This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found... See more...

Aliases for SERPINB9 Gene

Aliases for SERPINB9 Gene

  • Serpin Family B Member 9 2 3 5
  • CAP3 2 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 9 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 2 3
  • Cytoplasmic Antiproteinase 3 3 4
  • Peptidase Inhibitor 9 3 4
  • Serpin B9 3 4
  • CAP-3 3 4
  • PI-9 3 4
  • PI9 3 4
  • Serpin Peptidase Inhibitor, Clade B, Member 9 3
  • Protease Inhibitor 9 (Ovalbumin Type) 3
  • Testicular Tissue Protein Li 180 3
  • SERPINB9 5

External Ids for SERPINB9 Gene

Previous HGNC Symbols for SERPINB9 Gene

  • PI9

Previous GeneCards Identifiers for SERPINB9 Gene

  • GC06M002872
  • GC06M002832
  • GC06M002760

Summaries for SERPINB9 Gene

Entrez Gene Summary for SERPINB9 Gene

  • This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

GeneCards Summary for SERPINB9 Gene

SERPINB9 (Serpin Family B Member 9) is a Protein Coding gene. Diseases associated with SERPINB9 include Pituitary Adenoma 2, Growth Hormone-Secreting and Pituitary Adenoma 3, Multiple Types. Among its related pathways are Amoebiasis. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is SERPINB6.

UniProtKB/Swiss-Prot Summary for SERPINB9 Gene

Gene Wiki entry for SERPINB9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERPINB9 Gene

Genomics for SERPINB9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SERPINB9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERPINB9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERPINB9

Top Transcription factor binding sites by QIAGEN in the SERPINB9 gene promoter:
  • aMEF-2
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO1
  • FOXO1a
  • MEF-2
  • MEF-2A
  • SEF-1 (1)
  • TBP
  • TFIID

Genomic Locations for SERPINB9 Gene

Latest Assembly
chr6:2,887,270-2,903,318
(GRCh38/hg38)
Size:
16,049 bases
Orientation:
Minus strand

Previous Assembly
chr6:2,887,504-2,903,543
(GRCh37/hg19 by Entrez Gene)
Size:
16,040 bases
Orientation:
Minus strand

chr6:2,887,500-2,903,514
(GRCh37/hg19 by Ensembl)
Size:
16,015 bases
Orientation:
Minus strand

Genomic View for SERPINB9 Gene

Genes around SERPINB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB9 Gene

Proteins for SERPINB9 Gene

  • Protein details for SERPINB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50453-SPB9_HUMAN
    Recommended name:
    Serpin B9
    Protein Accession:
    P50453
    Secondary Accessions:
    • B2RBW3
    • Q5TD03

    Protein attributes for SERPINB9 Gene

    Size:
    376 amino acids
    Molecular mass:
    42404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERPINB9 Gene

Post-translational modifications for SERPINB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB9 Gene

No data available for DME Specific Peptides for SERPINB9 Gene

Domains & Families for SERPINB9 Gene

Gene Families for SERPINB9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SERPINB9 Gene

Suggested Antigen Peptide Sequences for SERPINB9 Gene

GenScript: Design optimal peptide antigens:
  • Peptidase inhibitor 9 (SPB9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P50453

UniProtKB/Swiss-Prot:

SPB9_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB9: view

Function for SERPINB9 Gene

Molecular function for SERPINB9 Gene

UniProtKB/Swiss-Prot Function:
Granzyme B inhibitor.

Phenotypes From GWAS Catalog for SERPINB9 Gene

Gene Ontology (GO) - Molecular Function for SERPINB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 16267761
GO:0004867 serine-type endopeptidase inhibitor activity IBA,IDA 8910377
GO:0005515 protein binding IPI 17479112
GO:0030414 peptidase inhibitor activity IEA --
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP 17479112
genes like me logo Genes that share ontologies with SERPINB9: view
genes like me logo Genes that share phenotypes with SERPINB9: view

Animal Models for SERPINB9 Gene

MGI Knock Outs for SERPINB9:

miRNA for SERPINB9 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINB9 Gene

Localization for SERPINB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB9 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
golgi apparatus 4
plasma membrane 2
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SERPINB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA,IDA 16267761
GO:0005634 nucleus IDA 11463822
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA,IDA 11463822
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with SERPINB9: view

Pathways & Interactions for SERPINB9 Gene

PathCards logo

SuperPathways for SERPINB9 Gene

SuperPathway Contained pathways
1 Amoebiasis
genes like me logo Genes that share pathways with SERPINB9: view

Pathways by source for SERPINB9 Gene

1 KEGG pathway for SERPINB9 Gene

Gene Ontology (GO) - Biological Process for SERPINB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002448 mast cell mediated immunity IEP 15739160
GO:0006915 apoptotic process IEA --
GO:0006955 immune response IDA 16306080
GO:0009617 response to bacterium IDA 22090449
GO:0010466 negative regulation of peptidase activity IEA --
genes like me logo Genes that share ontologies with SERPINB9: view

No data available for SIGNOR curated interactions for SERPINB9 Gene

Drugs & Compounds for SERPINB9 Gene

(5) Drugs for SERPINB9 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
raloxifene Approved, Investigational Pharma Target 0

(3) Additional Compounds for SERPINB9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB9: view

Transcripts for SERPINB9 Gene

mRNA/cDNA for SERPINB9 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB9

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: -
SP2:

Relevant External Links for SERPINB9 Gene

GeneLoc Exon Structure for
SERPINB9

Expression for SERPINB9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERPINB9 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINB9 Gene

This gene is overexpressed in Nerve - Tibial (x4.9).

Protein differential expression in normal tissues from HIPED for SERPINB9 Gene

This gene is overexpressed in Tlymphocyte (8.5), Peripheral blood mononuclear cells (8.4), Testis (7.1), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SERPINB9 Gene



Protein tissue co-expression partners for SERPINB9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERPINB9

SOURCE GeneReport for Unigene cluster for SERPINB9 Gene:

Hs.104879

Evidence on tissue expression from TISSUES for SERPINB9 Gene

  • Liver(4.4)
  • Bone marrow(4.4)
  • Blood(2.6)
  • Spleen(2.5)
  • Lymph node(2.4)
  • Intestine(2.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with SERPINB9: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB9 Gene

Orthologs for SERPINB9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SERPINB9 29 30
  • 99.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SERPINB9 29 30
  • 78.99 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Serpinb9 29
  • 78.34 (n)
Mouse
(Mus musculus)
Mammalia Serpinb9 29 16 30
  • 78.25 (n)
OneToMany
Serpinb9b 30
  • 66 (a)
OneToMany
Serpinb9d 30
  • 64 (a)
OneToMany
Serpinb9e 30
  • 63 (a)
OneToMany
Serpinb9f 30
  • 63 (a)
OneToMany
Serpinb9g 30
  • 62 (a)
OneToMany
Gm11397 30
  • 62 (a)
OneToMany
Serpinb9c 30
  • 61 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia SERPINB9 29 30
  • 74.15 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 60 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 57 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Spn1 31
  • 34 (a)
CG9455 31
  • 32 (a)
Spn2 31
  • 32 (a)
Spn43Aa 31
  • 32 (a)
CG9460 31
  • 31 (a)
Spn5 31
  • 29 (a)
CG7722 31
  • 28 (a)
CG6687 31
  • 27 (a)
Spn43Ab 31
  • 27 (a)
Species where no ortholog for SERPINB9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SERPINB9 Gene

ENSEMBL:
Gene Tree for SERPINB9 (if available)
TreeFam:
Gene Tree for SERPINB9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERPINB9: view image
Alliance of Genome Resources:
Additional Orthologs for SERPINB9

Paralogs for SERPINB9 Gene

Pseudogenes.org Pseudogenes for SERPINB9 Gene

genes like me logo Genes that share paralogs with SERPINB9: view

Variants for SERPINB9 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SERPINB9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SERPINB9 Gene

Variant ID Type Subtype PubMed ID
esv3378500 CNV insertion 20981092
esv3570730 CNV loss 25503493
nsv348854 CNV insertion 16902084
nsv830575 CNV loss 17160897

Variation tolerance for SERPINB9 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINB9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINB9
Leiden Open Variation Database (LOVD)
SERPINB9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERPINB9 Gene

Disorders for SERPINB9 Gene

MalaCards: The human disease database

(7) MalaCards diseases for SERPINB9 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERPINB9

genes like me logo Genes that share disorders with SERPINB9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB9 Gene

Publications for SERPINB9 Gene

  1. Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. (PMID: 8530382) Sprecher CA … Kisiel W (The Journal of biological chemistry 1995) 2 3 4 22
  2. A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes. (PMID: 9858835) Sun J … Bird PI (Cytogenetics and cell genetics 1998) 2 3 22
  3. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. (PMID: 8910377) Sun J … Bird PI (The Journal of biological chemistry 1996) 3 4 22
  4. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3
  5. Expression of proteinase inhibitor-9/serpinB9 in non-small cell lung carcinoma cells and tissues. (PMID: 19956856) Rousalova I … Benkova K (International journal of oncology 2010) 3 22

Products for SERPINB9 Gene

Sources for SERPINB9 Gene