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Aliases for SERPINB12 Gene

Aliases for SERPINB12 Gene

  • Serpin Family B Member 12 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 12 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 12 2 3
  • Serpin B12 3

External Ids for SERPINB12 Gene

Previous GeneCards Identifiers for SERPINB12 Gene

  • GC18P061062
  • GC18P061196
  • GC18P059372
  • GC18P059374
  • GC18P057923

Summaries for SERPINB12 Gene

GeneCards Summary for SERPINB12 Gene

SERPINB12 (Serpin Family B Member 12) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include enzyme binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB4.

UniProtKB/Swiss-Prot for SERPINB12 Gene

  • Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.

Additional gene information for SERPINB12 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB12 Gene

Genomics for SERPINB12 Gene

GeneHancer (GH) Regulatory Elements for SERPINB12 Gene

Promoters and enhancers for SERPINB12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I063518 Enhancer 0.8 FANTOM5 ENCODE 552.3 -0.5 -463 0.2 CTCF ZNF654 TRIM22 REST RAD21 ZSCAN5C SMC3 ZNF143 MIXL1 SERPINB12 SERPINB11 SERPINB5 KDSR GC18P063498
GH18I063584 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 10.7 +67.1 67145 3.1 MAFF KLF1 MAFK SERPINB13 SERPINB11 SERPINB12
GH18I063105 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 8.5 -412.5 -412514 1.6 PKNOX1 INSM2 BMI1 FEZF1 BATF IRF4 ZNF213 SCRT2 ZSCAN5C ATF7 SERPINB12 LOC105372161 PIR61307
GH18I063451 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 4.7 -65.5 -65468 4.9 MEIS2 KLF1 PKNOX1 FEZF1 E2F1 ZNF335 KLF7 FOS CHD2 TCF7L2 SERPINB5 SERPINB12 SERPINB10 VPS4B
GH18I063137 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.8 -380.2 -380228 2.7 PKNOX1 SMAD1 ZBTB40 IRF4 ZNF143 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 BCL2 ZCCHC2 SERPINB12 VPS4B GC18P063133 ENSG00000267766
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERPINB12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERPINB12 gene promoter:

Genomic Locations for SERPINB12 Gene

Genomic Locations for SERPINB12 Gene
50,240 bases
Plus strand

Genomic View for SERPINB12 Gene

Genes around SERPINB12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB12 Gene

Proteins for SERPINB12 Gene

  • Protein details for SERPINB12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serpin B12
    Protein Accession:
    Secondary Accessions:
    • Q3SYB4

    Protein attributes for SERPINB12 Gene

    405 amino acids
    Molecular mass:
    46276 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB12 Gene


neXtProt entry for SERPINB12 Gene

Post-translational modifications for SERPINB12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB12 Gene

No data available for DME Specific Peptides for SERPINB12 Gene

Domains & Families for SERPINB12 Gene

Gene Families for SERPINB12 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SERPINB12 Gene

Suggested Antigen Peptide Sequences for SERPINB12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serpin family. Ov-serpin subfamily.
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB12: view

Function for SERPINB12 Gene

Molecular function for SERPINB12 Gene

UniProtKB/Swiss-Prot Function:
Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.

Phenotypes From GWAS Catalog for SERPINB12 Gene

Gene Ontology (GO) - Molecular Function for SERPINB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IMP 11604408
GO:0019899 enzyme binding NAS 11604408
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB12: view
genes like me logo Genes that share phenotypes with SERPINB12: view

Animal Models for SERPINB12 Gene

MGI Knock Outs for SERPINB12:

Animal Model Products

  • Taconic Biosciences Mouse Models for SERPINB12

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINB12 Gene

Localization for SERPINB12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB12 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB12 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SERPINB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm NAS 11604408
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA,HDA 23376485
GO:0101003 ficolin-1-rich granule membrane TAS --
genes like me logo Genes that share ontologies with SERPINB12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINB12 Gene

Pathways & Interactions for SERPINB12 Gene

SuperPathways for SERPINB12 Gene

genes like me logo Genes that share pathways with SERPINB12: view

Pathways by source for SERPINB12 Gene

3 Reactome pathways for SERPINB12 Gene

Gene Ontology (GO) - Biological Process for SERPINB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0042177 negative regulation of protein catabolic process NAS 11604408
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with SERPINB12: view

No data available for SIGNOR curated interactions for SERPINB12 Gene

Drugs & Compounds for SERPINB12 Gene

No Compound Related Data Available

Transcripts for SERPINB12 Gene

mRNA/cDNA for SERPINB12 Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINB12 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB12 Gene

No ASD Table

Relevant External Links for SERPINB12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERPINB12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINB12 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINB12 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x14.7), Skin - Sun Exposed (Lower leg) (x14.5), Vagina (x13.8), and Cervix - Ectocervix (x8.5).

Protein differential expression in normal tissues from HIPED for SERPINB12 Gene

This gene is overexpressed in Cerebrospinal fluid (18.5) and Urine (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINB12 Gene

Protein tissue co-expression partners for SERPINB12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERPINB12 Gene:


SOURCE GeneReport for Unigene cluster for SERPINB12 Gene:


mRNA Expression by UniProt/SwissProt for SERPINB12 Gene:

Tissue specificity: Expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine.
genes like me logo Genes that share expression patterns with SERPINB12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB12 Gene

Orthologs for SERPINB12 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERPINB12 33 34
  • 99.34 (n)
(Canis familiaris)
Mammalia SERPINB12 33 34
  • 85.19 (n)
(Bos Taurus)
Mammalia SERPINB13 33
  • 82.55 (n)
  • 73 (a)
(Rattus norvegicus)
Mammalia Serpinb12 33
  • 79.01 (n)
(Mus musculus)
Mammalia Serpinb12 33 16 34
  • 78.68 (n)
(Monodelphis domestica)
Mammalia SERPINB12 34
  • 62 (a)
(Gallus gallus)
Aves SERPINB12 33
  • 58.04 (n)
-- 34
  • 45 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spn2 35
  • 33 (a)
Spn3 35
  • 31 (a)
CG6717 35
  • 28 (a)
CG7722 35
  • 28 (a)
CG6687 35
  • 26 (a)
Species where no ortholog for SERPINB12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINB12 Gene

Gene Tree for SERPINB12 (if available)
Gene Tree for SERPINB12 (if available)

Paralogs for SERPINB12 Gene

Variants for SERPINB12 Gene

Sequence variations from dbSNP and Humsavar for SERPINB12 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000003312 -- 63,562,896(+) T/C intron_variant
rs1000069636 -- 63,523,331(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000097662 -- 63,536,939(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000169752 -- 63,538,241(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000178370 -- 63,568,397(+) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINB12 Gene

Variant ID Type Subtype PubMed ID
esv3642773 CNV loss 21293372
nsv1066552 CNV gain 25217958

Variation tolerance for SERPINB12 Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINB12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB12 Gene

Disorders for SERPINB12 Gene

Additional Disease Information for SERPINB12

No disorders were found for SERPINB12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINB12 Gene

Publications for SERPINB12 Gene

  1. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3 58
  2. SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases. (PMID: 11604408) Askew YS … Silverman GA (The Journal of biological chemistry 2001) 3 4 58
  3. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58
  5. Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia. (PMID: 26220980) Niehaus JZ … Luke CJ (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2015) 3 58

Products for SERPINB12 Gene

Sources for SERPINB12 Gene

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