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Aliases for SERPINB5 Gene
Aliases for SERPINB5 Gene
External Ids for SERPINB5 Gene
- HGNC: 8949
- NCBI Entrez Gene: 5268
- Ensembl: ENSG00000206075
- OMIM®: 154790
- UniProtKB/Swiss-Prot: P36952
Previous HGNC Symbols for SERPINB5 Gene
- PI5
Previous GeneCards Identifiers for SERPINB5 Gene
- GC18P060982
- GC18P061117
- GC18P059293
- GC18P059297
- GC18P057843
Summaries for SERPINB5 Gene
GeneCards Summary for SERPINB5 Gene
SERPINB5 (Serpin Family B Member 5) is a Protein Coding gene. Diseases associated with SERPINB5 include Pleomorphic Adenoma and Syringoma. Among its related pathways are DNA Damage Response and Angiogenesis (CST). Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB1.
UniProtKB/Swiss-Prot Summary for SERPINB5 Gene
-
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Additional gene information for SERPINB5 Gene
- HGNC (8949)
- NCBI Entrez Gene (5268)
- Ensembl (ENSG00000206075)
- OMIM® (154790)
- UniProtKB/Swiss-Prot (P36952)
- Open Targets Platform(ENSG00000206075)
- Monarch Initiative
- Search for SERPINB5 at DataMed
- Search for SERPINB5 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERPINB5 Gene
Genomics for SERPINB5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SERPINB5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SERPINB5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERPINB5
- Top Transcription factor binding sites by QIAGEN in the SERPINB5 gene promoter:
-
- AML1a
- ATF-2
- C/EBPalpha
- C/EBPbeta
- HFH-1
- p300
- p53
- Sp1
Genomic Locations for SERPINB5 Gene
Latest Assembly
- chr18:63,476,958-63,505,085
- (GRCh38/hg38)
- Size:
- 28,128 bases
- Orientation:
- Plus strand
Previous Assembly
- chr18:61,144,191-61,172,318
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 28,128 bases
- Orientation:
- Plus strand
- chr18:61,143,994-61,172,318
- (GRCh37/hg19 by Ensembl)
- Size:
- 28,325 bases
- Orientation:
- Plus strand
Genomic View for SERPINB5 Gene
Genes around SERPINB5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.33 by HGNC
- 18q21.33 by Entrez Gene
- 18q21.33 by Ensembl
SERPINB5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SERPINB5 Gene
Proteins for SERPINB5 Gene
-
Protein details for SERPINB5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P36952-SPB5_HUMAN
- Recommended name:
- Serpin B5
- Protein Accession:
- P36952
- B2R6Y4
- Q6N0B4
- Q8WW89
Protein attributes for SERPINB5 Gene
- Size:
- 375 amino acids
- Molecular mass:
- 42100 Da
- Quaternary structure:
-
- Interacts with IRF6.
Three dimensional structures from OCA and Proteopedia for SERPINB5 Gene
Protein Expression for SERPINB5 Gene
Post-translational modifications for SERPINB5 Gene
Other Protein References for SERPINB5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences SERPINB5 / Maspin Antibody
- G Biosciences Immunotag™ SERPINB5 Antibody
- GeneTex Anti-MASPIN antibody [N3C3] and Anti-MASPIN antibody
- NSJ Bioreagents Ovalbumin Antibody
-
Custom Antibody ServicesOriGene Antibodies for SERPINB5
- Novus Biologicals Antibodies for SERPINB5
-
Abcam antibodies for SERPINB5
- Invitrogen Antibodies for SERPINB5 (AFLGC-SERPINB5)
- antibodies-online: Show 60 available SERPINB5 Antibodies ranked by validation data
- Compare Top SERPINB5 Antibodies
-
Recommended
-
Boster Bio Antibodies for SERPINB5
-
Custom Antibody ServicesProSci Antibodies for SERPINB5
- serpin peptidase inhibitor, clade B (ovalbumin), member 5 [15-339]
- serpin peptidase inhibitor, clade B (ovalbumin), member 5 [13-311]
- serpin peptidase inhibitor, clade B (ovalbumin), member 5 [38-244]
- serpin peptidase inhibitor, clade B (ovalbumin), member 5 [29-688]
- serpin peptidase inhibitor, clade B (ovalbumin), member 5 [38-278]
- Serpin B5 [56-219]
-
Santa Cruz Biotechnology (SCBT) Antibodies for SERPINB5
Protein products for research
- G Biosciences Human Serpin B5/Maspin, Lyophilized
- RayBiotech Recombinant Human Serpin B5
- Search Origene for MassSpec and Protein Over-expression Lysates for SERPINB5
- Origene Custom Protein Services for SERPINB5
- ProSpec Recombinant Proteins for SERPINB5
-
ProSci Proteins for SERPINB5
-
Abcam proteins for SERPINB5
Assay products for research
- G Biosciences Immunotag™ Human SERPINB5 (Serpin B5) ELISA and Immunotag™ Serpin B5 ELISA Kit
- RayBiotech Custom Human Serpin B5 ELISA
-
Abcam assays for SERPINB5
No data available for DME Specific Peptides for SERPINB5 Gene
Domains & Families for SERPINB5 Gene
Gene Families for SERPINB5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SERPINB5 Gene
- InterPro:
- Blocks:
-
- Serpin
- Maspin signature
- ProtoNet:
Suggested Antigen Peptide Sequences for SERPINB5 Gene
- GenScript: Design optimal peptide antigens:
-
- Peptidase inhibitor 5 (SPB5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P36952- Family:
-
- Belongs to the serpin family. Ov-serpin subfamily.
Function for SERPINB5 Gene
Molecular function for SERPINB5 Gene
- UniProtKB/Swiss-Prot Function:
- Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Phenotypes From GWAS Catalog for SERPINB5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 16049006 |
Phenotypes for SERPINB5 Gene
- MGI mutant phenotypes for SERPINB5:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for SERPINB5:
-
- Decreased viability
- no effect
- Synthetic lethal with Ras
- Decreased viability ratio
- Decreased NF-kappaB reporter expression
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased viability in ovarian lineage
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
Animal Models for SERPINB5 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SERPINB5 - Starting at $85 >
- * SERPINB5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SERPINB5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERPINB5
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERPINB5
miRNA for SERPINB5 Gene
- miRTarBase miRNAs that target SERPINB5
-
- hsa-miR-1-3p (MIRT002776)
- hsa-miR-21-5p (MIRT003567)
- hsa-miR-335-5p (MIRT017272)
- hsa-miR-30a-5p (MIRT028408)
- hsa-miR-26b-5p (MIRT029183)
- hsa-miR-16-5p (MIRT031536)
- mmu-miR-3057-5p (MIRT581084)
- mmu-miR-1843b-5p (MIRT581085)
- mmu-miR-1940 (MIRT581086)
- hsa-miR-2115-5p (MIRT662444)
- hsa-miR-3185 (MIRT662445)
- hsa-miR-4762-5p (MIRT662446)
- hsa-miR-141-5p (MIRT662447)
- hsa-miR-5197-3p (MIRT662448)
- hsa-miR-7-5p (MIRT731526)
- hsa-miR-103a-3p (MIRT731528)
- hsa-miR-107 (MIRT731529)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SERPINB5
- Browse OriGene Inhibitory RNA Products For SERPINB5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB5
Clone products for research
- Applied Biological Materials (abm): Clones for SERPINB5 - Starting at $45 >
- * SERPINB5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SERPINB5
- Addgene plasmids for SERPINB5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERPINB5
Cell Lines for research
-
Horizon Cell Lines for SERPINB5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINB5 Gene
Localization for SERPINB5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SERPINB5 Gene
- Secreted, extracellular space.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 4 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA,IBA | 21873635 |
| GO:0005737 | cytoplasm | IEA,IDA | 16049006 |
Pathways & Interactions for SERPINB5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Angiogenesis (CST) | ||
| 2 | Apoptosis and Autophagy | ||
| 3 | MicroRNAs in cancer | ||
| 4 | DNA Damage Response | ||
| 5 | ATF-2 transcription factor network | ||
Pathways by source for SERPINB5 Gene
2 BioSystems pathways for SERPINB5 Gene
2 KEGG pathways for SERPINB5 Gene
2 Cell Signaling Technology pathways for SERPINB5 Gene
Interacting Proteins for SERPINB5 Gene
Selected Interacting proteins:
P36952-SPB5_HUMAN
ENSP00000372221
for SERPINB5 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SERPINB5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002009 | morphogenesis of an epithelium | IEA | -- |
| GO:0010951 | negative regulation of endopeptidase activity | IEA,IBA | 21873635 |
| GO:0030198 | extracellular matrix organization | IEA | -- |
| GO:0050678 | regulation of epithelial cell proliferation | IEA | -- |
| GO:0060512 | prostate gland morphogenesis | IEA | -- |
Drugs & Compounds for SERPINB5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| S,S-(2-Hydroxyethyl)Thiocysteine | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
- G Biosciences Human Serpin B5/Maspin, Lyophilized
- RayBiotech Recombinant Human Serpin B5
Transcripts for SERPINB5 Gene
mRNA/cDNA for SERPINB5 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000382771 2586 nts (view in UCSC)
- ENST00000424602 560 nts (view in UCSC)
- ENST00000464346 485 nts (view in UCSC)
- ENST00000465652 454 nts (view in UCSC)
- ENST00000489441 1268 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SERPINB5 - Starting at $85 >
- * SERPINB5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SERPINB5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERPINB5
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERPINB5
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SERPINB5
- Browse OriGene Inhibitory RNA Products For SERPINB5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB5
Clone products for research
- Applied Biological Materials (abm): Clones for SERPINB5 - Starting at $45 >
- * SERPINB5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SERPINB5
- Addgene plasmids for SERPINB5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERPINB5
Relevant External Links for SERPINB5 Gene
- GeneLoc Exon Structure for
- SERPINB5
Expression for SERPINB5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Lung (Respiratory System)
- Basal Cells Trachea
- Trachea
- Hair (Integumentary System)
- Kidney (Urinary System)
- Ovary (Reproductive System)
-
Epithelial Cells
- Basal Cells Trachea
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
- Gut Tube (Gastrointestinal Tract)
- Epidermis (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for SERPINB5 Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x13.8), Skin - Not Sun Exposed (Suprapubic) (x13.7), Esophagus - Mucosa (x10.4), Minor Salivary Gland (x5.7), and Vagina (x4.4).
This gene is overexpressed in Cervix (20.8) and Oral epithelium (18.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SERPINB5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERPINB5
SOURCE GeneReport for Unigene cluster for SERPINB5 Gene:
Hs.55279mRNA Expression by UniProt/SwissProt for SERPINB5 Gene:
P36952-SPB5_HUMAN
Tissue specificity:
Normal mammary epithelial cells.
Evidence on tissue expression from TISSUES for SERPINB5 Gene
- Intestine(4.5)
- Skin(3.1)
- Lung(2.9)
Primer products for research
-
OriGene qPCR primer pairs for SERPINB5
-
OriGene qPCR primer pairs and template standards for SERPINB5
Gene Expression Assays for research
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB5 Gene
Orthologs for SERPINB5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SERPINB5 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SERPINB5 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SERPINB5 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Serpinb5 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Serpinb5 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | SERPINB5 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SERPINB5 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SERPINB5 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SERPINB5 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | serpinb5 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Spn1 31 |
|
ManyToMany | |
| Spn6 31 32 |
|
ManyToMany | |||
| Spn3 31 |
|
ManyToMany | |||
| Spn2 31 |
|
ManyToMany | |||
| CG6717 32 |
|
|
|||
| Spn7 31 |
|
ManyToMany | |||
| Spn43Ab 31 32 |
|
ManyToMany | |||
| Spn28Db 31 |
|
ManyToMany | |||
| CG7722 32 |
|
|
|||
| Spn28Da 31 |
|
ManyToMany | |||
| Spn43Aa 31 |
|
ManyToMany | |||
| Spn42Dc 31 |
|
ManyToMany | |||
| Spn42De 31 |
|
ManyToMany | |||
| Spn47C 31 |
|
ManyToMany | |||
| Spn42Db 31 |
|
ManyToMany | |||
| Spn4 31 |
|
ManyToMany | |||
| nec 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for SERPINB5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for SERPINB5 Gene
- ENSEMBL:
- Gene Tree for SERPINB5 (if available)
- TreeFam:
- Gene Tree for SERPINB5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SERPINB5: view image
Paralogs for SERPINB5 Gene
Paralogs for SERPINB5 Gene
- SERPINB1 5
- SERPINB10 5
- SERPINB8 5
- SERPINB6 5
- SERPINB3 5
- SERPINB9 5
- SERPINB4 5
- SERPINB11 5
- SERPINB2 5
- SERPINB13 5
- SERPINB12 5
- SERPINB7 5
- SERPINA7 5
- SERPINI2 5
- SERPINC1 5
- SERPINA3 5
- SERPINH1 5
- SERPINE1 5
- SERPINA9 5
- SERPINA12 5
- SERPINA1 5
- SERPINA5 5
- SERPINI1 5
- SERPIND1 5
- SERPINA10 5
- SERPINA6 5
- SERPINA4 5
- SERPINE2 5
- SERPINE3 5
- SERPINF2 5
- SERPINF1 5
- SERPINA11 5
- SERPING1 5
- AGT 5
- SERPINA2 5
- HMSD 5
(27) SIMAP similar genes for SERPINB5 Gene using alignment to 2 proteins:
- SPB5_HUMAN
- C9JLM5_HUMAN
Variants for SERPINB5 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv26779 | CNV | loss | 19812545 |
| esv2763190 | CNV | loss | 21179565 |
| esv3334527 | CNV | duplication | 20981092 |
| nsv1066552 | CNV | gain | 25217958 |
| nsv131597 | CNV | deletion | 16902084 |
Residual Variation Intolerance Score:
68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
14.19;
96.19% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SERPINB5 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB5 Gene
Disorders for SERPINB5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pleomorphic adenoma |
|
|
| syringoma |
|
|
| mandibular cancer |
|
|
| myoepithelioma |
|
|
| pituitary adenoma 2, growth hormone-secreting |
|
|
Search SERPINB5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SERPINB5
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB5 Gene
Publications for SERPINB5 Gene
- Maspin is physically associated with [beta]1 integrin regulating cell adhesion in mammary epithelial cells. (PMID: 16720730) Cella N … Zhang M (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 2 3 23
- The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. (PMID: 15760906) Law RH … Whisstock JC (The Journal of biological chemistry 2005) 3 4 23
- A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PMID: 7724531) Schneider SS … Silverman GA (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 23
- The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin. (PMID: 7797587) Pemberton PA … Barr PJ (The Journal of biological chemistry 1995) 3 4 23
- Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. (PMID: 8290962) Zou Z … Sager R (Science (New York, N.Y.) 1994) 2 3 4
ExternalLinks
Products for SERPINB5 Gene
- View all 6 R&D Systems SERPINB5 (Serpin B5/Maspin) Products
- View all 2 R&D Systems SERPINB5 (Serpin B5/Maspin) Primary Antibodies
- View all 4 R&D Systems SERPINB5 (Serpin B5/Maspin) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom SERPINB5 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for SERPINB5
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for SERPINB5
- Origene Custom Protein Services for SERPINB5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SERPINB5
- Browse OriGene Inhibitory RNA Products For SERPINB5
- OriGene qPCR primer pairs for SERPINB5
- OriGene qPCR primer pairs and template standards for SERPINB5
- OriGene CRISPR knockouts for SERPINB5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SERPINB5
- Sino Biological Human cDNA Clone for SERPINB5
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SERPINB5
- Novus Biologicals proteins and lysates for SERPINB5
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- Browse Peptides and Proteins
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- Abcam antibodies for SERPINB5
- Abcam proteins for SERPINB5
- Abcam assays for SERPINB5
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- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for SERPINB5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SERPINB5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SERPINB5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SERPINB5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SERPINB5
- Addgene plasmids for SERPINB5
- antibodies-online: Show 60 available SERPINB5 Antibodies ranked by validation data
- Compare Top SERPINB5 Antibodies
- Recommended
- antibodies-online: Show 27 available SERPINB5 Elisa Kits ranked by validation data
- Compare Top SERPINB5 Elisa Kits
- antibodies-online: Show 22 available SERPINB5 Proteins ranked by validation data
- Compare Top SERPINB5 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for SERPINB5
- Search Santa Cruz Biotechnology (SCBT) for SERPINB5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SERPINB5
- Custom Antibody ServicesProSci Antibodies for SERPINB5
- serpin peptidase inhibitor, clade B (ovalbumin), member 5 [15-339]
- serpin peptidase inhibitor, clade B (ovalbumin), member 5 [13-311]
- serpin peptidase inhibitor, clade B (ovalbumin), member 5 [38-244]
- serpin peptidase inhibitor, clade B (ovalbumin), member 5 [29-688]
- serpin peptidase inhibitor, clade B (ovalbumin), member 5 [38-278]
- Serpin B5 [56-219]
- ProSci Proteins for SERPINB5
- Horizon Cell Lines for SERPINB5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERPINB5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERPINB5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SERPINB5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB5
- Boster Bio Antibodies for SERPINB5
- Browse Boster Bio ELISA Kits
Sources for SERPINB5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB