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This gene is a member of the serpin peptidase inhibitor, clade B family and is found in a cluster of other similar genes on chromosome 18. The protein encoded by this gene appears to help control the regulation of protease functions during hematopoiesis. Variations in this gene may increase the risk of prostate cancer. [provided by RefSeq, Dec 2015]
SERPINB10 (Serpin Family B Member 10) is a Protein Coding gene. Diseases associated with SERPINB10 include Chronic Myelomonocytic Leukemia. Among its related pathways are Innate Immune System and Amoebiasis. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004867 | serine-type endopeptidase inhibitor activity | TAS,IBA | 21873635 |
GO:0030414 | peptidase inhibitor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Amoebiasis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010466 | negative regulation of peptidase activity | IEA | -- |
GO:0010951 | negative regulation of endopeptidase activity | IBA | 21873635 |
GO:0043066 | negative regulation of apoptotic process | IEA | -- |
GO:0043312 | neutrophil degranulation | TAS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SERPINB10 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SERPINB10 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SERPINB10 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Serpinb10 30 17 31 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Serpinb10 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SERPINB10 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LOC101749622 30 |
|
||
-- 31 |
|
OneToMany | |||
SERPINB10 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | SERPINB10 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | serpinb1l1 31 |
|
ManyToMany | |
serpinb1l4 31 |
|
ManyToMany | |||
zgc:173729 31 |
|
ManyToMany | |||
si:ch73-303g23.4 31 |
|
ManyToMany | |||
serpinb1l3 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Spn4 32 |
|
|
|
CG9455 32 |
|
|
|||
Spn2 32 |
|
|
|||
Spn3 32 |
|
|
|||
Spn43Aa 32 |
|
|
|||
nec 32 |
|
|
SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17072097 | - |
p.Ser3Ala |
|||
rs17072146 | - |
p.Gly135Asp |
|||
rs35453062 | - |
p.Asp360Asn |
|||
rs724558 | - |
p.Ile99Thr |
|||
rs8097425 | - |
p.Ile41Met |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv21739 | CNV | gain | 19812545 |
esv2758730 | CNV | loss | 17122850 |
esv3642785 | CNV | gain | 21293372 |
esv3642788 | CNV | gain | 21293372 |
nsv1066552 | CNV | gain | 25217958 |
nsv1067311 | CNV | loss | 25217958 |
nsv525889 | CNV | loss | 19592680 |
nsv833673 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
chronic myelomonocytic leukemia |
|
|