custom Knockout/knockin (KOKI) mouse models for SERPINE2
-
CRISPR Products
-
OriGene CRISPR knockouts for SERPINE2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERPINE2
- genomics-online: gRNA clones - Search results for 121 available SERPINE2 gene related products
- Overview of 121 available SERPINE2 gene related products
- Applied Biological Materials CRISPR for SERPINE2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERPINE2
- GenScript: Design CRISPR guide RNA sequences for SERPINE2
miRNA for SERPINE2 Gene
- miRTarBase miRNAs that target SERPINE2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SERPINE2
- Browse OriGene Inhibitory RNA Products For SERPINE2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINE2
- genomics-online: shRNA clones - Search results for 121 available SERPINE2 gene related products
- Overview of 121 available SERPINE2 gene related products
Clone Products
-
OriGene ORF clones in human for SERPINE2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SERPINE2
- VectorBuilder custom plasmid, inducible vectors for SERPINE2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SERPINE2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SERPINE2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERPINE2
- Applied Biological Materials Clones for SERPINE2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SERPINE2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINE2 Gene
Localization for SERPINE2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SERPINE2 Gene
- Secreted, extracellular space.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 4 |
| cytoskeleton | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| endosome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS,IDA | -- |
| GO:0005615 | extracellular space | IBA,IEA | -- |
| GO:0005829 | cytosol | IDA | 19855083 |
| GO:0031012 | extracellular matrix | IDA | 3279057 |
| GO:0031091 | platelet alpha granule | IMP,IDA | 19855083 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINE2 Gene
Pathways & Interactions for SERPINE2 Gene
Pathways by source for SERPINE2 Gene
5 Reactome pathways for SERPINE2 Gene
2 GeneGo (Thomson Reuters) pathways for SERPINE2 Gene
Interacting Proteins for SERPINE2 Gene
Selected Interacting proteins:
ENSP00000415786
P07093-GDN_HUMAN
for SERPINE2 Gene via
STRING
UniProtKB
IID
GPS-Prot Interaction Network for SERPINE2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0007596 | blood coagulation | TAS,IEA | -- |
| GO:0008285 | negative regulation of cell proliferation | IEA | -- |
| GO:0009611 | response to wounding | IEA | -- |
No data available for SIGNOR curated interactions for SERPINE2 Gene
Transcripts for SERPINE2 Gene
mRNA/cDNA for SERPINE2 Gene
- (6) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (391) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000409304 2161 bps (uc002vnv.3)
- ENST00000258405 2195 bps (uc002vnu.3)
- ENST00000473202 5989 bps (uc061tcr.1)
- ENST00000409840 2569 bps (uc031rrk.2)
- ENST00000447280 1716 bps (uc010zlr.2)
Unigene Clusters for SERPINE2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SERPINE2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERPINE2
- genomics-online: gRNA clones - Search results for 121 available SERPINE2 gene related products
- Overview of 121 available SERPINE2 gene related products
- Applied Biological Materials CRISPR for SERPINE2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERPINE2
- GenScript: Design CRISPR guide RNA sequences for SERPINE2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SERPINE2
- Browse OriGene Inhibitory RNA Products For SERPINE2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINE2
- genomics-online: shRNA clones - Search results for 121 available SERPINE2 gene related products
- Overview of 121 available SERPINE2 gene related products
Clone Products
-
OriGene ORF clones in human for SERPINE2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SERPINE2
- VectorBuilder custom plasmid, inducible vectors for SERPINE2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SERPINE2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SERPINE2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERPINE2
- Applied Biological Materials Clones for SERPINE2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - |
| ExUns: | 16b |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: |
Expression for SERPINE2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Brain (Nervous System)
- Endothelial Cells Blood Brain Barrier
- Hypothalamus
- Medulla Oblongata
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Endoderm (Gastrulation Derivatives)
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
- Bone (Muscoskeletal System)
- Limb (Muscoskeletal System)
-
Placenta (Extraembryonic Tissues)
-
Smooth Muscle (Muscoskeletal System)
This gene is overexpressed in Bone marrow mesenchymal stem cell (15.7), Amniocyte (12.1), and Peripheral blood mononuclear cells (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERPINE2 Gene
NURSA nuclear receptor signaling pathways regulating expression of SERPINE2 Gene:
SERPINE2SOURCE GeneReport for Unigene cluster for SERPINE2 Gene:
Hs.38449Evidence on tissue expression from TISSUES for SERPINE2 Gene
- Nervous system(5)
- Skin(4.9)
- Lung(3.8)
- Kidney(3.6)
- Intestine(3.4)
- Bone(2.7)
- Muscle(2.5)
- Heart(2.4)
- Pancreas(2.1)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for SERPINE2
-
OriGene qPCR primer pairs for SERPINE2
- genomics-online: primer clones - Search results for 121 available SERPINE2 gene related products
- Overview of 121 available SERPINE2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINE2 Gene
Orthologs for SERPINE2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SERPINE2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SERPINE2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SERPINE2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Serpine2 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SERPINE2 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Serpine2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SERPINE2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SERPINE2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SERPINE2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | serpine2 33 |
|
||
| MGC76024 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.12045 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | serpine2 34 33 |
|
OneToOne | |
| zgc55929 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6921 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | nec 35 |
|
|
- Species where no ortholog for SERPINE2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for SERPINE2 Gene
- ENSEMBL:
- Gene Tree for SERPINE2 (if available)
- TreeFam:
- Gene Tree for SERPINE2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SERPINE2: view image
Paralogs for SERPINE2 Gene
Paralogs for SERPINE2 Gene
(19) SIMAP similar genes for SERPINE2 Gene using alignment to 4 proteins:
- GDN_HUMAN
- C9JN98_HUMAN
- C9JRK5_HUMAN
- C9K031_HUMAN
Pseudogenes.org Pseudogenes for SERPINE2 Gene
Variants for SERPINE2 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036027 | A breast cancer sample | p.Lys204Asn | |||
| rs1000032376 | -- | 223,987,479(-) | C/A/T | intron_variant | |
| rs1000063400 | -- | 224,034,185(-) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000077032 | -- | 224,035,879(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000087328 | -- | 223,996,168(-) | T/C | intron_variant |
Residual Variation Intolerance Score:
22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.15;
23.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SERPINE2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SERPINE2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINE2 Gene
Disorders for SERPINE2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| visceral heterotaxy |
|
|
Search SERPINE2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SERPINE2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINE2 Gene
Publications for SERPINE2 Gene
- Genetic associations with hypoxemia and pulmonary arterial pressure in COPD. (PMID: 19017876) Castaldi PJ … Silverman EK (Chest 2009) 3 22 44 58
- Polymorphic variation in surfactant protein B is associated with COPD exacerbations. (PMID: 18550614) Foreman MG … Silverman EK (The European respiratory journal 2008) 3 22 44 58
- The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. (PMID: 17446335) Zhu G … International COPD Genetics Network (ICGN) Investigators (American journal of respiratory and critical care medicine 2007) 3 22 44 58
- The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes. (PMID: 7665170) Carter RE … Festoff BW (Genomics 1995) 2 3 22 58
- Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3 58
Products for SERPINE2 Gene
- R&D Systems Antibodies for SERPINE2 (Serpin E2/PN1)
- R&D Systems Proteins and Enzymes for SERPINE2 (Serpin E2/PN1)
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for SERPINE2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SERPINE2
- Search Origene for MassSpec and Protein Over-expression Lysates for SERPINE2
- Origene Custom Protein Services for SERPINE2
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SERPINE2
- Browse OriGene Inhibitory RNA Products For SERPINE2
- OriGene qPCR primer pairs and template standards for SERPINE2
- OriGene qPCR primer pairs for SERPINE2
- OriGene CRISPR knockouts for SERPINE2
- OriGene ORF clones in human for SERPINE2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SERPINE2
- GenScript: Next-day shipping of latest version cDNA ORF clones for SERPINE2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for SERPINE2
- GenScript Custom Assay Services for SERPINE2
- GenScript Custom overexpressing Cell Line Services for SERPINE2
- GenScript: Design CRISPR guide RNA sequences for SERPINE2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SERPINE2
- Sino Biological Human cDNA Clone for SERPINE2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SERPINE2
- Novus Biologicals lysates and proteins for SERPINE2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SERPINE2
- Abcam proteins for SERPINE2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for SERPINE2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for SERPINE2
- Cyagen custom Knockout/knockin (KOKI) mouse models for SERPINE2
- VectorBuilder custom plasmid, inducible vectors for SERPINE2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SERPINE2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SERPINE2
- GeneTex SERPINE2 Antibody for SERPINE2
- Search GeneTex for Proteins for SERPINE2
- Santa Cruz Biotechnology (SCBT) Antibodies for SERPINE2
- Search Santa Cruz Biotechnology (SCBT) for SERPINE2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SERPINE2
- Horizon Cell Lines for SERPINE2
- genomics-online: cdna clones - Search results for 121 available SERPINE2 gene related products
- Overview of 121 available SERPINE2 gene related products
- orf clones - Search results for 121 available SERPINE2 gene related products
- Overview of 121 available SERPINE2 gene related products
- genomics-online: gRNA clones - Search results for 121 available SERPINE2 gene related products
- Overview of 121 available SERPINE2 gene related products
- genomics-online: primer clones - Search results for 121 available SERPINE2 gene related products
- Overview of 121 available SERPINE2 gene related products
- genomics-online: shRNA clones - Search results for 121 available SERPINE2 gene related products
- Overview of 121 available SERPINE2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERPINE2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERPINE2
- GeneCopoeia miRNA 3'UTR Target clone products for SERPINE2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINE2
- Boster Bio Antibodies for SERPINE2
- Browse Boster Bio ELISA Kits
Sources for SERPINE2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt