Free for academic non-profit institutions. Other users need a Commercial license
SERPINB5 (Serpin Family B Member 5) is a Protein Coding gene. Diseases associated with SERPINB5 include Pleomorphic Adenoma and Syringoma. Among its related pathways are DNA Damage Response and Angiogenesis (CST). Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004867 | serine-type endopeptidase inhibitor activity | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 16049006 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IEA,IBA | 21873635 |
GO:0005737 | cytoplasm | IEA,IDA | 16049006 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Angiogenesis (CST) | ||
2 | Apoptosis and Autophagy | ||
3 | MicroRNAs in cancer | ||
4 | DNA Damage Response | ||
5 | ATF-2 transcription factor network |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002009 | morphogenesis of an epithelium | IEA | -- |
GO:0010951 | negative regulation of endopeptidase activity | IEA,IBA | 21873635 |
GO:0030198 | extracellular matrix organization | IEA | -- |
GO:0050678 | regulation of epithelial cell proliferation | IEA | -- |
GO:0060512 | prostate gland morphogenesis | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
S,S-(2-Hydroxyethyl)Thiocysteine | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SERPINB5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SERPINB5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SERPINB5 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Serpinb5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Serpinb5 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SERPINB5 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SERPINB5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SERPINB5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SERPINB5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | serpinb5 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Spn1 31 |
|
ManyToMany | |
Spn6 31 32 |
|
ManyToMany | |||
Spn3 31 |
|
ManyToMany | |||
Spn2 31 |
|
ManyToMany | |||
CG6717 32 |
|
|
|||
Spn7 31 |
|
ManyToMany | |||
Spn43Ab 31 32 |
|
ManyToMany | |||
Spn28Db 31 |
|
ManyToMany | |||
CG7722 32 |
|
|
|||
Spn28Da 31 |
|
ManyToMany | |||
Spn43Aa 31 |
|
ManyToMany | |||
Spn42Dc 31 |
|
ManyToMany | |||
Spn42De 31 |
|
ManyToMany | |||
Spn47C 31 |
|
ManyToMany | |||
Spn42Db 31 |
|
ManyToMany | |||
Spn4 31 |
|
ManyToMany | |||
nec 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv26779 | CNV | loss | 19812545 |
esv2763190 | CNV | loss | 21179565 |
esv3334527 | CNV | duplication | 20981092 |
nsv1066552 | CNV | gain | 25217958 |
nsv131597 | CNV | deletion | 16902084 |
Disorder | Aliases | PubMed IDs |
---|---|---|
pleomorphic adenoma |
|
|
syringoma |
|
|
mandibular cancer |
|
|
myoepithelioma |
|
|
pituitary adenoma 2, growth hormone-secreting |
|
|