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The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic in... See more...
Aliases for SERPINB4 Gene
Aliases for SERPINB4 Gene
External Ids for SERPINB4 Gene
- HGNC: 10570
- Entrez Gene: 6318
- Ensembl: ENSG00000206073
- OMIM: 600518
- UniProtKB: P48594
Previous HGNC Symbols for SERPINB4 Gene
- SCCA2
Previous GeneCards Identifiers for SERPINB4 Gene
- GC18M061143
- GC18M061277
- GC18M059456
- GC18M059419
- GC18M059458
- GC18M059459
- GC18M058004
Summaries for SERPINB4 Gene
-
The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]
GeneCards Summary for SERPINB4 Gene
SERPINB4 (Serpin Family B Member 4) is a Protein Coding gene. Diseases associated with SERPINB4 include Squamous Cell Carcinoma and Inverted Papilloma. Among its related pathways are Amoebiasis. Gene Ontology (GO) annotations related to this gene include enzyme binding and protease binding. An important paralog of this gene is SERPINB3.
UniProtKB/Swiss-Prot Summary for SERPINB4 Gene
-
May act as a protease inhibitor to modulate the host immune response against tumor cells.
Additional gene information for SERPINB4 Gene
- Monarch Initiative
- Search for SERPINB4 at DataMed
- Search for SERPINB4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERPINB4 Gene
Genomics for SERPINB4 Gene
GeneHancer (GH) Regulatory Elements for SERPINB4 Gene
Promoters and enhancers for SERPINB4 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH18J063644 | Promoter/Enhancer | 0.6 | EPDnew Ensembl | 500.7 | +0.4 | 418 | 3 | POLR2A | SERPINB4 lnc-SERPINB3-4 SERPINB11 SERPINB3 piR-42002-003 | |
| GH18J063641 | Enhancer | 0.5 | Ensembl | 0.7 | +3.1 | 3118 | 1.2 | POLR2A EP300 CEBPB JUN JUND STAT3 FOS | SERPINB3 SERPINB4 lnc-SERPINB3-4 piR-42002-003 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SERPINB4 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERPINB4
- Top Transcription factor binding sites by QIAGEN in the SERPINB4 gene promoter:
-
- HEN1
- HFH-1
- HNF-4alpha1
- HNF-4alpha2
- Pax-6
- POU3F2
- SRF
- SRF (504 AA)
Genomic Locations for SERPINB4 Gene
Genomic Locations for SERPINB4 Gene
- chr18:63,637,259-63,644,319
- (GRCh38/hg38)
- Size:
- 7,061 bases
- Orientation:
- Minus strand
- chr18:61,304,493-61,311,532
- (GRCh37/hg19)
- Size:
- 7,040 bases
- Orientation:
- Minus strand
Genomic View for SERPINB4 Gene
Genes around SERPINB4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.33 by HGNC
- 18q21.33 by Entrez Gene
- 18q21.33 by Ensembl
SERPINB4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SERPINB4 Gene
Proteins for SERPINB4 Gene
-
Protein details for SERPINB4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P48594-SPB4_HUMAN
- Recommended name:
- Serpin B4
- Protein Accession:
- P48594
- A8K847
Protein attributes for SERPINB4 Gene
- Size:
- 390 amino acids
- Molecular mass:
- 44854 Da
- Quaternary structure:
- No Data Available
Protein Expression for SERPINB4 Gene
Post-translational modifications for SERPINB4 Gene
Other Protein References for SERPINB4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ SCCA2 Polyclonal Antibody and Immunotag™ SERPINB4 Antibody
- Creative Diagnostics Anti-SERPINB4 monoclonal antibody, clone 3C0
-
Custom Antibody ServicesOriGene Antibodies for SERPINB4
- Novus Biologicals Antibodies for SERPINB4
- Invitrogen Antibodies for SERPINB4 (AFLGC-SERPINB4)
- antibodies-online: Show 70 available SCCA1 Antibodies ranked by validation data
- Compare Top SCCA1 Antibodies
-
Quality Products:
-
Biorbyt antibodies for SERPINB4
-
Boster Bio Antibodies for SERPINB4
-
Santa Cruz Biotechnology (SCBT) Antibodies for SERPINB4
- Sino Biological Antibodies for SERPINB4
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SERPINB4
- Origene Custom Protein Services for SERPINB4
- Sino Biological Recombinant Proteins for SERPINB4
- Sino Biological Cell Lysates for SERPINB4
- ProSpec Recombinant Proteins for SERPINB4
-
Abcam proteins for SERPINB4
Assay Products
- G Biosciences Immunotag™ Human SERPINB4 (Serpin B4) ELISA and Immunotag™ Serpin B4 ELISA Kit
- RayBiotech Custom Human SCCA2/Serpin B4 ELISA
- Aviva Systems Biology SERPINB4 ELISA Kit (Human) : 96 Wells (OKEH00254) and SERPINB4 ELISA Kit (Human) (OKCD00223)
No data available for DME Specific Peptides for SERPINB4 Gene
Domains & Families for SERPINB4 Gene
Gene Families for SERPINB4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SERPINB4 Gene
- Blocks:
-
- Serpin
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SERPINB4 Gene
- GenScript: Design optimal peptide antigens:
-
- Squamous cell carcinoma antigen 2 (Q86W03_HUMAN)
- Squamous cell carcinoma antigen 2 (Q86W05_HUMAN)
- Serpin peptidase inhibitor, clade B (Ovalbumin), member 4, isoform CRA_a (Q9BYF7_HUMAN)
- Squamous cell carcinoma antigen 2 (SPB4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P48594- Family:
-
- Belongs to the serpin family. Ov-serpin subfamily.
Function for SERPINB4 Gene
Molecular function for SERPINB4 Gene
- UniProtKB/Swiss-Prot Function:
- May act as a protease inhibitor to modulate the host immune response against tumor cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IPI | 21857942 |
| GO:0004867 | serine-type endopeptidase inhibitor activity | NAS,IBA | 7589435 |
| GO:0019899 | enzyme binding | IPI | 23382074 |
| GO:0030414 | peptidase inhibitor activity | IEA | -- |
Phenotypes for SERPINB4 Gene
- MGI mutant phenotypes for SERPINB4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SERPINB4:
Animal Models for SERPINB4 Gene
- MGI Knock Outs for SERPINB4:
-
- Serpinb3a Serpinb3a<tm1Gsil>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SERPINB4 - Select products 50% OFF >
- * SERPINB4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SERPINB4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERPINB4
- genomics-online: gRNA clones - Search results for available SCCA1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERPINB4
miRNA for SERPINB4 Gene
- miRTarBase miRNAs that target SERPINB4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SERPINB4
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- genomics-online: shRNA clones - Search results for available SCCA1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for SERPINB4 - Select products 50% OFF >
- * SERPINB4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for SERPINB4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERPINB4
- genomics-online: cdna clones - Search results for available SCCA1 gene related products
- orf clones - Search results for available SCCA1 gene related products
Cell Line Products
-
Horizon Cell Lines for SERPINB4
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINB4 Gene
Localization for SERPINB4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SERPINB4 Gene
- Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| nucleus | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IEA,IBA | 21873635 |
| GO:0005737 | cytoplasm | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINB4 Gene
Pathways & Interactions for SERPINB4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Amoebiasis | ||
Pathways by source for SERPINB4 Gene
1 KEGG pathway for SERPINB4 Gene
Interacting Proteins for SERPINB4 Gene
GPS-Prot Interaction Network for SERPINB4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010466 | negative regulation of peptidase activity | IEA,IDA | 12949073 |
| GO:0010951 | negative regulation of endopeptidase activity | IBA | 21873635 |
| GO:0030162 | regulation of proteolysis | NAS | 7589435 |
| GO:0042270 | protection from natural killer cell mediated cytotoxicity | IMP | 21857942 |
No data available for SIGNOR curated interactions for SERPINB4 Gene
Transcripts for SERPINB4 Gene
mRNA/cDNA for SERPINB4 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000341074 1707 bps (ENST00000341074.10)
- ENST00000413673 1116 bps (ENST00000413673.5)
- ENST00000436264 709 bps (ENST00000436264.1)
- ENST00000498496 559 bps (ENST00000498496.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SERPINB4 - Select products 50% OFF >
- * SERPINB4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SERPINB4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERPINB4
- genomics-online: gRNA clones - Search results for available SCCA1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for SERPINB4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SERPINB4
- Browse OriGene Inhibitory RNA Products For SERPINB4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB4
- genomics-online: shRNA clones - Search results for available SCCA1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for SERPINB4 - Select products 50% OFF >
- * SERPINB4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for SERPINB4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERPINB4
- genomics-online: cdna clones - Search results for available SCCA1 gene related products
- orf clones - Search results for available SCCA1 gene related products
Relevant External Links for SERPINB4 Gene
- GeneLoc Exon Structure for
- SERPINB4
Expression for SERPINB4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Endothelium (Cardiovascular System)
-
Lung (Respiratory System)
-
Epidermis (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for SERPINB4 Gene
This gene is overexpressed in Vagina (x20.0), Esophagus - Mucosa (x13.4), Cervix - Ectocervix (x12.7), and Minor Salivary Gland (x5.2).
This gene is overexpressed in Cervix (24.7), Nasal epithelium (19.0), and Stomach (10.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERPINB4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERPINB4
SOURCE GeneReport for Unigene cluster for SERPINB4 Gene:
Hs.123035mRNA Expression by UniProt/SwissProt for SERPINB4 Gene:
P48594-SPB4_HUMAN
Tissue specificity:
Squamous cells.
Evidence on tissue expression from TISSUES for SERPINB4 Gene
- Bone marrow(4)
- Lung(2.3)
- Skin(2.3)
Primer Products
-
OriGene qPCR primer pairs for SERPINB4
-
OriGene qPCR primer pairs and template standards for SERPINB4
- genomics-online: primer clones - Search results for available SCCA1 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB4 Gene
Orthologs for SERPINB4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SERPINB4 30 |
|
||
| dog (Canis familiaris) |
Mammalia | SERPINB4 30 |
|
||
| -- 31 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | LOC100337240 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| SERPINB4 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Serpinb3a 17 31 30 |
|
||
| Serpinb3d 31 |
|
ManyToMany | |||
| Serpinb3b 31 |
|
ManyToMany | |||
| Serpinb3c 31 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Serpinb3a 30 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| chicken (Gallus gallus) |
Aves | OVALY 31 30 |
|
ManyToMany | |
| SERPINB14 31 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100490314 30 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Spn42Dd 30 |
|
||
| Spn4 32 |
|
|
|||
| Spn1 32 |
|
|
|||
| serpin-27A 32 |
|
|
|||
| Spn6 32 |
|
|
|||
| Spn2 32 |
|
|
|||
| CG9455 32 |
|
|
|||
| Spn3 32 |
|
|
|||
| CG9460 32 |
|
|
|||
| Spn43Aa 32 |
|
|
|||
| CG6717 32 |
|
|
|||
| Spn5 32 |
|
|
|||
| CG7722 32 |
|
|
|||
| nec 32 |
|
|
|||
| CG6687 32 |
|
|
|||
| Spn43Ab 32 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | srp-5 30 |
|
||
| srp-7 32 |
|
|
|||
| srp-6 32 |
|
|
|||
| srp-1 32 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | SRP3 30 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0610700 30 |
|
- Species where no ortholog for SERPINB4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Evolution for SERPINB4 Gene
- ENSEMBL:
- Gene Tree for SERPINB4 (if available)
- TreeFam:
- Gene Tree for SERPINB4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SERPINB4: view image
Paralogs for SERPINB4 Gene
Paralogs for SERPINB4 Gene
- SERPINB3 5
- SERPINB13 5
- SERPINB12 5
- SERPINB1 5
- SERPINB6 5
- SERPINB9 5
- SERPINB8 5
- SERPINB10 5
- SERPINB2 5
- SERPINC1 5
- SERPINB7 5
- SERPINI2 5
- SERPINB11 5
- SERPINB5 5
- SERPINI1 5
- SERPINA9 5
- SERPINA4 5
- SERPINA1 5
- SERPINA3 5
- SERPINA11 5
- SERPINA7 5
- SERPINA5 5
- SERPINE2 5
- SERPINE1 5
- SERPINA12 5
- SERPINA6 5
- SERPIND1 5
- SERPINA10 5
- SERPINH1 5
- SERPINF2 5
- SERPING1 5
- SERPINE3 5
- SERPINF1 5
- SERPINA2 5
- AGT 5
- HMSD 5
(40) SIMAP similar genes for SERPINB4 Gene using alignment to 6 proteins:
- SPB4_HUMAN
- C9JZ65_HUMAN
- F8W9L1_HUMAN
- H0Y5H9_HUMAN
- Q86W03_HUMAN
- Q86W05_HUMAN
- SCCA1
- HUR 7
- SCCA2
- SERPINB3
- SERPINB13
- DKFZp686O07189
- PLANH2
- SERPINB11
- DKFZp686D06190
- SERPINB10
- SERPINB1
- SERPINB7
- SERPINB12
- SERPINB8
- SERPINB6
- HMSD
- SERPINB9
- SERPINB2
- AT3
- SERPINA3
- SERPINC1
- SERPINB5
- SERPINA5
- SERPINA1
- SERPINA12
- SERPIND1
- SERPINI2
- SERPINA11
- SERPINA9
- SERPINE1
- SERPINI1
- SERPINA6
- SERPINE2
- SERPINA2P
- SERPINA4
- SERPINA10
- SERPINA7
- ra-a47
- SERPINH1
- SERPINA2
Variants for SERPINB4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERPINB4 Gene
| SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193921093 | Uncertain Significance: Malignant tumor of prostate | 63,639,770(-) | A/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv621e214 | CNV | loss | 21293372 |
| dgv994e212 | CNV | loss | 25503493 |
| esv2313855 | CNV | deletion | 18987734 |
| esv2717205 | CNV | deletion | 23290073 |
| esv3642777 | CNV | loss | 21293372 |
| esv3642778 | CNV | loss | 21293372 |
| esv3642779 | CNV | gain | 21293372 |
| nsv1066552 | CNV | gain | 25217958 |
| nsv833672 | CNV | gain | 17160897 |
| nsv978638 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.17;
39.36% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SERPINB4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB4 Gene
Disorders for SERPINB4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| squamous cell carcinoma |
|
|
| inverted papilloma |
|
|
| maxillary sinus inverted papilloma |
|
|
| maxillary sinus neoplasm |
|
|
| childhood central nervous system primitive neuroectodermal neoplasm |
|
|
Search SERPINB4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SERPINB4
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB4 Gene
Publications for SERPINB4 Gene
- A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PMID: 7724531) Schneider SS … Silverman GA (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 23 54
- The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1. (PMID: 14630915) Sakata Y … Izuhara K (The Journal of biological chemistry 2004) 2 3 23 54
- Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter. (PMID: 11267667) Hamada K … Ito M (Biochimica et biophysica acta 2001) 3 4 23 54
- Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. (PMID: 10956412) Uemura Y … Silverman GA (International journal of cancer 2000) 3 4 23 54
- Identification of a novel human serpin gene; cloning sequencing and expression of leupin. (PMID: 7589435) Barnes RC … Worrall DM (FEBS letters 1995) 3 4 23 54
ExternalLinks
Products for SERPINB4 Gene
- Custom Antibody ServicesOriGene Antibodies for SERPINB4
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- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for SERPINB4
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for SERPINB4
- Browse OriGene Inhibitory RNA Products For SERPINB4
- OriGene qPCR primer pairs for SERPINB4
- OriGene qPCR primer pairs and template standards for SERPINB4
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- Browse Sino Biological Assays
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SERPINB4
- Novus Biologicals proteins and lysates for SERPINB4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for SERPINB4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for SERPINB4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SERPINB4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SERPINB4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SERPINB4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SERPINB4
- Addgene plasmids for SERPINB4
- antibodies-online: Show 70 available SCCA1 Antibodies ranked by validation data
- Compare Top SCCA1 Antibodies
- Quality Products:
- antibodies-online: Show 35 available SCCA1 Elisa Kits ranked by validation data
- Compare Top SCCA1 Elisa Kits
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- antibodies-online: Show 17 available SCCA1 Proteins ranked by validation data
- Compare Top SCCA1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for SERPINB4
- Search Santa Cruz Biotechnology (SCBT) for SERPINB4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SERPINB4
- Horizon Cell Lines for SERPINB4
- genomics-online: cdna clones - Search results for available SCCA1 gene related products
- orf clones - Search results for available SCCA1 gene related products
- genomics-online: gRNA clones - Search results for available SCCA1 gene related products
- genomics-online: primer clones - Search results for available SCCA1 gene related products
- genomics-online: shRNA clones - Search results for available SCCA1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SERPINB4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SERPINB4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SERPINB4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB4
- Boster Bio Antibodies for SERPINB4
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for SERPINB4
Sources for SERPINB4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody