Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provide... See more...
Aliases for SERPINE2 Gene
Aliases for SERPINE2 Gene
External Ids for SERPINE2 Gene
- HGNC: 8951
- Entrez Gene: 5270
- Ensembl: ENSG00000135919
- OMIM: 177010
- UniProtKB: P07093
Previous HGNC Symbols for SERPINE2 Gene
- PI7
Previous GeneCards Identifiers for SERPINE2 Gene
- GC02M222862
- GC02M223560
- GC02M224803
- GC02M225042
- GC02M224665
- GC02M224548
- GC02M224839
- GC02M216691
Summaries for SERPINE2 Gene
-
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for SERPINE2 Gene
SERPINE2 (Serpin Family E Member 2) is a Protein Coding gene. Diseases associated with SERPINE2 include Rigid Spine Muscular Dystrophy 1 and Visceral Heterotaxy. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINE1.
UniProtKB/Swiss-Prot Summary for SERPINE2 Gene
-
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
Additional gene information for SERPINE2 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERPINE2 Gene
Genomics for SERPINE2 Gene
GeneHancer (GH) Regulatory Elements for SERPINE2 Gene
Promoters and enhancers for SERPINE2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SERPINE2 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERPINE2
- Top Transcription factor binding sites by QIAGEN in the SERPINE2 gene promoter:
-
- Chx10
- FAC1
- Nkx3-1
- Nkx3-1 v1
- RORalpha1
Genomic Locations for SERPINE2 Gene
Genomic Locations for SERPINE2 Gene
- chr2:223,975,045-224,039,319
- (GRCh38/hg38)
- Size:
- 64,275 bases
- Orientation:
- Minus strand
- chr2:224,839,765-224,904,036
- (GRCh37/hg19)
- Size:
- 64,272 bases
- Orientation:
- Minus strand
Genomic View for SERPINE2 Gene
Genes around SERPINE2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q36.1 by HGNC
- 2q36.1 by Entrez Gene
- 2q36.1 by Ensembl
SERPINE2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SERPINE2 Gene
Proteins for SERPINE2 Gene
-
Protein details for SERPINE2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07093-GDN_HUMAN
- Recommended name:
- Glia-derived nexin
- Protein Accession:
- P07093
- B2R6A4
- B4DIF2
- Q53S15
- Q5D0C4
Protein attributes for SERPINE2 Gene
- Size:
- 398 amino acids
- Molecular mass:
- 44002 Da
- Quaternary structure:
- No Data Available
Protein Expression for SERPINE2 Gene
Post-translational modifications for SERPINE2 Gene
Other Protein References for SERPINE2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences SERPINE2 / Nexin Monoclonal Antibody (LS-B15899) and SERPINE2 / Nexin Monoclonal Antibody (LS-B12173)
- Creative Diagnostics Anti-SERPINE2 (aa 163-385) polyclonal antibody
- Novus Biologicals Antibodies for SERPINE2
- Invitrogen Antibodies for SERPINE2 (AFLGC-SERPINE2)
-
Biorbyt antibodies for SERPINE2
-
Santa Cruz Biotechnology (SCBT) Antibodies for SERPINE2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SERPINE2
- Origene Custom Protein Services for SERPINE2
- Novus Biologicals lysates for SERPINE2
-
ProSci Proteins for SERPINE2
-
Abcam proteins for SERPINE2
Assay Products
- Aviva Systems Biology SERPINE2 ELISA Kit (Human) (OKCD00386) and SERPINE2 ELISA Kit (Human) (OKCD09572)
- antibodies-online: Show 27 available SERPINE2 Elisa Kits ranked by validation data
- Compare Top SERPINE2 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for SERPINE2
No data available for DME Specific Peptides for SERPINE2 Gene
Domains & Families for SERPINE2 Gene
Gene Families for SERPINE2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted secreted proteins
Protein Domains for SERPINE2 Gene
- Blocks:
-
- Serpin
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SERPINE2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ55211, highly similar to Glia-derived nexin (B4DIF2_HUMAN)
- Serpin E2 (GDN_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P07093- Family:
-
- Belongs to the serpin family.
Function for SERPINE2 Gene
Molecular function for SERPINE2 Gene
- UniProtKB/Swiss-Prot Function:
- Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
Phenotypes From GWAS Catalog for SERPINE2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity | IMP | 19855083 |
| GO:0005102 | signaling receptor binding | IEA,IPI | 17379830 |
| GO:0005515 | protein binding | IPI | 3279057 |
| GO:0005539 | glycosaminoglycan binding | IDA | 19855083 |
| GO:0008201 | heparin binding | IDA | 1939253 |
Phenotypes for SERPINE2 Gene
- MGI mutant phenotypes for SERPINE2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SERPINE2:
Animal Models for SERPINE2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for SERPINE2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SERPINE2 - Select products 50% OFF >
- * SERPINE2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SERPINE2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERPINE2
- genomics-online: gRNA clones - Search for available SERPINE2 gRNA products
- Overview of 159 available SERPINE2 gene related products
-
Recommended
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERPINE2
miRNA for SERPINE2 Gene
- miRTarBase miRNAs that target SERPINE2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SERPINE2
- Browse OriGene Inhibitory RNA Products For SERPINE2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINE2
- genomics-online: shRNA clones - Search for available SERPINE2 shRNA products
- Overview of 159 available SERPINE2 gene related products
-
Recommended
Clone Products
- Applied Biological Materials (abm): Clones for SERPINE2 - Select products 50% OFF >
- * SERPINE2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206227
- MR206227
- MR206227L3
- MR206227L4
- RC204904
- RC204904L1
- RC204904L2
- RC204904L3
- RC204904L4
- RC227630
- RC227630L3
- RC227630L4
- RC227928
- RC227928L1
- RC227928L2
- RC227928L3
- RC227928L4
- RG204904
- RG227630
- RG227928
- RR213667
- RR213667L3
- RR213667L4
- MR206227L3V
- MR206227L4V
- RC204904L1V
- RC204904L2V
- RC204904L3V
- RC204904L4V
- RC227630L3V
- RC227630L4V
- RC227928L1V
- RC227928L2V
- RC227928L3V
- RC227928L4V
- RR213667L3V
- RR213667L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SERPINE2
- Addgene plasmids for SERPINE2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERPINE2
- genomics-online: cdna clones - Search for available SERPINE2 CDNA products
- Overview of 159 available SERPINE2 gene related products
-
Recommended
- orf clones - Search for available SERPINE2 ORF products
- Overview of 159 available SERPINE2 gene related products
-
Recommended
Cell Line Products
-
Horizon Cell Lines for SERPINE2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINE2 Gene
Localization for SERPINE2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SERPINE2 Gene
- Secreted, extracellular space.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 4 |
| cytosol | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA,TAS | -- |
| GO:0005615 | extracellular space | IEA,IBA | 21873635 |
| GO:0005829 | cytosol | IDA | 19855083 |
| GO:0031091 | platelet alpha granule | IDA,IMP | 19855083 |
| GO:0031232 | extrinsic component of external side of plasma membrane | IDA | 19855083 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINE2 Gene
Pathways & Interactions for SERPINE2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Formation of Fibrin Clot (Clotting Cascade) | ||
| 2 | Dissolution of Fibrin Clot | ||
| 3 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 4 | Regulation of lipid metabolism Insulin signaling-generic cascades |
Cell adhesion PLAU signaling
.35
|
|
| 5 | Cell adhesion_ECM remodeling |
Cell adhesion_ECM remodeling
-
|
|
Pathways by source for SERPINE2 Gene
5 Reactome pathways for SERPINE2 Gene
2 GeneGo (Thomson Reuters) pathways for SERPINE2 Gene
- Cell adhesion PLAU signaling
- Cell adhesion_ECM remodeling
Interacting Proteins for SERPINE2 Gene
Selected Interacting proteins:
P07093-GDN_HUMAN
ENSP00000415786
for SERPINE2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SERPINE2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0007596 | blood coagulation | IEA,TAS | -- |
| GO:0008285 | negative regulation of cell proliferation | IEA | -- |
| GO:0009611 | response to wounding | IEA | -- |
No data available for SIGNOR curated interactions for SERPINE2 Gene
Transcripts for SERPINE2 Gene
mRNA/cDNA for SERPINE2 Gene
- 3 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000258405 2229 bps (ENST00000258405.9)
- ENST00000409304 2161 bps (ENST00000409304.5)
- ENST00000409840 2569 bps (ENST00000409840.7)
- ENST00000423446 581 bps (ENST00000423446.1)
- ENST00000432738 988 bps (ENST00000432738.5)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SERPINE2 - Select products 50% OFF >
- * SERPINE2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SERPINE2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERPINE2
- genomics-online: gRNA clones - Search for available SERPINE2 gRNA products
- Overview of 159 available SERPINE2 gene related products
-
Recommended
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERPINE2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SERPINE2
- Browse OriGene Inhibitory RNA Products For SERPINE2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINE2
- genomics-online: shRNA clones - Search for available SERPINE2 shRNA products
- Overview of 159 available SERPINE2 gene related products
-
Recommended
Clone Products
- Applied Biological Materials (abm): Clones for SERPINE2 - Select products 50% OFF >
- * SERPINE2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206227
- MR206227
- MR206227L3
- MR206227L4
- RC204904
- RC204904L1
- RC204904L2
- RC204904L3
- RC204904L4
- RC227630
- RC227630L3
- RC227630L4
- RC227928
- RC227928L1
- RC227928L2
- RC227928L3
- RC227928L4
- RG204904
- RG227630
- RG227928
- RR213667
- RR213667L3
- RR213667L4
- MR206227L3V
- MR206227L4V
- RC204904L1V
- RC204904L2V
- RC204904L3V
- RC204904L4V
- RC227630L3V
- RC227630L4V
- RC227928L1V
- RC227928L2V
- RC227928L3V
- RC227928L4V
- RR213667L3V
- RR213667L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SERPINE2
- Addgene plasmids for SERPINE2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERPINE2
- genomics-online: cdna clones - Search for available SERPINE2 CDNA products
- Overview of 159 available SERPINE2 gene related products
-
Recommended
- orf clones - Search for available SERPINE2 ORF products
- Overview of 159 available SERPINE2 gene related products
-
Recommended
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - |
| ExUns: | 16b |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: |
Relevant External Links for SERPINE2 Gene
- GeneLoc Exon Structure for
- SERPINE2
Expression for SERPINE2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Brain (Nervous System)
- Endothelial Cells Blood Brain Barrier
- Hypothalamus
- Medulla Oblongata
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Endoderm (Gastrulation Derivatives)
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
- Bone (Muscoskeletal System)
- Limb (Muscoskeletal System)
-
Placenta (Extraembryonic Tissues)
-
Smooth Muscle (Muscoskeletal System)
This gene is overexpressed in Bone marrow mesenchymal stem cell (15.7), Amniocyte (12.1), and Peripheral blood mononuclear cells (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERPINE2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERPINE2
SOURCE GeneReport for Unigene cluster for SERPINE2 Gene:
Hs.38449Evidence on tissue expression from TISSUES for SERPINE2 Gene
- Nervous system(5)
- Skin(4.9)
- Lung(3.8)
- Kidney(3.6)
- Intestine(3.4)
- Bone(2.7)
- Muscle(2.5)
- Heart(2.4)
- Pancreas(2.1)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for SERPINE2
-
OriGene qPCR primer pairs and template standards for SERPINE2
- genomics-online: primer clones - Search for available SERPINE2 Primer products
- Overview of 159 available SERPINE2 gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINE2 Gene
Orthologs for SERPINE2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SERPINE2 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SERPINE2 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SERPINE2 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Serpine2 17 31 30 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SERPINE2 31 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Serpine2 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SERPINE2 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SERPINE2 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SERPINE2 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | serpine2 30 |
|
||
| MGC76024 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.12045 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | serpine2 31 30 |
|
OneToOne | |
| zgc55929 30 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6921 30 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | nec 32 |
|
|
- Species where no ortholog for SERPINE2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for SERPINE2 Gene
- ENSEMBL:
- Gene Tree for SERPINE2 (if available)
- TreeFam:
- Gene Tree for SERPINE2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SERPINE2: view image
Paralogs for SERPINE2 Gene
Paralogs for SERPINE2 Gene
- SERPINE1 5
- SERPINI1 5
- SERPINI2 5
- SERPINB1 5
- SERPINB4 5
- SERPINB12 5
- SERPINB3 5
- SERPINB10 5
- SERPINE3 5
- SERPINC1 5
- SERPINB6 5
- SERPINB9 5
- SERPINB8 5
- SERPINB2 5
- SERPINA3 5
- SERPINA9 5
- SERPINB13 5
- SERPINA6 5
- SERPINB7 5
- SERPIND1 5
- SERPINA5 5
- SERPINA10 5
- SERPINA4 5
- SERPINA7 5
- SERPINA12 5
- SERPINF2 5
- SERPINA1 5
- SERPINB5 5
- SERPING1 5
- SERPINA11 5
- SERPINH1 5
- SERPINF1 5
- SERPINB11 5
- AGT 5
- SERPINA2 5
- HMSD 5
(19) SIMAP similar genes for SERPINE2 Gene using alignment to 4 proteins:
- GDN_HUMAN
- C9JN98_HUMAN
- C9JRK5_HUMAN
- C9K031_HUMAN
Pseudogenes.org Pseudogenes for SERPINE2 Gene
Variants for SERPINE2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERPINE2 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 735799 | Likely Benign: not provided | 224,001,691(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| VAR_036027 | A breast cancer sample | p.Lys204Asn | |||
| rs3795875 | - | p.Ile51Met |
Residual Variation Intolerance Score:
22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.15;
23.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SERPINE2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SERPINE2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINE2 Gene
Disorders for SERPINE2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rigid spine muscular dystrophy 1 |
|
|
| visceral heterotaxy |
|
|
| ciliary dyskinesia, primary, 1 |
|
|
| kartagener syndrome |
|
|
| alzheimer disease |
|
Search SERPINE2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SERPINE2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINE2 Gene
Publications for SERPINE2 Gene
- Genetic associations with hypoxemia and pulmonary arterial pressure in COPD. (PMID: 19017876) Castaldi PJ … Silverman EK (Chest 2009) 3 23 41 54
- Polymorphic variation in surfactant protein B is associated with COPD exacerbations. (PMID: 18550614) Foreman MG … Silverman EK (The European respiratory journal 2008) 3 23 41 54
- The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. (PMID: 17446335) Zhu G … International COPD Genetics Network (ICGN) Investigators (American journal of respiratory and critical care medicine 2007) 3 23 41 54
- The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes. (PMID: 7665170) Carter RE … Festoff BW (Genomics 1995) 2 3 23 54
- Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3 54
ExternalLinks
Products for SERPINE2 Gene
- Custom Antibody ServicesOriGene Antibodies for SERPINE2
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for SERPINE2
- Origene Custom Protein Services for SERPINE2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SERPINE2
- Browse OriGene Inhibitory RNA Products For SERPINE2
- OriGene qPCR primer pairs for SERPINE2
- OriGene qPCR primer pairs and template standards for SERPINE2
- OriGene CRISPR knockouts for SERPINE2
- MG206227
- MR206227
- MR206227L3
- MR206227L4
- RC204904
- RC204904L1
- RC204904L2
- RC204904L3
- RC204904L4
- RC227630
- RC227630L3
- RC227630L4
- RC227928
- RC227928L1
- RC227928L2
- RC227928L3
- RC227928L4
- RG204904
- RG227630
- RG227928
- RR213667
- RR213667L3
- RR213667L4
- MR206227L3V
- MR206227L4V
- RC204904L1V
- RC204904L2V
- RC204904L3V
- RC204904L4V
- RC227630L3V
- RC227630L4V
- RC227928L1V
- RC227928L2V
- RC227928L3V
- RC227928L4V
- RR213667L3V
- RR213667L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SERPINE2
- Sino Biological Human cDNA Clone for SERPINE2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SERPINE2
- Novus Biologicals lysates for SERPINE2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for SERPINE2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for SERPINE2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for SERPINE2 (AFLGC-SERPINE2)
- VectorBuilder Custom and pre-made DNA vectors for SERPINE2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SERPINE2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SERPINE2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SERPINE2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SERPINE2
- Addgene plasmids for SERPINE2
- antibodies-online: Show 26 available SERPINE2 Antibodies ranked by validation data
- Compare Top SERPINE2 Antibodies
- antibodies-online: Show 27 available SERPINE2 Elisa Kits ranked by validation data
- Compare Top SERPINE2 Elisa Kits
- Quality Products:
- antibodies-online: Show 19 available SERPINE2 Proteins ranked by validation data
- Compare Top SERPINE2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for SERPINE2
- Search Santa Cruz Biotechnology (SCBT) for SERPINE2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SERPINE2
- Horizon Cell Lines for SERPINE2
- genomics-online: cdna clones - Search for available SERPINE2 CDNA products
- Overview of 159 available SERPINE2 gene related products
- Recommended
- orf clones - Search for available SERPINE2 ORF products
- Overview of 159 available SERPINE2 gene related products
- Recommended
- genomics-online: gRNA clones - Search for available SERPINE2 gRNA products
- Overview of 159 available SERPINE2 gene related products
- Recommended
- genomics-online: primer clones - Search for available SERPINE2 Primer products
- Overview of 159 available SERPINE2 gene related products
- Recommended
- genomics-online: shRNA clones - Search for available SERPINE2 shRNA products
- Overview of 159 available SERPINE2 gene related products
- Recommended
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERPINE2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERPINE2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SERPINE2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINE2
- Biorbyt antibodies for SERPINE2
Sources for SERPINE2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody