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Aliases for SERPINB10 Gene

Aliases for SERPINB10 Gene

  • Serpin Family B Member 10 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 10 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 10 2 3
  • Protease Inhibitor 10 (Ovalbumin Type, Bomapin) 2 3
  • Peptidase Inhibitor 10 3 4
  • Bomapin 3 4
  • PI-10 3 4
  • PI10 3 4
  • Serpin B10 3

External Ids for SERPINB10 Gene

Previous HGNC Symbols for SERPINB10 Gene

  • PI10

Previous GeneCards Identifiers for SERPINB10 Gene

  • GC18P061421
  • GC18P061556
  • GC18P061367
  • GC18P059731
  • GC18P059733
  • GC18P058283

Summaries for SERPINB10 Gene

Entrez Gene Summary for SERPINB10 Gene

  • This gene is a member of the serpin peptidase inhibitor, clade B family and is found in a cluster of other similar genes on chromosome 18. The protein encoded by this gene appears to help control the regulation of protease functions during hematopoiesis. Variations in this gene may increase the risk of prostate cancer. [provided by RefSeq, Dec 2015]

GeneCards Summary for SERPINB10 Gene

SERPINB10 (Serpin Family B Member 10) is a Protein Coding gene. Among its related pathways are Innate Immune System and Amoebiasis. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB2.

UniProtKB/Swiss-Prot for SERPINB10 Gene

  • Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.

Additional gene information for SERPINB10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB10 Gene

Genomics for SERPINB10 Gene

GeneHancer (GH) Regulatory Elements for SERPINB10 Gene

Promoters and enhancers for SERPINB10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I063896 Enhancer 0.4 dbSUPER 575.3 +0.3 329 1 POLR2A HLF SERPINB10 SERPINB2 HMSD
GH18I063968 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 27.7 +73.5 73501 3.4 HDGF PKNOX1 ATF1 SIN3A DMAP1 ZNF48 YY1 ETS1 GLIS2 ELK1 SERPINB8 LOC105372165 SERPINB10 HMSD RPL12P39
GH18I063889 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 27.1 -5.8 -5814 3.7 CTCF GATA3 POLR2A ZNF143 CEBPB EP300 RAD21 SERPINB2 SERPINB10
GH18I063935 Enhancer 1.2 Ensembl ENCODE dbSUPER 31.3 +39.4 39400 1.7 ELF3 RB1 BATF IRF4 RAD21 GLIS2 SCRT2 ZNF143 ETV6 BCLAF1 SERPINB10 SERPINB8 HMSD
GH18I063878 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 26.5 -16.1 -16097 6 MXI1 JUN MAX CEBPG EBF1 BATF RFX5 NFATC1 RCOR1 ETV6 SERPINB2 SERPINB10 SERPINB8 VPS4B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERPINB10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERPINB10 gene promoter:

Genomic Locations for SERPINB10 Gene

Genomic Locations for SERPINB10 Gene
chr18:63,897,174-63,936,111
(GRCh38/hg38)
Size:
38,938 bases
Orientation:
Plus strand
chr18:61,564,408-61,603,345
(GRCh37/hg19)

Genomic View for SERPINB10 Gene

Genes around SERPINB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB10 Gene

Proteins for SERPINB10 Gene

  • Protein details for SERPINB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48595-SPB10_HUMAN
    Recommended name:
    Serpin B10
    Protein Accession:
    P48595
    Secondary Accessions:
    • Q4VAX4
    • Q4VAX7

    Protein attributes for SERPINB10 Gene

    Size:
    397 amino acids
    Molecular mass:
    45403 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERPINB10 Gene

Post-translational modifications for SERPINB10 Gene

No Post-translational modifications

Other Protein References for SERPINB10 Gene

No data available for DME Specific Peptides for SERPINB10 Gene

Domains & Families for SERPINB10 Gene

Gene Families for SERPINB10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SERPINB10 Gene

Suggested Antigen Peptide Sequences for SERPINB10 Gene

Graphical View of Domain Structure for InterPro Entry

P48595

UniProtKB/Swiss-Prot:

SPB10_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB10: view

Function for SERPINB10 Gene

Molecular function for SERPINB10 Gene

UniProtKB/Swiss-Prot Function:
Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.

Phenotypes From GWAS Catalog for SERPINB10 Gene

Gene Ontology (GO) - Molecular Function for SERPINB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB10: view
genes like me logo Genes that share phenotypes with SERPINB10: view

Animal Model Products

miRNA for SERPINB10 Gene

miRTarBase miRNAs that target SERPINB10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERPINB10 Gene

Localization for SERPINB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB10 Gene

Nucleus. Cytoplasm. Note=Mostly found in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB10 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 4
lysosome 1

Gene Ontology (GO) - Cellular Components for SERPINB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005634 nucleus IDA,IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SERPINB10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINB10 Gene

Pathways & Interactions for SERPINB10 Gene

genes like me logo Genes that share pathways with SERPINB10: view

Pathways by source for SERPINB10 Gene

3 Reactome pathways for SERPINB10 Gene
1 KEGG pathway for SERPINB10 Gene

Gene Ontology (GO) - Biological Process for SERPINB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with SERPINB10: view

No data available for SIGNOR curated interactions for SERPINB10 Gene

Drugs & Compounds for SERPINB10 Gene

(1) Drugs for SERPINB10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SERPINB10: view

Transcripts for SERPINB10 Gene

mRNA/cDNA for SERPINB10 Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINB10 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB10 Gene

No ASD Table

Relevant External Links for SERPINB10 Gene

GeneLoc Exon Structure for
SERPINB10
ECgene alternative splicing isoforms for
SERPINB10

Expression for SERPINB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB10 Gene

This gene is overexpressed in Whole Blood (x21.6).

Protein differential expression in normal tissues from HIPED for SERPINB10 Gene

This gene is overexpressed in Monocytes (27.3), Peripheral blood mononuclear cells (19.9), and Neutrophil (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINB10 Gene



Protein tissue co-expression partners for SERPINB10 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERPINB10 Gene:

SERPINB10

SOURCE GeneReport for Unigene cluster for SERPINB10 Gene:

Hs.158339

mRNA Expression by UniProt/SwissProt for SERPINB10 Gene:

P48595-SPB10_HUMAN
Tissue specificity: Expressed specifically in myeloid cells and the bone marrow.

Evidence on tissue expression from TISSUES for SERPINB10 Gene

  • Bone marrow(4.4)
genes like me logo Genes that share expression patterns with SERPINB10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB10 Gene

Orthologs for SERPINB10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB10 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINB10 33 34
  • 85.98 (n)
dog
(Canis familiaris)
Mammalia SERPINB10 33 34
  • 84.89 (n)
mouse
(Mus musculus)
Mammalia Serpinb10 33 16 34 34
  • 80.39 (n)
rat
(Rattus norvegicus)
Mammalia Serpinb10 33
  • 79.51 (n)
oppossum
(Monodelphis domestica)
Mammalia SERPINB10 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101749622 33
  • 61.7 (n)
-- 34
  • 49 (a)
OneToMany
SERPINB10 34
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SERPINB10 34
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii serpinb1l1 34
  • 49 (a)
ManyToMany
serpinb1l4 34
  • 44 (a)
ManyToMany
zgc:173729 34
  • 43 (a)
ManyToMany
serpinb1l3 34
  • 42 (a)
ManyToMany
si:ch73-303g23.4 34
  • 42 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Spn4 35
  • 34 (a)
CG9455 35
  • 32 (a)
Spn2 35
  • 31 (a)
Spn3 35
  • 31 (a)
Spn43Aa 35
  • 29 (a)
nec 35
  • 26 (a)
Species where no ortholog for SERPINB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINB10 Gene

ENSEMBL:
Gene Tree for SERPINB10 (if available)
TreeFam:
Gene Tree for SERPINB10 (if available)

Paralogs for SERPINB10 Gene

Variants for SERPINB10 Gene

Sequence variations from dbSNP and Humsavar for SERPINB10 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000102140 -- 63,912,632(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000225277 -- 63,927,643(+) G/T intron_variant
rs1000310770 -- 63,907,532(+) G/A/C upstream_transcript_variant
rs1000353850 -- 63,932,494(+) A/G/T intron_variant
rs1000406137 -- 63,932,857(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINB10 Gene

Variant ID Type Subtype PubMed ID
nsv833673 CNV gain 17160897
nsv525889 CNV loss 19592680
nsv1067311 CNV loss 25217958
nsv1066552 CNV gain 25217958
esv3642788 CNV gain 21293372
esv3642785 CNV gain 21293372
esv2758730 CNV loss 17122850
esv21739 CNV gain 19812545

Variation tolerance for SERPINB10 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.91; 99.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINB10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB10 Gene

Disorders for SERPINB10 Gene

Additional Disease Information for SERPINB10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SERPINB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINB10 Gene

Publications for SERPINB10 Gene

  1. Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence for the formation of intracellular high M(r) protease inhibitor 10-containing complexes. (PMID: 10871600) Schleef RR … Chuang TL (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. Bomapin is a redox-sensitive nuclear serpin that affects responsiveness of myeloid progenitor cells to growth environment. (PMID: 20433722) Przygodzka P … Wilczynska M (BMC cell biology 2010) 3 4 22 58
  3. Nucleotide variations in genes encoding plasminogen activator inhibitor-2 and serine proteinase inhibitor B10 associated with prostate cancer. (PMID: 16172807) Shioji G … Emi M (Journal of human genetics 2005) 3 22 44 58
  4. Identification of a nuclear targeting domain in the insertion between helices C and D in protease inhibitor-10. (PMID: 10196205) Chuang TL … Schleef RR (The Journal of biological chemistry 1999) 3 4 22 58
  5. Molecular cloning of bomapin (protease inhibitor 10), a novel human serpin that is expressed specifically in the bone marrow. (PMID: 7592909) Riewald M … Schleef RR (The Journal of biological chemistry 1995) 3 4 22 58

Products for SERPINB10 Gene

Sources for SERPINB10 Gene

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