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This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are asso... See more...
Aliases for SERPINE1 Gene
Aliases for SERPINE1 Gene
External Ids for SERPINE1 Gene
- HGNC: 8583
- Entrez Gene: 5054
- Ensembl: ENSG00000106366
- OMIM: 173360
- UniProtKB: P05121
Previous HGNC Symbols for SERPINE1 Gene
- PLANH1
- PAI1
Previous GeneCards Identifiers for SERPINE1 Gene
- GC07P099254
- GC07P100316
- GC07P100330
- GC07P100363
- GC07P100558
- GC07P100770
- GC07P095363
Summaries for SERPINE1 Gene
-
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for SERPINE1 Gene
SERPINE1 (Serpin Family E Member 1) is a Protein Coding gene. Diseases associated with SERPINE1 include Plasminogen Activator Inhibitor-1 Deficiency and Hepatic Veno-Occlusive Disease. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protease binding. An important paralog of this gene is SERPINE2.
UniProtKB/Swiss-Prot Summary for SERPINE1 Gene
-
Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).
Additional gene information for SERPINE1 Gene
- HGNC(8583)
- Entrez Gene(5054)
- Ensembl(ENSG00000106366)
- OMIM(173360)
- UniProtKB(P05121)
- Open Targets Platform(ENSG00000106366)
- Monarch Initiative
- Search for SERPINE1 at DataMed
- Search for SERPINE1 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERPINE1 Gene
Genomics for SERPINE1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SERPINE1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SERPINE1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERPINE1
- Top Transcription factor binding sites by QIAGEN in the SERPINE1 gene promoter:
-
- AML1a
- AP-1
- AP-2gamma
- ATF6
- CREB
- deltaCREB
- GATA-2
- HEN1
- JunB
- SEF-1 (1)
Genomic Locations for SERPINE1 Gene
Genomic Locations for SERPINE1 Gene
- chr7:101,127,104-101,139,247
- (GRCh38/hg38)
- Size:
- 12,144 bases
- Orientation:
- Plus strand
- chr7:100,770,370-100,782,547
- (GRCh37/hg19)
- Size:
- 12,178 bases
- Orientation:
- Plus strand
Genomic View for SERPINE1 Gene
Genes around SERPINE1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q22.1 by HGNC
- 7q22.1 by Entrez Gene
- 7q22.1 by Ensembl
SERPINE1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SERPINE1 Gene
Proteins for SERPINE1 Gene
-
Protein details for SERPINE1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05121-PAI1_HUMAN
- Recommended name:
- Plasminogen activator inhibitor 1
- Protein Accession:
- P05121
- B7Z4S0
- F8WD53
Protein attributes for SERPINE1 Gene
- Size:
- 402 amino acids
- Molecular mass:
- 45060 Da
- Quaternary structure:
-
- Forms a heterodimer with TMPRSS7 (PubMed:15853774). Interacts with VTN (PubMed:7522053). Binds LRP1B; binding is followed by internalization and degradation (PubMed:11384978). Interacts with PPP1CB (PubMed:28296156). In complex with PLAU/uPA, interacts with PLAUR/uPAR (PubMed:15053742). Interacts with SORL1 and LRP1, either alone or in complex with PLAU; these interactions are abolished in the presence of LRPAP1/RAP (PubMed:15053742). The ternary complex composed of PLAUR-PLAU-PAI1 also interacts with SORL1 (PubMed:15053742). Also interacts with SORL1, when complexed to PLAT/tPA (PubMed:15053742).
Three dimensional structures from OCA and Proteopedia for SERPINE1 Gene
Protein Expression for SERPINE1 Gene
Post-translational modifications for SERPINE1 Gene
Other Protein References for SERPINE1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PAI 1 Antibody
- HUABIO Anti-SERPINE1 Antibody
- Novus Biologicals Antibodies for SERPINE1
-
Abcam antibodies for SERPINE1
- Invitrogen Antibodies for SERPINE1 (AFLGC-Serpine1)
- antibodies-online: Show 210 available SERPINE1 Antibodies ranked by validation data
- Compare Top SERPINE1 Antibodies
-
Recommended
- 287 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 6 RIA Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 83 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 93 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 EIA Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for SERPINE1
- Sino Biological Antibodies for SERPINE1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SERPINE1
- Origene Custom Protein Services for SERPINE1
- Sino Biological Recombinant Proteins for SERPINE1
- Sino Biological Cell Lysates for SERPINE1
- ProSpec Recombinant Proteins for SERPINE1
-
ProSci Proteins for SERPINE1
-
Abcam proteins for SERPINE1
Assay Products
- RayBiotech Human PAI-1 ELISA
-
Custom Assay ServicesOriGene ELISA Kits for SERPINE1
- Novus Biologicals ELISA Kits for SERPINE1
- antibodies-online: Show 137 available SERPINE1 Elisa Kits ranked by validation data
- Compare Top SERPINE1 Elisa Kits
-
Quality Products:
- ABIN411404
- ABIN2010722
- ABIN1116528
- ABIN5499278
- ABIN415046
- ABIN612750
- ABIN625343
- ABIN456178
- ABIN1029562
- ABIN492021
- ABIN1116526
- ABIN2010772
- ABIN2010725
- ABIN415629
- ABIN367785
- ABIN1029563
- ABIN2748504
- ABIN2748503
- ABIN5524215
- ABIN5596646
- ABIN368177
- ABIN416381
- ABIN1116527
- ABIN1571709
- ABIN5524218
- ABIN579657
- ABIN2010782
- ABIN2010733
- ABIN5670852
- ABIN1081810
- ABIN431335
- ABIN1571710
- ABIN368488
- ABIN5524217
- ABIN2010731
- ABIN511147
- ABIN1565448
- ABIN5657859
- ABIN2537933
- ABIN2950424
-
Boster Bio ELISA Kits for SERPINE1
-
Abcam assays for SERPINE1
- Sino Biological Assays for SERPINE1
No data available for DME Specific Peptides for SERPINE1 Gene
Domains & Families for SERPINE1 Gene
Gene Families for SERPINE1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Disease related genes
- FDA approved drug targets
- Plasma proteins
- Predicted secreted proteins
Protein Domains for SERPINE1 Gene
- InterPro:
- Blocks:
-
- Serpin
- ProtoNet:
Suggested Antigen Peptide Sequences for SERPINE1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ61097, highly similar to Plasminogen activator inhibitor 1 (B7Z1D9_HUMAN)
- Serpin E1 (PAI1_HUMAN)
- PAI1 protein (Q6LEK1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P05121- Family:
-
- Belongs to the serpin family.
Function for SERPINE1 Gene
Molecular function for SERPINE1 Gene
- UniProtKB/Swiss-Prot Function:
- Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).
Phenotypes From GWAS Catalog for SERPINE1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IPI | 2503541 |
| GO:0004867 | serine-type endopeptidase inhibitor activity | IDA | 1695900 |
| GO:0005102 | signaling receptor binding | IPI | 8626514 |
| GO:0005515 | protein binding | IPI | 16272158 |
| GO:0030414 | peptidase inhibitor activity | IEA | -- |
Phenotypes for SERPINE1 Gene
- MGI mutant phenotypes for SERPINE1:
-
inferred from 2 alleles
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- hematopoietic system phenotype
- integument phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for SERPINE1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- shRNA abundance <= 50%
- Moderately decreased NFAT1-GFP nuclear translocation
- Decreased viability
- Negative genetic interaction between BLM-/- and BLM+/+
- Increased IL-8 secretion
- Increased NF-kappaB reporter expression
- Increased replication of vaccinia virus (VACV)
- Increased HPV18 LCR reporter activity
- Increased transcriptional activity
- Decreased melanin production
Animal Models for SERPINE1 Gene
- MGI Knock Outs for SERPINE1:
-
- Serpine1 Serpine1<tm1Mlg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SERPINE1 - Select products 50% OFF >
- * SERPINE1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SERPINE1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERPINE1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERPINE1
miRNA for SERPINE1 Gene
- miRTarBase miRNAs that target SERPINE1
-
- hsa-miR-204-5p (MIRT005844)
- hsa-miR-30c-5p (MIRT005971)
- hsa-miR-301a-3p (MIRT005972)
- hsa-miR-99a-5p (MIRT005973)
- hsa-miR-143-3p (MIRT006316)
- hsa-miR-145-5p (MIRT006317)
- hsa-miR-138-5p (MIRT021688)
- hsa-miR-124-3p (MIRT022189)
- hsa-miR-148a-3p (MIRT053477)
- hsa-miR-486-5p (MIRT054106)
- hsa-miR-30b-5p (MIRT054139)
- hsa-miR-30a-5p (MIRT244292)
- hsa-miR-30d-5p (MIRT244293)
- hsa-miR-224-5p (MIRT244294)
- hsa-miR-30e-5p (MIRT244295)
- hsa-miR-6882-5p (MIRT244297)
- hsa-miR-3977 (MIRT534384)
- hsa-miR-519d-5p (MIRT534385)
- hsa-miR-3145-5p (MIRT534386)
- hsa-miR-1273d (MIRT534387)
- mmu-miR-320-3p (MIRT596349)
- mmu-miR-3470b (MIRT596350)
- mmu-miR-875-3p (MIRT596351)
- mmu-miR-1970 (MIRT596352)
- mmu-miR-599 (MIRT596353)
- mmu-miR-1894-3p (MIRT596354)
- mmu-miR-1943-5p (MIRT596355)
- mmu-miR-30a-5p (MIRT596356)
- mmu-miR-30c-5p (MIRT596357)
- mmu-miR-30d-5p (MIRT596358)
- mmu-miR-30b-5p (MIRT596359)
- mmu-miR-30e-5p (MIRT596360)
- mmu-miR-384-5p (MIRT596361)
- mmu-miR-125b-2-3p (MIRT596362)
- mmu-miR-224-5p (MIRT596363)
- hsa-miR-10a-5p (MIRT731180)
- hsa-miR-192-5p (MIRT735499)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SERPINE1
- Browse OriGene Inhibitory RNA Products For SERPINE1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINE1
Clone Products
- Applied Biological Materials (abm): Clones for SERPINE1 - Select products 50% OFF >
- * SERPINE1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SERPINE1
- Addgene plasmids for SERPINE1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERPINE1
Cell Line Products
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for SERPINE1
-
Horizon Cell Lines for SERPINE1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SERPINE1 Gene
Localization for SERPINE1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SERPINE1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 3 |
| nucleus | 3 |
| cytosol | 3 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA,TAS | -- |
| GO:0005615 | extracellular space | IBA,IDA | 1695900 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0031093 | platelet alpha granule lumen | TAS | -- |
| GO:0062023 | collagen-containing extracellular matrix | IDA | 1632457 |
Pathways & Interactions for SERPINE1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 2 | Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer | ||
| 3 | Folate Metabolism | ||
| 4 | Complement and coagulation cascades | ||
| 5 | Formation of Fibrin Clot (Clotting Cascade) | ||
Pathways by source for SERPINE1 Gene
17 BioSystems pathways for SERPINE1 Gene
15 Reactome pathways for SERPINE1 Gene
8 KEGG pathways for SERPINE1 Gene
5 GeneGo (Thomson Reuters) pathways for SERPINE1 Gene
- Cell adhesion PLAU signaling
- Cell adhesion_ECM remodeling
- Development_Glucocorticoid receptor signaling
- Development_TGF-beta receptor signaling
- Immune response IL-1 signaling pathway
1 R&D Systems pathway for SERPINE1 Gene
1 Qiagen pathway for SERPINE1 Gene
- UPA-UPAR Pathway
2 Cell Signaling Technology pathways for SERPINE1 Gene
Interacting Proteins for SERPINE1 Gene
Selected Interacting proteins:
P05121-PAI1_HUMAN
ENSP00000223095
for SERPINE1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SERPINE1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001300 | chronological cell aging | IEP | 18974388 |
| GO:0001525 | angiogenesis | IEP | 11866539 |
| GO:0002576 | platelet degranulation | TAS | -- |
| GO:0007623 | circadian rhythm | TAS | -- |
| GO:0010466 | negative regulation of peptidase activity | IEA | -- |
Drugs & Compounds for SERPINE1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Urokinase | Approved, Investigational, Withdrawn | Pharma | Target, substrate, inducer, activator | 0 | ||
| Dexamethasone | Approved, Investigational, Vet_approved | Pharma | Agonist | Anti-inflammatory glucocorticoid | 2886 | |
| Troglitazone | Approved, Investigational, Withdrawn | Pharma | Agonist, Full agonist, Channel blocker, Target, antagonist | Selective PPARγ agonist, Selective PPARgamma agonist; antidiabetic agent | 8 | |
| Atorvastatin | Approved | Pharma | Inhibitor, Competitive | 893 | ||
| Simvastatin | Approved | Pharma | Inhibitor, Competitive | HMG-CoA reductase inhibitor | 582 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for SERPINE1 Gene
mRNA/cDNA for SERPINE1 Gene
- 2 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000223095 3156 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SERPINE1 - Select products 50% OFF >
- * SERPINE1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SERPINE1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERPINE1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERPINE1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SERPINE1
- Browse OriGene Inhibitory RNA Products For SERPINE1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINE1
Clone Products
- Applied Biological Materials (abm): Clones for SERPINE1 - Select products 50% OFF >
- * SERPINE1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SERPINE1
- Addgene plasmids for SERPINE1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERPINE1
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - |
Relevant External Links for SERPINE1 Gene
- GeneLoc Exon Structure for
- SERPINE1
Expression for SERPINE1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Placenta (Extraembryonic Tissues)
- Extravillous Cytotrophoblast Cells Extravillous Cytotrophoblast Layer
- Placenta-derived mesenchymal stem cells (family)
- Decidua-derived mesenchymal stem cells
- Mesenchymal Stem Cells
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
- Basal Cells Respiratory Bronchioles
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
- Detroit 551
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Mural Cells Extraembryonic Mesoderm
-
Epiblast (Early Embryo)
- Extraembryonic Mural Cells Extraembryonic Mesoderm
-
Primitive Streak (Early Embryo)
- Extraembryonic Mural Cells Extraembryonic Mesoderm
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
- Smooth Muscle (Muscoskeletal System)
- Dermis (Integumentary System)
- Amnion (Extraembryonic Tissues)
- Endothelium (Cardiovascular System)
-
Umbilical Cord (Extraembryonic Tissues)
-
Gall Bladder (Hepatobiliary System)
-
Adrenal Gland (Endocrine System)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for SERPINE1 Gene
This gene is overexpressed in Artery - Aorta (x8.2), Artery - Coronary (x6.6), and Liver (x5.4).
This gene is overexpressed in Amniocyte (31.3), Bone marrow mesenchymal stem cell (16.5), and Serum (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SERPINE1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERPINE1
SOURCE GeneReport for Unigene cluster for SERPINE1 Gene:
Hs.414795mRNA Expression by UniProt/SwissProt for SERPINE1 Gene:
P05121-PAI1_HUMAN
Tissue specificity:
Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells.
Evidence on tissue expression from TISSUES for SERPINE1 Gene
- Lung(4.8)
- Skin(4.7)
- Liver(4.4)
- Pancreas(4.2)
- Blood(3.9)
- Heart(3.8)
- Nervous system(3.5)
- Bone(3.5)
- Kidney(3.4)
- Intestine(3.4)
- Muscle(3.3)
- Gall bladder(3)
- Adrenal gland(2.9)
- Lymph node(2.9)
- Eye(2.8)
- Thyroid gland(2.7)
- Spleen(2.7)
- Urine(2.4)
- Stomach(2.4)
- Bone marrow(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINE1 Gene
Germ Layers:
- mesoderm
Systems:
- cardiovascular
- reproductive
Regions:
Pelvis:
- uterus
General:
- blood
- coagulation system
Primer Products
-
OriGene qPCR primer pairs for SERPINE1
-
OriGene qPCR primer pairs and template standards for SERPINE1
Gene Expression Assay Products
No data available for Protein tissue co-expression partners for SERPINE1 Gene
Orthologs for SERPINE1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SERPINE1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SERPINE1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PAI-1 31 |
|
OneToOne | |
| SERPINE1 30 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | Serpine1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Serpine1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SERPINE1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SERPINE1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | serpine1 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.25094 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | serpine1 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | SRPN1 30 |
|
- Species where no ortholog for SERPINE1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SERPINE1 Gene
- ENSEMBL:
- Gene Tree for SERPINE1 (if available)
- TreeFam:
- Gene Tree for SERPINE1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SERPINE1: view image
Paralogs for SERPINE1 Gene
Paralogs for SERPINE1 Gene
- SERPINE2 5
- SERPINI1 5
- SERPINB6 5
- SERPINA1 5
- SERPINA5 5
- SERPINA3 5
- SERPINI2 5
- SERPINA9 5
- SERPINA4 5
- SERPINB4 5
- SERPINB2 5
- SERPINB8 5
- SERPINB1 5
- SERPINB9 5
- SERPINB3 5
- SERPINB10 5
- SERPINC1 5
- SERPINA10 5
- SERPINA6 5
- SERPINA7 5
- SERPINF2 5
- SERPINB12 5
- SERPINB13 5
- SERPINB7 5
- SERPINE3 5
- SERPIND1 5
- SERPING1 5
- SERPINA12 5
- SERPINH1 5
- SERPINA11 5
- SERPINB5 5
- SERPINF1 5
- AGT 5
- SERPINB11 5
- SERPINA2 5
- HMSD 5
(26) SIMAP similar genes for SERPINE1 Gene using alignment to 1 proteins:
- PAI1_HUMAN
Variants for SERPINE1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERPINE1 Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 627494 | Likely Pathogenic: Abnormal bleeding | 101,127,037(+) | GGAACATGAGTTCATC | ||
| 717078 | Benign/Likely Benign: Congenital plasminogen activator inhibitor type 1 deficiency; not provided | 101,130,506(+) | G/A | SYNONYMOUS_VARIANT | |
| 740992 | Likely Benign: not provided | 101,133,810(+) | C/A | SYNONYMOUS_VARIANT | |
| 768189 | Benign: not provided | 101,132,017(+) | C/T | SYNONYMOUS_VARIANT | |
| 771414 | Benign/Likely Benign: Congenital plasminogen activator inhibitor type 1 deficiency; not provided | 101,136,992(+) | C/T | INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1941e212 | CNV | loss | 25503493 |
| dgv1942e212 | CNV | loss | 25503493 |
| esv2422376 | CNV | duplication | 17116639 |
| esv2734888 | CNV | deletion | 23290073 |
| nsv1018841 | CNV | gain | 25217958 |
| nsv1030604 | CNV | gain | 25217958 |
| nsv1033081 | CNV | gain | 25217958 |
| nsv607972 | CNV | loss | 21841781 |
| nsv607973 | CNV | loss | 21841781 |
| nsv831075 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.51;
64.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SERPINE1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINE1 Gene
Disorders for SERPINE1 Gene
(138) MalaCards diseases for SERPINE1 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| plasminogen activator inhibitor-1 deficiency |
|
|
| hepatic veno-occlusive disease |
|
|
| fibrosarcoma |
|
|
| thrombophilia |
|
|
| disseminated intravascular coagulation |
|
Search SERPINE1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PAI1_HUMAN- Plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:613329]: A hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen. {ECO:0000269 PubMed:8481516, ECO:0000269 PubMed:9207454}. Note=The disease is caused by mutations affecting the gene represented in this entry. A rare PAI-1D mutation resulting in a frameshift and protein truncation has been found in an Old Order Amish community. Homozygous mutation carriers suffer from episodes of major hemorrhage, while heterozygous carriers do not manifest abnormal bleeding (PubMed:9207454). Heterozygosity for the mutation is associated with longer leukocyte telomere length, lower fasting insulin levels, lower prevalence of diabetes mellitus, and a longer life span (PubMed:29152572). {ECO:0000269 PubMed:29152572, ECO:0000269 PubMed:9207454}.
Additional Disease Information for SERPINE1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for SERPINE1 Gene
Publications for SERPINE1 Gene
- Polymorphisms in NOS3, ACE and PAI-1 genes and risk of spontaneous recurrent miscarriage in the Gaza Strip. (PMID: 20134171) Al Sallout RJ … Sharif FA (Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2010) 3 23 41
- Impact of genetic polymorphisms on platelet function and aspirin resistance. (PMID: 19923980) Pamukcu B … Nisanci Y (Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2010) 3 23 41
- Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants. (PMID: 20161734) Bentley P … Sharma P (PloS one 2010) 3 23 41
- Angiotensin-converting enzyme D/I and plasminogen activator inhibitor-1 4G/5G gene polymorphisms are associated with increased risk of spontaneous abortions in polycystic ovarian syndrome. (PMID: 19636212) Sun L … Guan Y (Journal of endocrinological investigation 2010) 3 23 41
- Hemostatic gene polymorphisms in young Sardinian with non-fatal acute myocardial infarction. (PMID: 20036902) Musino L … Carru C (Frontiers in bioscience (Elite edition) 2010) 3 23 41
ExternalLinks
Products for SERPINE1 Gene
- View all 24 R&D Systems SERPINE1 (Serpin E1/PAI-1) Products
- View all R&D Systems SERPINE1 (Serpin E1/PAI-1) Proteins and Enzymes
- View all 7 R&D Systems SERPINE1 (Serpin E1/PAI-1) Primary Antibodies
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- OriGene qPCR primer pairs and template standards for SERPINE1
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- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
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- Novus Biologicals proteins and lysates for SERPINE1
- Novus Biologicals ELISA Kits for SERPINE1
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for SERPINE1
- Abcam proteins for SERPINE1
- Abcam assays for SERPINE1
- Find your target
- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for SERPINE1
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for SERPINE1
- Invitrogen Antibodies for SERPINE1 (AFLGC-Serpine1)
- VectorBuilder Custom and pre-made DNA vectors for SERPINE1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SERPINE1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SERPINE1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SERPINE1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SERPINE1
- Addgene plasmids for SERPINE1
- antibodies-online: Show 210 available SERPINE1 Antibodies ranked by validation data
- Compare Top SERPINE1 Antibodies
- Recommended
- 287 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 6 RIA Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 83 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 93 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 EIA Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 137 available SERPINE1 Elisa Kits ranked by validation data
- Compare Top SERPINE1 Elisa Kits