SERPINB2 Gene (Protein Coding)

Serpin Family B Member 2

GC18P063871
GIFtS:
45
See more...

Aliases for SERPINB2 Gene

Aliases for SERPINB2 Gene

  • Serpin Family B Member 2 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 2 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 2 3
  • Placental Plasminogen Activator Inhibitor 3 4
  • Plasminogen Activator Inhibitor 2 3 4
  • Monocyte Arg-Serpin 3 4
  • Urokinase Inhibitor 3 4
  • Serpin B2 3 4
  • HsT1201 2 3
  • PLANH2 3 4
  • PAI-2 3 4
  • PAI2 3 4
  • Plasminogen Activator Inhibitor, Type II (Arginine-Serpin) 3
  • SERPINB2 5
  • PAI 3

External Ids for SERPINB2 Gene

Previous HGNC Symbols for SERPINB2 Gene

  • PLANH2
  • PAI2

Previous GeneCards Identifiers for SERPINB2 Gene

  • GC18P061393
  • GC18P061528
  • GC18P061339
  • GC18P059703
  • GC18P059294
  • GC18P059705
  • GC18P058256

Summaries for SERPINB2 Gene

GeneCards Summary for SERPINB2 Gene

SERPINB2 (Serpin Family B Member 2) is a Protein Coding gene. Diseases associated with SERPINB2 include Gingivitis and Pre-Eclampsia. Among its related pathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Formation of Fibrin Clot (Clotting Cascade). Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB1.

UniProtKB/Swiss-Prot Summary for SERPINB2 Gene

  • Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

Gene Wiki entry for SERPINB2 Gene

Additional gene information for SERPINB2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERPINB2 Gene

Genomics for SERPINB2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SERPINB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH18J063887 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 250.4 +18.1 18130 5.2 CEBPB CTCF EP300 SMC3 RAD21 SPI1 TCF7 POLR2A JUNB ATF7 SERPINB2 SERPINB10 lnc-SERPINB3-6
GH18J063828 Promoter/Enhancer 0.5 EPDnew Ensembl 250.3 -43.4 -43391 0.2 HSALNG0122068-001 SERPINB2 SERPINB10 HSALNG0122067 SERPINB7
GH18J063903 Promoter 0.3 EPDnew 250.3 +31.7 31690 0.1 lnc-SERPINB3-7 SERPINB2 SERPINB10 HMSD
GH18J063872 Enhancer 0.2 FANTOM5 264.7 +1.1 1064 0.2 SERPINB2 SERPINB10 SERPINB8 SERPINB12 VPS4B lnc-SERPINB3-6
GH18J063878 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 33.4 +9.7 9709 6.8 CEBPB MAX EP300 EBF1 RFX5 STAT3 TCF7L2 JUND SPI1 BATF SERPINB2 SERPINB10 SERPINB8 VPS4B lnc-SERPINB3-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERPINB2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERPINB2

Top Transcription factor binding sites by QIAGEN in the SERPINB2 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • c-Rel
  • C/EBPbeta

Genomic Locations for SERPINB2 Gene

Latest Assembly
chr18:63,871,692-63,903,890
(GRCh38/hg38)
Size:
32,199 bases
Orientation:
Plus strand

Previous Assembly
chr18:61,554,939-61,571,122
(GRCh37/hg19 by Entrez Gene)
Size:
16,184 bases
Orientation:
Plus strand

chr18:61,538,926-61,571,124
(GRCh37/hg19 by Ensembl)
Size:
32,199 bases
Orientation:
Plus strand

Genomic View for SERPINB2 Gene

Genes around SERPINB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SERPINB2 Gene

Proteins for SERPINB2 Gene

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  • Protein details for SERPINB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05120-PAI2_HUMAN
    Recommended name:
    Plasminogen activator inhibitor 2
    Protein Accession:
    P05120
    Secondary Accessions:
    • Q96E96

    Protein attributes for SERPINB2 Gene

    Size:
    415 amino acids
    Molecular mass:
    46596 Da
    Quaternary structure:
    • Interacts with PSMB1.

    Three dimensional structures from OCA and Proteopedia for SERPINB2 Gene

neXtProt entry for SERPINB2 Gene

Protein Expression for SERPINB2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SERPINB2 Gene

  • The signal sequence is not cleaved.
  • Glycosylation at Asn75, Asn115, and Asn339
  • Modification sites at PhosphoSitePlus

Other Protein References for SERPINB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERPINB2 Gene

Domains & Families for SERPINB2 Gene

Gene Families for SERPINB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SERPINB2 Gene

InterPro:
Blocks:
  • Serpin
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINB2 Gene

GenScript: Design optimal peptide antigens:
  • Urokinase inhibitor (PAI2_HUMAN)
  • PLANH2 protein (Q6LDR6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05120

UniProtKB/Swiss-Prot:

PAI2_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB2: view

Function for SERPINB2 Gene

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  6. Cell Lines for research

Molecular function for SERPINB2 Gene

UniProtKB/Swiss-Prot Function:
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

Phenotypes From GWAS Catalog for SERPINB2 Gene

Gene Ontology (GO) - Molecular Function for SERPINB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA 21873635
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB2: view
genes like me logo Genes that share phenotypes with SERPINB2: view

Animal Models for SERPINB2 Gene

MGI Knock Outs for SERPINB2:

Animal Models for research

miRNA for SERPINB2 Gene

miRTarBase miRNAs that target SERPINB2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB2

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINB2 Gene

Localization for SERPINB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB2 Gene

Cytoplasm. Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB2 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SERPINB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SERPINB2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINB2 Gene

Pathways & Interactions for SERPINB2 Gene

genes like me logo Genes that share pathways with SERPINB2: view

Pathways by source for SERPINB2 Gene

2 Reactome pathways for SERPINB2 Gene
1 KEGG pathway for SERPINB2 Gene
1 GeneGo (Thomson Reuters) pathway for SERPINB2 Gene
  • Cell adhesion PLAU signaling
1 R&D Systems pathway for SERPINB2 Gene

SIGNOR curated interactions for SERPINB2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SERPINB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IBA 21873635
GO:0035722 interleukin-12-mediated signaling pathway TAS --
GO:0042060 wound healing IEA --
GO:0042730 fibrinolysis TAS --
genes like me logo Genes that share ontologies with SERPINB2: view

Drugs & Compounds for SERPINB2 Gene

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(22) Drugs for SERPINB2 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urokinase Approved, Investigational, Withdrawn Pharma Target, substrate, inducer, activator 0
Tenecteplase Approved Pharma Target 58
Lanoteplase Investigational Pharma Target 0

(25) Additional Compounds for SERPINB2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB2: view

Transcripts for SERPINB2 Gene

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mRNA/cDNA for SERPINB2 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB2

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11
SP1: - - -
SP2: - - - - - - -
SP3:
SP4: - -
SP5: -

Relevant External Links for SERPINB2 Gene

GeneLoc Exon Structure for
SERPINB2

Expression for SERPINB2 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERPINB2 Gene

mRNA expression in normal human tissues for SERPINB2 Gene
mRNA expression by BioGPS for SERPINB2 GenemRNA expression by GTEx for SERPINB2 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINB2 Gene

This gene is overexpressed in Minor Salivary Gland (x17.2) and Esophagus - Mucosa (x17.0).

Protein differential expression in normal tissues from HIPED for SERPINB2 Gene

This gene is overexpressed in Liver (33.5), Cervix (11.9), and Placenta (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERPINB2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERPINB2

SOURCE GeneReport for Unigene cluster for SERPINB2 Gene:

Hs.594481

Evidence on tissue expression from TISSUES for SERPINB2 Gene

  • Blood(4.9)
  • Nervous system(4.4)
  • Lung(3.6)
  • Skin(2.4)
  • Heart(2.3)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with SERPINB2: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB2 Gene

Orthologs for SERPINB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINB2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SERPINB2 30 31
  • 98.71 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SERPINB2 30 31
  • 83.57 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SERPINB2 30 31 31
  • 82.25 (n)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Serpinb2 30 17 31
  • 80.32 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Serpinb2 30
  • 77.99 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia SERPINB2 31
  • 65 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia SERPINB2 31
  • 60 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves SERPINB2 30 31
  • 58.48 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia SERPINB2 31
  • 47 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii serpinb1l1 31
  • 47 (a)
 ManyToMany
serpinb1l4 31
  • 45 (a)
 ManyToMany
si:ch73-303g23.4 31
  • 43 (a)
 ManyToMany
serpinb1l3 31
  • 43 (a)
 ManyToMany
zgc:173729 31
  • 43 (a)
 ManyToMany
Species where no ortholog for SERPINB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SERPINB2 Gene

ENSEMBL:
Gene Tree for SERPINB2 (if available)
TreeFam:
Gene Tree for SERPINB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERPINB2: view image

Paralogs for SERPINB2 Gene

Paralogs for SERPINB2 Gene

(28) SIMAP similar genes for SERPINB2 Gene using alignment to 4 proteins:

  • PAI2_HUMAN
  • E7EPJ9_HUMAN
  • E7ERB5_HUMAN
  • E9PDK7_HUMAN
genes like me logo Genes that share paralogs with SERPINB2: view

Variants for SERPINB2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERPINB2 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs138183373 Benign: not provided 63,895,334(+) G/A
NM_002575.3(SERPINB2):c.239G>A (p.Gly80Glu) 		MISSENSE
rs139893427 Likely Benign: not provided 63,903,168(+) G/A
NM_002575.3(SERPINB2):c.1111G>A (p.Ala371Thr) 		MISSENSE
rs140108044 Benign: not provided 63,897,207(+) G/A
NM_002575.3(SERPINB2):c.405G>A (p.Ala135=) 		SYNONYMOUS
rs147312209 Likely Benign: not provided 63,902,544(+) C/T
NM_002575.3(SERPINB2):c.819C>T (p.Ala273=) 		SYNONYMOUS
rs148240038 Benign: not provided 63,902,526(+) G/A
NM_002575.3(SERPINB2):c.801G>A (p.Leu267=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SERPINB2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SERPINB2 Gene

Variant ID Type Subtype PubMed ID
esv21739 CNV gain 19812545
esv2758730 CNV loss 17122850
esv3642785 CNV gain 21293372
esv3642787 CNV loss 21293372
nsv1066552 CNV gain 25217958
nsv1067311 CNV loss 25217958
nsv525889 CNV loss 19592680
nsv833673 CNV gain 17160897

Variation tolerance for SERPINB2 Gene

Residual Variation Intolerance Score: 79.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.82; 95.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINB2 Gene

Human Gene Mutation Database (HGMD)
SERPINB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINB2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB2 Gene

Disorders for SERPINB2 Gene

MalaCards: The human disease database

(11) MalaCards diseases for SERPINB2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
gingivitis
  • acute gingivitis
pre-eclampsia
  • gestational hypertension
lipodermatosclerosis
  • acute lipodermatosclerosis
endometrial cancer
  • endometrial cancer, familial
adult respiratory distress syndrome
  • acute respiratory distress syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERPINB2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SERPINB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB2 Gene

Publications for SERPINB2 Gene

  1. Genetic polymorphisms and spontaneous preterm birth. (PMID: 17267840) Gibson CS … Nelson KB (Obstetrics and gynecology 2007) 3 23 41
  2. Chromosomal organization and localization of the human urokinase inhibitor gene: perfect structural conservation with ovalbumin. (PMID: 2303256) Samia JA … Webb AC (Genomics 1990) 3 4 23
  3. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41

ExternalLinks

View latest publications for SERPINB2 gene in Mastermind

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Sources for SERPINB2 Gene