SERPINB11 Gene (Protein Coding)

Serpin Family B Member 11

GC18P063647
GIFtS:
33
See more...

Aliases for SERPINB11 Gene

Aliases for SERPINB11 Gene

  • Serpin Family B Member 11 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 11 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 11 2 3
  • Serpin B11 3 4
  • EPIPIN 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 11 (Gene/Pseudogene) 2
  • Serpin Family B Member 11 (Gene/Pseudogene) 2
  • SERPINB11 5
  • SERPIN11 3

External Ids for SERPINB11 Gene

Previous GeneCards Identifiers for SERPINB11 Gene

  • GC18P061216
  • GC18P061350
  • GC18P059526
  • GC18P059528
  • GC18P058071

Summaries for SERPINB11 Gene

GeneCards Summary for SERPINB11 Gene

SERPINB11 (Serpin Family B Member 11) is a Protein Coding gene. Diseases associated with SERPINB11 include Endometrioid Ovary Carcinoma and Ovarian Endometrial Cancer. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB1.

UniProtKB/Swiss-Prot Summary for SERPINB11 Gene

  • Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.

Additional gene information for SERPINB11 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SERPINB11 Gene

Genomics for SERPINB11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SERPINB11 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH18J063702 Promoter 0.3 EPDnew 283.1 +55.4 55362 0.1 SERPINB11 piR-50968-052 HSALNG0122064 SERPINB3 SERPINB7 HSALNG0122061
GH18J063648 Enhancer 0.3 Ensembl 262.8 +0.7 722 0.2 JUND SERPINB11 HSALNG0122061 SERPINB5 SERPINB3 HSALNG0122062
GH18J063584 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 26.1 -61.3 -61320 3.1 MAFF SPI1 MAFK KLF1 SERPINB13 SERPINB11 SERPINB12 hsa-miR-5095-249
GH18J063708 Enhancer 0.5 Ensembl ENCODE 36.4 +61.4 61421 0.8 MAFK FOS SERPINB11 piR-50968-052 HSALNG0122064 SERPINB7 SERPINB3 HSALNG0122061
GH18J063514 Enhancer 0.7 Ensembl ENCODE 22.8 -132.8 -132793 2 DEK BRCA1 CEBPB CTCF MAX EP300 YY1 STAT3 TCF7L2 HSALNG0122056 SERPINB11 SERPINB5 SERPINB10 SERPINB12 lnc-SERPINB12-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERPINB11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SERPINB11

Top Transcription factor binding sites by QIAGEN in the SERPINB11 gene promoter:
  • AML1a
  • AP-4
  • Brachyury
  • FOXO4
  • GATA-1
  • GATA-2
  • GATA-3
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for SERPINB11 Gene

Latest Assembly
chr18:63,647,579-63,726,432
(GRCh38/hg38)
Size:
78,854 bases
Orientation:
Plus strand

Previous Assembly
chr18:61,369,538-61,391,127
(GRCh37/hg19 by Entrez Gene)
Size:
21,590 bases
Orientation:
Plus strand

chr18:61,314,813-61,391,127
(GRCh37/hg19 by Ensembl)
Size:
76,315 bases
Orientation:
Plus strand

Genomic View for SERPINB11 Gene

Genes around SERPINB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB11 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SERPINB11 Gene

Proteins for SERPINB11 Gene

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  • Protein details for SERPINB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P15-SPB11_HUMAN
    Recommended name:
    Serpin B11
    Protein Accession:
    Q96P15
    Secondary Accessions:
    • A8K9R0
    • Q5Q120
    • Q5Q121
    • Q5Q122
    • Q5Q123
    • Q6ISD3
    • Q96P13
    • Q96P14

    Protein attributes for SERPINB11 Gene

    Size:
    392 amino acids
    Molecular mass:
    44099 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB11 Gene

Protein Expression for SERPINB11 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SERPINB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERPINB11 Gene

Domains & Families for SERPINB11 Gene

Gene Families for SERPINB11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SERPINB11 Gene

InterPro:
Blocks:
  • Serpin
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINB11 Gene

GenScript: Design optimal peptide antigens:
  • Serpin B11 (SPB11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96P15

UniProtKB/Swiss-Prot:

SPB11_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB11: view

Function for SERPINB11 Gene

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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for SERPINB11 Gene

UniProtKB/Swiss-Prot Function:
Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.

Phenotypes From GWAS Catalog for SERPINB11 Gene

Gene Ontology (GO) - Molecular Function for SERPINB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA 21873635
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB11: view
genes like me logo Genes that share phenotypes with SERPINB11: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINB11 Gene

Localization for SERPINB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB11 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB11 gene
Compartment Confidence
extracellular 4
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SERPINB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA,IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SERPINB11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINB11 Gene

Pathways & Interactions for SERPINB11 Gene

PathCards logo

SuperPathways for SERPINB11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERPINB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IBA 21873635
genes like me logo Genes that share ontologies with SERPINB11: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINB11 Gene

Drugs & Compounds for SERPINB11 Gene

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No Compound Related Data Available

Transcripts for SERPINB11 Gene

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mRNA/cDNA for SERPINB11 Gene

4 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SERPINB11

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB11 Gene

No ASD Table

Relevant External Links for SERPINB11 Gene

GeneLoc Exon Structure for
SERPINB11

Expression for SERPINB11 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERPINB11 Gene

mRNA expression in normal human tissues for SERPINB11 Gene
mRNA expression by BioGPS for SERPINB11 GenemRNA expression by GTEx for SERPINB11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB11 Gene

This gene is overexpressed in Esophagus - Mucosa (x17.6), Vagina (x17.5), and Cervix - Ectocervix (x11.5).

Protein differential expression in normal tissues from HIPED for SERPINB11 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERPINB11 Gene



Protein tissue co-expression partners for SERPINB11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SERPINB11

SOURCE GeneReport for Unigene cluster for SERPINB11 Gene:

Hs.350958

mRNA Expression by UniProt/SwissProt for SERPINB11 Gene:

Q96P15-SPB11_HUMAN
Tissue specificity: Detected in a restricted number of tissues, including lung, placenta, prostate, and tonsil.
genes like me logo Genes that share expression patterns with SERPINB11: view

Primer products for research

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB11 Gene

Orthologs for SERPINB11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SERPINB11 30
  • 98.3 (n)
Dog
(Canis familiaris)
 Mammalia SERPINB11 30 31
  • 86.82 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Serpinb11 30
  • 76.03 (n)
Mouse
(Mus musculus)
 Mammalia Serpinb11 30 17 31
  • 75.95 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia SERPINB11 31
  • 67 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia SERPINB11 31
  • 59 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves -- 31
  • 45 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 47 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC100490487 30
  • 55.47 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Spn1 32
  • 32 (a)
CG9455 32
  • 31 (a)
Spn3 32
  • 31 (a)
Spn5 32
  • 29 (a)
nec 32
  • 28 (a)
CG7722 32
  • 27 (a)
Worm
(Caenorhabditis elegans)
 Secernentea srp-7 32
  • 32 (a)
srp-6 32
  • 30 (a)
srp-1 32
  • 27 (a)
Species where no ortholog for SERPINB11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for SERPINB11 Gene

ENSEMBL:
Gene Tree for SERPINB11 (if available)
TreeFam:
Gene Tree for SERPINB11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERPINB11: view image

Paralogs for SERPINB11 Gene

Paralogs for SERPINB11 Gene

(38) SIMAP similar genes for SERPINB11 Gene using alignment to 4 proteins:

  • SPB11_HUMAN
  • F5GWT8_HUMAN
  • F5GY69_HUMAN
  • F5GYW9_HUMAN
genes like me logo Genes that share paralogs with SERPINB11: view

Variants for SERPINB11 Gene

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Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB11 Gene

SPB11_HUMAN-Q96P15
According to some authors, 4 of the identified SERPIN11 transcripts contained coding sequences that could be distinguished by different combinations of single nucleotide polymorphisms (designated SERPINB11a, SERPINB11b, SERPINB11c, and SERPINB11d), and one contained a nonsense mutation introducing a premature stop codon in position 90 identified in the official genome sequence (SERPINB11f) (PubMed:17562709). The sequence displayed here corresponds to SERPINB11a.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SERPINB11 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs1395266 - p.Ile293Thr
rs1395267 - p.Pro303Ser
rs1395268 - p.Ala51Glu
rs1506419 - p.Arg188Trp
rs17071550 - p.Met148Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SERPINB11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SERPINB11 Gene

Variant ID Type Subtype PubMed ID
dgv995e212 CNV loss 25503493
esv21739 CNV gain 19812545
esv3642781 CNV gain 21293372
nsv1066552 CNV gain 25217958
nsv833672 CNV gain 17160897

Additional Variant Information for SERPINB11 Gene

Human Gene Mutation Database (HGMD)
SERPINB11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINB11

SNP Genotyping and Copy Number Assays for research

No data available for Variation tolerance for SERPINB11 Gene

Disorders for SERPINB11 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SERPINB11 Gene - From: COP

Disorder Aliases PubMed IDs
endometrioid ovary carcinoma
  • endometrioid carcinoma of ovary
ovarian endometrial cancer
  • endometrioid neoplasm of ovary
osteogenesis imperfecta, type vi
  • oi6
spherocytosis, type 2
  • sph2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERPINB11

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SERPINB11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB11 Gene

Publications for SERPINB11 Gene

  1. SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change. (PMID: 17562709) Askew DJ … Silverman GA (The Journal of biological chemistry 2007) 2 3 4
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

ExternalLinks

View latest publications for SERPINB11 gene in Mastermind

Products for SERPINB11 Gene

Sources for SERPINB11 Gene